Detailed information for compound 138226

Basic information

Technical information
  • TDR Targets ID: 138226
  • Name: N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-mor pholin-4-ylethyl)amino]acetamide
  • MW: 373.425 | Formula: C15H23N3O6S
  • H donors: 2 H acceptors: 4 LogP: -0.44 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)CN(S(=O)(=O)c1ccc(cc1)OC)CCN1CCOCC1
  • InChi: 1S/C15H23N3O6S/c1-23-13-2-4-14(5-3-13)25(21,22)18(12-15(19)16-20)7-6-17-8-10-24-11-9-17/h2-5,20H,6-12H2,1H3,(H,16,19)
  • InChiKey: JKXLPZUCXZNXTD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-methoxyphenyl)sulfonyl-(2-morpholinoethyl)amino]ethanehydroxamic acid
  • N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-morpholin-4-ylethyl)amino]ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 3 (stromelysin 1, progelatinase) 477 aa 431 aa 34.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0635 0.072
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.0016 0.0075 0.0065
Schistosoma mansoni hypothetical protein 0.0094 0.1154 0.1544
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Echinococcus multilocularis neuroligin 0.0012 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Schistosoma mansoni ap endonuclease 0.0061 0.0689 0.0916
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0062 0.0047
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0087
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0096 0.118 0.118
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0433 0.049
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0025
Loa Loa (eye worm) hypoxia-induced factor 1 0.0176 0.2269 0.2267
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0209 0.2722 0.3663
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0113 0.1402 0.1402
Loa Loa (eye worm) acetylcholinesterase 1 0.0071 0.0831 0.0829
Leishmania major protein kinase, putative 0.0015 0.0062 0.0047
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0016 0.0075 0.0084
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0011 0.001
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0135 0.1703 0.2273
Echinococcus granulosus geminin 0.0364 0.4852 0.5514
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0094 0.1154 0.153
Onchocerca volvulus 0.0434 0.5811 0.6601
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0062 0.0068
Brugia malayi exodeoxyribonuclease III family protein 0.0061 0.0689 0.0689
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0635 0.0823
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0209 0.2722 0.2722
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0022
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0433 0.049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0061 0.0689 0.0896
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0094 0.1154 0.153
Onchocerca volvulus Matrix metalloproteinase homolog 0.0058 0.066 0.0738
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0011 0.001
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0209 0.2722 0.2722
Brugia malayi hypothetical protein 0.0096 0.118 0.118
Schistosoma mansoni cpg binding protein 0.0035 0.0345 0.0452
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0011 0.0011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.078 0.1019
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Onchocerca volvulus Putative neutral sphingomyelinase 0.0012 0.0027 0.0018
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0635 0.0843
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0027 0.0025
Toxoplasma gondii cytochrome p450 superfamily protein 0.0094 0.1154 0.1526
Onchocerca volvulus 0.0012 0.0024 0.0015
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0094 0.1154 0.153
Loa Loa (eye worm) hypothetical protein 0.0191 0.2471 0.247
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0011 0.0009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0096 0.0107
Loa Loa (eye worm) hypothetical protein 0.0113 0.1402 0.14
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0551 0.7413 0.7413
Schistosoma mansoni hypothetical protein 0.0012 0.0027 0.0022
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0551 0.7413 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0096 0.0094
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0689 0.0896
Loa Loa (eye worm) matrix metalloproteinase 0.0026 0.022 0.0219
Brugia malayi Carboxylesterase family protein 0.0012 0.0024 0.0024
Schistosoma mansoni nAChR subunit 0.0209 0.2722 0.3663
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0062 0.0137
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0209 0.2722 0.2722
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0096 0.118 0.118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0011 0.0011
Entamoeba histolytica myo-inositol monophosphatase, putative 0.015 0.1919 0.6801
Schistosoma mansoni hypothetical protein 0.0364 0.4852 0.6539
Echinococcus granulosus cpg binding protein 0.0035 0.0345 0.0391
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0027 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.1903 0.2162
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0551 0.7413 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0011 0.0011
Schistosoma mansoni cpg binding protein 0.0034 0.0319 0.0416
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0652 0.8798 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0025
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0453 0.154
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0209 0.2722 0.2722
Brugia malayi CCR4 0.0012 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0433 0.1469
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0094 0.1154 0.153
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0096 0.0094
Echinococcus multilocularis nAChR subunit 0.0113 0.1402 0.1592
