TDR Targets

Basic information

Technical information

TDR Targets ID: 1380999
Name: N-(3-furan-2-yl-4-methylpentyl)-N-[(4-propan- 2-yloxyphenyl)methyl]acetamide
MW: 357.486 | Formula: C22H31NO3
H donors: 0 H acceptors: 1 LogP: 4.53 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CC(Oc1ccc(cc1)CN(C(=O)C)CCC(c1ccco1)C(C)C)C
InChi: 1S/C22H31NO3/c1-16(2)21(22-7-6-14-25-22)12-13-23(18(5)24)15-19-8-10-20(11-9-19)26-17(3)4/h6-11,14,16-17,21H,12-13,15H2,1-5H3
InChiKey: WZZSCTHMUHIZED-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[3-(2-furyl)-4-methyl-pentyl]-N-[(4-isopropoxyphenyl)methyl]acetamide
N-[3-(2-furyl)-4-methylpentyl]-N-[(4-isopropoxyphenyl)methyl]acetamide
N-[3-(2-furyl)-4-methyl-pentyl]-N-(4-isopropoxybenzyl)acetamide
N-(3-furan-2-yl-4-methyl-pentyl)-N-[(4-propan-2-yloxyphenyl)methyl]ethanamide
MLS000332208
N-(3-Furan-2-yl-4-methyl-pentyl)-N-(4-isopropoxy-benzyl)-acetamide
SMR000434906

