Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0112 | 0.0511 | 0.0511 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0709 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0709 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0709 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0511 | 0.0222 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0112 | 0.0511 | 0.0511 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0709 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0338 | 0.4097 | 0.3917 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0709 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0338 | 0.4097 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0709 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0709 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0709 | 1 | 1 |
Onchocerca volvulus | 0.0709 | 1 | 0.5 | |
Mycobacterium ulcerans | thymidylate synthase | 0.0709 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0709 | 1 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0112 | 0.0511 | 0.0511 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0098 | 0.0296 | 0.0296 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0709 | 1 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0098 | 0.0296 | 0.0296 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0112 | 0.0511 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0709 | 1 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0112 | 0.0511 | 0.0511 |
Echinococcus granulosus | thymidylate synthase | 0.0709 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Hydrolysis (functional) | < 0.05 | Susceptibility to be hydrolysed by a partially purified cAMP phosphodiesterase from rabbit kidney | ChEMBL. | 6245211 |
I50 (binding) | = 11 uM | Inhibition of cAMP phosphodiesterase preparation from bovine heart at a substrate concentration of 0.14 microM | ChEMBL. | 6245211 |
I50 (binding) | = 25 uM | Inhibition of cAMP phosphodiesterase preparation from rabbit lung at a substrate concentration of 0.14 microM | ChEMBL. | 6245211 |
Ka' (binding) | = 0.71 | Activate a partially purified type II cAMP-dependent protein kinase from bovine brain | ChEMBL. | 6245211 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.