TDR Targets

Basic information

Technical information

TDR Targets ID: 1382127
Name: 2,5-dichloro-N-(3-dimethylaminopropyl)benzene sulfonamide
MW: 311.228 | Formula: C11H16Cl2N2O2S
H donors: 1 H acceptors: 2 LogP: 2.54 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCCNS(=O)(=O)c1cc(Cl)ccc1Cl)C
InChi: 1S/C11H16Cl2N2O2S/c1-15(2)7-3-6-14-18(16,17)11-8-9(12)4-5-10(11)13/h4-5,8,14H,3,6-7H2,1-2H3
InChiKey: ZVNJMYWCXADFBF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

MLS000078529
ST042724
SMR000036805

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	BC026374 protein (S09 family)	0.1527	0.1662	0.1662
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0044	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0062	0.0062
Brugia malayi	beta-lactamase family protein	0.0043	0.0015	0.0015
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0239	0.0232	0.1398
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.0185	0.0185
Toxoplasma gondii	DNA topoisomerase family protein	0.0038	0.0009	0.0074
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.0185	0.0185
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.1108	0.1196	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.0015	0.0015
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.9039	1	1
Onchocerca volvulus		0.0043	0.0015	0.0089
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0015	0.0015
Brugia malayi	Carboxylesterase family protein	0.1527	0.1662	0.1662
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0015	0.0036
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0015	0.0124
Onchocerca volvulus		0.1527	0.1662	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.1053	0.1053
Echinococcus multilocularis	rho GTPase activating protein 20	0.0038	0.0009	0.0009
Plasmodium falciparum	DNA gyrase subunit B	0.0533	0.0558	0.4625
Giardia lamblia	DNA topoisomerase II	0.0223	0.0214	1
Echinococcus granulosus	DNA topoisomerase 3 alpha	0.0038	0.0009	0.0009
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0533	0.0558	0.3297
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0015	0.011
Onchocerca volvulus		0.0054	0.0027	0.0161
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0015	0.0037
Onchocerca volvulus		0.0038	0.0009	0.0053
Loa Loa (eye worm)	hypothetical protein	0.9039	1	1
Chlamydia trachomatis	DNA gyrase subunit A	0.1108	0.1196	1
Loa Loa (eye worm)	carboxylesterase	0.1527	0.1662	0.1662
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0015	0.0037
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.0015	0.0015
Schistosoma mansoni	prokaryotic DNA topoisomerase	0.0038	0.0009	0.0009
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.0015	0.0015
Echinococcus multilocularis	lamin dm0	0.0054	0.0027	0.0027
Mycobacterium tuberculosis	Carboxylesterase LipT	0.1527	0.1662	1
Brugia malayi	GRF zinc finger family protein	0.0038	0.0009	0.0009
Brugia malayi	beta-lactamase family protein	0.0043	0.0015	0.0015
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0239	0.0232	0.1398
Schistosoma mansoni	alpha-glucosidase	0.0169	0.0154	0.0154
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.1108	0.1196	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0015	0.0015
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0201	0.019	0.4244
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0015	0.0015
Mycobacterium ulcerans	carboxylesterase, LipT	0.1527	0.1662	1
Onchocerca volvulus		0.1527	0.1662	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.9039	1	1
Loa Loa (eye worm)	hypothetical protein	0.1527	0.1662	0.1662
Mycobacterium leprae	Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0528	0.0553	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.1527	0.1662	1
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0015	0.0036
Schistosoma mansoni	alpha glucosidase	0.0044	0.0015	0.0015
Onchocerca volvulus		0.1527	0.1662	1
Echinococcus granulosus	intermediate filament protein	0.0054	0.0027	0.0027
Echinococcus granulosus	BC026374 protein S09 family	0.1527	0.1662	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0094	0.0094
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0015	0.0036
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.0015	0.0015
Echinococcus granulosus	carboxylesterase 5A	0.9039	1	1
Brugia malayi	beta-lactamase	0.0043	0.0015	0.0015
Loa Loa (eye worm)	DNA topoisomerase III	0.0038	0.0009	0.0009
Leishmania major	DNA topoisomerase ii	0.0201	0.019	0.4244
Plasmodium vivax	DNA gyrase subunit A, putative	0.1108	0.1196	1
Brugia malayi	Carboxylesterase family protein	0.9039	1	1
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0533	0.0558	0.4625
Schistosoma mansoni	DNA topoisomerase II	0.0239	0.0232	0.0232
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0015	0.014
Brugia malayi	hypothetical protein	0.1527	0.1662	0.1662