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	neuropeptide S receptor 1	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Get druggable targets OG5_136011	All targets in OG5_136011
Echinococcus multilocularis	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Echinococcus granulosus	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Echinococcus multilocularis	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Echinococcus granulosus	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0018	0.0089	0.0214
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0229	0.0549
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0018	0.0089	0.0214
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0229	0.0549
Brugia malayi	Proteasome A-type and B-type family protein	0.0018	0.0089	0.0214
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0018	0.0089	0.0089
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0018	0.0089	0.0214
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0018	0.0089	0.0089
Trypanosoma brucei	proteasome beta 6 subunit	0.0018	0.0089	0.0214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Echinococcus multilocularis	neuropeptide receptor A26	0.0558	1	1
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0018	0.0089	0.0214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0018	0.0089	0.0214
Echinococcus multilocularis	cysteine protease	0.0026	0.0229	0.0229
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0018	0.0089	0.0214
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0018	0.0089	0.0214
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0229	0.0549
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0106	0.0253
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0106	0.0106
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0018	0.0089	0.0214
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0018	0.0089	0.0089
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0229	1
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0018	0.0089	0.0214
Onchocerca volvulus		0.0026	0.0229	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0241	0.4177	1
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0018	0.0089	0.0214
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0018	0.0089	0.0214
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0018	0.0089	0.0214
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0018	0.0089	0.0214
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0018	0.0089	0.0214
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0018	0.0089	0.0214
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0018	0.0089	0.0214
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0018	0.0089	0.5
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0018	0.0089	0.004
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0229	0.0549
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0018	0.0089	0.0089
Echinococcus granulosus	proteasome subunit alpha type 6	0.0018	0.0089	0.0089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0229	0.0549
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0018	0.0089	0.0214
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0229	0.0549
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0018	0.0089	0.004
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0018	0.0089	0.0214
Brugia malayi	proteasome subunit alpha type 1	0.0018	0.0089	0.0214
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0018	0.0089	0.004
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0018	0.0089	0.0214
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0018	0.0089	0.0089
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0018	0.0089	0.0214
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0018	0.0089	0.0214
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0229	0.0229
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0018	0.0089	0.004
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0018	0.0089	0.0089
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0018	0.0089	0.004
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0018	0.0089	0.0214
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0018	0.0089	0.0214
Schistosoma mansoni	hypothetical protein	0.0019	0.0106	0.0253
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0018	0.0089	0.0214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0229	0.0549
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0018	0.0089	0.0214
Toxoplasma gondii	cathepsin CPL	0.0026	0.0229	0.0343
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0229	0.0549
Trypanosoma brucei	proteasome beta 7 subunit	0.0018	0.0089	0.0214
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0229	0.0549
Echinococcus multilocularis	neuropeptide s receptor	0.0558	1	1
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0018	0.0089	0.004
Toxoplasma gondii	proteasome subunit beta type, putative	0.0241	0.4177	1
Echinococcus granulosus	proteasome subunit beta t family	0.0018	0.0089	0.0089
Trypanosoma cruzi	20S proteasome subunit	0.0018	0.0089	0.0214
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0229	0.0549
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0018	0.0089	0.0214
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0241	0.4177	1
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0073	0.0175
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0229	0.0549
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0018	0.0089	0.0214
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0018	0.0089	0.0214
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0229	0.0549
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0229	0.0549
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0018	0.0089	0.0214
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0018	0.0089	0.0214
Plasmodium vivax	vivapain-2	0.0026	0.0229	0.0549
Brugia malayi	20S proteasome alpha5 subunit	0.0018	0.0089	0.0214
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0229	0.0549
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0073	0.0175
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0018	0.0089	0.0214
Echinococcus granulosus	Proteasome subunit alpha beta	0.0018	0.0089	0.0089
Schistosoma mansoni	hypothetical protein	0.0019	0.0106	0.0253
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0229	0.0549
Leishmania major	cathepsin L-like protease	0.0026	0.0229	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0106	0.0079
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0018	0.0089	0.0214
Leishmania major	cathepsin L-like protease	0.0026	0.0229	0.0343
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0018	0.0089	0.0214
Loa Loa (eye worm)	PAS-3 protein	0.0018	0.0089	0.004
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0018	0.0089	0.0214
Leishmania major	cathepsin L-like protease	0.0026	0.0229	0.0343
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0018	0.0089	0.0089
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0018	0.0089	0.0214
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0018	0.0089	0.0214
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0018	0.0089	0.0214
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0018	0.0089	0.0214
Onchocerca volvulus		0.0026	0.0229	1
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0018	0.0089	0.0214
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0018	0.0089	0.0214
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0018	0.0089	0.0214
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0018	0.0089	0.0214
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0018	0.0089	0.0214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0229	0.0549
Leishmania major	cysteine peptidase A (CPA)	0.0026	0.0229	0.0343
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0018	0.0089	0.0214
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0229	0.0549
Schistosoma mansoni	hypothetical protein	0.0019	0.0106	0.0253
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0229	0.0549
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0018	0.0089	0.0214
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0018	0.0089	0.0214
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0018	0.0089	0.0214
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0229	0.0549
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0018	0.0089	0.0214
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0018	0.0089	0.0089
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0018	0.0089	0.0214
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0229	0.0549
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0018	0.0089	0.0214
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0018	0.0089	0.0214
Echinococcus multilocularis	proteasome subunit beta type 7	0.0018	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0229	0.0381
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0018	0.0089	0.0214
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0229	0.0229
Echinococcus multilocularis	proteasome subunit beta type 6	0.0018	0.0089	0.0089
Brugia malayi	Proteasome A-type and B-type family protein	0.0018	0.0089	0.0214
Onchocerca volvulus	Notchless protein homolog	0.0018	0.0089	0.1044
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0073	0.0175
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0106	0.0106
Echinococcus granulosus	proteasome subunit beta type 6	0.0018	0.0089	0.0089
Trypanosoma brucei	proteasome alpha 7 subunit	0.0018	0.0089	0.0214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0229	0.0549
Brugia malayi	Proteasome A-type and B-type family protein	0.0241	0.4177	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0106	0.0106
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0018	0.0089	0.0089
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0018	0.0089	0.0214
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0511	0.1224
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0229	0.0549
Brugia malayi	Proteasome subunit alpha type 7-1	0.0018	0.0089	0.0214
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0018	0.0089	0.0214
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0018	0.0089	0.0214
Onchocerca volvulus	Cathepsin F homolog	0.0026	0.0229	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0018	0.0089	0.0214
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0106	0.0079
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0018	0.0089	0.0214
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0018	0.0089	0.004
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0106	0.0106
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0018	0.0089	0.0214
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.0229	0.0229
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0018	0.0089	0.0089
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0018	0.0089	0.0089
