Detailed information for compound 1383444

Basic information

Technical information
  • TDR Targets ID: 1383444
  • Name: 8-(3-methyl-[1,2,4]triazolo[3,4-f]pyridazin-6 -yl)-1,4-dioxa-8-azaspiro[4.5]decane
  • MW: 275.306 | Formula: C13H17N5O2
  • H donors: 0 H acceptors: 3 LogP: 0.54 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nnc2n1nc(cc2)N1CCC2(CC1)OCCO2
  • InChi: 1S/C13H17N5O2/c1-10-14-15-11-2-3-12(16-18(10)11)17-6-4-13(5-7-17)19-8-9-20-13/h2-3H,4-9H2,1H3
  • InChiKey: ALKNPSYKVZDAJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1,4-dioxa-8-azaspiro[4.5]decane
  • MLS000093312
  • SMR000028935

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pleckstrin Homology Domain 0.004 0.0022 0.0013
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Entamoeba histolytica protein kinase, putative 0.0051 0.0063 0.0277
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Brugia malayi C-terminal src kinase protein 1 0.0043 0.0032 0.0023
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0034 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0043 0.0032 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Echinococcus multilocularis transcription factor collier 0.0122 0.0329 0.0383
Echinococcus granulosus tyrosine protein kinase Srms 0.0043 0.0032 0.0028
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0043 0.0032 0.0913
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0025
Loa Loa (eye worm) hypothetical protein 0.0122 0.0329 0.032
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0043 0.0032 0.0023
Schistosoma mansoni cell adhesion molecule 0.0114 0.0296 0.0275
Loa Loa (eye worm) hypothetical protein 0.0122 0.0329 0.032
Brugia malayi hypothetical protein 0.0439 0.1513 0.1505
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Echinococcus multilocularis Pleckstrin y 0.004 0.0022 0.0015
Loa Loa (eye worm) hypothetical protein 0.028 0.0916 0.0908
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Schistosoma mansoni semaphorin 5-related 0.028 0.0916 0.0897
Loa Loa (eye worm) hypothetical protein 0.0286 0.0939 0.093
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Echinococcus granulosus tyrosine protein kinase 0.0043 0.0032 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0329 0.2174
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0043 0.0032 0.0045
Schistosoma mansoni regulator of G protein signaling 0.0439 0.1513 0.1495
Plasmodium vivax tyrosine kinase-like protein, putative 0.0043 0.0032 0.0913
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0135 0.0126
Leishmania major protein kinase, putative 0.0054 0.0073 0.4553
Echinococcus multilocularis activated cdc42 kinase 1 0.0043 0.0032 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Echinococcus multilocularis DCC interacting protein 13 beta 0.004 0.0022 0.0015
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0135 0.0126
Echinococcus granulosus beta-adrenergic receptor kinase 0.2077 0.7635 0.9135
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0043 0.0032 0.0045
Brugia malayi PH domain containing protein 0.004 0.0022 0.0013
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0034 0.0029
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Brugia malayi Dynamin 0.004 0.0022 0.0013
Brugia malayi TBC domain containing protein 0.004 0.0022 0.0013
Loa Loa (eye worm) serine/threonine protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Echinococcus granulosus tyrosine protein kinase Lyn 0.0054 0.0073 0.0077
Loa Loa (eye worm) TK/INSR protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis centaurin beta, putative 0.004 0.0022 0.0143
Loa Loa (eye worm) hypothetical protein 0.0439 0.1513 0.1505
Echinococcus multilocularis protein kinase 0.0043 0.0032 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0032 0.0212
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0089 0.008
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0073 0.0347
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0051 0.0063 0.3639
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Entamoeba histolytica hypothetical protein 0.0043 0.0032 0.007
Echinococcus multilocularis myotubularin protein 13 0.004 0.0022 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0034 0.1048
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0043 0.0032 0.0028
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0071 0.0135 0.0151
Plasmodium vivax protein kinase, putative 0.0043 0.0032 0.0913
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Echinococcus granulosus oxysterol binding protein 1 0.004 0.0022 0.0015
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Echinococcus multilocularis protein tyrosine kinase 0.0043 0.0032 0.0028
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0043 0.0032 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Onchocerca volvulus 0.0043 0.0032 0.0045
Brugia malayi protein-tyrosine kinase 0.0043 0.0032 0.0023
Echinococcus multilocularis ephrin type A receptor 4 A 0.0043 0.0032 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Brugia malayi SH2 domain containing protein 0.0043 0.0032 0.0023
Brugia malayi Oxysterol binding protein 0.004 0.0022 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Entamoeba histolytica tyrosin kinase, putative 0.0043 0.0032 0.007
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.004 0.0022 0.0015
Entamoeba histolytica serine/threonine kinase, putative 0.0043 0.0032 0.007
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0043 0.0032 0.0028
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0051 0.0063 0.3639
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Echinococcus granulosus dynamin 1 0.004 0.0022 0.0015
Entamoeba histolytica hypothetical protein 0.0122 0.0329 0.206
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis esterase, putative 0.0043 0.0034 0.0222
Loa Loa (eye worm) hypothetical protein 0.0439 0.1513 0.1505
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.0032 0.0028
Leishmania major protein kinase, putative 0.0051 0.0063 0.3639
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0034 0.1048
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0122 0.0329 0.2174
Entamoeba histolytica hypothetical protein 0.0043 0.0032 0.007
Trypanosoma brucei Pseudokinase, putative 0.0043 0.0032 0.0913
Echinococcus granulosus tyrosine protein kinase pr2 0.0043 0.0032 0.0028
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0043 0.0032 0.0028
Loa Loa (eye worm) hypothetical protein 0.0114 0.0296 0.0287
Brugia malayi Protein kinase domain containing protein 0.0051 0.0063 0.0054
Onchocerca volvulus Tyrosine kinase homolog 0.0043 0.0032 0.0045
Brugia malayi Plexin repeat family protein 0.0656 0.2322 0.2315
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Schistosoma mansoni protein kinase 0.0043 0.0032 0.001