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0094 0.1154 0.153
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0074
Loa Loa (eye worm) hypothetical protein 0.0113 0.1402 0.14
Schistosoma mansoni nAChR subunit 0.0209 0.2722 0.3663
Loa Loa (eye worm) LGC-31 protein 0.0209 0.2722 0.2721
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0094 0.1154 0.153
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0096 0.0094
Brugia malayi Carboxylesterase family protein 0.0012 0.0024 0.0024
Loa Loa (eye worm) ACC-1 protein 0.0209 0.2722 0.2721
Schistosoma mansoni neurotransmitter gated ion channel 0.0096 0.118 0.1579
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0011 0.0009
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0209 0.2722 0.3093
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0027 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0149 0.1903 0.1903
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0215 0.2809 0.3192
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0009
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0096 0.0094
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0027 0.0029
Brugia malayi cytochrome P450 0.0094 0.1154 0.1154
Brugia malayi Cation transporter family protein 0.0209 0.2722 0.2722
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0024 0.0017
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0652 0.8798 0.8798
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0016 0.0075 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0209 0.2722 0.2721
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0113 0.1402 0.1879
Schistosoma mansoni hypothetical protein 0.0037 0.0371 0.0486
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0027 0.0029
Echinococcus multilocularis synaptojanin 1 0.0012 0.0027 0.0029
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0027 0.0029
Echinococcus granulosus inositol monophosphatase 0.0016 0.0075 0.0084
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0453 0.0513
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0096 0.0107
Loa Loa (eye worm) hypothetical protein 0.0026 0.022 0.0219
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0551 0.7413 0.7413
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0453 0.0576
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0009
Onchocerca volvulus Matrilysin homolog 0.0058 0.066 0.0738
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0209 0.2722 0.2721
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0433 0.0549
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0215 0.2809 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0011 0.001
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0027 0.0012
Echinococcus multilocularis cpg binding protein 0.0035 0.0345 0.0391
Schistosoma mansoni BC026374 protein (S09 family) 0.0012 0.0024 0.0017
Onchocerca volvulus 0.0096 0.118 0.1331
Onchocerca volvulus 0.0034 0.0319 0.0351
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0094 0.1154 0.153
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0027 0.0012
Onchocerca volvulus 0.0012 0.0024 0.0015
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0027 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0022
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0403 0.5682
Loa Loa (eye worm) matrixin family protein 0.0058 0.066 0.0658
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0209 0.2722 0.3093
Mycobacterium leprae PROBABLE HYDROLASE 0.0032 0.0299 0.0322
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0094 0.1154 0.153
Brugia malayi Carboxylesterase family protein 0.0012 0.0024 0.0024
Brugia malayi excitatory GABA receptor EXP-1A 0.0209 0.2722 0.2722
Plasmodium falciparum dihydroorotate dehydrogenase 0.0551 0.7413 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.1402 0.14
Schistosoma mansoni nocturnin 0.0012 0.0027 0.0022
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0209 0.2722 0.3663
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.1903 0.2556
Mycobacterium ulcerans monophosphatase 0.0016 0.0075 0.007
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0434 0.5811 0.7835
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0094 0.1154 0.153
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0433 0.057
Echinococcus multilocularis dnaJ subfamily B 0.0477 0.6404 0.7279
Leishmania major cytochrome p450-like protein 0.0094 0.1154 0.1526
Brugia malayi Inositol monophosphatase family protein 0.0016 0.0075 0.0075
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0016 0.0075 0.0186
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.182 0.2067
Echinococcus granulosus glycine receptor subunit alpha 1 0.0209 0.2722 0.3093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0011 0.0009
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0209 0.2722 0.2722
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0433 0.049
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0453 0.0576
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0025
Echinococcus multilocularis glycine receptor subunit beta 0.0209 0.2722 0.3093
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0096 0.0098
Brugia malayi hypothetical protein 0.0096 0.118 0.118
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0011 0.001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0689 0.0896
Mycobacterium ulcerans monophosphatase CysQ 0.0016 0.0075 0.007
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0096 0.0094
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0434 0.5811 0.7835
Onchocerca volvulus 0.0209 0.2722 0.3086
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0009
Echinococcus granulosus glycine receptor subunit beta 0.0209 0.2722 0.3093
Brugia malayi nuclear receptor NHR-88 0.0011 0.0011 0.0011
Schistosoma mansoni cytochrome P450 0.0094 0.1154 0.1544