Brugia malayi	proteasome subunit beta type 3	0.0018	0.0089	0.0214
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0018	0.0089	0.0214
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0018	0.0089	0.0214
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0018	0.0089	0.0214
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0241	0.4177	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0018	0.0089	0.0214
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.0229	0.0381
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0018	0.0089	0.0214
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0229	0.0549
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0026	0.0229	0.0549
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0229	0.0549
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0018	0.0089	0.0214
Onchocerca volvulus		0.0026	0.0229	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0511	0.1224
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0018	0.0089	0.0214
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0018	0.0089	0.0214
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0018	0.0089	0.0214
Onchocerca volvulus		0.0026	0.0229	1
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0018	0.0089	0.004
Brugia malayi	Proteasome A-type and B-type family protein	0.0018	0.0089	0.0214
Loa Loa (eye worm)	cysteine protease	0.0026	0.0229	0.0381
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0229	0.0549
Echinococcus granulosus	proteasome subunit beta type 7	0.0018	0.0089	0.0089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0229	0.0549
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.086	0.206
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0018	0.0089	0.0214
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0018	0.0089	0.0089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0229	0.0549
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0018	0.0089	0.0089
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0018	0.0089	0.0214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0018	0.0089	0.0214
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0018	0.0089	0.0214
Onchocerca volvulus		0.0026	0.0229	1
Plasmodium falciparum	proteasome subunit beta type-5	0.0241	0.4177	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0511	0.1068
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0241	0.4177	0.4177
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0018	0.0089	0.0214
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0018	0.0089	0.0214
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0018	0.0089	0.0214
Echinococcus granulosus	cathepsin l1	0.0026	0.0229	0.0229
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0018	0.0089	0.0214
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0018	0.0089	0.0214
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0229	0.0549
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.0229	0.0229
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0241	0.4177	1
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0073	0.0175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Loa Loa (eye worm)	hypothetical protein	0.006	0.086	0.1919
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0018	0.0089	0.0214
Leishmania major	cathepsin L-like protease	0.0026	0.0229	0.0343
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0018	0.0089	0.004
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0229	0.0381
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0018	0.0089	0.0214
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0018	0.0089	0.0214
Leishmania major	proteasome beta 5 subunit, putative	0.0241	0.4177	1
Brugia malayi	proteasome subunit beta type 2	0.0018	0.0089	0.0214
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0018	0.0089	0.0214
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0018	0.0089	0.0089
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0018	0.0089	0.0089
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0018	0.0089	0.004
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0018	0.0089	0.0214
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0229	0.0229
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0018	0.0089	0.0214
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0017	0.0073	0.0175
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0229	0.0549
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0229	0.0549
Leishmania major	cathepsin L-like protease	0.0026	0.0229	0.0343
Onchocerca volvulus		0.0026	0.0229	1
Echinococcus granulosus	neuropeptide receptor A26	0.0558	1	1
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0018	0.0089	0.0214
Brugia malayi	cathepsin L-like precursor	0.0017	0.0073	0.0175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0018	0.0089	0.0214
Mycobacterium ulcerans	proteasome PrcB	0.0241	0.4177	1
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0018	0.0089	0.0214
Onchocerca volvulus		0.0026	0.0229	1
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0018	0.0089	0.004
Loa Loa (eye worm)	fibroinase	0.0026	0.0229	0.0381
Echinococcus granulosus	GPCR family 2	0.0019	0.0106	0.0106
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0241	0.4177	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0018	0.0089	0.0214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0073	0.0175
Leishmania major	cathepsin L-like protease	0.0026	0.0229	0.0343
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0229	0.0549
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0018	0.0089	0.0214
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0106	0.0106
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0241	0.4177	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0017	0.0073	0.0175
Brugia malayi	proteasome subunit alpha type 6	0.0018	0.0089	0.0214
Brugia malayi	proteasome subunit beta type 1	0.0018	0.0089	0.0214
Plasmodium falciparum	proteasome subunit beta type-4	0.0018	0.0089	0.0214
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0018	0.0089	0.0214
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0229	0.0549
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.086	0.1919
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0018	0.0089	0.0214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Brugia malayi	proteasome subunit alpha type 4	0.0018	0.0089	0.0214
Echinococcus granulosus	proteasome prosome macropain	0.0241	0.4177	0.4177
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0018	0.0089	0.0214
Brugia malayi	Proteasome subunit alpha type 1	0.0018	0.0089	0.0214
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0018	0.0089	0.0214
Echinococcus multilocularis	cysteine protease	0.0026	0.0229	0.0229
Trypanosoma cruzi	cruzipain precursor, putative	0.0026	0.0229	0.0549
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0229	0.0549
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0018	0.0089	0.0214
Leishmania major	cathepsin L-like protease	0.0026	0.0229	0.0343
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0229	0.0229
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0018	0.0089	0.0214
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0018	0.0089	0.0089
Brugia malayi	proteasome subunit alpha type 3	0.0018	0.0089	0.0214
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0018	0.0089	0.0214
Loa Loa (eye worm)	ctsf protein	0.0026	0.0229	0.0381
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0241	0.4177	1
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0018	0.0089	0.0214
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0229	0.0549
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0018	0.0089	0.0214
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0018	0.0089	0.0214
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0018	0.0089	0.0089
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0018	0.0089	0.0214
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0026	0.0229	0.0549
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0018	0.0089	0.0214
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0026	0.0229	0.0549
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0106	0.0253
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0229	0.0549
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0229	0.0549
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0018	0.0089	0.0214
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0241	0.4177	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0106	0.0253
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0018	0.0089	0.0214
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0018	0.0089	0.0214
Plasmodium vivax	vivapain-2	0.0026	0.0229	0.0549
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0229	1
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0018	0.0089	0.0089
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0018	0.0089	0.0214
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0241	0.4177	1
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0241	0.4177	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0229	0.0549
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0018	0.0089	0.0214
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0241	0.4177	1
Brugia malayi	proteasome subunit alpha type 2	0.0018	0.0089	0.0214
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0018	0.0089	0.0214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0018	0.0089	0.0214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0229	0.0549
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0018	0.0089	0.0089
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0018	0.0089	0.004
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0018	0.0089	0.0089
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0018	0.0089	0.0214
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0018	0.0089	0.0214
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0229	0.0549
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0018	0.0089	0.0214
Echinococcus granulosus	cathepsin l1	0.0017	0.0073	0.0073
Echinococcus granulosus	proteasome subunit alpha type 2	0.0018	0.0089	0.0089
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.086	0.206
Leishmania major	cathepsin L-like protease	0.0026	0.0229	0.0343
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0018	0.0089	0.0214
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0018	0.0089	0.0214
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0073	0.0175
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0018	0.0089	0.0214
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0018	0.0089	0.0214

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 44.6684 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1508985

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1380999