Detailed information for compound 1383609

Basic information

Technical information
  • TDR Targets ID: 1383609
  • Name: 2-(4-methoxyphenyl)-N-[5-(3-nitrophenyl)-1,3, 4-thiadiazol-2-yl]acetamide
  • MW: 370.382 | Formula: C17H14N4O4S
  • H donors: 1 H acceptors: 5 LogP: 2.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CC(=O)Nc1nnc(s1)c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C17H14N4O4S/c1-25-14-7-5-11(6-8-14)9-15(22)18-17-20-19-16(26-17)12-3-2-4-13(10-12)21(23)24/h2-8,10H,9H2,1H3,(H,18,20,22)
  • InChiKey: CJOFHWHUZUTGPO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methoxyphenyl)-N-[5-(3-nitrophenyl)-1,3,4-thiadiazol-2-yl]ethanamide
  • MLS000696925
  • Oprea1_467295
  • SMR000237331
  • ZINC04079016

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Deterin homolog 0.011 0.0076 0.1076
Leishmania major arginine N-methyltransferase-like protein 0.0191 0.0156 0.126
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0079 0.0123
Giardia lamblia Tenascin-37 0.0091 0.0057 0.0094
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0002
Brugia malayi hypothetical protein 0.0548 0.0509 0.0509
Brugia malayi Integrin alpha pat-2 precursor 0.0452 0.0414 0.0414
Brugia malayi EGF-like domain containing protein 0.0091 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Loa Loa (eye worm) AMP-binding enzyme family protein 0.008 0.0046 0.0046
Toxoplasma gondii PA14 domain-containing protein 0.0052 0.0018 0.0395
Loa Loa (eye worm) hypothetical protein 0.0052 0.0019 0.0019
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0062 0.0028 0.0655
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.0016 0.0018
Schistosoma mansoni protein kinase 0.0136 0.0102 0.01
Echinococcus granulosus high affinity choline transporter 1 0.0038 0.0005 0.0003
Schistosoma mansoni integrin beta subunit 0.2098 0.2042 0.204
Onchocerca volvulus 0.0208 0.0173 0.2491
Loa Loa (eye worm) hypothetical protein 1.0144 1 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0769 0.0728 0.0728
Leishmania major UDP-galactopyranose mutase 0.0136 0.0102 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.2018 0.1963 0.3213
Plasmodium vivax hypothetical protein, conserved 0.0136 0.0102 0.2456
Giardia lamblia Furin precursor putative serine protease 0.2018 0.1963 0.533
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0186 0.0152 0.0152
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0113 0.0079 0.0796
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0769 0.0728 1
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.62 0.6099 0.6098
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0079 0.0123
Loa Loa (eye worm) hypothetical protein 0.0091 0.0057 0.0057
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Schistosoma mansoni hypothetical protein 0.0056 0.0023 0.0021
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0018 0.0016
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0038 0.0005 0.0053
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.008 0.0046 0.1105
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0113 0.0079 0.0096
Onchocerca volvulus 0.008 0.0046 0.0642
Giardia lamblia High cysteine protein 0.0091 0.0057 0.0094
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0083 0.0049 0.0784
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0075 0.0041 0.0039
Schistosoma mansoni integrin alpha-ps 0.0105 0.0071 0.0069
Echinococcus multilocularis adam 0.0208 0.0173 0.0213
Schistosoma mansoni integrin alpha 0.0452 0.0414 0.0412
Loa Loa (eye worm) WD40 repeat protein 0.0208 0.0173 0.0173
Schistosoma mansoni glutamate receptor NMDA 0.0278 0.0242 0.024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0005
Schistosoma mansoni growth factor receptor-bound protein 0.013 0.0096 0.0094
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0018 0.0395
Onchocerca volvulus 0.0728 0.0687 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Loa Loa (eye worm) sex muscle abnormal protein 5 0.013 0.0096 0.0096
Plasmodium falciparum plasmepsin V 0.0426 0.0388 0.9514
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0005 0.0003
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0005 0.0002
Brugia malayi proprotein convertase 2 0.6407 0.6305 0.6305
Schistosoma mansoni chromatin regulatory protein sir2 0.0113 0.0079 0.0077
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0079 0.0123
Onchocerca volvulus 0.0052 0.0018 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0052 0.0018 0.0023
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0477 0.0439 0.5578
Echinococcus granulosus protein kinase c epsilon type 0.0186 0.0152 0.0149
Echinococcus granulosus fibrillin 2 0.0091 0.0057 0.0055
Schistosoma mansoni hypothetical protein 0.0056 0.0023 0.0021
Schistosoma mansoni chromatin regulatory protein sir2 0.0113 0.0079 0.0077
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Loa Loa (eye worm) aspartyl protease 6 0.0038 0.0005 0.0005
Toxoplasma gondii subtilisin SUB11 0.0446 0.0408 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0446 0.0408 0.0406
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0002
Brugia malayi Protein arginine N-methyltransferase 0.0108 0.0074 0.0074
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0278 0.0242 0.03
Echinococcus granulosus chromatin regulatory protein sir2 0.0769 0.0728 0.0726
