Detailed information for compound 1381642

Basic information

Technical information
  • TDR Targets ID: 1381642
  • Name: 2-[(2,5-dimethylphenyl)-methylsulfonylamino]- N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]ac etamide
  • MW: 420.589 | Formula: C21H28N2O3S2
  • H donors: 1 H acceptors: 3 LogP: 3.65 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)C)c1cc(C)ccc1C)NCCSCc1ccc(cc1)C
  • InChi: 1S/C21H28N2O3S2/c1-16-6-9-19(10-7-16)15-27-12-11-22-21(24)14-23(28(4,25)26)20-13-17(2)5-8-18(20)3/h5-10,13H,11-12,14-15H2,1-4H3,(H,22,24)
  • InChiKey: XRLAWBUXPSSHEO-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[(2,5-dimethylphenyl)-methylsulfonyl-amino]-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide
  • 2-[(2,5-dimethylphenyl)-methylsulfonylamino]-N-[2-[(4-methylphenyl)methylthio]ethyl]acetamide
  • 2-[(2,5-dimethylphenyl)-mesyl-amino]-N-[2-[(4-methylbenzyl)thio]ethyl]acetamide
  • 2-[(2,5-dimethylphenyl)-methylsulfonyl-amino]-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]ethanamide
  • MLS000676566
  • N~2~-(2,5-dimethylphenyl)-N~1~-{2-[(4-methylbenzyl)thio]ethyl}-N~2~-(methylsulfonyl)glycinamide
  • SMR000298459
  • ZINC02937458

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0614 0.0432 1
Loa Loa (eye worm) proprotein convertase 2 0.3395 0.2392 0.2392
Echinococcus granulosus g protein coupled receptor 0.0005 0.0002 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0012 0.0012
Schistosoma mansoni protein kinase 0.0019 0.0012 0.0012
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0069 0.0047 0.0077
Schistosoma mansoni cell polarity protein 0.0005 0.0002 0.0002
Echinococcus granulosus somatostatin receptor 0.0005 0.0002 0.0002
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0005 0.0002 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0003 0 0.0002
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0005 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0029 0.067
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0005 0.0002 0.0002
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.5539 0.3905 0.3905
Schistosoma mansoni hypothetical protein 0.0005 0.0002 0.0002
Toxoplasma gondii ABC1 family protein 0.0043 0.0029 0.067
Trypanosoma cruzi ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0122
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0069 0.0047 0.0047
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0038 0.0025 0.0025
Loa Loa (eye worm) neuropeptide F receptor 0.0005 0.0002 0.0002
Echinococcus multilocularis sex peptide receptor 0.0005 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0029 0.0048
Schistosoma mansoni kinase 0.0007 0.0003 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0041 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0024 0.0024
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.278 0.1959 0.3215
Echinococcus granulosus neuropeptide Y receptor 0.0005 0.0002 0.0002
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0614 0.0432 0.0432
Plasmodium vivax ribosomal RNA large subunit methyltransferase J, putative 0.001 0.0005 0.0122
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0005 0.0002 0.0002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0005 0.0002 0.0002
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0005 0.0002 0.0002
Plasmodium vivax calcium-dependent protein kinase, putative 0.0003 0 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.278 0.1959 0.3215
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0005 0.0122
Trypanosoma cruzi subtilisin peptidase 0.0614 0.0432 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0194 0.4499
Brugia malayi celfurPC protein 1.1402 0.8039 0.8039
Echinococcus granulosus alpha 1A adrenergic receptor 0.0005 0.0002 0.0002
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 1.4182 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni myosin xvIII 0.0005 0.0002 0.0002
Schistosoma mansoni ribosomal RNA methyltransferase 0.001 0.0005 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Plasmodium falciparum large subunit rRNA methyltransferase, putative 0.001 0.0005 0.0122
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.0005 0.0002 0.0002
Trypanosoma cruzi polo-like protein kinase, putative 0.0013 0.0007 0.0164
Echinococcus granulosus g protein coupled receptor 0.0005 0.0002 0.0002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0005 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Trichomonas vaginalis CAMK family protein kinase 0.0013 0.0007 0.0012
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0614 0.0432 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Echinococcus multilocularis membrane bound transcription factor site 1 0.0614 0.0432 0.0537
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3395 0.2392 0.3926
