Detailed information for compound 1381010

Basic information

Technical information
  • TDR Targets ID: 1381010
  • Name: 3-(4-fluorophenyl)-8-(4-methyl-6-pyrrolidin-1 -ylpyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3 -ol
  • MW: 382.474 | Formula: C22H27FN4O
  • H donors: 1 H acceptors: 3 LogP: 3.88 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc(nc(c1)N1CCCC1)N1C2CCC1CC(C2)(O)c1ccc(cc1)F
  • InChi: 1S/C22H27FN4O/c1-15-12-20(26-10-2-3-11-26)25-21(24-15)27-18-8-9-19(27)14-22(28,13-18)16-4-6-17(23)7-5-16/h4-7,12,18-19,28H,2-3,8-11,13-14H2,1H3
  • InChiKey: GLAILRRRRZFJII-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-fluorophenyl)-8-(4-methyl-6-pyrrolidin-1-yl-pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-ol
  • 3-(4-fluorophenyl)-8-(4-methyl-6-1-pyrrolidinyl-2-pyrimidinyl)-8-azabicyclo[3.2.1]octan-3-ol
  • ASN 07480427
  • MLS000710201
  • SMR000287368

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.181 0.181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.181 0.181
Plasmodium falciparum cysteine proteinase falcipain 3 0.0024 0.181 0.181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Brugia malayi Cathepsin L-like precursor 0.0016 0.0576 0.0576
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.1585 0.1585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.181 0.181
Onchocerca volvulus 0.0024 0.181 0.4876
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0033 0.3106 0.281
Plasmodium vivax proteasome subunit beta type-5, putative 0.0077 1 1
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0077 1 1
Onchocerca volvulus 0.0024 0.181 0.4876
Leishmania major cysteine peptidase A (CPA) 0.0024 0.181 0.0267
Loa Loa (eye worm) ctsf protein 0.0024 0.181 0.1457
Echinococcus granulosus cathepsin l cysteine peptidase 0.0024 0.181 0.181
Onchocerca volvulus 0.0033 0.3106 1
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.181 0.181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0576 0.0576
Echinococcus multilocularis cysteine protease 0.0024 0.181 0.181
Onchocerca volvulus 0.0024 0.181 0.4876
Echinococcus granulosus proteasome prosome macropain 0.0077 1 1
Onchocerca volvulus 0.0024 0.181 0.4876
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.181 0.181
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.181 0.181
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.181 0.181
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.181 0.181
Toxoplasma gondii proteasome subunit beta type, putative 0.0077 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0024 0.181 0.181
Echinococcus multilocularis lamin dm0 0.0033 0.3106 0.3106
Brugia malayi Cathepsin L-like precursor 0.0024 0.181 0.181
Loa Loa (eye worm) hypothetical protein 0.0016 0.0576 0.017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0576 0.017
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.1585 0.1585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.181 0.181
Onchocerca volvulus 0.0024 0.181 0.4876
Echinococcus multilocularis cathepsin L cysteine protease 0.0024 0.181 0.181
Plasmodium vivax vivapain-2 0.0024 0.181 0.181
Schistosoma mansoni ap endonuclease 0.0023 0.1585 0.1585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.181 0.181
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0077 1 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Leishmania major cathepsin L-like protease 0.0024 0.181 0.0267
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.181 0.181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.181 0.181
Plasmodium falciparum proteasome subunit beta type-5 0.0077 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.1585 0.1585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.1585 0.1585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.181 0.181
Echinococcus granulosus intermediate filament protein 0.0033 0.3106 0.3106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.181 0.181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0077 1 1
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0077 1 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.1585 0.1585
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0024 0.181 0.181
Brugia malayi cathepsin L-like precursor 0.0016 0.0576 0.0576
Brugia malayi Cathepsin L-like precursor 0.0024 0.181 0.181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.181 0.181
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0576 0.0576
Brugia malayi Cathepsin L-like precursor 0.0024 0.181 0.181
Mycobacterium ulcerans proteasome PrcB 0.0077 1 1
Echinococcus multilocularis lamin 0.0033 0.3106 0.3106
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.3106 0.3106
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0576 0.0576
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.181 0.181
Echinococcus granulosus lamin dm0 0.0033 0.3106 0.3106
Schistosoma mansoni ap endonuclease 0.0023 0.1585 0.1585
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.1585 0.5
Leishmania major cathepsin L-like protease 0.0024 0.181 0.0267
Trypanosoma cruzi cruzipain precursor, putative 0.0024 0.181 0.181
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0024 0.181 0.1457
