TDR Targets

Basic information

Technical information

TDR Targets ID: 1384118
Name: 2-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]ben zonitrile
MW: 321.373 | Formula: C19H19N3O2
H donors: 0 H acceptors: 2 LogP: 2.73 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccccc1OCC(=O)N1CCN(CC1)c1ccccc1
InChi: 1S/C19H19N3O2/c20-14-16-6-4-5-9-18(16)24-15-19(23)22-12-10-21(11-13-22)17-7-2-1-3-8-17/h1-9H,10-13,15H2
InChiKey: CIJYZUXZPJXOTC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[2-oxo-2-(4-phenyl-1-piperazinyl)ethoxy]benzonitrile
2-[2-keto-2-(4-phenylpiperazin-1-yl)ethoxy]benzonitrile
NCGC00113004-01
ZINC03445205
C790-0268

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutaminase	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/FAK protein kinase	0.006	0.0046	0.0046
Trypanosoma cruzi	hypothetical protein	0.0083	0.0087	0.5014
Trichomonas vaginalis	centaurin beta, putative	0.0083	0.0087	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0105	0.0127	1
Echinococcus multilocularis	pdz domain containing protein	0.0083	0.0087	0.0092
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0134	0.018	0.0204
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0105	0.0127	1
Trichomonas vaginalis	conserved hypothetical protein	0.017	0.0246	0.1539
Echinococcus multilocularis	oxysterol binding protein 3	0.0083	0.0087	0.0092
Loa Loa (eye worm)	TK protein kinase	0.006	0.0046	0.0046
Trypanosoma brucei	protein kinase, putative	0.0083	0.0086	0.4986
Echinococcus multilocularis	epidermal growth factor receptor	0.006	0.0046	0.0044
Echinococcus granulosus	tyrosine protein kinase Srms	0.006	0.0046	0.0044
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0083	0.0087	0.5014
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0083	0.0087	0.0266
Echinococcus granulosus	regulator of G protein signaling 7	0.0901	0.1568	0.1865
Schistosoma mansoni	dynamin	0.0083	0.0087	0.007
Onchocerca volvulus	Tyrosine kinase homolog	0.006	0.0046	0.0007
Schistosoma mansoni	tyrosine protein kinase	0.006	0.0046	0.003
Echinococcus multilocularis	tyrosine protein kinase Blk	0.006	0.0046	0.0044
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.006	0.0046	0.0044
Leishmania major	hypothetical protein, conserved	0.0083	0.0087	0.5014
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.006	0.0046	0.0044
Echinococcus granulosus	Oxysterol binding protein 11	0.0083	0.0087	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Schistosoma mansoni	oxysterol-binding protein 1	0.0083	0.0087	0.007
Trichomonas vaginalis	alpha chimerin, putative	0.0083	0.0087	0.0523
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Echinococcus granulosus	tyrosine kinase	0.006	0.0046	0.0044
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0134	0.018	0.0164
Trypanosoma cruzi	PH domain containing protein, putative	0.0083	0.0087	0.5014
Entamoeba histolytica	hypothetical protein	0.0105	0.0127	0.053
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0046	0.0264
Schistosoma mansoni	hypothetical protein	0.0083	0.0087	0.007
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.006	0.0046	0.0044
Echinococcus multilocularis	aurora kinase A	0.0087	0.0095	0.0102
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Plasmodium vivax	hypothetical protein, conserved	0.0083	0.0087	0.5014
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Brugia malayi	Tyrosine-protein kinase PR2	0.006	0.0046	0.0037
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.006	0.0046	0.003
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Schistosoma mansoni	fibrocystin l	0.017	0.0246	0.023
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.006	0.0046	0.0264
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Onchocerca volvulus		0.006	0.0046	0.0007
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus granulosus	regulator of G protein signaling 3	0.0901	0.1568	0.1865
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0083	0.0087	0.0523
Brugia malayi	Probable exocyst complex component Sec5	0.017	0.0246	0.0236
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0901	0.1568	0.1555
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Brugia malayi	Dynamin	0.0083	0.0087	0.0077
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0083	0.0087	0.0092