Schistosoma mansoni cpg binding protein 0.0035 0.0345 0.0452
Loa Loa (eye worm) hypothetical protein 0.0113 0.1402 0.14
Loa Loa (eye worm) follicle stimulating hormone receptor 0.074 1 1
Echinococcus granulosus glycine receptor subunit beta 0.0209 0.2722 0.3093
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0012 0.0024 0.0025
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0096 0.118 0.118
Brugia malayi Matrixin family protein 0.0064 0.0732 0.0732
Loa Loa (eye worm) carboxylesterase 0.0071 0.0831 0.0829
Brugia malayi hypothetical protein 0.0096 0.118 0.118
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0027 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0094 0.1154 0.153
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0113 0.1402 0.1879
Brugia malayi Carboxylesterase family protein 0.0071 0.0831 0.0831
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0096 0.118 0.118
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0094 0.1154 0.153
Trypanosoma cruzi cytochrome P450, putative 0.0196 0.2542 0.3405
Onchocerca volvulus 0.0113 0.1402 0.1583
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0551 0.7413 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0215 0.2809 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0113 0.1402 0.1879
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0652 0.8798 0.8797
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0209 0.2722 0.2722
Loa Loa (eye worm) hypothetical protein 0.0016 0.0075 0.0074
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.015 0.1919 0.2561
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0551 0.7413 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0062 0.0068
Onchocerca volvulus Putative nachr subunit 0.0652 0.8798 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0016 0.0075 0.0186
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Schistosoma mansoni inositol monophosphatase 0.015 0.1919 0.2578
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0011 0.001
Echinococcus multilocularis inositol monophosphatase 0.0016 0.0075 0.0084
Brugia malayi Inositol-1 0.015 0.1919 0.1919
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0011 0.001
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0209 0.2722 0.3093
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0096 0.0115
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Echinococcus granulosus glycine receptor subunit alpha 1 0.0209 0.2722 0.3093
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0209 0.2722 0.2722
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0094 0.1154 0.153
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0209 0.2722 0.2722
Brugia malayi Matrixin family protein 0.0026 0.022 0.022
Onchocerca volvulus 0.0096 0.118 0.1331
Schistosoma mansoni gliotactin 0.0012 0.0024 0.0017
Brugia malayi hypothetical protein 0.0012 0.0024 0.0024
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0209 0.2722 0.3093
Brugia malayi Hemopexin family protein 0.0037 0.0371 0.0371
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0652 0.8798 0.8797
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.1903 0.2162
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0689 0.2389
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0062 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.1903 0.2556
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0062 0.0047
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0062 0.0047
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0403 0.1352
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0027 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0094 0.1154 0.153
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1876 0.2131
Loa Loa (eye worm) hypothetical protein 0.0026 0.022 0.0219
Brugia malayi Matrixin family protein 0.0026 0.022 0.022
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0094 0.1154 0.153
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0011 0.001
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0096 0.118 0.134
Schistosoma mansoni nAChR subunit 0.0096 0.118 0.1579
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Leishmania major cytochrome p450-like protein 0.0094 0.1154 0.1526
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0209 0.2722 0.2722
Loa Loa (eye worm) hypothetical protein 0.0042 0.0433 0.0431
Loa Loa (eye worm) cytochrome P450 family protein 0.0237 0.3103 0.3102
Brugia malayi Cytochrome P450 family protein 0.0094 0.1154 0.1154
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0209 0.2722 0.3093
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0094 0.1154 0.1526
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0027 0.0025
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0096 0.0094
Onchocerca volvulus 0.0012 0.0024 0.0015
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0011 0.0011
Brugia malayi ecdysteroid receptor 0.0011 0.0011 0.0011
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0583 0.0581
Loa Loa (eye worm) matrixin family protein 0.0064 0.0732 0.073
Brugia malayi Carboxylesterase family protein 0.0071 0.0831 0.0831
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0319 0.0317
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0094 0.1154 0.153
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0062 0.0137
Loa Loa (eye worm) ACC-1 protein 0.0209 0.2722 0.2721
Echinococcus granulosus carboxylesterase 5A 0.0071 0.0831 0.0943
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0209 0.2722 0.2721
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0433 0.0433
Loa Loa (eye worm) carboxylesterase 0.0012 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.015 0.1919 0.2565
Loa Loa (eye worm) GABA receptor subunit 0.0113 0.1402 0.14
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0011 0.001
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0032 0.0299 0.0372