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0769 0.0728 1
Trypanosoma brucei subtilisin peptidase 0.0446 0.0408 0.5114
Schistosoma mansoni chromatin regulatory protein sir2 0.0769 0.0728 0.0726
Brugia malayi Calcium binding EGF domain containing protein 0.004 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0056 0.0023 0.0021
Loa Loa (eye worm) subtilase 0.0446 0.0408 0.0408
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0089 0.0055 0.0053
Schistosoma mansoni discoidin domain receptor 0.0052 0.0018 0.0016
Toxoplasma gondii hypothetical protein 0.0091 0.0057 0.1354
Plasmodium falciparum plasmepsin I 0.0038 0.0005 0.0053
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0057 0.0023 0.0021
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.016 0.0125 0.0125
Schistosoma mansoni septate junction protein 0.0061 0.0028 0.0025
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0071 0.0038 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Echinococcus granulosus expressed protein 0.0365 0.0328 0.0326
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0052 0.0018 0.0418
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0066 0.0032 0.0359
Plasmodium vivax plasmepsin V, putative 0.0426 0.0388 0.9514
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.011 0.0076 0.0076
Echinococcus granulosus integrin beta 2 0.2646 0.2584 0.2582
Mycobacterium leprae Probable polyketide synthase Pks1 0.0088 0.0054 0.0919
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0298 0.0262 0.2886
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0079 0.0123
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0149 0.0115 0.014
Echinococcus granulosus serine:threonine protein kinase N2 0.0152 0.0118 0.0115
Brugia malayi amine oxidase, flavin-containing family protein 0.0193 0.0158 0.0158
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0002
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0471 0.0433 0.0431
Schistosoma mansoni inositol transporter 0.0149 0.0115 0.0112
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Mycobacterium tuberculosis Probable thioesterase TesA 0.0071 0.0038 0.0895
Brugia malayi SWIRM domain containing protein 0.0728 0.0687 0.0687
Loa Loa (eye worm) TK/ALK protein kinase 0.0097 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0002 0.0002
Onchocerca volvulus 0.0097 0.0063 0.0883
Brugia malayi hypothetical protein 0.0036 0.0002 0.0002
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0088 0.0054 0.1299
Brugia malayi Will die slowly protein 0.0208 0.0173 0.0173
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0018 0.002
Toxoplasma gondii subtilisin SUB1 0.0446 0.0408 1
Loa Loa (eye worm) hypothetical protein 0.0355 0.0318 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Giardia lamblia Tenascin-like 0.0091 0.0057 0.0094
Echinococcus multilocularis integrin beta 2 0.2646 0.2584 0.3226
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0018 0.002
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0083 0.0049 0.1169
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0108 0.0074 0.0113
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0108 0.0074 0.0712
Onchocerca volvulus 0.0038 0.0005 0.0032
Brugia malayi hypothetical protein 0.0036 0.0002 0.0002
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0113 0.0079 0.009
Loa Loa (eye worm) hypothetical protein 0.0298 0.0262 0.0262
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0298 0.0262 0.3393
Echinococcus granulosus protein arginine N methyltransferase 8 0.0191 0.0156 0.0154
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0016 0.0014
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0005 0.0005
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0005 0.0053
Echinococcus granulosus fibrillin 1 0.0094 0.006 0.0057
Brugia malayi Protein kinase domain containing protein 0.0097 0.0063 0.0063
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Loa Loa (eye worm) hypothetical protein 0.0249 0.0214 0.0214
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.2018 0.1963 0.3213
Echinococcus multilocularis membrane bound transcription factor site 1 0.0446 0.0408 0.0507
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0191 0.0156 0.0154
Plasmodium falciparum plasmepsin IX 0.0038 0.0005 0.0053
Onchocerca volvulus 0.0038 0.0005 0.0032
Echinococcus granulosus adam 0.0208 0.0173 0.0171
Echinococcus granulosus solute carrier family 5 0.0149 0.0115 0.0112
Loa Loa (eye worm) hypothetical protein 0.0036 0.0002 0.0002
Echinococcus granulosus membrane bound transcription factor site 1 0.0446 0.0408 0.0406
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0056 0.0023 0.0021
Schistosoma mansoni protein kinase 0.0136 0.0102 0.01
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Plasmodium falciparum LCCL domain-containing protein 0.0052 0.0018 0.0395
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0136 0.0102 0.2456
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0136 0.0102 0.2456
Plasmodium vivax subtilisin-like serine protease, putative 0.0446 0.0408 1
Toxoplasma gondii aspartyl protease ASP1 0.0038 0.0005 0.0053
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0231 0.0196 0.0242
Schistosoma mansoni chromatin regulatory protein sir2 0.0113 0.0079 0.0077