Brugia malayi	Pleckstrin Homology Domain	0.0083	0.0087	0.0077
Brugia malayi	DNA-binding protein LAG-1	0.017	0.0246	0.0236
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0046	0.0264
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.006	0.0046	0.0037
Echinococcus multilocularis	tyrosine kinase	0.006	0.0046	0.0044
Schistosoma mansoni	axis inhibition protein axin	0.0901	0.1568	0.1555
Brugia malayi	Oxysterol-binding protein	0.0083	0.0087	0.0077
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.017	0.0246	0.1539
Loa Loa (eye worm)	TK protein kinase	0.006	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Loa Loa (eye worm)	AUR protein kinase	0.0087	0.0095	0.0095
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0083	0.0086	0.0092
Schistosoma mansoni	serine/threonine-protein kinase	0.0105	0.0127	0.0111
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Toxoplasma gondii	hypothetical protein	0.0083	0.0087	0.5014
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.006	0.0046	0.0037
Echinococcus multilocularis	Pleckstrin y	0.0083	0.0087	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0046	0.003
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0323	0.0323
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus granulosus	epidermal growth factor receptor	0.006	0.0046	0.0044
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.006	0.0046	0.0044
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Brugia malayi	hypothetical protein	0.0901	0.1568	0.156
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0083	0.0087	0.5014
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0083	0.0087	0.5014
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.006	0.0046	0.003
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.006	0.0046	0.003
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Brugia malayi	serine/threonine kinase 12	0.0087	0.0095	0.0085
Echinococcus granulosus	tyrosine protein kinase csk	0.006	0.0046	0.0044
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.006	0.0046	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0134	0.018	0.018
Echinococcus granulosus	expressed protein	0.0901	0.1568	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0134	0.018	0.018
Schistosoma mansoni	serine/threonine protein kinase	0.4258	0.765	0.7647
Echinococcus multilocularis	tyrosine protein kinase csk	0.006	0.0046	0.0044
Schistosoma mansoni	regulator of G protein signaling	0.0901	0.1568	0.1555
Toxoplasma gondii	hypothetical protein	0.0083	0.0087	0.5014
Brugia malayi	Fibronectin type III domain containing protein	0.0139	0.0189	0.018
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.017	0.0246	0.1539
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.017	0.0246	0.1539
Brugia malayi	PH domain containing protein	0.0083	0.0087	0.0077
Brugia malayi	hypothetical protein	0.006	0.0046	0.0037
Schistosoma mansoni	cell adhesion molecule	0.0139	0.0189	0.0173
Trichomonas vaginalis	protein kinase atn1, putative	0.006	0.0046	0.0264
Echinococcus multilocularis	tyrosine protein kinase shark	0.006	0.0046	0.0044
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.006	0.0046	0.0044
Brugia malayi	Furin-like cysteine rich region family protein	0.006	0.0046	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Schistosoma mansoni	centaurin alpha	0.0083	0.0087	0.007
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.006	0.0046	0.0044
Toxoplasma gondii	Oxysterol-binding protein	0.0083	0.0087	0.5014
Echinococcus multilocularis	natriuretic peptide receptor 1	0.006	0.0046	0.0044
Schistosoma mansoni	protein kinase	0.006	0.0046	0.003
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Brugia malayi	PH domain containing protein	0.0083	0.0087	0.0077
Leishmania major	protein kinase, putative	0.0083	0.0086	0.4986
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Trichomonas vaginalis	kinesin light chain, putative	0.0083	0.0087	0.0523
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0083	0.0087	0.5014
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Loa Loa (eye worm)	TK/Met protein kinase	0.006	0.0046	0.0046
Loa Loa (eye worm)	glutaminase	0.033	0.0535	0.0535
Echinococcus granulosus	activin receptor type	0.0083	0.0086	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0046	0.0264