Echinococcus granulosus epidermal growth factor receptor 0.0043 0.0032 0.0028
Echinococcus granulosus tyrosine protein kinase csk 0.0043 0.0032 0.0028
Echinococcus multilocularis Immunoglobulin 0.0114 0.0296 0.0344
Schistosoma mansoni survival motor neuron protein 0.0058 0.0089 0.0067
Entamoeba histolytica cysteine surface protein, putative 0.0043 0.0032 0.007
Echinococcus multilocularis pleckstrin y domain containing family A 0.004 0.0022 0.0015
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0043 0.0032 0.0028
Echinococcus granulosus integrin linked protein kinase 0.0043 0.0032 0.0028
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Loa Loa (eye worm) hypothetical protein 0.028 0.0916 0.0908
Echinococcus multilocularis protein kinase 0.0043 0.0032 0.0028
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Loa Loa (eye worm) hypothetical protein 0.0114 0.0296 0.0287
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0051 0.0063 0.3639
Echinococcus multilocularis epidermal growth factor receptor 0.0043 0.0032 0.0028
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0043 0.0032 0.0028
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0051 0.0063 0.3639
Echinococcus granulosus Immunoglobulin 0.0114 0.0296 0.0344
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Trypanosoma cruzi Protein kinase B 0.0051 0.0063 0.3639
Brugia malayi Regulator of G protein signaling domain containing protein 0.0439 0.1513 0.1505
Schistosoma mansoni axis inhibition protein axin 0.0439 0.1513 0.1495
Echinococcus multilocularis receptor type guanylyl cyclase 0.0043 0.0032 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Plasmodium falciparum protein kinase, putative 0.0043 0.0032 0.0913
Echinococcus granulosus protein tyrosine kinase 0.0043 0.0032 0.0028
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0043 0.0032 0.0028
Entamoeba histolytica protein kinase, putative 0.0071 0.0135 0.0762
Echinococcus multilocularis axis inhibition protein axin 0.0439 0.1513 0.1802
Echinococcus granulosus Oxysterol binding protein 11 0.004 0.0022 0.0015
Brugia malayi PH domain containing protein 0.004 0.0022 0.0013
Schistosoma mansoni tyrosine protein kinase 0.0043 0.0032 0.001
Brugia malayi hypothetical protein 0.028 0.0916 0.0908
Entamoeba histolytica protein kinase, putative 0.0071 0.0135 0.0762
Echinococcus granulosus tyrosine kinase 0.0043 0.0032 0.0028
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0043 0.0032 0.0212
Echinococcus multilocularis semaphorin 5B 0.028 0.0916 0.1087
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0034 0.0025
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0071 0.0135 0.0762
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Schistosoma mansoni protein kinase 0.0043 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0114 0.0296 0.0287
Entamoeba histolytica serine/threonine kinase, putative 0.0043 0.0032 0.007
Echinococcus multilocularis heat shock protein 70 0.0043 0.0032 0.0028
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.227 0.8358 0.8356
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0043 0.0032 0.007
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0043 0.0032 0.001
Onchocerca volvulus 0.0043 0.0032 0.0045
Trichomonas vaginalis protein tyrosine kinase, putative 0.0043 0.0032 0.0212
Brugia malayi Fibronectin type III domain containing protein 0.0114 0.0296 0.0287
Onchocerca volvulus 0.0043 0.0034 0.0052
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0439 0.1513 0.1495
Echinococcus multilocularis tyrosine protein kinase Abl 0.0043 0.0032 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Loa Loa (eye worm) TK/ALK protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0032 0.0212
Schistosoma mansoni serine/threonine protein kinase 0.2077 0.7635 0.763
Loa Loa (eye worm) TK protein kinase 0.0043 0.0032 0.0023
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Brugia malayi A-kinase anchor protein 10, precursor 0.0439 0.1513 0.1505
Echinococcus granulosus semaphorin 1A 0.028 0.0916 0.1087
Entamoeba histolytica protein kinase, putative 0.0051 0.0063 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0157 0.0457 0.0448
Loa Loa (eye worm) hypothetical protein 0.028 0.0916 0.0908
Echinococcus granulosus Regulator of G protein signaling 20 0.0439 0.1513 0.1802
Echinococcus multilocularis FL cytokine receptor 0.0043 0.0032 0.0028
Toxoplasma gondii protein kinase domain-containing protein 0.0043 0.0032 0.0913
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Echinococcus multilocularis raf serine:threonine protein kinase 0.0043 0.0032 0.0028
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0051 0.0063 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0032 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0043 0.0032 0.0028
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0032 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0439 0.1513 1
Entamoeba histolytica protein kinase, putative 0.0051 0.0063 0.0277
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0043 0.0032 0.0028
Echinococcus multilocularis GRB2 associated binding protein 3 0.004 0.0022 0.0015
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0051 0.0063 0.3639
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0122 0.0329 0.2174
Entamoeba histolytica tyrosin kinase, putative 0.0043 0.0032 0.007
Echinococcus multilocularis protein KINase family member (kin 25) 0.0043 0.0032 0.0028
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0329 0.2174
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Entamoeba histolytica hypothetical protein 0.0122 0.0329 0.206
Brugia malayi Sema domain containing protein 0.028 0.0916 0.0908
Plasmodium falciparum protein kinase, putative 0.0054 0.0073 0.4553
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Echinococcus multilocularis Pleckstrin y 0.004 0.0022 0.0015
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Echinococcus multilocularis G protein coupled receptor kinase 6 0.227 0.8358 1
Brugia malayi integrin-linked kinase 0.0043 0.0032 0.0023
Loa Loa (eye worm) uncoordinated protein 104 0.004 0.0022 0.0013
Trypanosoma brucei protein kinase, putative 0.0054 0.0073 0.4553
Echinococcus granulosus Rho GTPase activating protein 24 0.004 0.0022 0.0015
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Schistosoma mansoni protein kinase 0.0043 0.0032 0.001
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.227 0.8358 0.8356
Echinococcus multilocularis integrin linked protein kinase 0.0043 0.0032 0.0028
Echinococcus multilocularis Oxysterol binding protein 11 0.004 0.0022 0.0015
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.091 1
Echinococcus granulosus Pleckstrin y 0.004 0.0022 0.0015
Loa Loa (eye worm) TK/ACK protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis STE family protein kinase 0.0043 0.0032 0.0212