Echinococcus multilocularis	musashi	0.0054	0.0027	0.0027
Toxoplasma gondii	ABC1 family protein	0.0043	0.0015	0.0124
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0015	0.0145
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0015	0.0036
Mycobacterium ulcerans	lipase LipD	0.0043	0.0015	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0015	0.0015
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.1527	0.1662	1
Schistosoma mansoni	hypothetical protein	0.017	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.1527	0.1662	0.1662
Brugia malayi	DNA topoisomerase III beta-1	0.0038	0.0009	0.0009
Onchocerca volvulus		0.0043	0.0015	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0027	0.0027
Mycobacterium ulcerans	DNA gyrase subunit B	0.0533	0.0558	0.3321
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.021	0.02	0.02
Brugia malayi	Carboxylesterase family protein	0.1527	0.1662	0.1662
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.1527	0.1662	0.1662
Chlamydia trachomatis	DNA gyrase subunit B	0.0533	0.0558	0.4625
Loa Loa (eye worm)	hypothetical protein	0.006	0.0033	0.0033
Onchocerca volvulus		0.006	0.0033	0.0197
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0015	0.0015
Loa Loa (eye worm)	carboxylesterase	0.9039	1	1
Loa Loa (eye worm)	carboxylesterase	0.1527	0.1662	0.1662
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.1527	0.1662	0.1662
Echinococcus granulosus	acetylcholinesterase	0.9039	1	1
Loa Loa (eye worm)	hypothetical protein	0.1527	0.1662	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0094	0.0094
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0201	0.019	0.4244
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0127	0.0127
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0127	0.0127
Onchocerca volvulus		0.0043	0.0015	0.0089
Echinococcus multilocularis	neuroligin	0.1527	0.1662	0.1662
Loa Loa (eye worm)	hypothetical protein	0.1527	0.1662	0.1662
Echinococcus multilocularis	BC026374 protein (S09 family)	0.1527	0.1662	0.1662
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0239	0.0232	0.0232
Onchocerca volvulus		0.1527	0.1662	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0015	0.0036
Echinococcus granulosus	tumor protein p63	0.0408	0.0419	0.0419
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.0185	0.0185
Loa Loa (eye worm)	TOPoisomerase family member	0.0239	0.0232	0.0232
Echinococcus granulosus	para nitrobenzyl esterase	0.1527	0.1662	0.1662
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0239	0.0232	0.1943
Onchocerca volvulus		0.0054	0.0027	0.0161
Echinococcus multilocularis	lamin	0.0054	0.0027	0.0027
Echinococcus multilocularis	para nitrobenzyl esterase	0.1527	0.1662	0.1662
Onchocerca volvulus		0.0239	0.0232	0.1397
Schistosoma mansoni	prokaryotic DNA topoisomerase	0.0038	0.0009	0.0009
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0044	0.0015	0.0125
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0015	0.0036
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0015	0.0037
Loa Loa (eye worm)	hypothetical protein	0.1527	0.1662	0.1662
Echinococcus multilocularis	acetylcholinesterase	0.9039	1	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0015	0.0277
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0423	0.0436	1
Plasmodium vivax	DNA gyrase subunit B, putative	0.0533	0.0558	0.4664
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0015	0.0036
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0015	0.0037
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0015	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0015	0.0015
Entamoeba histolytica	DNA topoisomerase II, putative	0.0239	0.0232	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1527	0.1662	0.1662
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0062	0.0062
Trichomonas vaginalis	set domain proteins, putative	0.0239	0.0232	0.1351
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0027	0.0027
Schistosoma mansoni	gliotactin	0.1527	0.1662	0.1662
Loa Loa (eye worm)	hypothetical protein	0.9039	1	1
Plasmodium vivax	DNA topoisomerase II, putative	0.0239	0.0232	0.1943
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0308	0.0308	0.2578
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0015	0.0015
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0015	0.0015
Echinococcus granulosus	DNA topoisomerase 3 beta 1	0.0038	0.0009	0.0009
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.1527	0.1662	1
Loa Loa (eye worm)	DNA topoisomerase III beta-1	0.0038	0.0009	0.0009
Echinococcus multilocularis	tumor protein p63	0.0408	0.0419	0.0419
Echinococcus granulosus	neuroligin	0.1527	0.1662	0.1662
Echinococcus granulosus	acetylcholinesterase	0.9039	1	1
Echinococcus multilocularis	acetylcholinesterase	0.9039	1	1
Echinococcus multilocularis	geminin	0.017	0.0155	0.0155