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0005 0.0002
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0113 0.0079 0.0096
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0057 0.0023 0.0026
Brugia malayi hypothetical protein 0.0038 0.0005 0.0005
Plasmodium falciparum LCCL domain-containing protein 0.0052 0.0018 0.0395
Schistosoma mansoni discoidin domain receptor 0.0052 0.0018 0.0016
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0446 0.0408 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.0084 0.0084
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0084 0.0051 0.5
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0136 0.0102 0.01
Trichomonas vaginalis conserved hypothetical protein 0.2018 0.1963 0.3213
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0113 0.0079 0.0096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0002 0.0002
Brugia malayi Kelch motif family protein 0.0578 0.0539 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0113 0.0079 0.0077
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0005 0.0057
Plasmodium falciparum plasmepsin VII 0.0038 0.0005 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0446 0.0408 0.0662
Giardia lamblia High cysteine protein 0.0091 0.0057 0.0094
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0136 0.0102 0.2109
Echinococcus multilocularis integrin alpha 3 0.0346 0.031 0.0384
Loa Loa (eye worm) transcriptional regulator 0.0113 0.0079 0.0079
Echinococcus granulosus glutamate receptor 2 0.005 0.0016 0.0014
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0231 0.0196 0.0196
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0067 0.0034 0.0789
Mycobacterium leprae Possible secreted protease 0.0446 0.0408 1
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0446 0.0408 0.5114
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2464 0.2404 0.2402
Echinococcus multilocularis fibrillin 2 0.0091 0.0057 0.0069
Brugia malayi Disintegrin family protein 0.0037 0.0004 0.0004
Toxoplasma gondii aspartyl protease 0.0038 0.0005 0.0053
Giardia lamblia Sirtuin type 2 0.0113 0.0079 0.0154
Schistosoma mansoni inositol transporter 0.0149 0.0115 0.0112
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0113 0.0079 0.1916
Giardia lamblia hypothetical protein 0.0091 0.0057 0.0094
Schistosoma mansoni integrin alpha-ps 0.0202 0.0167 0.0165
Toxoplasma gondii subtilisin SUB9 0.0446 0.0408 1
Giardia lamblia Tenascin-X 0.0091 0.0057 0.0094
Schistosoma mansoni high-affinity choline transporter 0.0038 0.0005 0.0003
Schistosoma mansoni hypothetical protein 0.0097 0.0063 0.0061
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0113 0.0079 0.009
Loa Loa (eye worm) hypothetical protein 0.0097 0.0063 0.0063
Schistosoma mansoni memapsin-2 (A01 family) 0.0038 0.0005 0.0002
Echinococcus granulosus inhibitor of apoptosis protein 0.011 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0097 0.0063 0.0063
Plasmodium vivax aspartyl protease, putative 0.0038 0.0005 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2464 0.2404 0.3937
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0038 0.0005 0.0002
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0088 0.0054 0.0919
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0052 0.0018 0.0023
Echinococcus granulosus growth factor receptor bound protein 2 0.013 0.0096 0.0094
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0446 0.0408 1
Onchocerca volvulus 0.0446 0.0408 0.5924
Plasmodium falciparum plasmepsin III 0.0038 0.0005 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Loa Loa (eye worm) hypothetical protein 0.0036 0.0002 0.0002
Giardia lamblia Neurogenic locus Notch protein precursor 0.0091 0.0057 0.0094
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0079 0.1896
Trichomonas vaginalis hypothetical protein 0.0091 0.0057 0.0087
Schistosoma mansoni site-1 peptidase (S08 family) 0.0446 0.0408 0.0406
Brugia malayi Stress-activated protein kinase jnk-1 0.0231 0.0196 0.0196
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.001 0.0187
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.2018 0.1963 0.3213
Toxoplasma gondii subtilisin SUB6 0.0446 0.0408 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0191 0.0156 0.0248
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Echinococcus granulosus disintegrin and metalloproteinase 0.0037 0.0004 0.0001
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0066 0.0032 0.0313
Schistosoma mansoni amine oxidase 0.0136 0.0102 0.01
Trichomonas vaginalis conserved hypothetical protein 0.2018 0.1963 0.3213
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0769 0.0728 0.1187
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Echinococcus granulosus integrin alpha ps 0.0097 0.0063 0.0061
Echinococcus granulosus lysine specific histone demethylase 1A 0.0671 0.0631 0.0629
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0083 0.0049 0.1178
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0113 0.0079 0.009
Schistosoma mansoni chromatin regulatory protein sir2 0.0769 0.0728 0.0726
Echinococcus multilocularis solute carrier family 5 0.0149 0.0115 0.014
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0016 0.0018
Toxoplasma gondii type I fatty acid synthase, putative 0.0061 0.0028 0.0619
