Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | nitric oxide synthase, putative | 0.0129 | 0.6728 | 1 |
Treponema pallidum | flavodoxin | 0.0049 | 0 | 0.5 |
Loa Loa (eye worm) | TTK protein kinase | 0.0168 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0129 | 0.6728 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0129 | 0.6728 | 0.5602 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0115 | 0.5489 | 0.5489 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0049 | 0 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0129 | 0.6728 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0129 | 0.6728 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0049 | 0 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0129 | 0.6728 | 0.6728 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0129 | 0.6728 | 0.5602 |
Brugia malayi | flavodoxin family protein | 0.0129 | 0.6728 | 0.6728 |
Leishmania major | p450 reductase, putative | 0.0129 | 0.6728 | 1 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0168 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0129 | 0.6728 | 0.5602 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0168 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0115 | 0.5489 | 0.8159 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0129 | 0.6728 | 0.6266 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0168 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0049 | 0 | 0.5 |
Giardia lamblia | Kinase, TTK | 0.0168 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0064 | 0.1239 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0064 | 0.1239 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0129 | 0.6728 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.6728 | 0.6728 |
Chlamydia trachomatis | sulfite reductase | 0.008 | 0.256 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0129 | 0.6728 | 0.5602 |
Brugia malayi | FAD binding domain containing protein | 0.008 | 0.256 | 0.256 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0168 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.008 | 0.256 | 0.1508 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0168 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0129 | 0.6728 | 0.6728 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0129 | 0.6728 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0129 | 0.6728 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0065 | 0.1322 | 0.0095 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0129 | 0.6728 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0168 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.008 | 0.256 | 0.256 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0129 | 0.6728 | 0.6728 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0115 | 0.5489 | 0.8159 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0049 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0129 | 0.6728 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0129 | 0.6728 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0129 | 0.6728 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0049 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0129 | 0.6728 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.000000001 M | Ability to induce differentiation of mouse F9 embryonal carcinoma cells. | ChEMBL. | 2836589 |
ED50 (functional) | = 0.000000001 M | Ability to induce differentiation of mouse F9 embryonal carcinoma cells. | ChEMBL. | 2836589 |
RA (binding) | = 90 % | Relative percent binding to cellular retinoic acid binding protein (CRABP) in chick embryo skin. | ChEMBL. | 2836589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.