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0901	0.1568	0.1568
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0198	0.0198
Echinococcus multilocularis	expressed protein	0.0901	0.1568	0.1865
Echinococcus multilocularis	receptor type guanylyl cyclase	0.006	0.0046	0.0044
Trypanosoma cruzi	hypothetical protein	0.0083	0.0087	0.5014
Onchocerca volvulus		0.0083	0.0087	0.0268
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.006	0.0046	0.0044
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Entamoeba histolytica	hypothetical protein	0.017	0.0246	0.131
Echinococcus granulosus	tyrosine protein kinase pr2	0.006	0.0046	0.0044
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.006	0.0046	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Echinococcus granulosus	transcription factor collier	0.017	0.0246	0.0282
Brugia malayi	SH2 domain containing protein	0.006	0.0046	0.0037
Echinococcus granulosus	tyrosine kinase	0.006	0.0046	0.0044
Loa Loa (eye worm)	TK protein kinase	0.006	0.0046	0.0046
Onchocerca volvulus		0.006	0.0046	0.0007
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0083	0.0087	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0901	0.1568	0.1555
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.006	0.0046	0.0044
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0901	0.1568	0.156
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0105	0.0127	1
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.1568	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.006	0.0046	0.0044
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0083	0.0087	0.0266
Entamoeba histolytica	protein kinase, putative	0.0105	0.0127	0.053
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0083	0.0087	0.0092
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0083	0.0086	0.4986
Brugia malayi	hypothetical protein	0.0389	0.0641	0.0632
Echinococcus granulosus	semaphorin 1A	0.0389	0.0641	0.0756
Echinococcus granulosus	tumor protein p63	0.0408	0.0676	0.0797
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.1568	1
Leishmania major	protein kinase, putative	0.0087	0.0095	0.6017
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.004	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0901	0.1568	0.1568
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus granulosus	pdz domain containing protein	0.0083	0.0087	0.0092
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0105	0.0127	1
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0083	0.0087	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.006	0.0046	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0389	0.0641	0.0641
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Loa Loa (eye worm)	TK protein kinase	0.006	0.0046	0.0046
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0083	0.0086	0.4986
Schistosoma mansoni	hypothetical protein	0.0083	0.0087	0.007
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0105	0.0127	1
Loa Loa (eye worm)	hypothetical protein	0.0901	0.1568	0.1568
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus multilocularis	regulator of G protein signaling	0.0901	0.1568	0.1865
Echinococcus multilocularis	oxysterol binding protein 9	0.0083	0.0087	0.0092
Echinococcus granulosus	tyrosine protein kinase Blk	0.006	0.0046	0.0044
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.3357	0.6019	0.7189
Echinococcus multilocularis	regulator of G protein signaling 7	0.0901	0.1568	0.1865
Brugia malayi	glutaminase DH11.1	0.033	0.0535	0.0526
Trichomonas vaginalis	conserved hypothetical protein	0.017	0.0246	0.1539
Schistosoma mansoni	serine/threonine-protein kinase	0.0105	0.0127	0.0111
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.006	0.0046	0.0264
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0083	0.0087	0.0266
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus granulosus	serine/threonine protein kinase	0.0105	0.0127	0.014
Echinococcus granulosus	tyrosine protein kinase Src42A	0.006	0.0046	0.0044
Trypanosoma cruzi	hypothetical protein	0.0083	0.0087	0.5014
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.006	0.0046	0.0044
Schistosoma mansoni	plexin	0.0916	0.1597	0.1583
Brugia malayi	hypothetical protein	0.0389	0.0641	0.0632
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Onchocerca volvulus		0.006	0.0046	0.0007