Echinococcus granulosus GPCR family 2 0.0019 0.0012 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Echinococcus granulosus tm gpcr rhodopsin 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0029 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3395 0.2392 0.3926
Brugia malayi putative neuropeptide receptor NPR1 0.0005 0.0002 0.0002
Brugia malayi RE15519p 0.0005 0.0002 0.0002
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0003 0 0.0002
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0104 0.0072 0.1665
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.8643 0.6093 0.6093
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0005 0.0002 0.0002
Mycobacterium ulcerans cytotoxin/hemolysin, TlyA 0.001 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0003 0 0.0004
Loa Loa (eye worm) G-protein coupled receptor 0.0005 0.0002 0.0002
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0038 0.0025 0.3454
Onchocerca volvulus 0.0005 0.0002 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0005 0.0002 0.0042
Toxoplasma gondii subtilisin SUB5 0.0614 0.0432 1
Echinococcus multilocularis 1.1402 0.8039 1
Onchocerca volvulus 0.0036 0.0024 0.055
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0005 0.0009
Schistosoma mansoni biogenic amine (5HT) receptor 0.0005 0.0002 0.0002
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0067 0.0045 0.0075
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0005 0.0002 0.0002
Echinococcus multilocularis G-protein coupled receptor, putative 0.0005 0.0002 0.0002
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0005 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0037 0.0037
Echinococcus multilocularis ribosomal RNA large subunit methyltransferase 0.001 0.0005 0.0007
Echinococcus multilocularis dro:myosuppressin receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0037 0.0037
Brugia malayi neuropeptide F receptor 0.0005 0.0002 0.0002
Echinococcus granulosus G protein coupled receptor 139 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0092 0.0063 0.1457
Brugia malayi Subtilase family protein 0.0614 0.0432 0.0432
Plasmodium vivax subtilisin-like serine protease, putative 0.0614 0.0432 1
Plasmodium falciparum subtilisin-like protease 3 0.0614 0.0432 1
Onchocerca volvulus 0.0043 0.0029 0.0672
Echinococcus granulosus cap specific mRNA 0.001 0.0005 0.0005
Entamoeba histolytica ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0743
Toxoplasma gondii subtilisin SUB9 0.0614 0.0432 1
Trichomonas vaginalis conserved hypothetical protein 0.278 0.1959 0.3215
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0069 0.0047 0.0047
Toxoplasma gondii subtilisin SUB10 0.0614 0.0432 1
Onchocerca volvulus 0.0043 0.0029 0.0672
Echinococcus multilocularis orexin receptor type 2 0.0005 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0024 0.0024
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0013 0.0007 0.0007
Brugia malayi FtsJ-like methyltransferase family protein 0.001 0.0005 0.0005
Toxoplasma gondii subtilisin SUB4 0.0614 0.0432 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.8643 0.6093 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.001 0.0005 0.0122
Echinococcus multilocularis GPCR, family 2 0.0019 0.0012 0.0015
Toxoplasma gondii subtilisin SUB1 0.0614 0.0432 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3395 0.2392 0.3926
Toxoplasma gondii subtilisin SUB7 0.0614 0.0432 1
Trichomonas vaginalis CAMK family protein kinase 0.0013 0.0007 0.0012
Trichomonas vaginalis ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0009
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0614 0.0432 0.0432
Onchocerca volvulus 0.0286 0.02 0.4635
Leishmania major methyltransferase, putative,ensangp00000010174-like protein 0.001 0.0005 0.0122
Echinococcus granulosus neuropeptide FF receptor 2 0.0005 0.0002 0.0002
Brugia malayi G-protein coupled receptor 0.0005 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus sex peptide receptor 0.0005 0.0002 0.0002
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0023 0.0015 0.0015
Toxoplasma gondii subtilisin SUB2 0.0614 0.0432 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0043 0.0029 0.0029
Brugia malayi Dopamine receptor protein 2 0.0005 0.0002 0.0002
Leishmania major arginine N-methyltransferase-like protein 0.0067 0.0045 0.1051
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0013 0.0007 0.0007
Mycobacterium ulcerans hypothetical protein 0.0043 0.0029 0.067
Loa Loa (eye worm) Carm1-pending protein 0.0038 0.0025 0.0025
Echinococcus granulosus protein arginine N methyltransferase 7 0.0038 0.0025 0.0025
Plasmodium falciparum calcium-dependent protein kinase 3 0.0003 0 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.278 0.1959 0.3215