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.004 0.0022 0.0015
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0043 0.0032 0.0028
Loa Loa (eye worm) RGC/RGC protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0043 0.0032 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0032 0.0212
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0025
Loa Loa (eye worm) hypothetical protein 0.0114 0.0296 0.0287
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.004 0.0022 0.0015
Brugia malayi hypothetical protein 0.0439 0.1513 0.1505
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.0032 0.0028
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0439 0.1513 0.1505
Entamoeba histolytica tyrosin kinase, putative 0.0043 0.0032 0.007
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0114 0.0296 0.0344
Toxoplasma gondii STE kinase 0.0043 0.0032 0.0913
Brugia malayi Guanylyl cyclase protein 23 0.0043 0.0032 0.0023
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0043 0.0032 0.0028
Echinococcus granulosus kinase suppressor of Ras 1 0.0043 0.0032 0.0028
Trichomonas vaginalis centaurin/arf, putative 0.004 0.0022 0.0143
Brugia malayi beta-lactamase 0.0043 0.0034 0.0025
Echinococcus granulosus retinal guanylyl cyclase 2 0.0043 0.0032 0.0028
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Brugia malayi hypothetical protein 0.0043 0.0032 0.0023
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0122 0.0329 0.2174
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Echinococcus multilocularis Pleckstrin y 0.004 0.0022 0.0015
Entamoeba histolytica hypothetical protein 0.0043 0.0032 0.007
Brugia malayi PXA domain containing protein 0.0439 0.1513 0.1505
Entamoeba histolytica p21-activated kinase 0.0051 0.0063 0.0277
Echinococcus granulosus regulator of G protein signaling 3 0.0439 0.1513 0.1802
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Brugia malayi serine/threonine-protein kinase 6 0.0071 0.0135 0.0126
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0043 0.0032 0.0028
Entamoeba histolytica receptor protein kinase, putative 0.0043 0.0032 0.007
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0043 0.0032 0.0028
Schistosoma mansoni z-protein (S1r protein) 0.0439 0.1513 0.1495
Loa Loa (eye worm) sema domain-containing protein 0.028 0.0916 0.0908
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0939 0.1114
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Brugia malayi Sema domain containing protein 0.028 0.0916 0.0908
Loa Loa (eye worm) PH domain-containing protein 0.004 0.0022 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Mycobacterium ulcerans beta-lactamase 0.0043 0.0034 0.5
Entamoeba histolytica hypothetical protein 0.0439 0.1513 1
Echinococcus granulosus regulator of G protein signaling 3 0.0439 0.1513 0.1802
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0051 0.0063 0.3639
Echinococcus granulosus calcium dependent secretion activator 1 0.004 0.0022 0.0015
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0054 0.0073 0.4553
Echinococcus multilocularis oxysterol binding protein 1 0.004 0.0022 0.0015
Schistosoma mansoni hypothetical protein 0.028 0.0916 0.0897
Loa Loa (eye worm) RhoGEF domain-containing protein 0.004 0.0022 0.0013
Echinococcus multilocularis tyrosine protein kinase csk 0.0043 0.0032 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Entamoeba histolytica protein kinase, putative 0.0051 0.0063 0.0277
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0034 0.0029
Echinococcus multilocularis tyrosine protein kinase csk 0.0043 0.0032 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Plasmodium falciparum calcium-dependent protein kinase 7 0.0051 0.0063 0.3639
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0032 0.001
Echinococcus multilocularis tyrosine kinase 0.0043 0.0032 0.0028
Echinococcus granulosus GRB2 associated binding protein 3 0.004 0.0022 0.0015
Entamoeba histolytica serine/threonine kinase, putative 0.0043 0.0032 0.007
Schistosoma mansoni protein tyrosine kinase 0.0043 0.0032 0.001
Echinococcus granulosus G protein coupled receptor kinase 1 0.1637 0.5993 0.7168
Brugia malayi serine/threonine kinase 12 0.0071 0.0135 0.0126
Echinococcus granulosus exocyst complex component 2 0.0122 0.0329 0.0383
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Entamoeba histolytica protein kinase domain containing protein 0.0166 0.049 0.314
Schistosoma mansoni regulator of G protein signaling 0.0439 0.1513 0.1495
Schistosoma mansoni regulator of G protein signaling 0.0439 0.1513 0.1495
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Echinococcus multilocularis axis inhibition protein axin 0.0439 0.1513 0.1802
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Echinococcus multilocularis activin receptor type 0.0054 0.0073 0.0077
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.004 0.0022 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0034 0.0222
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0054 0.0073 0.0077
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0043 0.0032 0.0212
Loa Loa (eye worm) hypothetical protein 0.0656 0.2322 0.2315
Onchocerca volvulus 0.0043 0.0032 0.0045
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Loa Loa (eye worm) sema domain-containing protein 0.028 0.0916 0.0908
Brugia malayi PH domain containing protein 0.004 0.0022 0.0013
Echinococcus multilocularis neuroglian 0.0114 0.0296 0.0344
Schistosoma mansoni fibrocystin l 0.0122 0.0329 0.0308
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Brugia malayi PXA domain containing protein 0.0439 0.1513 0.1505
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0329 0.2174
Brugia malayi beta-lactamase family protein 0.0043 0.0034 0.0025
Echinococcus granulosus twitchin 0.0125 0.0337 0.0393
Loa Loa (eye worm) TK/DDR protein kinase 0.0043 0.0032 0.0023
Echinococcus granulosus ephrin type A receptor 4 A 0.0043 0.0032 0.0028
Onchocerca volvulus 0.0043 0.0032 0.0045
Echinococcus multilocularis tyrosine protein kinase csk 0.0043 0.0032 0.0028
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0135 0.0126
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0051 0.0063 0.3639
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0022 0.00000578
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0043 0.0032 0.0028
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0051 0.0063 0.3639
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0043 0.0032 0.0028
Entamoeba histolytica hypothetical protein 0.0122 0.0329 0.206
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0051 0.0063 0.3639
Schistosoma mansoni regulator of G protein signaling 0.0439 0.1513 0.1495
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0043 0.0032 0.0028