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0062 0.0137
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0062 0.0137
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0094 0.1154 0.153
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0209 0.2722 0.3093
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0101 0.1248 0.1246
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0094 0.1154 0.153
Schistosoma mansoni inositol monophosphatase 0.015 0.1919 0.2578
Brugia malayi hypoxia-induced factor 1 0.0176 0.2269 0.2269
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0215 0.2809 0.3767
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0011 0.0009
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0011 0.001
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0094 0.1154 0.153
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0096 0.0094
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0652 0.8798 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0096 0.1171 0.1329
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0094 0.1154 0.153
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0096 0.0107
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0032 0.0299 0.0299
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0209 0.2722 0.2722
Onchocerca volvulus 0.0042 0.0436 0.0483
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0062 0.0137
Brugia malayi Cytochrome P450 family protein 0.0196 0.2542 0.2542
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0011 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0011 0.0009
Schistosoma mansoni nAChR subunit 0.0209 0.2722 0.3663
Mycobacterium tuberculosis Monophosphatase CysQ 0.0016 0.0075 0.007
Leishmania major dihydroorotate dehydrogenase 0.0551 0.7413 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Loa Loa (eye worm) carboxylesterase 0.0012 0.0024 0.0022
Mycobacterium tuberculosis Probable monophosphatase 0.0016 0.0075 0.007
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0096 0.118 0.134
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Brugia malayi Zinc finger, C2H2 type family protein 0.0215 0.2809 0.2809
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0094 0.1154 0.1526
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0061 0.0689 0.0896
Schistosoma mansoni dihydroorotate dehydrogenase 0.0551 0.7413 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0096 0.118 0.134
Echinococcus granulosus BC026374 protein S09 family 0.0012 0.0024 0.0025
Echinococcus granulosus single minded 2 0.0042 0.0436 0.0493
Onchocerca volvulus 0.0012 0.0024 0.0015
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0209 0.2722 0.2722
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.153 0.1529
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0024 0.0017
Treponema pallidum exodeoxyribonuclease (exoA) 0.0061 0.0689 1
Brugia malayi Cation transporter family protein 0.0209 0.2722 0.2722
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0011 0.0009
Echinococcus multilocularis inositol monophosphatase 1 0.015 0.1919 0.218
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0022
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0061 0.0689 0.0781
Echinococcus granulosus acetylcholinesterase 0.0071 0.0831 0.0943
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0011 0.001
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0094 0.1154 0.153
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Schistosoma mansoni nAChR subunit 0.0209 0.2722 0.3663
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0011 0.0011
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0096 0.0094
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0209 0.2722 0.2722
Loa Loa (eye worm) CYP4Cod1 0.0196 0.2542 0.2541
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0433 0.049
Schistosoma mansoni acetylcholine receptor-related 0.0096 0.118 0.1579
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0635 0.0828
Echinococcus multilocularis acetylcholinesterase 0.0071 0.0831 0.0943
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0027 0.0025
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0011 0.0011
Mycobacterium leprae putative cytochrome p450 0.0094 0.1154 0.1486
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0027 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0011 0.0011
Trichomonas vaginalis myo inositol monophosphatase, putative 0.015 0.1919 0.6804
Echinococcus granulosus acetylcholinesterase 0.0071 0.0831 0.0943
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0096 0.118 0.134
Echinococcus multilocularis para nitrobenzyl esterase 0.0012 0.0024 0.0025
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0096 0.118 0.1178
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0215 0.2809 1
Echinococcus multilocularis glycine receptor subunit beta 0.0209 0.2722 0.3093
Loa Loa (eye worm) hypothetical protein 0.0032 0.0299 0.0297
Brugia malayi steroid hormone receptor 0.0011 0.0011 0.0011
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.015 0.1919 0.2561
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0215 0.2809 0.3192
Loa Loa (eye worm) acetylcholine receptor protein 0.0096 0.118 0.1178
Onchocerca volvulus 0.0012 0.0027 0.0018
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0027 0.0029
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0635 0.0635
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0096 0.0096
Entamoeba histolytica hypothetical protein 0.0113 0.1402 0.4941
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0551 0.7413 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0012 0.0024 0.0017
Brugia malayi PAS domain containing protein 0.0057 0.0638 0.0638
Schistosoma mansoni nAChR subunit 0.0209 0.2722 0.3663
Loa Loa (eye worm) hypothetical protein 0.0113 0.1402 0.14