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0083	0.0087	0.0266
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0083	0.0086	0.4986
Brugia malayi	PXA domain containing protein	0.0901	0.1568	0.156
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Onchocerca volvulus		0.006	0.0046	0.0007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0195	0.0289	0.028
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0105	0.0127	1
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Trichomonas vaginalis	centaurin gamma, putative	0.0083	0.0087	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0189	0.0189
Schistosoma mansoni	hypothetical protein	0.017	0.0246	0.023
Entamoeba histolytica	hypothetical protein	0.0083	0.0087	0.0266
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0083	0.0087	0.5014
Loa Loa (eye worm)	TK/ALK protein kinase	0.0302	0.0485	0.0485
Loa Loa (eye worm)	TK/EPH protein kinase	0.006	0.0046	0.0046
Loa Loa (eye worm)	SRC-1	0.006	0.0046	0.0046
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Brugia malayi	hypothetical protein	0.0139	0.0189	0.018
Echinococcus granulosus	tyrosine protein kinase Src64B	0.006	0.0046	0.0044
Onchocerca volvulus		0.0916	0.1597	1
Echinococcus granulosus	epidermal growth factor receptor	0.006	0.0046	0.0044
Loa Loa (eye worm)	glutaminase 2	0.033	0.0535	0.0535
Plasmodium falciparum	oxysterol-binding protein, putative	0.0083	0.0087	0.5014
Echinococcus granulosus	Pleckstrin y	0.0083	0.0087	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Schistosoma mansoni	protein tyrosine kinase	0.006	0.0046	0.003
Entamoeba histolytica	protein kinase, putative	0.0105	0.0127	0.053
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus granulosus	tyrosine protein kinase	0.006	0.0046	0.0044
Brugia malayi	serine/threonine-protein kinase 6	0.0087	0.0095	0.0085
Echinococcus granulosus	defective proboscis extension response	0.0134	0.018	0.0204
Trypanosoma cruzi	hypothetical protein	0.0083	0.0087	0.5014
Trichomonas vaginalis	conserved hypothetical protein	0.017	0.0246	0.1539
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.006	0.0046	0.0037
Entamoeba histolytica	hypothetical protein, conserved	0.0083	0.0087	0.0266
Echinococcus multilocularis	tyrosine protein kinase csk	0.006	0.0046	0.0044
Loa Loa (eye worm)	oxysterol binding protein	0.0083	0.0087	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Echinococcus multilocularis	integrin linked protein kinase	0.006	0.0046	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Schistosoma mansoni	regulator of G protein signaling	0.0901	0.1568	0.1555
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0105	0.0127	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.006	0.0046	0.0046
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.006	0.0046	0.0044
Entamoeba histolytica	hypothetical protein	0.0083	0.0087	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0901	0.1568	0.1568
Onchocerca volvulus		0.0389	0.0641	0.3844
Schistosoma mansoni	z-protein (S1r protein)	0.0901	0.1568	0.1555
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0045	0.0029
Echinococcus multilocularis	FL cytokine receptor	0.006	0.0046	0.0044
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Brugia malayi	Receptor family ligand binding region containing protein	0.006	0.0046	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0105	0.0127	0.053
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Schistosoma mansoni	hypothetical protein	0.0389	0.0641	0.0626
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0083	0.0087	0.0523
Echinococcus granulosus	tyrosine protein kinase csk	0.006	0.0046	0.0044
Echinococcus granulosus	protein tyrosine kinase	0.006	0.0046	0.0044
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.4655	0.8368	1
Entamoeba histolytica	protein kinase, putative	0.0105	0.0127	0.053
Brugia malayi	PH domain containing protein	0.0083	0.0087	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0189	0.0189
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.006	0.0046	0.0044
Trypanosoma cruzi	hypothetical protein	0.0083	0.0087	0.5014
Echinococcus granulosus	neuroglian	0.0134	0.018	0.0204
Entamoeba histolytica	hypothetical protein	0.0083	0.0087	0.0266