Schistosoma mansoni hypothetical protein 0.0043 0.0032 0.001
Entamoeba histolytica hypothetical protein 0.0043 0.0032 0.007
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0043 0.0032 0.0212
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) TK protein kinase 0.0043 0.0032 0.0023
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Echinococcus multilocularis tyrosine protein kinase csk 0.0043 0.0032 0.0028
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Loa Loa (eye worm) TK protein kinase 0.0043 0.0032 0.0023
Entamoeba histolytica ankyrin repeat protein 0.0043 0.0032 0.007
Brugia malayi Raf kinase 0.0043 0.0032 0.0023
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0071 0.0135 0.0762
Loa Loa (eye worm) beta-lactamase 0.0043 0.0034 0.0025
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.004 0.0022 0.0015
Loa Loa (eye worm) hypothetical protein 0.0114 0.0296 0.0287
Echinococcus granulosus pdz domain containing protein 0.004 0.0022 0.0015
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Echinococcus multilocularis aurora kinase A 0.0071 0.0135 0.0151
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Plasmodium falciparum serine/threonine protein kinase, putative 0.0071 0.0135 1
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Echinococcus granulosus tyrosine protein kinase Blk 0.0043 0.0032 0.0028
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Toxoplasma gondii aurora kinase 0.0071 0.0135 1
Echinococcus multilocularis dynamin 1 0.004 0.0022 0.0015
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Echinococcus multilocularis beta 1 syntrophin 0.004 0.0022 0.0015
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Entamoeba histolytica cell surface protease gp63, putative 0.0122 0.0329 0.206
Entamoeba histolytica hypothetical protein 0.0043 0.0032 0.007
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0329 0.2174
Entamoeba histolytica hypothetical protein 0.0439 0.1513 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0439 0.1513 1
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Echinococcus multilocularis roundabout 2 0.0114 0.0296 0.0344
Loa Loa (eye worm) cytohesin 3 0.004 0.0022 0.0013
Loa Loa (eye worm) TK protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis centaurin alpha, putative 0.004 0.0022 0.0143
Loa Loa (eye worm) TK/EGFR protein kinase 0.0043 0.0032 0.0023
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0043 0.0032 0.0028
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.004 0.0022 0.0015
Echinococcus multilocularis exocyst complex component 2 0.0122 0.0329 0.0383
Plasmodium vivax tyrosine kinase-like protein, putative 0.0043 0.0032 0.0913
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0043 0.0032 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0439 0.1513 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0043 0.0032 0.0023
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0043 0.0032 0.0028
Trypanosoma cruzi protein kinase, putative 0.0043 0.0032 0.0913
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0135 0.0894
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Echinococcus multilocularis natriuretic peptide receptor 1 0.0043 0.0032 0.0028
Trypanosoma cruzi NIMA-related kinase, putative 0.0051 0.0063 0.3639
Echinococcus multilocularis regulator of G protein signaling 3 0.0439 0.1513 0.1802
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Toxoplasma gondii protein kinase domain-containing protein 0.0051 0.0063 0.3639
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) oxysterol binding protein 0.004 0.0022 0.0013
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Echinococcus granulosus oxysterol binding protein 9 0.004 0.0022 0.0015
Brugia malayi Probable exocyst complex component Sec5 0.0122 0.0329 0.032
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Loa Loa (eye worm) Plekhf2 protein 0.004 0.0022 0.0013
Echinococcus multilocularis regulator of G protein signaling 3 0.0439 0.1513 0.1802
Brugia malayi SH2 domain containing protein 0.0043 0.0032 0.0023
Echinococcus granulosus defective proboscis extension response 0.0114 0.0296 0.0344
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0043 0.0032 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0135 0.0114
Echinococcus multilocularis beta adrenergic receptor kinase 0.2077 0.7635 0.9135
Entamoeba histolytica PH domain containing protein kinase, putative 0.0051 0.0063 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0043 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0122 0.0329 0.2174
Loa Loa (eye worm) hypothetical protein 0.0122 0.0329 0.032
Brugia malayi hypothetical protein 0.0114 0.0296 0.0287
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.004 0.0022 0.0013
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Echinococcus granulosus roundabout 2 0.0114 0.0296 0.0344
Loa Loa (eye worm) hypothetical protein 0.0439 0.1513 0.1505
Echinococcus granulosus raf serine:threonine protein kinase 0.0043 0.0032 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Brugia malayi beta-lactamase family protein 0.0043 0.0034 0.0025
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.004 0.0022 0.0015
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0043 0.0032 0.001
Trypanosoma cruzi protein kinase, putative 0.0043 0.0032 0.0913
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Echinococcus multilocularis Ras associated and pleckstrin y 0.004 0.0022 0.0015
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0043 0.0032 0.007
Trypanosoma brucei protein kinase, putative 0.0051 0.0063 0.3639
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0022 0.00000578
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0439 0.1513 0.1495
Loa Loa (eye worm) hypothetical protein 0.0376 0.1277 0.1269
Entamoeba histolytica hypothetical protein 0.0051 0.0063 0.0277
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0043 0.0032 0.0028
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0034 0.1048
Leishmania major serine/threonine-protein kinase a, putative 0.0051 0.0063 0.3639
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0071 0.0135 0.0762
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Schistosoma mansoni serine/threonine RGC 0.0043 0.0032 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0032 0.001
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0043 0.0032 0.0028
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0071 0.0135 1
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) hypothetical protein 0.0114 0.0296 0.0287
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Plasmodium falciparum tyrosine kinase-like protein 0.0043 0.0032 0.0913
Echinococcus granulosus tyrosine protein kinase shark 0.0043 0.0032 0.0028
Onchocerca volvulus 0.0058 0.0089 0.0292
Loa Loa (eye worm) hypothetical protein 0.0114 0.0296 0.0287