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0113 0.1402 0.1402
Brugia malayi nuclear hormone receptor 0.0011 0.0011 0.0011
Brugia malayi Cation transporter family protein 0.0434 0.5811 0.5811
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0009
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0061 0.0689 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0094 0.1154 0.153
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0149 0.1903 0.1902
Schistosoma mansoni hypothetical protein 0.0016 0.0075 0.0087
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0094 0.1154 0.153
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0209 0.2722 0.2722
Echinococcus granulosus glycine receptor subunit alpha 1 0.0209 0.2722 0.3093
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0027 0.0029
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0062 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0062 0.0137
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0113 0.1402 0.1402
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0338 0.449 0.4489
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.015 0.1919 0.2561
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0652 0.8798 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0433 0.049
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0094 0.1154 0.153
Schistosoma mansoni single-minded 0.0057 0.0638 0.0847
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0215 0.2809 0.3192
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0011 0.001
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0094 0.1154 0.153
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0027 0.0029
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0094 0.1154 0.153
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0009
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0027 0.0029
Schistosoma mansoni synaptojanin 0.0012 0.0027 0.0022
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0094 0.1154 0.153
Brugia malayi Carboxylesterase family protein 0.0012 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0094 0.1154 0.153
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0094 0.1154 0.153
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0215 0.2809 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0011 0.0011
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.0638 0.0847
Brugia malayi Cytochrome P450 family protein 0.0237 0.3103 0.3103
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0209 0.2722 0.3093
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0096 0.1171 0.1329
Brugia malayi hypothetical protein 0.0096 0.118 0.118
Brugia malayi Matrixin family protein 0.0026 0.022 0.022
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0094 0.1154 0.153
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.153 0.1529
Loa Loa (eye worm) cytochrome P450 family protein 0.0196 0.2542 0.2541
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0061 0.0689 0.238
Loa Loa (eye worm) inositol-1 0.015 0.1919 0.1918
Trichomonas vaginalis myo inositol monophosphatase, putative 0.015 0.1919 0.6804
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0652 0.8798 1
Schistosoma mansoni ap endonuclease 0.0061 0.0689 0.0916
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0027 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0011 0.0011
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0209 0.2722 0.3093
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.0016 0.0075 0.007
Loa Loa (eye worm) hypothetical protein 0.0071 0.0831 0.0829
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0012 0.0024 0.0025
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0096 0.0094
Schistosoma mansoni acetylcholine receptor subunit beta 0.0096 0.118 0.1579
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0027 0.0012
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0635 0.0828
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0436 0.0436
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0027 0.0027
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0209 0.2722 0.3663
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0831 0.1108
Trypanosoma cruzi cytochrome P450, putative 0.0196 0.2542 0.3405
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0011 0.001
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0016 0.0075 0.0073
Schistosoma mansoni cript-related 0.0012 0.0027 0.0022
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0027 0.0027
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0096 0.0107
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0215 0.2809 1
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0026 0.022 0.0283
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0209 0.2722 0.2722
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0027 0.0027
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0453 0.154
Leishmania major myo-inositol-1 phosphatase, putative 0.0016 0.0075 0.0065
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0096 0.118 0.1178
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0094 0.1154 0.1526
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0113 0.1402 0.1402
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0196 0.2542 0.3408
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0062 0.0137
Mycobacterium tuberculosis Probable exported protein 0.0012 0.0027 0.0005
Loa Loa (eye worm) hypothetical protein 0.0113 0.1402 0.14
Brugia malayi CXXC zinc finger family protein 0.0034 0.0319 0.0319
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0061 0.0689 0.09
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0094 0.1154 0.153
Trichomonas vaginalis inositol monophosphatase, putative 0.015 0.1919 0.6804
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0094 0.1154 0.1526
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0436 0.0493