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0077 1 1
Brugia malayi Cathepsin L-like precursor 0.0024 0.181 0.181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.181 0.181
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0771 0.0375
Leishmania major cathepsin L-like protease 0.0024 0.181 0.0267
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.3106 0.281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Onchocerca volvulus Cathepsin L homolog 0.0024 0.181 0.4876
Echinococcus granulosus lamin 0.0033 0.3106 0.3106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.181 0.181
Echinococcus multilocularis cathepsin L cysteine protease 0.0024 0.181 0.181
Onchocerca volvulus 0.0033 0.3106 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.181 0.181
Brugia malayi Cathepsin L-like cysteine proteinase 0.0016 0.0576 0.0576
Echinococcus multilocularis proteasome (prosome, macropain) 0.0077 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0576 0.017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0504 0.0096
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0077 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Loa Loa (eye worm) fibroinase 0.0024 0.181 0.1457
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0576 0.0576
Leishmania major proteasome beta 5 subunit, putative 0.0077 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.181 0.181
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.1585 0.1585
Echinococcus multilocularis cysteine protease 0.0024 0.181 0.181
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0024 0.181 0.181
Echinococcus granulosus cathepsin l1 0.0016 0.0576 0.0576
Brugia malayi intermediate filament protein 0.0033 0.3106 0.3106
Leishmania major cathepsin L-like protease 0.0024 0.181 0.0267
Loa Loa (eye worm) cysteine protease 0.0024 0.181 0.1457
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.181 0.181
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.181 0.181
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.1585 0.1585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Plasmodium vivax vivapain-2 0.0024 0.181 0.181
Onchocerca volvulus 0.0024 0.181 0.4876
Entamoeba histolytica cysteine protease, putative 0.0024 0.181 0.181
Leishmania major cathepsin L-like protease 0.0024 0.181 0.0267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.181 0.181
Schistosoma mansoni intermediate filament proteins 0.0033 0.3106 0.3106
Loa Loa (eye worm) hypothetical protein 0.0024 0.181 0.1457
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0016 0.0576 0.0576
Brugia malayi Cathepsin L-like precursor 0.0024 0.181 0.181
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0077 1 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0504 0.0504
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0024 0.181 0.181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.1585 0.1585
Leishmania major cathepsin L-like protease 0.0024 0.181 0.0267
Brugia malayi Cathepsin L-like precursor 0.0016 0.0576 0.0576
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0077 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.1585 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.181 0.181
Onchocerca volvulus 0.0024 0.181 0.4876
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.181 0.181
Echinococcus granulosus cathepsin l1 0.0024 0.181 0.181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.181 0.181
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.1585 0.1223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.181 0.181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.181 0.181
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.1585 0.1585
Loa Loa (eye worm) hypothetical protein 0.0032 0.3014 0.2714
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0771 0.0771
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0024 0.181 0.181
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0077 1 1
Leishmania major cathepsin L-like protease 0.0024 0.181 0.0267
Loa Loa (eye worm) intermediate filament protein 0.0033 0.3106 0.281
Onchocerca volvulus Cathepsin L homolog 0.0024 0.181 0.4876
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.181 0.181
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0024 0.181 0.181
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.1585 0.1585
Schistosoma mansoni lamin 0.0033 0.3106 0.3106
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0024 0.181 0.1457
Leishmania major cathepsin L-like protease 0.0024 0.181 0.0267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.181 0.181
Toxoplasma gondii cathepsin CPL 0.0024 0.181 0.0267
Schistosoma mansoni lamin 0.0033 0.3106 0.3106
Echinococcus multilocularis musashi 0.0033 0.3106 0.3106
Onchocerca volvulus Cathepsin F homolog 0.0024 0.181 0.4876
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.1585 0.1585
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0024 0.181 0.181
Brugia malayi Cathepsin L-like precursor 0.0024 0.181 0.181
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0077 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3294 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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