Onchocerca volvulus 0.0043 0.0032 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Entamoeba histolytica PH domain containing protein kinase, putative 0.0051 0.0063 0.0277
Entamoeba histolytica hypothetical protein 0.0439 0.1513 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0054 0.0073 0.0077
Mycobacterium leprae Probable lipase LipE 0.0043 0.0034 0.5
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Echinococcus granulosus myotubularin protein 13 0.004 0.0022 0.0015
Loa Loa (eye worm) TK protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0025
Brugia malayi PH domain containing protein 0.004 0.0022 0.0013
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Echinococcus multilocularis Regulator of G protein signaling 20 0.0439 0.1513 0.1802
Echinococcus multilocularis expressed protein 0.0439 0.1513 0.1802
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.004 0.0022 0.0143
Schistosoma mansoni hypothetical protein 0.0122 0.0329 0.0308
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0043 0.0032 0.0023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.004 0.0022 0.0015
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Echinococcus granulosus oxysterol binding protein 3 0.004 0.0022 0.0015
Brugia malayi Furin-like cysteine rich region family protein 0.0043 0.0032 0.0023
Loa Loa (eye worm) TK/FAK protein kinase 0.0043 0.0032 0.0023
Brugia malayi PH domain containing protein 0.004 0.0022 0.0013
Onchocerca volvulus 0.0043 0.0032 0.0045
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0439 0.1513 0.1505
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0043 0.0032 0.007
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Echinococcus granulosus pleckstrin y domain containing family A 0.004 0.0022 0.0015
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0051 0.0063 0.3639
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0034 0.0222
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0043 0.0032 0.0023
Loa Loa (eye worm) hypothetical protein 0.0122 0.0329 0.032
Loa Loa (eye worm) TK/CSK protein kinase 0.0043 0.0032 0.0023
Entamoeba histolytica hypothetical protein 0.0043 0.0032 0.007
Echinococcus multilocularis plexin a4 0.0778 0.278 0.3319
Brugia malayi DNA-binding protein LAG-1 0.0122 0.0329 0.032
Entamoeba histolytica protein kinase , putative 0.0071 0.0135 0.0762
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Onchocerca volvulus 0.0043 0.0032 0.0045
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0043 0.0032 0.0028
Trichomonas vaginalis kinesin light chain, putative 0.004 0.0022 0.0143
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Echinococcus multilocularis cytohesin 1 0.004 0.0022 0.0015
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0043 0.0032 0.0023
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Brugia malayi Cytohesin 3 0.004 0.0022 0.0013
Onchocerca volvulus 0.0656 0.2322 1
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Loa Loa (eye worm) hypothetical protein 0.0114 0.0296 0.0287
Loa Loa (eye worm) RGC/RGC protein kinase 0.0043 0.0032 0.0023
Entamoeba histolytica protein kinase, putative 0.0051 0.0063 0.0277
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.004 0.0022 0.0015
Echinococcus multilocularis regulator of G protein signaling 7 0.0439 0.1513 0.1802
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Echinococcus granulosus fibroblast growth factor receptor 4 0.0043 0.0032 0.0028
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0043 0.0032 0.001
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2709 1 1
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.004 0.0022 0.0143
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0034 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Echinococcus granulosus axis inhibition protein axin 0.0439 0.1513 0.1802
Echinococcus granulosus expressed protein 0.0439 0.1513 0.1802
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0034 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0329 0.2174
Echinococcus multilocularis oxysterol binding protein 3 0.004 0.0022 0.0015
Echinococcus granulosus activin receptor type 0.0054 0.0073 0.0077
Loa Loa (eye worm) TK protein kinase 0.0043 0.0032 0.0023
Brugia malayi GTP-ase activating protein for Arf containing protein 0.004 0.0022 0.0013
Loa Loa (eye worm) TK/Met protein kinase 0.0043 0.0032 0.0023
Entamoeba histolytica PH domain containing protein kinase, putative 0.0051 0.0063 0.0277
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0043 0.0032 0.0028
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) TK/EPH protein kinase 0.0043 0.0032 0.0023
Echinococcus granulosus tyrosine protein kinase Src64B 0.0043 0.0032 0.0028
Echinococcus multilocularis epidermal growth factor receptor 0.0043 0.0032 0.0028
Echinococcus multilocularis regulator of G protein signaling 0.0439 0.1513 0.1802
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0043 0.0032 0.0028
Echinococcus granulosus aurora kinase A 0.0071 0.0135 0.0151
Brugia malayi Immunoglobulin I-set domain containing protein 0.0114 0.0296 0.0287
Schistosoma mansoni hypothetical protein 0.0376 0.1277 0.1258
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0439 0.1513 1
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Entamoeba histolytica hypothetical protein 0.0043 0.0032 0.007
Schistosoma mansoni protein kinase 0.0054 0.0073 0.0052
Trichomonas vaginalis protein transport protein sec7, putative 0.004 0.0022 0.0143
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0032 0.001
Loa Loa (eye worm) syntrophin-1 0.004 0.0022 0.0013
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0043 0.0032 0.0028
Echinococcus granulosus tyrosine protein kinase HCK 0.0043 0.0032 0.0028
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0043 0.0032 0.0913
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.0032 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) hypothetical protein 0.0439 0.1513 0.1505
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0043 0.0032 0.0028
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0043 0.0032 0.0028
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0939 0.1114
Trypanosoma brucei rac serine-threonine kinase, putative 0.0051 0.0063 0.3639
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0043 0.0032 0.0028
Trypanosoma brucei Flagellum attachment zone protein 20 0.0043 0.0032 0.0913
Schistosoma mansoni axis inhibition protein axin 0.0439 0.1513 0.1495
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0043 0.0032 0.0028
Schistosoma mansoni hypothetical protein 0.028 0.0916 0.0897
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0043 0.0032 0.007
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) RGS-3 protein 0.0439 0.1513 0.1505