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0614 0.0432 0.0537
Trypanosoma cruzi polo-like protein kinase, putative 0.0013 0.0007 0.0164
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0069 0.0047 0.0077
Schistosoma mansoni site-1 peptidase (S08 family) 0.0614 0.0432 0.0432
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0038 0.0025 0.0574
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0029 0.067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0037 0.0046
Brugia malayi Carm1-pending protein 0.0038 0.0025 0.0025
Loa Loa (eye worm) ribosomal RNA methyltransferase 0.001 0.0005 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0005 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0614 0.0432 0.0708
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0029 0.0029
Brugia malayi follicle stimulating hormone receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) TK/EGFR protein kinase 0.0366 0.0257 0.0257
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0043 0.0029 0.0672
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.278 0.1959 0.3215
Leishmania major arginine N-methyltransferase, type I 0.0038 0.0025 0.0574
Trichomonas vaginalis CAMK family protein kinase 0.0013 0.0007 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0012
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0005 0.0002 0.0002
Plasmodium falciparum subtilisin-like protease 2 0.0614 0.0432 1
Trichomonas vaginalis conserved hypothetical protein 0.278 0.1959 0.3215
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.0087 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Trypanosoma brucei ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0122
Onchocerca volvulus 0.0005 0.0002 0.0042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0003 0 0.0002
Echinococcus granulosus neuroendocrine convertase 2 0.8934 0.6299 0.6299
Giardia lamblia High cysteine membrane protein Group 2 0.5248 0.3699 1
Toxoplasma gondii subtilisin SUB12 0.0614 0.0432 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0005 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0037 0.0037
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0614 0.0432 1
Schistosoma mansoni hypothetical protein 0.0019 0.0012 0.0012
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni neuropeptide F-like receptor 0.0005 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3395 0.2392 0.3926
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0005 0.0002 0.0002
Echinococcus multilocularis protein arginine methyltransferase 0.0069 0.0047 0.0059
Trichomonas vaginalis CAMK family protein kinase 0.0006 0.0003 0.0005
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0038 0.0025 0.0031
Trichomonas vaginalis ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0009
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0005 0.0002 0.0002
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) endoprotease bli-4 1.4182 1 1
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0614 0.0432 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0002 0.0002
Loa Loa (eye worm) beta-lactamase 0.0043 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus alkylated dna repair protein alkb 8 0.0002 0.0000080773 0.0000080773
Schistosoma mansoni ribosomal RNA methyltransferase 0.001 0.0005 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Brugia malayi AKH receptor 0.0005 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0005 0.0002 0.0002
Brugia malayi proprotein convertase 2 0.8934 0.6299 0.6299
Loa Loa (eye worm) hypothetical protein 0.0043 0.0029 0.0029
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0015 0.0015
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0005 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.278 0.1959 0.3215
Echinococcus granulosus neuropeptide Y receptor 0.0005 0.0002 0.0002
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein 0.001 0.0005 0.0122
Schistosoma mansoni opsin-like receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Brugia malayi Pre-SET motif family protein 0.0251 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.0043 0.0029 0.067
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0012 0.0012
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0038 0.0025 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0002 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0029 0.0048
Echinococcus granulosus disks large 3 0.0005 0.0002 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0006 0.0003 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0012 0.0015
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0019 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.001 0.0005 0.0005
Schistosoma mansoni protein arginine n-methyltransferase 0.0002 0.0000080773 0.0000080773