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Loa Loa (eye worm)	PH domain-containing protein	0.0083	0.0087	0.0087
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0105	0.0127	1
Echinococcus granulosus	beta-adrenergic receptor kinase	0.4258	0.765	0.9141
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0083	0.0087	0.5014
Brugia malayi	hypothetical protein	0.0083	0.0087	0.0077
Entamoeba histolytica	hypothetical protein	0.0901	0.1568	1
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0083	0.0087	0.0268
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0095	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0389	0.0641	0.0641
Trichomonas vaginalis	glutaminase, putative	0.033	0.0535	0.3389
Entamoeba histolytica	hypothetical protein	0.0083	0.0087	0.0266
Brugia malayi	Variant SH3 domain containing protein	0.0083	0.0087	0.0077
Loa Loa (eye worm)	TK/ABL protein kinase	0.006	0.0046	0.0046
Schistosoma mansoni	semaphorin 5-related	0.0389	0.0641	0.0626
Schistosoma mansoni	regulator of G protein signaling	0.0901	0.1568	0.1555
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0083	0.0087	0.0092
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0105	0.0127	1
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Echinococcus multilocularis	epidermal growth factor receptor	0.006	0.0046	0.0044
Schistosoma mansoni	axis inhibition protein axin	0.0901	0.1568	0.1555
Echinococcus granulosus	myotubularin protein 13	0.0083	0.0087	0.0092
Entamoeba histolytica	protein kinase domain containing protein	0.0083	0.0086	0.0264
Echinococcus multilocularis	transfer RNA-Thr	0.006	0.0046	0.0044
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.006	0.0046	0.0044
Echinococcus multilocularis	Oxysterol binding protein 11	0.0083	0.0087	0.0092
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0083	0.0087	0.0266
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trichomonas vaginalis	hypothetical protein	0.0083	0.0087	0.0523
Echinococcus multilocularis	rac serine:threonine kinase	0.0105	0.0127	0.014
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.1568	1
Echinococcus multilocularis	actin binding protein anillin	0.0083	0.0087	0.0092
Schistosoma mansoni	growth factor receptor-bound protein	0.0083	0.0087	0.007
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.017	0.0246	0.1539
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.017	0.0246	0.1539
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.006	0.0046	0.0044
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0083	0.0087	0.0266
Leishmania major	folate/biopterin transporter, putative	0.0105	0.0127	1
Brugia malayi	IPT/TIG domain containing protein	0.017	0.0246	0.0236
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0083	0.0087	0.0266
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.006	0.0046	0.0044
Trichomonas vaginalis	TK family protein kinase	0.006	0.0046	0.0264
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.006	0.0046	0.0044
Echinococcus granulosus	retinal guanylyl cyclase 2	0.006	0.0046	0.0044
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4655	0.8368	0.8368
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Trypanosoma cruzi	hypothetical protein	0.0083	0.0087	0.5014
Loa Loa (eye worm)	hypothetical protein	0.0389	0.0641	0.0641
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0105	0.0127	0.053
Loa Loa (eye worm)	TK/ACK protein kinase	0.006	0.0046	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Loa Loa (eye worm)	RGC/RGC protein kinase	0.006	0.0046	0.0046
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.4655	0.8368	0.8367
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.017	0.0246	0.1539
Giardia lamblia	Aurora kinase	0.0087	0.0095	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.006	0.0046	0.0037
Echinococcus granulosus	tyrosine kinase	0.006	0.0046	0.0044
Loa Loa (eye worm)	TK/RYK protein kinase	0.006	0.0046	0.0046
Brugia malayi	Plekhf2 protein	0.0083	0.0087	0.0077
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.006	0.0046	0.0044
Echinococcus multilocularis	protein KINase family member (kin 25)	0.006	0.0046	0.0044
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0083	0.0087	0.007
Onchocerca volvulus		0.006	0.0046	0.0007
Entamoeba histolytica	cell surface protease gp63, putative	0.017	0.0246	0.131
Brugia malayi	SRC-1	0.006	0.0046	0.0037