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Echinococcus granulosus beta 1 syntrophin 0.004 0.0022 0.0015
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Brugia malayi PH domain containing protein 0.004 0.0022 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Schistosoma mansoni protein kinase 0.0071 0.0135 0.0114
Entamoeba histolytica PH domain containing protein kinase, putative 0.0051 0.0063 0.0277
Echinococcus multilocularis calcium dependent secretion activator 1 0.004 0.0022 0.0015
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.004 0.0022 0.0015
Echinococcus multilocularis oxysterol binding protein 9 0.004 0.0022 0.0015
Schistosoma mansoni protein kinase 0.0054 0.0073 0.0052
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.004 0.0022 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0034 0.0222
Echinococcus granulosus cytohesin 1 0.004 0.0022 0.0015
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0034 0.0222
Brugia malayi Variant SH3 domain containing protein 0.004 0.0022 0.0013
Trichomonas vaginalis hypothetical protein 0.004 0.0022 0.0143
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Echinococcus multilocularis kinase suppressor of Ras 1 0.0043 0.0032 0.0028
Echinococcus granulosus Pleckstrin domain containing protein family B 0.004 0.0022 0.0015
Brugia malayi Receptor family ligand binding region containing protein 0.0043 0.0032 0.0023
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0054 0.0073 0.4553
Echinococcus multilocularis tyrosine kinase 0.0043 0.0032 0.0028
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Brugia malayi probable spectrin beta chain 0.004 0.0022 0.0013
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Brugia malayi Tyrosine-protein kinase abl-1 0.0043 0.0032 0.0023
Entamoeba histolytica PH domain containing protein kinase, putative 0.0051 0.0063 0.0277
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.004 0.0022 0.0015
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0043 0.0032 0.0023
Brugia malayi PH domain containing protein 0.004 0.0022 0.0013
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0439 0.1513 0.1802
Echinococcus multilocularis tyrosine protein kinase Srms 0.0043 0.0032 0.0028
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Loa Loa (eye worm) RGC/RGC protein kinase 0.0043 0.0032 0.0023
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0051 0.0063 0.3639
Loa Loa (eye worm) hypothetical protein 0.028 0.0916 0.0908
Echinococcus granulosus serine/threonine protein kinase 0.0051 0.0063 0.0065
Toxoplasma gondii ABC1 family protein 0.0043 0.0034 0.1048
Onchocerca volvulus 0.0043 0.0034 0.0052
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0114 0.0296 0.0275
Brugia malayi Uncoordinated protein 104 0.004 0.0022 0.0013
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) TK protein kinase 0.0043 0.0032 0.0023
Brugia malayi hypothetical protein 0.0286 0.0939 0.093
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0051 0.0063 0.3639
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0043 0.0032 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0034 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0439 0.1513 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0157 0.0457 0.0448
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0051 0.0063 0.3639
Trypanosoma brucei aurora B kinase 0.0071 0.0135 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0043 0.0032 0.0028
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0051 0.0063 0.3639
Echinococcus multilocularis tyrosine protein kinase 0.0043 0.0032 0.0028
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0043 0.0032 0.0023
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Echinococcus multilocularis transfer RNA-Thr 0.0043 0.0032 0.0028
Leishmania major hypothetical protein, conserved 0.0043 0.0032 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Brugia malayi hypothetical protein 0.004 0.0022 0.0013
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Loa Loa (eye worm) protein kinase domain-containing protein 0.0043 0.0032 0.0023
Mycobacterium ulcerans hypothetical protein 0.0043 0.0034 0.5
Loa Loa (eye worm) plexin A 0.0778 0.278 0.2774
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Echinococcus granulosus regulator of G protein signaling 7 0.0439 0.1513 0.1802
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Echinococcus multilocularis tyrosine protein kinase shark 0.0043 0.0032 0.0028
Brugia malayi Plekhf2 protein 0.004 0.0022 0.0013
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0043 0.0032 0.0913
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0135 0.0894
Schistosoma mansoni protein kinase 0.0043 0.0032 0.001
Echinococcus multilocularis tyrosine protein kinase HCK 0.0043 0.0032 0.0028
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.004 0.0022 0.0015
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Schistosoma mansoni serine/threonine-protein kinase 0.0051 0.0063 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0439 0.1513 1
Schistosoma mansoni plexin 0.0656 0.2322 0.2306
Onchocerca volvulus 0.0043 0.0032 0.0045
Entamoeba histolytica PH domain containing protein kinase, putative 0.0051 0.0063 0.0277
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0054 0.0073 0.4553
Loa Loa (eye worm) hypothetical protein 0.0439 0.1513 0.1505
Echinococcus granulosus plexin a4 0.0778 0.278 0.3319
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Echinococcus granulosus semaphorin 5B 0.028 0.0916 0.1087
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Echinococcus multilocularis rac serine:threonine kinase 0.0051 0.0063 0.0065
Onchocerca volvulus 0.0043 0.0032 0.0045
Echinococcus granulosus axis inhibition protein axin 0.0439 0.1513 0.1802
Brugia malayi hypothetical protein 0.028 0.0916 0.0908
Echinococcus granulosus receptor type guanylyl cyclase 0.0043 0.0032 0.0028
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0114 0.0296 0.0275
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Echinococcus multilocularis c src tyrosine kinase 0.0043 0.0032 0.0028
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0043 0.0032 0.0023
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Echinococcus granulosus regulator of G protein signaling 7 0.0439 0.1513 0.1802
Echinococcus granulosus protein kinase 0.0043 0.0032 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Brugia malayi serine/threonine protein kinase 6 0.0071 0.0135 0.0126
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) RGC/RGC protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.004 0.0022 0.0143
Entamoeba histolytica ankyrin repeat protein 0.0043 0.0032 0.007
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.004 0.0022 0.0143
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.004 0.0022 0.0015