Brugia malayi protein R74.7 0.001 0.0005 0.0005
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) regulatory protein 0.0002 0.0000080773 0.0000080773
Brugia malayi Serotonin receptor 0.0005 0.0002 0.0002
Brugia malayi Melatonin receptor type 1A 0.0005 0.0002 0.0002
Schistosoma mansoni amine GPCR 0.0005 0.0002 0.0002
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Brugia malayi putative neuropeptide receptor 0.0005 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0041 0.0027 0.0027
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0043 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus cell division protein 0.001 0.0005 0.0005
Echinococcus multilocularis fmrfamide receptor 0.0005 0.0002 0.0002
Schistosoma mansoni histamine h1 receptor 0.0005 0.0002 0.0002
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0614 0.0432 0.0432
Echinococcus multilocularis fmrfamide receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) melatonin receptor type 1A 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni growth hormone secretagogue receptor 0.0005 0.0002 0.0002
Echinococcus multilocularis epidermal growth factor receptor 0.0366 0.0257 0.0319
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.278 0.1959 0.3215
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Entamoeba histolytica ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0743
Trichomonas vaginalis conserved hypothetical protein 0.278 0.1959 0.3215
Brugia malayi Dopamine receptor protein 1 0.0005 0.0002 0.0002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0005 0.0002 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0029 0.067
Schistosoma mansoni neuropeptide f receptor 76f 0.0005 0.0002 0.0002
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0005 0.0002 0.0002
Echinococcus multilocularis disks large 3 0.0005 0.0002 0.0003
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0003 0 0.0002
Brugia malayi regulatory protein 0.0002 0.0000080773 0.0000080773
Loa Loa (eye worm) hypothetical protein 0.0041 0.0027 0.0027
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0029 0.067
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.8643 0.6093 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0038 0.0025 0.0041
Onchocerca volvulus 0.0005 0.0002 0.0042
Brugia malayi sulfakinin receptor protein 0.0005 0.0002 0.0002
Giardia lamblia Kinase, PLK 0.0013 0.0007 0.0005
Schistosoma mansoni hypothetical protein 0.0019 0.0012 0.0012
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0024 0.003
Toxoplasma gondii hypothetical protein 0.001 0.0005 0.0122
Leishmania major protein kinase, putative 0.0003 0 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Loa Loa (eye worm) hypothetical protein 1.4182 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0005 0.0002 0.0002
Plasmodium vivax subtilisin-like protease 1 0.0614 0.0432 1
Schistosoma mansoni biogenic amine receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Brugia malayi Tachykinin-like peptides receptor 99D 0.0005 0.0002 0.0002
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0614 0.0432 1
Trypanosoma brucei subtilisin peptidase 0.0614 0.0432 1
Onchocerca volvulus Putative ribosomal RNA methyltransferase 0.001 0.0005 0.0124
Echinococcus granulosus rrna methyltransferase 3 0.001 0.0005 0.0005
Trypanosoma cruzi methyltransferase, putative 0.001 0.0005 0.0122
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0017 0.001 0.001
Echinococcus granulosus fmrfamide receptor 0.0005 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0015 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Echinococcus multilocularis Furin 1 0.3395 0.2392 0.2976
Trichomonas vaginalis conserved hypothetical protein 0.0614 0.0432 0.0708
Loa Loa (eye worm) hypothetical protein 0.0036 0.0024 0.0024
Onchocerca volvulus 0.0005 0.0002 0.0042
Schistosoma mansoni furin-1 (S08 family) 0.6154 0.4338 0.4338
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0002 0.0002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0012 0.0012
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0038 0.0025 0.0574
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.3395 0.2392 0.2392
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0614 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0104 0.0072 0.0072
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus neuropeptide receptor 0.0005 0.0002 0.0002
Toxoplasma gondii subtilisin SUB8 0.0614 0.0432 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0024 0.0024
Schistosoma mansoni amine GPCR 0.0005 0.0002 0.0002
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0067 0.0045 0.0045
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0029 0.0029
Echinococcus multilocularis cell division protein 0.001 0.0005 0.0007
