Detailed information for compound 1382455

Basic information

Technical information
  • TDR Targets ID: 1382455
  • Name: N-[[3-[(2-methylbenzoyl)amino]phenyl]carbamot hioyl]thiophene-2-carboxamide
  • MW: 395.498 | Formula: C20H17N3O2S2
  • H donors: 3 H acceptors: 2 LogP: 4.73 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(NC(=O)c1cccs1)Nc1cccc(c1)NC(=O)c1ccccc1C
  • InChi: 1S/C20H17N3O2S2/c1-13-6-2-3-9-16(13)18(24)21-14-7-4-8-15(12-14)22-20(26)23-19(25)17-10-5-11-27-17/h2-12H,1H3,(H,21,24)(H2,22,23,25,26)
  • InChiKey: DNHDTNPQCBXEDD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[[[3-[[(2-methylphenyl)-oxomethyl]amino]phenyl]amino]-thioxomethyl]-2-thiophenecarboxamide
  • N-[[3-[(2-methylbenzoyl)amino]phenyl]thiocarbamoyl]thiophene-2-carboxamide
  • N-[[3-[(2-methylphenyl)carbonylamino]phenyl]carbamothioyl]thiophene-2-carboxamide
  • ZINC01172718
  • MLS000572806
  • N-[({3-[(2-methylbenzoyl)amino]phenyl}amino)carbonothioyl]-2-thiophenecarboxamide
  • SMR000194667
  • STK081692