Echinococcus granulosus nmda type glutamate receptor 0.0117 0.0083 0.0081
Schistosoma mansoni tyrosine kinase 0.0638 0.0598 0.0596
Onchocerca volvulus Fatty acid synthase homolog 0.0155 0.012 0.1717
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0125 0.0091 0.2201
Mycobacterium ulcerans polyketide synthase Pks13 0.0125 0.0091 0.1822
Onchocerca volvulus 0.0097 0.0063 0.0883
Loa Loa (eye worm) hypothetical protein 0.0097 0.0063 0.0063
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0119 0.0085 0.0085
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0108 0.0074 0.0071
Loa Loa (eye worm) hypothetical protein 0.004 0.0007 0.0007
Brugia malayi ADAMTS-like protease 0.0052 0.0019 0.0019
Echinococcus granulosus sodium:glucose cotransporter 0.0149 0.0115 0.0112
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0088 0.0054 0.0877
Brugia malayi NAD-dependent deacetylase SIRT1 0.0113 0.0079 0.0079
Brugia malayi aspartic protease BmAsp-2, identical 0.0038 0.0005 0.0005
Loa Loa (eye worm) reprolysin 0.0089 0.0055 0.0055
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0066 0.0032 0.0313
Schistosoma mansoni hypothetical protein 0.0097 0.0063 0.0061
Trichomonas vaginalis WD repeat domain, putative 0.0208 0.0173 0.0276
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0446 0.0408 0.0408
Echinococcus granulosus sodium:glucose cotransporter 2 0.0149 0.0115 0.0112
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0089 0.0055 0.0066
Trypanosoma brucei SIR2-like protein 4, putative 0.0113 0.0079 0.009
Echinococcus granulosus glutamate NMDA receptor subunit 0.0278 0.0242 0.024
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0083 0.0049 0.1178
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0136 0.0102 0.01
Brugia malayi EGF-like domain containing protein 0.0091 0.0057 0.0057
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0446 0.0408 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0056 0.0022 0.0487
Chlamydia trachomatis protoporphyrinogen oxidase 0.0136 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0671 0.0631 0.0631
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0037 0.0004 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Loa Loa (eye worm) fatty acid synthase 0.0085 0.0051 0.0051
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0049 0.0015 0.0342
Mycobacterium ulcerans Type I modular polyketide synthase 0.0083 0.0049 0.0741
Echinococcus multilocularis chromatin regulatory protein sir2 0.0769 0.0728 0.0907
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2464 0.2404 0.3937
Brugia malayi hypothetical protein 0.0136 0.0102 0.0102
Onchocerca volvulus 0.0149 0.0115 0.1641
Mycobacterium ulcerans Type I modular polyketide synthase 0.0083 0.0049 0.0741
Brugia malayi hypothetical protein 0.0036 0.0002 0.0002
Brugia malayi hypothetical protein 0.0097 0.0063 0.0063
Plasmodium falciparum subtilisin-like protease 1 0.0446 0.0408 1
Echinococcus multilocularis 0.0136 0.0102 0.0125
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0769 0.0728 1
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0113 0.0079 0.0154
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0083 0.0049 0.1169
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.2018 0.1963 0.3213
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Toxoplasma gondii type I fatty acid synthase, putative 0.0088 0.0054 0.1278
Plasmodium falciparum plasmepsin II 0.0038 0.0005 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0136 0.0102 0.2109
Echinococcus multilocularis protein arginine methyltransferase 0.0191 0.0156 0.0192
Schistosoma mansoni hypothetical protein 0.011 0.0076 0.0074
Leishmania major silent information regulator 2, putative 0.0769 0.0728 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0002 0.0002
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0005 0.0053
Schistosoma mansoni protein kinase 0.0136 0.0102 0.01
Brugia malayi angiogenesis inhibito 0.0052 0.0019 0.0019
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0089 0.0055 0.0053
Onchocerca volvulus Putative cubilin 0.004 0.0007 0.0061
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0191 0.0156 0.0154
Loa Loa (eye worm) sirtuin 4 0.0113 0.0079 0.0079
Brugia malayi hypothetical protein 0.0117 0.0083 0.0083
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0108 0.0074 0.0089
Mycobacterium ulcerans polyketide synthase 0.0088 0.0054 0.0877
Echinococcus multilocularis neuroendocrine convertase 2 0.6407 0.6305 0.7876
Brugia malayi aspartic protease BmAsp-1, identical 0.0038 0.0005 0.0005
Toxoplasma gondii histone deacetylase SIR2-like 0.0113 0.0079 0.1896
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0113 0.0079 0.0077
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0446 0.0408 1
Giardia lamblia Neurogenic locus notch-like protein 0.0091 0.0057 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0002
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0446 0.0408 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0136 0.0102 0.2456
Mycobacterium ulcerans polyketide synthase 0.0083 0.0049 0.0741
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0016 0.0014
Mycobacterium ulcerans Type I modular polyketide synthase 0.0083 0.0049 0.0741
Echinococcus multilocularis integrin alpha ps 0.0202 0.0167 0.0206