Schistosoma mansoni site-1 peptidase (S08 family) 0.0614 0.0432 0.0432
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0003 0 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.0005 0.0002 0.0002
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0023 0.0015 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0023 0.0023
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0069 0.0047 0.1091
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Trichomonas vaginalis ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0009
Onchocerca volvulus 0.0614 0.0432 1
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0104 0.0072 0.1665
Brugia malayi G-protein coupled receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0015
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0069 0.0047 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Echinococcus multilocularis serotonin receptor 0.0005 0.0002 0.0002
Plasmodium falciparum calcium-dependent protein kinase 4 0.0003 0 0.0002
Echinococcus multilocularis neuropeptide receptor 0.0005 0.0002 0.0002
Brugia malayi G protein-coupled receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus peptide allatostatin:somatostatin 0.0005 0.0002 0.0002
Echinococcus granulosus protein arginine methyltransferase 0.0069 0.0047 0.0047
Schistosoma mansoni protein kinase 0.0019 0.0012 0.0012
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus multilocularis neuroendocrine convertase 2 0.8934 0.6299 0.7836
Brugia malayi FtsJ-like methyltransferase family protein 0.001 0.0005 0.0005
Trypanosoma brucei 2'-O-ribose RNA methyltransferase SPB1 homolog 0.001 0.0005 0.0122
Brugia malayi Stress-activated protein kinase jnk-1 0.0125 0.0087 0.0087
Echinococcus granulosus hypothetical protein 0.0005 0.0002 0.0002
Onchocerca volvulus Serine\/threonine kinase homolog 0.0013 0.0007 0.0166
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0038 0.0025 0.0041
Brugia malayi Guanylate kinase family protein 0.0006 0.0002 0.0002
Trichomonas vaginalis ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni biogenic amine receptor 0.0005 0.0002 0.0002
Echinococcus granulosus protein arginine N methyltransferase 8 0.0069 0.0047 0.0047
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0029 0.067
Brugia malayi Pre-SET motif family protein 0.0036 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Loa Loa (eye worm) guanylate kinase 0.0004 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0013 0.0007 0.0012
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0005 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.278 0.1959 0.1959
Leishmania major hypothetical protein, conserved 0.001 0.0005 0.0122
Echinococcus granulosus neuropeptide receptor 0.0005 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0002 0.0002
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0013 0.0007 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0024 0.0024
Echinococcus granulosus Furin 1 0.3395 0.2392 0.2392
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0002 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0614 0.0432 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0005 0.0002 0.0002
Brugia malayi beta-lactamase family protein 0.0043 0.0029 0.0029
Echinococcus multilocularis g protein coupled receptor 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0029 0.067
Entamoeba histolytica hypothetical protein 0.0104 0.0072 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0005 0.0002 0.0002
Trypanosoma cruzi ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0029 0.0029
Brugia malayi Protein arginine N-methyltransferase 0.0038 0.0025 0.0025
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0005 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0013 0.0007 0.0012
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0003 0 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.278 0.1959 0.3215
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0005 0.0002 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.006 0.0041 0.0041
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0029 0.067
Trypanosoma brucei methyltransferase, putative 0.001 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Echinococcus multilocularis potassium voltage gated channel protein 0.0023 0.0015 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Plasmodium falciparum ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0122
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0029 0.067
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0614 0.0432 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0029 0.067
Schistosoma mansoni tyrosine kinase 0.0366 0.0257 0.0257
Plasmodium falciparum calcium-dependent protein kinase 5 0.0003 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Brugia malayi ribosomal RNA methyltransferase 0.001 0.0005 0.0005