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0122 0.0329 0.2174
Toxoplasma gondii protein kinase 0.0043 0.0032 0.0913
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis alpha chimerin, putative 0.004 0.0022 0.0143
Entamoeba histolytica protein kinase, putative 0.0051 0.0063 0.0277
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Echinococcus granulosus tyrosine kinase 0.0043 0.0032 0.0028
Brugia malayi Oxysterol-binding protein 0.004 0.0022 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0135 0.0894
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Echinococcus granulosus DCC interacting protein 13 beta 0.004 0.0022 0.0015
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Entamoeba histolytica hypothetical protein 0.0051 0.0063 0.0277
Loa Loa (eye worm) TK protein kinase 0.0043 0.0032 0.0023
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0032 0.0023
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Brugia malayi MAX-1A 0.004 0.0022 0.0013
Echinococcus granulosus epidermal growth factor receptor 0.0043 0.0032 0.0028
Echinococcus granulosus transcription factor collier 0.0122 0.0329 0.0383
Leishmania major hypothetical protein, conserved 0.0043 0.0034 0.1048
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0043 0.0032 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Brugia malayi Syntrophin-1 0.004 0.0022 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Brugia malayi bone morphogenetic protein type 1 receptor 0.0043 0.0032 0.0023
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.227 0.8358 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0439 0.1513 0.1505
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Entamoeba histolytica tyrosin kinase, putative 0.0166 0.049 0.314
Echinococcus multilocularis pdz domain containing protein 0.004 0.0022 0.0015
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Loa Loa (eye worm) hypothetical protein 0.028 0.0916 0.0908
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.227 0.8358 0.8356
Brugia malayi ephrin receptor 1 precursor 0.0043 0.0032 0.0023
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0043 0.0032 0.0028
Schistosoma mansoni protein kinase 0.0043 0.0032 0.001
Onchocerca volvulus 0.0043 0.0032 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0329 0.2174
Echinococcus granulosus Pleckstrin y 0.004 0.0022 0.0015
Echinococcus granulosus tyrosine protein kinase csk 0.0043 0.0032 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Onchocerca volvulus 0.028 0.0916 0.3888
Echinococcus granulosus activated cdc42 kinase 1 0.0043 0.0032 0.0028
Loa Loa (eye worm) rho-GTPase-activating 0.004 0.0022 0.0013
Onchocerca volvulus 0.0043 0.0032 0.0045
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0043 0.0032 0.0028
Schistosoma mansoni vesicular amine transporter 0.0116 0.0305 0.0284
Onchocerca volvulus 0.0043 0.0032 0.0045
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Loa Loa (eye worm) TK/RYK protein kinase 0.0043 0.0032 0.0023
Trichomonas vaginalis centaurin gamma, putative 0.004 0.0022 0.0143
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1637 0.5993 0.7168
Echinococcus multilocularis Rho GTPase activating protein 24 0.004 0.0022 0.0015
Brugia malayi Variant SH3 domain containing protein 0.004 0.0022 0.0013
Entamoeba histolytica receptor protein kinase, putative 0.0043 0.0032 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Entamoeba histolytica hypothetical protein 0.0043 0.0032 0.007
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Brugia malayi Tyrosine-protein kinase PR2 0.0043 0.0032 0.0023
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Schistosoma mansoni protein kinase 0.0043 0.0032 0.001
Brugia malayi hypothetical protein 0.0043 0.0032 0.0023
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0439 0.1513 0.1495
Loa Loa (eye worm) hypothetical protein 0.0114 0.0296 0.0287
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0025
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Echinococcus granulosus tyrosine protein kinase ABL1 0.0043 0.0032 0.0028
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0043 0.0032 0.0028
Brugia malayi Cadps2 protein 0.004 0.0022 0.0013
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.0032 0.0028
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0043 0.0032 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0032 0.001
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Loa Loa (eye worm) SRC-1 0.0043 0.0032 0.0023
Echinococcus granulosus tyrosine kinase 0.0043 0.0032 0.0028
Loa Loa (eye worm) PXA domain-containing protein 0.0439 0.1513 0.1505
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0043 0.0032 0.0028
Echinococcus granulosus activated cdc42 kinase 1 0.0043 0.0032 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0032 0.0212
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0032 0.0028
Schistosoma mansoni regulator of G protein signaling 0.0439 0.1513 0.1495
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0043 0.0032 0.0028
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0043 0.0032 0.0028
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Echinococcus multilocularis tyrosine protein kinase pr2 0.0043 0.0032 0.0028
Schistosoma mansoni protein kinase 0.0043 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.028 0.0916 0.0908
Schistosoma mansoni plexin 0.0376 0.1277 0.1258
Trichomonas vaginalis TK family protein kinase 0.0043 0.0032 0.0212
Trypanosoma cruzi aurora B kinase, putative 0.0071 0.0135 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.004 0.0022 0.0013
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0043 0.0032 0.007
Echinococcus granulosus retinal guanylyl cyclase 2 0.0043 0.0032 0.0028
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Brugia malayi regulator of G-protein signaling egl-10 0.0439 0.1513 0.1505
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0043 0.0032 0.0028
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.0032 0.0028
Echinococcus granulosus neuroglian 0.0114 0.0296 0.0344
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0032 0.0028
Brugia malayi hypothetical protein 0.0043 0.0032 0.0023
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0051 0.0063 0.3639
Trichomonas vaginalis protein transport protein sec7, putative 0.004 0.0022 0.0143
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0043 0.0032 0.0028
Schistosoma mansoni ephrin receptor 0.0043 0.0032 0.001
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0034 0.1048
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0034 0.0012
Brugia malayi IPT/TIG domain containing protein 0.0122 0.0329 0.032
Entamoeba histolytica hypothetical protein 0.0043 0.0032 0.007