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0446 0.0408 0.0406
Onchocerca volvulus 0.0038 0.0005 0.0034
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0018 0.002
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0011 0.0009
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0446 0.0408 0.0406
Schistosoma mansoni hypothetical protein 0.0208 0.0173 0.0171
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0002
Loa Loa (eye worm) integrin beta-2 0.358 0.3508 0.3508
Brugia malayi GH02984p 0.0038 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0136 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0113 0.0079 0.0796
Brugia malayi transcriptional regulator, Sir2 family protein 0.0113 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.2018 0.1963 0.3213
Loa Loa (eye worm) hypothetical protein 0.0037 0.0004 0.0004
Echinococcus multilocularis integrin alpha ps 0.0097 0.0063 0.0076
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0113 0.0079 0.1896
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0446 0.0408 0.0408
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0342 0.0305 0.0305
Echinococcus granulosus lysine specific histone demethylase 1A 0.0136 0.0102 0.01
Brugia malayi transcriptional regulator, Sir2 family protein 0.0113 0.0079 0.0079
Echinococcus granulosus protein will die slowly 0.0208 0.0173 0.0171
Plasmodium falciparum plasmepsin IV 0.0038 0.0005 0.0053
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0191 0.0156 0.0192
Brugia malayi ADAM-TS Spacer 1 family protein 0.0052 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Echinococcus multilocularis growth factor receptor bound protein 2 0.013 0.0096 0.0117
Plasmodium vivax LCCL domain-containing protein 0.0052 0.0018 0.0395
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0016 0.0014
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0052 0.0018 0.0023
Brugia malayi hypothetical protein 0.0036 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0018
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.011 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0036 0.0002 0.0002
Toxoplasma gondii histone deacetylase SIR2 0.0113 0.0079 0.1896
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0136 0.0102 0.2146
Plasmodium vivax hypothetical protein, conserved 0.0136 0.0102 0.2456
Echinococcus granulosus protein arginine N methyltransferase 7 0.0108 0.0074 0.0071
Toxoplasma gondii bicoid-interacting protein BIN3 0.0108 0.0074 0.1752
Loa Loa (eye worm) acyl carrier protein 0.0039 0.0006 0.0006
Echinococcus granulosus MAM 0.0097 0.0063 0.0061
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0038 0.0005 0.0005
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0191 0.0156 0.3785
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0056 0.0023 0.0026
Loa Loa (eye worm) apoptosis regulator protein 0.0056 0.0023 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2464 0.2404 0.3937
Loa Loa (eye worm) hypothetical protein 0.0091 0.0057 0.0057
Schistosoma mansoni chromatin regulatory protein sir2 0.0113 0.0079 0.0077
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0016 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.2018 0.1963 0.3213
Loa Loa (eye worm) hypothetical protein 0.0548 0.0509 0.0509
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0477 0.0439 0.5578
Plasmodium vivax subtilisin-like protease 1 0.0446 0.0408 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Echinococcus multilocularis high affinity choline transporter 1 0.0038 0.0005 0.0003
Brugia malayi hypothetical protein 0.0038 0.0005 0.0005
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0052 0.0018 0.002
Loa Loa (eye worm) transcriptional regulator 0.0769 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.0097 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0105 0.0071 0.0071
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0002
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0108 0.0074 0.0089
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0705 0.0664 0.0662
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0038 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0023 0.0031
Giardia lamblia Tenascin precursor 0.0091 0.0057 0.0094
Trichomonas vaginalis hypothetical protein 0.2018 0.1963 0.3213
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0108 0.0074 0.0113
Echinococcus granulosus adam 17 protease 0.0037 0.0004 0.0001
Loa Loa (eye worm) endoprotease bli-4 1.0144 1 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0102 0.0102
Schistosoma mansoni amine oxidase 0.0136 0.0102 0.01
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0091 0.0057 0.0087
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0119 0.0085 0.0085
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0018 0.0395
Schistosoma mansoni inhibitor of apoptosis protein 0.011 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0342 0.0305 0.0305
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0191 0.0156 0.3785
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.62 0.6099 0.762
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.0152 0.0149
Brugia malayi EGF-like domain containing protein 0.0091 0.0057 0.0057
Brugia malayi hypothetical protein 0.0036 0.0002 0.0002