Echinococcus multilocularis neuropeptide FF receptor 2 0.0005 0.0002 0.0002
Echinococcus granulosus 7TM GPCR rhodopsin 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0019 0.0012 0.0012
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0069 0.0047 0.1091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0037 0.0046
Giardia lamblia Furin precursor putative serine protease 0.278 0.1959 0.5289
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0005 0.0002 0.0002
Echinococcus granulosus allatostatin A receptor 0.0005 0.0002 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0005 0.0002 0.0002
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein 0.001 0.0005 0.0122
Echinococcus multilocularis neuropeptide s receptor 0.0005 0.0002 0.0002
Echinococcus multilocularis rrna methyltransferase 3 0.001 0.0005 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0005 0.0002 0.0002
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0005 0.0002 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.0005 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0614 0.0432 0.0708
Echinococcus multilocularis serotonin receptor 0.0005 0.0002 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0005 0.0002 0.0002
Toxoplasma gondii subtilisin SUB6 0.0614 0.0432 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0013 0.0007 0.0994
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0005 0.0002 0.0002
Echinococcus granulosus methyltransferase protein 5 0.0038 0.0025 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0013 0.0007 0.0012
Brugia malayi serine/threonine-protein kinase plk-2 0.0013 0.0007 0.0007
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0038 0.0025 0.0574
Schistosoma mansoni neuropeptide F-like receptor 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0005 0.0002 0.0042
Leishmania major FtsJ-like methyltransferase, putative 0.001 0.0005 0.0122
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0614 0.0432 1
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0614 0.0432 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0003 0 0.0002
Onchocerca volvulus 0.0005 0.0002 0.0042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0012 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.278 0.1959 0.3215
Trichomonas vaginalis conserved hypothetical protein 0.0614 0.0432 0.0708
Echinococcus granulosus epidermal growth factor receptor 0.0366 0.0257 0.0257
Onchocerca volvulus 0.0005 0.0002 0.0042
Trichomonas vaginalis set domain proteins, putative 0.0286 0.02 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.278 0.1959 0.3215
Echinococcus granulosus neuropeptide receptor A26 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0614 0.0432 1
Loa Loa (eye worm) subtilase 0.0614 0.0432 0.0432
Toxoplasma gondii bicoid-interacting protein BIN3 0.0038 0.0025 0.0574
Plasmodium vivax SET domain protein, putative 0.0036 0.0024 0.0549
Echinococcus multilocularis G protein coupled receptor 139 0.0005 0.0002 0.0002
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein 0.001 0.0005 0.0122
Schistosoma mansoni protein arginine n-methyltransferase 0.0038 0.0025 0.0025
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0029 0.0036
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0005 0.0002 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0041 0.0041
Brugia malayi beta-lactamase 0.0043 0.0029 0.0029
Onchocerca volvulus 0.0005 0.0002 0.0042
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0038 0.0025 0.0574
Echinococcus multilocularis cap specific mRNA 0.001 0.0005 0.0007
Loa Loa (eye worm) TYRA-2 protein 0.0005 0.0002 0.0002
Echinococcus multilocularis neuropeptide receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0005 0.0002 0.0042
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0005 0.0002 0.0002
Schistosoma mansoni adenoreceptor 0.0005 0.0002 0.0002
Treponema pallidum cell division protein (ftsJ) 0.001 0.0005 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0007 0.0007
Echinococcus granulosus membrane bound transcription factor site 1 0.0614 0.0432 0.0432
Brugia malayi hypothetical protein 0.0104 0.0072 0.0072
Echinococcus multilocularis neuropeptides capa receptor 0.0005 0.0002 0.0002
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0038 0.0025 0.0574
Mycobacterium tuberculosis Conserved protein 0.0043 0.0029 0.067
Echinococcus granulosus g protein coupled receptor 0.0005 0.0002 0.0002
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0038 0.0025 0.0574
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0038 0.0025 0.0574
Trypanosoma brucei ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0122