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0061 0.0689 0.0896
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0062 0.0068
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0551 0.7413 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Loa Loa (eye worm) hypothetical protein 0.0071 0.0831 0.0829
Schistosoma mansoni pap-inositol-14-phosphatase 0.0016 0.0075 0.0087
Schistosoma mansoni hypothetical protein 0.0364 0.4852 0.6539
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0094 0.1154 0.153
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0025
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0209 0.2722 0.3663
Loa Loa (eye worm) cytochrome P450 0.0094 0.1154 0.1153
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0027 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0009
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.0016 0.0075 0.0065
Brugia malayi Inositol monophosphatase family protein 0.0016 0.0075 0.0075
Brugia malayi Matrixin family protein 0.0026 0.022 0.022
Loa Loa (eye worm) cytochrome P450 family protein 0.0196 0.2542 0.2541
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0551 0.7413 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0094 0.1154 0.153
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0062 0.0047
Brugia malayi MH2 domain containing protein 0.0122 0.153 0.153
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0016 0.0075 0.0174
Echinococcus granulosus synaptojanin 1 0.0012 0.0027 0.0029
Onchocerca volvulus 0.0015 0.0062 0.0058
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0209 0.2722 0.3093
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0094 0.1154 0.153
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0094 0.1154 0.153
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0096 0.0107
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0094 0.1154 0.153
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.1903 0.2162
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0027 0.0027
Mycobacterium ulcerans monophosphatase CysQ 0.0016 0.0075 0.007
Onchocerca volvulus 0.0096 0.118 0.1331
Echinococcus granulosus cytochrome P450 2K1 0.0094 0.1154 0.131
Schistosoma mansoni synaptojanin 0.0012 0.0027 0.0022
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0209 0.2722 0.3093
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0062 0.0047
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0024 0.0017
Loa Loa (eye worm) hypothetical protein 0.0113 0.1402 0.14
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0551 0.7413 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0011 0.0009
Echinococcus granulosus neuroligin 0.0012 0.0024 0.0025
Mycobacterium ulcerans hydrolase 0.0032 0.0299 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0433 0.1469
Mycobacterium leprae POSSIBLE MONOPHOSPHATASE CYSQ 0.0016 0.0075 0.0018
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0016 0.0075 0.0186
Mycobacterium ulcerans putative regulatory protein 0.0042 0.0436 0.0558
Onchocerca volvulus 0.0012 0.0024 0.0015
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0096 0.118 0.118
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0011 0.0011
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0551 0.7413 1
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.0016 0.0075 0.0065
Echinococcus granulosus nAChR subunit 0.0209 0.2722 0.3093
Onchocerca volvulus 0.0209 0.2722 0.3086
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.0016 0.0075 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0062 0.0137
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0433 0.1459
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0834 0.1112
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0027 0.0027
Echinococcus multilocularis acetylcholinesterase 0.0071 0.0831 0.0943
Loa Loa (eye worm) hypothetical protein 0.0113 0.1402 0.14
Leishmania major cytochrome p450-like protein 0.0196 0.2542 0.3405
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0403 0.0509
Onchocerca volvulus Matrilysin homolog 0.0026 0.022 0.0238
Loa Loa (eye worm) hypothetical protein 0.0096 0.118 0.1178
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0011 0.0011
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0027 0.0029
Echinococcus granulosus dnaJ subfamily B 0.0477 0.6404 0.7279
Echinococcus granulosus nAChR subunit 0.0113 0.1402 0.1592
Echinococcus multilocularis 0.0094 0.1154 0.131
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.015 0.1919 0.2561
Echinococcus multilocularis carboxylesterase 5A 0.0071 0.0831 0.0943
Echinococcus multilocularis nAChR subunit 0.0209 0.2722 0.3093
Onchocerca volvulus 0.0209 0.2722 0.3086
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0094 0.1154 0.1526
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0096 0.0094
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0016 0.0075 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0011 0.0011
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0094 0.1154 0.153
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0209 0.2722 0.2722
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0011 0.001
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0027 0.0029
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0209 0.2722 0.3093
Schistosoma mansoni hypothetical protein 0.0477 0.6404 0.8637
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0094 0.1154 0.153
Toxoplasma gondii exonuclease III APE 0.0061 0.0689 0.0896
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0096 0.118 0.134
Schistosoma mansoni nAChR subunit 0.0209 0.2722 0.3663
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Loa Loa (eye worm) hypothetical protein 0.0434 0.5811 0.581
Onchocerca volvulus 0.0434 0.5811 0.6601
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0061 0.0689 0.09