Brugia malayi hypothetical protein 0.0036 0.0002 0.0002
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0083 0.0049 0.0049
Schistosoma mansoni furin-1 (S08 family) 0.439 0.4309 0.4308
Echinococcus multilocularis discoidin domain receptor 0.0052 0.0018 0.002
Schistosoma mansoni hypothetical protein 0.2018 0.1963 0.1961
Echinococcus multilocularis protoporphyrinogen oxidase 0.0136 0.0102 0.0125
Toxoplasma gondii subtilisin SUB12 0.0446 0.0408 1
Brugia malayi Integrin beta pat-3 precursor 0.358 0.3508 0.3508
Mycobacterium tuberculosis Conserved hypothetical protein 0.0136 0.0102 0.2474
Loa Loa (eye worm) hypothetical protein 0.0057 0.0023 0.0023
Leishmania major sir2-family protein-like protein 0.0113 0.0079 0.009
Schistosoma mansoni growth factor receptor-bound protein 0.013 0.0096 0.0094
Schistosoma mansoni sodium/solute symporter 0.0038 0.0005 0.0003
Mycobacterium ulcerans Sir2-like regulatory protein 0.0113 0.0079 0.1524
Schistosoma mansoni protein arginine n-methyltransferase 0.0108 0.0074 0.0071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0016 0.0014
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0446 0.0408 0.0406
Toxoplasma gondii subtilisin SUB4 0.0446 0.0408 1
Echinococcus granulosus integrin alpha 3 0.0346 0.031 0.0307
Plasmodium vivax LCCL domain-containing protein 0.0052 0.0018 0.0395
Loa Loa (eye worm) hypothetical protein 0.011 0.0076 0.0076
Brugia malayi AMP-binding enzyme family protein 0.008 0.0046 0.0046
Leishmania major subtilisin-like serine peptidase 0.0446 0.0408 0.5114
Echinococcus granulosus sodium:myo inositol cotransporter 0.0149 0.0115 0.0112
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0769 0.0728 0.1187
Loa Loa (eye worm) hypothetical protein 0.0141 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0193 0.0158 0.0158
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0113 0.0079 0.009
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0446 0.0408 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0705 0.0664 0.0827
Trichomonas vaginalis conserved hypothetical protein 0.2018 0.1963 0.3213
Toxoplasma gondii subtilisin SUB8 0.0446 0.0408 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0671 0.0631 0.0786
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0038 0.0005 0.0053
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0036 0.0002 0.0002
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0477 0.0439 0.5578
Brugia malayi neuroendocrine convertase 1 precursor 0.6407 0.6305 0.6305
Giardia lamblia High cysteine membrane protein Group 2 0.3736 0.3663 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0638 0.0598 0.0598
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0083 0.0049 0.0741
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0079 0.0123
Plasmodium vivax subtilisin-like protease 2, putative 0.0446 0.0408 1
Trichomonas vaginalis conserved hypothetical protein 0.2018 0.1963 0.3213
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0446 0.0408 1
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0108 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.2018 0.1963 0.3213
Echinococcus granulosus protein arginine methyltransferase 0.0191 0.0156 0.0154
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0125 0.0091 0.2201
Entamoeba histolytica PH domain containing protein kinase, putative 0.0152 0.0118 0.1339
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0056 0.0023 0.0021
Brugia malayi Sex muscle abnormal protein 5 0.013 0.0096 0.0096
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0298 0.0262 0.2886
Trichomonas vaginalis conserved hypothetical protein 0.0446 0.0408 0.0662
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.2018 0.1963 0.3213
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.011 0.0076 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0023 0.0031
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0671 0.0631 0.0629
Entamoeba histolytica hypothetical protein 0.0298 0.0262 0.3393
Brugia malayi pregnancy-associated plasma protein-A 0.0036 0.0002 0.0002
Echinococcus multilocularis protein jagged 2 0.0091 0.0057 0.0069
Schistosoma mansoni hypothetical protein 0.0097 0.0063 0.0061
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0016 0.0018
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 1.0144 1 1
Plasmodium vivax NAD-dependent deacetylase, putative 0.0113 0.0079 0.1896
Echinococcus granulosus methyltransferase protein 5 0.0108 0.0074 0.0071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0108 0.0074 0.1752
Echinococcus multilocularis protein kinase c epsilon type 0.0186 0.0152 0.0187
Brugia malayi Eukaryotic aspartyl protease family protein 0.0038 0.0005 0.0005
Toxoplasma gondii SWIRM domain-containing protein 0.0057 0.0023 0.0515
Echinococcus granulosus Furin 1 0.2464 0.2404 0.2402
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0136 0.0102 0.2456
Toxoplasma gondii subtilisin SUB7 0.0446 0.0408 1
Mycobacterium ulcerans monoamine oxidase 0.0136 0.0102 0.2109
Schistosoma mansoni apoptosis regulator bax 0.0056 0.0023 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0231 0.0196 0.0194
Trypanosoma cruzi UDP-galactopyranose mutase 0.0136 0.0102 0.0437
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0149 0.0115 0.014