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0614 0.0432 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus putative ribosomal RNA methyltransferase/cell division FtsJ protein 0.001 0.0005 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3395 0.2392 0.3926
Mycobacterium ulcerans beta-lactamase 0.0043 0.0029 0.067
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni amine GPCR 0.0005 0.0002 0.0002
Brugia malayi neuropeptide F receptor 0.0005 0.0002 0.0002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0029 0.067
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0038 0.0025 0.0025
Onchocerca volvulus 0.0005 0.0002 0.0042
Schistosoma mansoni biogenic amine receptor 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0005 0.0002 0.0042
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0029 0.0048
Brugia malayi beta-lactamase family protein 0.0043 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Toxoplasma gondii ribosomal RNA methyltransferase (FtsJ) family protein 0.001 0.0005 0.0122
Schistosoma mansoni biogenic amine (5HT) receptor 0.0005 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3395 0.2392 0.3926
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0005 0.0002 0.0002
Schistosoma mansoni cell division protein ftsj 0.001 0.0005 0.0005
Plasmodium vivax FtsJ-like methyltransferase, putative 0.001 0.0005 0.0122
Echinococcus multilocularis neuropeptide Y receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0029 0.0029
Schistosoma mansoni neuropeptide receptor 0.0005 0.0002 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0029 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0614 0.0432 0.0708
Brugia malayi larval opioid receptor 0.0005 0.0002 0.0002
Entamoeba histolytica protein kinase, putative 0.0003 0 0.0022
Echinococcus multilocularis allatostatin A receptor 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0005 0.0002 0.0042
Plasmodium falciparum calcium-dependent protein kinase 2 0.0003 0 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Schistosoma mansoni neuropeptide receptor 0.0005 0.0002 0.0002
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0125 0.0087 0.0108
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0024 0.003
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0038 0.0025 0.0574
Entamoeba histolytica protein kinase, putative 0.0003 0 0.0022
Schistosoma mansoni alpha-1 adrenergic receptor 0.0005 0.0002 0.0002
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0104 0.0072 0.1665
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0024 0.0549
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0029 0.067
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0041 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0029 0.067
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus multilocularis somatostatin receptor 0.0005 0.0002 0.0002
Brugia malayi Furin-like cysteine rich region family protein 0.0366 0.0257 0.0257
Trichomonas vaginalis esterase, putative 0.0043 0.0029 0.0048
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0176 0.0176
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus 7tm_1 domain containing protein 0.0005 0.0002 0.0002
Echinococcus multilocularis g protein coupled receptor 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0029 0.067
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Brugia malayi Dopamine receptor 0.0005 0.0002 0.0002
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.278 0.1959 0.3215
Wolbachia endosymbiont of Brugia malayi 23S rRNA methylase 0.001 0.0005 0.5
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0003 0 0.0002
Toxoplasma gondii subtilisin SUB11 0.0614 0.0432 1
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Echinococcus multilocularis neuropeptide Y receptor 0.0005 0.0002 0.0002
Echinococcus granulosus potassium voltage gated channel protein 0.0023 0.0015 0.0015
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0013 0.0007 0.0009
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0125 0.0087 0.0087
Schistosoma mansoni opsin-like receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0005 0.0002 0.0002
Mycobacterium leprae cytotoxin/hemolysin homologue TlyA 0.001 0.0005 0.0122
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0005 0.0002 0.0002
Echinococcus granulosus orexin receptor type 2 0.0005 0.0002 0.0002
Mycobacterium leprae Probable lipase LipE 0.0043 0.0029 0.067
Plasmodium falciparum ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0122
Echinococcus granulosus dro:myosuppressin receptor 0.0005 0.0002 0.0002
Plasmodium falciparum subtilisin-like protease 1 0.0614 0.0432 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0019 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0038 0.0025 0.0025
Trypanosoma brucei polo-like protein kinase 0.0013 0.0007 0.0164