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0094 0.1154 0.153
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0209 0.2722 0.2721
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0061 0.0689 0.0687
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0096 0.0107
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.0016 0.0075 0.0065
Schistosoma mansoni nAChR subunit 0.0209 0.2722 0.3663
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0453 0.0576
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0209 0.2722 0.2721
Loa Loa (eye worm) acetyltransferase 0.0147 0.1876 0.1875
Onchocerca volvulus 0.0113 0.1402 0.1583
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1876 0.1876
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.015 0.1919 0.2561
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0009
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0433 0.0549
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0027 0.0029
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0652 0.8798 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0062 0.006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0011 0.0011
Echinococcus multilocularis BC026374 protein (S09 family) 0.0012 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.0434 0.5811 0.581
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0433 0.1469
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0215 0.2809 1
Schistosoma mansoni myo inositol monophosphatase 0.0016 0.0075 0.0087
Mycobacterium leprae Conserved hypothetical protein 0.0094 0.1154 0.1486
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0094 0.1154 0.153
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.015 0.1919 0.1829
Toxoplasma gondii hypothetical protein 0.0016 0.0075 0.0065
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0433 0.0549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.1903 0.2556
Giardia lamblia Hypothetical protein 0.0016 0.0075 0.073
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0016 0.0075 0.0084
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1876 0.252
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0011 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0062 0.0137
Brugia malayi Cytochrome P450 family protein 0.0196 0.2542 0.2542
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0209 0.2722 0.3093
Leishmania major protein kinase, putative 0.0015 0.0062 0.0047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0061 0.0689 0.0896
Loa Loa (eye worm) hypothetical protein 0.0026 0.022 0.0219
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0062 0.0047
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0096 0.118 0.118
Brugia malayi isocitrate dehydrogenase 0.0017 0.0096 0.0096
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0433 0.049
Echinococcus multilocularis geminin 0.0364 0.4852 0.5514
Schistosoma mansoni nAChR subunit 0.0096 0.118 0.1579
Trypanosoma brucei cytochrome P450, putative 0.0196 0.2542 0.3405
Onchocerca volvulus 0.0434 0.5811 0.6601
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0689 0.2389
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0062 0.006
Mycobacterium leprae Probable monophosphatase 0.0016 0.0075 0.0018
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0215 0.2809 1
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0062 0.0137
Onchocerca volvulus 0.0012 0.0027 0.0018
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0027 0.0029
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0433 0.6129
Trichomonas vaginalis inositol monophosphatase, putative 0.0016 0.0075 0.0186
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0551 0.7413 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.1903 0.2162
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0433 0.057
Echinococcus granulosus para nitrobenzyl esterase 0.0012 0.0024 0.0025
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0027 0.0022
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0027 0.0022
Schistosoma mansoni neurotransmitter gated ion channel 0.0096 0.118 0.1579
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0433 0.0549
Brugia malayi hypothetical protein 0.0191 0.2471 0.2471
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0011 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0011 0.001
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0135 0.1703 0.2233
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0011 0.0009
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0027 0.0025
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0635 0.0828
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0215 0.2809 0.3192
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0061 0.0689 0.0781
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0027 0.0027
Echinococcus granulosus inositol monophosphatase 1 0.015 0.1919 0.218
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0027 0.0025
Schistosoma mansoni acetylcholinesterase 0.0012 0.0024 0.0017
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0635 0.072
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0094 0.1154 0.153
Onchocerca volvulus 0.0026 0.022 0.0238
Loa Loa (eye worm) hypothetical protein 0.0209 0.2722 0.2721
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0652 0.8798 1
Brugia malayi hypothetical protein 0.0096 0.118 0.118
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0062 0.0047
Onchocerca volvulus 0.0037 0.0371 0.041

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.236 uM Inhibition activity against recombinant human stromelysin (Matrix metalloproteinase-3) ChEMBL. 9258358
Ki (binding) = 0.236 uM Inhibition activity against recombinant human stromelysin (Matrix metalloproteinase-3) ChEMBL. 9258358

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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