Echinococcus multilocularis glutamate receptor 2 0.005 0.0016 0.0018
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0191 0.0156 0.0154
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0083 0.0049 0.1169
Trichomonas vaginalis conserved hypothetical protein 0.0446 0.0408 0.0662
Echinococcus granulosus discoidin domain receptor 0.0052 0.0018 0.0016
Plasmodium vivax plasmepsin IV, putative 0.0038 0.0005 0.0053
Loa Loa (eye worm) proprotein convertase 2 0.2464 0.2404 0.2404
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0037 0.0004 0.0001
Giardia lamblia Transcriptional regulator, Sir2 family 0.0113 0.0079 0.0154
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0136 0.0102 0.2109
Loa Loa (eye worm) hypothetical protein 0.0052 0.0019 0.0019
Echinococcus granulosus neuroendocrine convertase 2 0.6407 0.6305 0.6304
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0191 0.0156 0.0248
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0088 0.0054 0.0877
Brugia malayi Angiotensin-converting enzyme family protein 0.0642 0.0602 0.0602
Brugia malayi celfurPC protein 0.8126 0.8004 0.8004
Toxoplasma gondii histone lysine-specific demethylase 0.0136 0.0102 0.2456
Mycobacterium ulcerans thioesterase TesA 0.0071 0.0038 0.0453
Brugia malayi Reprolysin 0.0052 0.0019 0.0019
Brugia malayi protein kinase C II. 0.0186 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0036 0.0002 0.0002
Echinococcus multilocularis MAM 0.0097 0.0063 0.0076
Loa Loa (eye worm) Carm1-pending protein 0.0108 0.0074 0.0074
Plasmodium falciparum plasmepsin VI 0.0038 0.0005 0.0053
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0088 0.0054 0.0919
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0018 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Schistosoma mansoni dihydroceramide desaturase 0.0037 0.0004 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.62 0.6099 1
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0052 0.0018 0.002
Onchocerca volvulus 0.0052 0.0018 0.0234
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0769 0.0728 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0769 0.0728 0.0907
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0084 0.0051 0.0784
Plasmodium falciparum subtilisin-like protease 3 0.0446 0.0408 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Echinococcus granulosus baculoviral IAP repeat containing protein 0.011 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0091 0.0057 0.0057
Schistosoma mansoni dock 0.0052 0.0018 0.0016
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0018 0.0395
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0108 0.0074 0.1752
Plasmodium falciparum subtilisin-like protease 2 0.0446 0.0408 1
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0446 0.0408 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0079 0.0123
Schistosoma mansoni btb and poz domain-containing protein 0.0052 0.0018 0.0016
Loa Loa (eye worm) integrin alpha pat-2 0.0696 0.0656 0.0656
Echinococcus multilocularis nmda type glutamate receptor 0.0117 0.0083 0.0101
Echinococcus granulosus epidermal growth factor receptor 0.0638 0.0598 0.0596
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2464 0.2404 0.3937
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0113 0.0079 0.0077
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.62 0.6099 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0136 0.0102 0.0437
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0113 0.0079 0.1896
Loa Loa (eye worm) hypothetical protein 0.0671 0.0631 0.0631
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Plasmodium falciparum protoporphyrinogen oxidase 0.0136 0.0102 0.2456
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0117 0.0083 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0446 0.0408 0.0662
Brugia malayi Furin-like cysteine rich region family protein 0.0638 0.0598 0.0598
Echinococcus multilocularis expressed protein 0.0365 0.0328 0.0407
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0088 0.0054 0.1299
Echinococcus multilocularis epidermal growth factor receptor 0.0638 0.0598 0.0745
Trichomonas vaginalis conserved hypothetical protein 0.2018 0.1963 0.3213
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Echinococcus granulosus c-Jun N-terminal kinases 0.0231 0.0196 0.0194
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.011 0.0076 0.0092
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0079 0.0123
Echinococcus multilocularis serine:threonine protein kinase N2 0.017 0.0136 0.0167
Onchocerca volvulus 0.0175 0.014 0.2007
Echinococcus multilocularis disintegrin and metalloproteinase 0.0037 0.0004 0.0002
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0298 0.0262 0.2886
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Brugia malayi Subtilase family protein 0.0446 0.0408 0.0408
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0117 0.0083 0.008
Brugia malayi hypothetical protein 0.0298 0.0262 0.0262
Toxoplasma gondii subtilisin SUB5 0.0446 0.0408 1
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0642 0.0602 0.0602
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0446 0.0408 0.0507
Plasmodium falciparum plasmepsin VIII, putative 0.0038 0.0005 0.0053
Mycobacterium tuberculosis Possible oxidoreductase 0.0136 0.0102 0.2474