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0022 0.0014 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Schistosoma mansoni hypothetical protein 0.0019 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.278 0.1959 0.3215
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0012 0.0012
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.0002 0.0002
Trichomonas vaginalis hypothetical protein 0.278 0.1959 0.3215
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0029 0.0029
Echinococcus granulosus furin 1.4182 1 1
Schistosoma mansoni amine GPCR 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0005 0.0002 0.0042
Schistosoma mansoni opsin-like receptor 0.0005 0.0002 0.0002
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0005 0.0002 0.0042
Brugia malayi GnHR receptor homolog 0.0005 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Echinococcus multilocularis neuropeptide receptor A26 0.0005 0.0002 0.0002
Brugia malayi ORL1-like opioid receptor 0.0005 0.0002 0.0002
Onchocerca volvulus Neuropeptide F receptor homolog 0.0005 0.0002 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0005 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Brugia malayi rRNA methyltransferase 0.001 0.0005 0.0005
Mycobacterium tuberculosis Conserved protein 0.0043 0.0029 0.067
Toxoplasma gondii ribosomal RNA large subunit methyltransferase FTSJ1, putative 0.001 0.0005 0.0122
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0029 0.067
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0614 0.0432 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0005 0.0002 0.0042
Leishmania major ribosomal RNA methyltransferase-like protein 0.001 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) neuropeptide F receptor 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0005 0.0002 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0002 0.0002
Echinococcus granulosus neuropeptides capa receptor 0.0005 0.0002 0.0002
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0069 0.0047 0.1091
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0005 0.0002 0.0002
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.8643 0.6093 0.758
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein 0.001 0.0005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0614 0.0432 0.0432
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Leishmania major subtilisin-like serine peptidase 0.0614 0.0432 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0038 0.0025 0.0041
Schistosoma mansoni amine GPCR 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Trypanosoma cruzi ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0122
Brugia malayi neuroendocrine convertase 1 precursor 0.8934 0.6299 0.6299
Brugia malayi Serotonin receptor 0.0005 0.0002 0.0002
Trypanosoma brucei rRNA methyltransferase, putative 0.001 0.0005 0.0122
Schistosoma mansoni protein kinase 0.0019 0.0012 0.0012
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0029 0.0029
Echinococcus granulosus serotonin receptor 0.0005 0.0002 0.0002
Echinococcus granulosus tachykinin peptides receptor 99D 0.0005 0.0002 0.0002
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0005 0.0002 0.0002
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0614 0.0432 1
Schistosoma mansoni neuropeptide receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0017 0.001 0.001
Echinococcus granulosus neuropeptide s receptor 0.0005 0.0002 0.0002
Leishmania major hypothetical protein, conserved 0.0043 0.0029 0.067
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0029 0.0048
Echinococcus multilocularis g-protein coupled receptor 0.0005 0.0002 0.0002
Brugia malayi G protein-coupled receptor F59B2.13 0.0005 0.0002 0.0002
Echinococcus granulosus c-Jun N-terminal kinases 0.0125 0.0087 0.0087
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0005 0.0002 0.0002
Schistosoma mansoni neuropeptide receptor 0.0005 0.0002 0.0002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0037 0.0037
Plasmodium vivax subtilisin-like protease 2, putative 0.0614 0.0432 1
Plasmodium vivax ribosomal RNA methyltransferase, putative 0.001 0.0005 0.0122
Mycobacterium ulcerans lipase LipD 0.0043 0.0029 0.067
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Mycobacterium leprae Possible secreted protease 0.0614 0.0432 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0614 0.0432 0.0708
Echinococcus granulosus tm gpcr rhodopsin 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0614 0.0432 0.0432
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0013 0.0007 0.0012
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0104 0.0072 1
Echinococcus granulosus g-protein coupled receptor 0.0005 0.0002 0.0002

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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