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1472 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0468 0.0562
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.6728 0.7125
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0268 0.0284
Brugia malayi Cathepsin L-like precursor 0.0014 0.0468 0.0591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.1002 0.1002
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.1472 0.1833
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0268 0.0284
Trypanosoma brucei cytochrome P450, putative 0.0028 0.2591 0.2591
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0268 0.0309
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0268 0.0284
Entamoeba histolytica cysteine proteinase, putative 0.002 0.1472 1
Loa Loa (eye worm) CYP4Cod1 0.0028 0.2591 0.325
Brugia malayi nuclear hormone receptor 0.0012 0.0268 0.0339
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0268 0.0284
Loa Loa (eye worm) hypothetical protein 0.0012 0.0268 0.0309
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0268 0.0284
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0268 0.0284
Trypanosoma cruzi cysteine peptidase, putative 0.0077 1 1
Loa Loa (eye worm) ctsf protein 0.002 0.1472 0.1833
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0268 0.0309
Trypanosoma cruzi cysteine peptidase, putative 0.0077 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.9443 1
Leishmania major cathepsin L-like protease 0.002 0.1472 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Brugia malayi ecdysteroid receptor 0.0012 0.0268 0.0339
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.6728 0.7125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1472 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0268 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.6728 0.7125
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0268 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0268 0.0339
Brugia malayi Cathepsin L-like precursor 0.0014 0.0468 0.0591
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0468 0.0591
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.1472 0.1472
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.2591 0.1882
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Leishmania major cysteine peptidase A (CPA) 0.002 0.1472 0.0521
Leishmania major cathepsin L-like protease 0.002 0.1472 0.0521
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.8997 0.8997
Onchocerca volvulus 0.002 0.1472 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0268 0.0309
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.1472 0.1558
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1472 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.1002 0.1002
Leishmania major cathepsin L-like protease 0.002 0.1472 0.0521
Leishmania major cytochrome p450-like protein 0.0028 0.2591 0.1765
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.2591 0.2591
Onchocerca volvulus 0.002 0.1472 1
Onchocerca volvulus Cathepsin F homolog 0.002 0.1472 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0268 0.0284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Onchocerca volvulus 0.002 0.1472 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.9443 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0268 0.0284
Loa Loa (eye worm) cysteine protease 0.002 0.1472 0.1833
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.1472 0.1558
Brugia malayi Cytochrome P450 family protein 0.0017 0.1002 0.1266
Leishmania major cathepsin L-like protease 0.002 0.1472 0.0521
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.2591 0.2591
Loa Loa (eye worm) hypothetical protein 0.0014 0.0468 0.0562
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1472 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0268 0.0309
Loa Loa (eye worm) hypothetical protein 0.0012 0.0268 0.0309
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1472 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0268 0.0339
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.6728 0.7125
Brugia malayi Cathepsin L-like precursor 0.002 0.1472 0.1858
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0268 0.0284
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.2591 0.325
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0268 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0268 0.0339
Onchocerca volvulus 0.0014 0.0468 0.166
Leishmania major cathepsin L-like protease 0.0077 1 1
Onchocerca volvulus Cathepsin L homolog 0.002 0.1472 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0268 0.0339
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.1472 0.1558
Loa Loa (eye worm) hypothetical protein 0.002 0.1472 0.1833
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.6728 0.7125
Loa Loa (eye worm) cytochrome P450 0.0017 0.1002 0.1238
Trypanosoma cruzi cysteine peptidase, putative 0.0077 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.1472 0.1858
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0268 0.0284
Echinococcus granulosus cathepsin l1 0.002 0.1472 0.1558
Brugia malayi steroid hormone receptor 0.0012 0.0268 0.0339
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.9443 1
Brugia malayi Cytochrome P450 family protein 0.0063 0.7919 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1472 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.1472 0.1558
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.9443 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.1472 0.1558
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0268 0.0284
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.1472 0.1558
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0268 0.0339
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.1002 0.1002
Onchocerca volvulus 0.002 0.1472 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.9443 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.1472 0.1833
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.6728 0.7125
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0268 0.0284
Echinococcus granulosus cathepsin l1 0.0014 0.0468 0.0496
Plasmodium vivax vivapain-2 0.002 0.1472 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0268 0.0284
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0268 0.0284
Echinococcus multilocularis 0.0017 0.1002 0.1062
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0268 0.0339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.2591 0.325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Entamoeba histolytica cysteine proteinase, putative 0.002 0.1472 1
Toxoplasma gondii cathepsin CPL 0.002 0.1472 0.0556
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.6728 0.8495
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Entamoeba histolytica cysteine protease, putative 0.002 0.1472 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0268 0.0309
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0268 0.0284
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0268 0.0309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0268 0.0284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0468 0.3182
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.1002 0.1062
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.1472 0.1558
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1472 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.9443 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0268 0.0284
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0268 0.0339
Brugia malayi Cathepsin L-like precursor 0.002 0.1472 0.1858
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.1472 0.1558
Brugia malayi Cathepsin L-like precursor 0.002 0.1472 0.1858
Echinococcus multilocularis cysteine protease 0.002 0.1472 0.1558
Schistosoma mansoni cytochrome P450 0.0017 0.1002 0.1062
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0268 0.0284
Echinococcus multilocularis cysteine protease 0.002 0.1472 0.1558
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.6728 0.849
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0268 0.0284
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0268 0.0284
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0268 0.0339
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0268 0.0284
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.7525 0.7525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0268 0.0309
Loa Loa (eye worm) hypothetical protein 0.0012 0.0268 0.0309
Plasmodium vivax vivapain-2 0.002 0.1472 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0268 0.0339
Leishmania major cathepsin L-like protease 0.0077 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0268 0.0284
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.1472 1
Brugia malayi Cytochrome P450 family protein 0.0028 0.2591 0.3271
Leishmania major cathepsin L-like protease 0.002 0.1472 0.0521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Onchocerca volvulus 0.002 0.1472 1
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.1002 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0268 0.0284
Loa Loa (eye worm) hypothetical protein 0.0012 0.0268 0.0309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Onchocerca volvulus 0.002 0.1472 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.6728 0.7125
Loa Loa (eye worm) fibroinase 0.002 0.1472 0.1833
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0077 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.1472 0.1858
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.9443 1
Brugia malayi cytochrome P450 0.0017 0.1002 0.1266
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0268 0.0339
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0268 0.0309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0468 0.3182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Brugia malayi nuclear receptor NHR-88 0.0012 0.0268 0.0339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.1472 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.1472 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1472 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.1472 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0268 0.0309
Mycobacterium leprae putative cytochrome p450 0.0017 0.1002 0.5
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.1002 0.1002
Brugia malayi cathepsin L-like precursor 0.0014 0.0468 0.0591
Onchocerca volvulus Cathepsin L homolog 0.002 0.1472 1
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.9443 1
Schistosoma mansoni coup transcription factor 0.0012 0.0268 0.0284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.1472 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0268 0.0284
Brugia malayi Cathepsin L-like precursor 0.002 0.1472 0.1858
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.1472 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0268 0.0284
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0268 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0268 0.0339
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.9443 0.9381
Schistosoma mansoni hypothetical protein 0.0017 0.1002 0.1062
Loa Loa (eye worm) hypothetical protein 0.0014 0.0468 0.0562
Onchocerca volvulus 0.002 0.1472 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0268 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0268 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0268 0.0339
Loa Loa (eye worm) hypothetical protein 0.0012 0.0268 0.0309
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0468 0.3182
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.1472 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0268 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0268 0.0309
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.7919 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.9443 1
Brugia malayi Cytochrome P450 family protein 0.0028 0.2591 0.3271
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0468 0.0496
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0268 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0268 0.0309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0268 0.0339
Brugia malayi Papain family cysteine protease containing protein 0.002 0.1472 0.1858

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.16227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.548133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.548133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.548133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.0029 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.4147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.