Echinococcus multilocularis tyrosine protein kinase Blk 0.0043 0.0032 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Trichomonas vaginalis protein kinase atn1, putative 0.0043 0.0032 0.0212
Echinococcus granulosus insulin receptor 0.0043 0.0032 0.0028
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0034 0.0025
Schistosoma mansoni tyrosine kinase 0.0043 0.0032 0.001
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0043 0.0032 0.0023
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0043 0.0032 0.001
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0034 0.0012
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Onchocerca volvulus 0.0043 0.0032 0.0045
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0034 0.0025
Leishmania major protein kinase, putative 0.0043 0.0032 0.0913
Schistosoma mansoni hypothetical protein 0.0058 0.0089 0.0067
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0043 0.0032 0.0028
Entamoeba histolytica serine/threonine kinase, putative 0.0043 0.0032 0.007
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.004 0.0022 0.0143
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Entamoeba histolytica hypothetical protein 0.0043 0.0032 0.007
Echinococcus granulosus Pleckstrin y 0.004 0.0022 0.0015
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Schistosoma mansoni protein kinase 0.0043 0.0032 0.001
Loa Loa (eye worm) TK protein kinase 0.0043 0.0032 0.0023
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Entamoeba histolytica protein kinase, putative 0.0051 0.0063 0.0277
Entamoeba histolytica serine/threonine kinase, putative 0.0043 0.0032 0.007
Echinococcus granulosus natriuretic peptide receptor 1 0.0043 0.0032 0.0028
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Entamoeba histolytica serine/threonine kinase, putative 0.0043 0.0032 0.007
Schistosoma mansoni serine/threonine-protein kinase 0.0051 0.0063 0.0041
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Onchocerca volvulus 0.0043 0.0034 0.0052
Echinococcus multilocularis regulator of G protein signaling 7 0.0439 0.1513 0.1802
Schistosoma mansoni ephrin receptor 0.0043 0.0032 0.001
Brugia malayi PH domain containing protein 0.004 0.0022 0.0013
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0071 0.0135 0.0151
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0051 0.0063 0.3639
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.004 0.0022 0.0015
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.004 0.0022 0.0015
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0051 0.0063 0.0417
Echinococcus multilocularis Immunoglobulin 0.0114 0.0296 0.0344
Giardia lamblia Aurora kinase 0.0071 0.0135 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0114 0.0296 0.0344
Entamoeba histolytica hypothetical protein 0.0122 0.0329 0.206
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Brugia malayi GTP-ase activating protein for Arf containing protein 0.004 0.0022 0.0013
Brugia malayi PH domain containing protein 0.004 0.0022 0.0013
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0135 0.0894
Echinococcus multilocularis actin binding protein anillin 0.004 0.0022 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0439 0.1513 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0034 0.5
Plasmodium falciparum protein kinase, putative 0.0043 0.0032 0.0913
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Echinococcus granulosus retinal guanylyl cyclase 2 0.0043 0.0032 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) hypothetical protein 0.0043 0.0032 0.0023
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0043 0.0032 0.0212
Schistosoma mansoni nephrin 0.0114 0.0296 0.0275
Brugia malayi Protein kinase domain containing protein 0.0043 0.0032 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.2077 0.7635 0.763
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Brugia malayi plexin A 0.0778 0.278 0.2774
Echinococcus multilocularis hypothetical protein 0.028 0.0916 0.1087
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0022 0.0143
Brugia malayi regulator of G-protein signaling rgs-7 0.0439 0.1513 0.1505
Leishmania major protein kinase, putative 0.0051 0.0063 0.3639
Schistosoma mansoni serine/threonine protein kinase 0.2709 1 1
Entamoeba histolytica protein kinase, putative 0.0043 0.0032 0.007
Trypanosoma cruzi NIMA-related kinase, putative 0.0051 0.0063 0.3639
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Brugia malayi SRC-1 0.0043 0.0032 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0043 0.0032 0.0212
Loa Loa (eye worm) TK protein kinase 0.0043 0.0032 0.0023
Entamoeba histolytica protein kinase domain containing protein 0.0071 0.0135 0.0762
Onchocerca volvulus 0.0043 0.0032 0.0045
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.004 0.0022 0.0013
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0329 0.2174
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0032 0.0212
Entamoeba histolytica tyrosine kinase, putative 0.0043 0.0032 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0043 0.0032 0.0023
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0054 0.0073 0.4553
Trichomonas vaginalis centaurin/arf, putative 0.004 0.0022 0.0143
Echinococcus granulosus c src tyrosine kinase 0.0043 0.0032 0.0028
Echinococcus multilocularis insulin receptor 0.0043 0.0032 0.0028
Onchocerca volvulus 0.0043 0.0032 0.0045
Entamoeba histolytica protein kinase domain containing protein 0.0043 0.0032 0.007
Schistosoma mansoni hypothetical protein 0.0122 0.0329 0.0308
Brugia malayi Dynamin 0.004 0.0022 0.0013
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.004 0.0022 0.0143
Schistosoma mansoni protein kinase 0.0054 0.0073 0.0052
Echinococcus granulosus tyrosine protein kinase csk 0.0043 0.0032 0.0028
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Leishmania major protein kinase, putative 0.0071 0.0135 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0439 0.1513 0.1802
Leishmania major folate/biopterin transporter, putative 0.0051 0.0063 0.3639
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0032 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0032 0.0212
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0051 0.0063 0.3639
Entamoeba histolytica hypothetical protein, conserved 0.0043 0.0032 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0032 0.0212
Loa Loa (eye worm) AGC/AKT protein kinase 0.0051 0.0063 0.0054
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0063 0.0417
Entamoeba histolytica hypothetical protein 0.0043 0.0032 0.007
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.2077 0.7635 0.7633
Loa Loa (eye worm) hypothetical protein 0.004 0.0022 0.0013
Loa Loa (eye worm) TK/ROR protein kinase 0.0043 0.0032 0.0023

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (binding) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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