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0018 0.0023
Toxoplasma gondii subtilisin SUB2 0.0446 0.0408 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0079 0.0123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0005 0.0003
Mycobacterium ulcerans NAD-dependent deacetylase 0.0113 0.0079 0.1524
Loa Loa (eye worm) hypothetical protein 0.3944 0.3868 0.3868
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0054 0.002 0.0047
Echinococcus granulosus integrin alpha ps 0.0202 0.0167 0.0165
Brugia malayi Protein kinase domain containing protein 0.0052 0.0018 0.0018
Trichomonas vaginalis hypothetical protein 0.0052 0.0018 0.0023
Brugia malayi hypothetical protein 0.0036 0.0002 0.0002
Trypanosoma cruzi subtilisin peptidase 0.0446 0.0408 0.5114
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0038 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0005
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0018 0.0016
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0052 0.0018 0.0016
Echinococcus multilocularis fibrillin 1 0.0094 0.006 0.0072
Plasmodium vivax aspartyl protease, putative 0.0038 0.0005 0.0053
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0136 0.0102 0.0125
Mycobacterium ulcerans dehydrogenase 0.0136 0.0102 0.2109
Loa Loa (eye worm) hypothetical protein 0.0728 0.0687 0.0687
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2464 0.2404 0.3937
Mycobacterium ulcerans thioesterase 0.0071 0.0038 0.0453
Brugia malayi GCC2 and GCC3 family protein 0.0045 0.0012 0.0012
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0089 0.0055 0.0053
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0002
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0769 0.0728 0.0726
Brugia malayi Carm1-pending protein 0.0108 0.0074 0.0074
Mycobacterium ulcerans oxidoreductase 0.0136 0.0102 0.2109
Echinococcus multilocularis Furin 1 0.2464 0.2404 0.3002
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0011 0.0009
Echinococcus multilocularis integrin alpha ps 0.0202 0.0167 0.0206
Schistosoma mansoni hypothetical protein 0.0108 0.0074 0.0071
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0446 0.0408 1
Onchocerca volvulus 0.0091 0.0057 0.0802
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0083 0.0049 0.0784
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0578 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0005
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0191 0.0156 0.3785
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Echinococcus multilocularis protein will die slowly 0.0208 0.0173 0.0213
Schistosoma mansoni SWI/SNF complex-related 0.0057 0.0023 0.0021
Loa Loa (eye worm) transcriptional regulator 0.0113 0.0079 0.0079
Echinococcus granulosus furin 1.0144 1 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0191 0.0156 0.0248
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0084 0.0051 0.1211
Brugia malayi SWIRM domain containing protein 0.0057 0.0023 0.0023
Echinococcus multilocularis 0.8126 0.8004 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0446 0.0408 0.0662
Loa Loa (eye worm) hypothetical protein 0.0091 0.0057 0.0057
Brugia malayi Pepsin A precursor 0.0038 0.0005 0.0005
Plasmodium vivax aspartyl protease, putative 0.0038 0.0005 0.0053
Giardia lamblia Hypothetical protein 0.0769 0.0728 0.1936
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0079 0.0123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0446 0.0408 0.0662
Echinococcus multilocularis inhibitor of apoptosis protein 0.011 0.0076 0.0092
Brugia malayi EGF-like domain containing protein 0.0091 0.0057 0.0057
Brugia malayi Sushi domain 0.0036 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.2018 0.1963 0.3213
Loa Loa (eye worm) hypothetical protein 0.0089 0.0055 0.0055
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0056 0.0023 0.0023
Toxoplasma gondii aspartyl protease ASP3 0.0038 0.0005 0.0053
Toxoplasma gondii aspartyl protease ASP5 0.0388 0.0351 0.8591
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2464 0.2404 0.3937
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0084 0.0051 0.5
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0769 0.0728 1
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.259 0.2529 0.2527
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0136 0.0102 0.2456
Loa Loa (eye worm) hypothetical protein 0.0446 0.0408 0.0408
Toxoplasma gondii subtilisin SUB10 0.0446 0.0408 1
Mycobacterium leprae Polyketide synthase Pks13 0.0125 0.0091 0.1861
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0108 0.0074 0.0113
Loa Loa (eye worm) hypothetical protein 0.011 0.0076 0.0076
Schistosoma mansoni chromatin regulatory protein sir2 0.0769 0.0728 0.0726
Loa Loa (eye worm) hypothetical protein 0.0056 0.0023 0.0023
Plasmodium falciparum plasmepsin X 0.0038 0.0005 0.0053
Schistosoma mansoni hypothetical protein 0.0052 0.0018 0.0016
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0088 0.0054 0.1299
Entamoeba histolytica hypothetical protein, conserved 0.0113 0.0079 0.0796
Loa Loa (eye worm) hypothetical protein 0.0113 0.0079 0.0079
Onchocerca volvulus 0.011 0.0076 0.1076
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0002

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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