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0239	0.0232	0.0232
Trypanosoma brucei	glucosidase, putative	0.0044	0.0015	0.0145
Mycobacterium leprae	Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0183	0.017	0.2966
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0239	0.0232	0.1352
Brugia malayi	MH2 domain containing protein	0.0144	0.0127	0.0127
Schistosoma mansoni	lamin	0.0054	0.0027	0.0027
Brugia malayi	Carboxylesterase family protein	0.1527	0.1662	0.1662
Plasmodium falciparum	DNA topoisomerase 2	0.0239	0.0232	0.1883
Brugia malayi	Carboxylesterase family protein	0.1527	0.1662	0.1662
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0015	0.0036
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0033	0.0033
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.0185	0.0185
Schistosoma mansoni	alpha-glucosidase	0.0169	0.0154	0.0154
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0015	0.014
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0015	0.0145
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.1108	0.1196	0.7172
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0239	0.0232	0.0232
Chlamydia trachomatis	DNA gyrase subunit B	0.0349	0.0354	0.291
Brugia malayi	Pre-SET motif family protein	0.021	0.02	0.02
Brugia malayi	DNA topoisomerase III	0.0038	0.0009	0.0009
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0533	0.0558	0.4625
Chlamydia trachomatis	DNA gyrase subunit A	0.0115	0.0094	0.0719
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0027	0.0027
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.0275	0.1579
Plasmodium falciparum	DNA gyrase subunit A	0.1108	0.1196	1
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0201	0.019	0.4244
Echinococcus granulosus	geminin	0.017	0.0155	0.0155
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0239	0.0232	0.1398
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0015	0.0015
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0015	0.0015
Trypanosoma brucei	DNA topoisomerase ii	0.0423	0.0436	1
Loa Loa (eye worm)	hypothetical protein	0.1527	0.1662	0.1662
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0423	0.0436	1
Echinococcus multilocularis	DNA topoisomerase 3 beta 1	0.0038	0.0009	0.0009
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0044	0.0015	0.0037
Onchocerca volvulus		0.1527	0.1662	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0027	0.0027
Schistosoma mansoni	neuroligin 3 (S09 family)	0.1527	0.1662	0.1662
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0015	0.014
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0015	0.0015
Schistosoma mansoni	hypothetical protein	0.017	0.0155	0.0155
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1527	0.1662	0.1662
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0015	0.0037
Brugia malayi	intermediate filament protein	0.0054	0.0027	0.0027
Schistosoma mansoni	acetylcholinesterase	0.1527	0.1662	0.1662
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0015	0.0037
Leishmania major	mitochondrial DNA topoisomerase II	0.0423	0.0436	1
Trichomonas vaginalis	esterase, putative	0.0043	0.0015	0.0036
Leishmania major	alpha glucosidase II subunit, putative	0.0044	0.0015	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0015	0.0015
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0027	0.0027
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0015	0.0277
Echinococcus multilocularis	carboxylesterase 5A	0.9039	1	1
Schistosoma mansoni	lamin	0.0054	0.0027	0.0027
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0201	0.019	0.4244
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.1527	0.1662	0.1662
Echinococcus granulosus	lamin dm0	0.0054	0.0027	0.0027
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1527	0.1662	0.1662
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.0185	0.0185
Echinococcus granulosus	lamin	0.0054	0.0027	0.0027
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.1108	0.1196	1
Leishmania major	hypothetical protein, conserved	0.0043	0.0015	0.014
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0015	0.011
Brugia malayi	Probable DNA topoisomerase II	0.0239	0.0232	0.0232
Plasmodium vivax	DNA topoisomerase 3, putative	0.0038	0.0009	0.0074
Onchocerca volvulus		0.0114	0.0093	0.0559
Mycobacterium ulcerans	DNA gyrase subunit A	0.1108	0.1196	0.7182
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.1527	0.1662	1
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0239	0.0232	0.0232
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0038	0.0009	0.0074

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 1.2589 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	2.6169 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709]	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1535337

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1382127