Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (17-beta) dehydrogenase 10 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | hydroxysteroid (17-beta) dehydrogenase 10 | 252 aa | 251 aa | 24.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2676 | 0.2463 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0074 | 1 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2676 | 0.2463 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7568 | 0.7568 |
Onchocerca volvulus | 0.0033 | 0.2676 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4196 | 0.5026 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2676 | 0.3206 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0284 | 0.0284 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2676 | 0.2463 |
Schistosoma mansoni | lamin | 0.0033 | 0.2676 | 0.2463 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2676 | 0.2676 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0074 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.2676 | 0.2463 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0284 | 0.034 |
Onchocerca volvulus | 0.0033 | 0.2676 | 0.5 | |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0074 | 1 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 0.2676 | 0.2463 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2676 | 0.3206 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.4196 | 0.4196 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2676 | 0.2463 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0074 | 1 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2676 | 0.2676 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0065 | 0.8349 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0074 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2571 | 0.3079 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.2676 | 0.2463 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0074 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.4196 | 0.4027 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0284 | 0.0284 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7568 | 0.9065 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0284 | 0.034 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7568 | 0.7568 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7568 | 0.9065 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2676 | 0.2463 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2676 | 0.3206 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.