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0083	0.0087	0.007
Trichomonas vaginalis	conserved hypothetical protein	0.017	0.0246	0.1539
Echinococcus multilocularis	regulator of G protein signaling 3	0.0901	0.1568	0.1865
Brugia malayi	PH domain containing protein	0.0083	0.0087	0.0077
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0139	0.0189	0.018
Onchocerca volvulus		0.006	0.0046	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Schistosoma mansoni	hypothetical protein	0.0389	0.0641	0.0626
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0083	0.0087	0.0077
Brugia malayi	hypothetical protein	0.006	0.0046	0.0037
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.006	0.0046	0.0044
Schistosoma mansoni	protein kinase	0.006	0.0046	0.003
Brugia malayi	Sema domain containing protein	0.0389	0.0641	0.0632
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.006	0.0046	0.0046
Echinococcus granulosus	beta 1 syntrophin	0.0083	0.0087	0.0092
Loa Loa (eye worm)	hypothetical protein	0.017	0.0246	0.0246
Schistosoma mansoni	protein kinase	0.006	0.0046	0.003
Echinococcus multilocularis	ephrin type A receptor 4 A	0.006	0.0046	0.0044
Echinococcus granulosus	axis inhibition protein axin	0.0901	0.1568	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0389	0.0641	0.0641
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.006	0.0046	0.003
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0134	0.018	0.0204
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0105	0.0127	1
Schistosoma mansoni	serine/threonine protein kinase	0.4258	0.765	0.7647
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Entamoeba histolytica	protein kinase, putative	0.0105	0.0127	0.053
Echinococcus multilocularis	Immunoglobulin	0.0134	0.018	0.0204
Onchocerca volvulus		0.0083	0.0087	0.0268
Loa Loa (eye worm)	TK protein kinase	0.006	0.0046	0.0046
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0087	0.0095	0.0319
Schistosoma mansoni	protein kinase	0.006	0.0046	0.003
Trichomonas vaginalis	centaurin/arf, putative	0.0083	0.0087	0.0523
Brugia malayi	PH domain containing protein	0.0083	0.0087	0.0077
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0083	0.0087	0.0268
Echinococcus granulosus	cytohesin 1	0.0083	0.0087	0.0092
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.006	0.0046	0.0044
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.006	0.0046	0.0046
Brugia malayi	A-kinase anchor protein 10, precursor	0.0901	0.1568	0.156
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Trichomonas vaginalis	protein transport protein sec7, putative	0.0083	0.0087	0.0523
Echinococcus granulosus	tyrosine protein kinase Fyn	0.006	0.0046	0.0044
Plasmodium falciparum	protein kinase, putative	0.0083	0.0086	0.4986
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0083	0.0087	0.0087
Brugia malayi	Oxysterol binding protein	0.0083	0.0087	0.0077
Entamoeba histolytica	protein kinase, putative	0.0087	0.0095	0.0319
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0105	0.0127	0.078
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0095	0.0574
Trypanosoma brucei	aurora B kinase	0.0087	0.0095	0.6017
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Loa Loa (eye worm)	AUR protein kinase	0.0087	0.0095	0.0095
Echinococcus granulosus	retinal guanylyl cyclase 2	0.006	0.0046	0.0044
Trypanosoma brucei	protein kinase, putative	0.0105	0.0127	1
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Echinococcus multilocularis	heat shock protein 70	0.006	0.0046	0.0044
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0046	0.003
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Onchocerca volvulus	Protein melted homolog	0.0083	0.0087	0.0268
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Schistosoma mansoni	hypothetical protein	0.0083	0.0087	0.007
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0083	0.0087	0.0092
Brugia malayi	Raf kinase	0.006	0.0046	0.0037
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus multilocularis	raf serine:threonine protein kinase	0.006	0.0046	0.0044
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0046	0.003
Leishmania major	serine/threonine-protein kinase a, putative	0.0105	0.0127	1
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0083	0.0087	0.0092
Onchocerca volvulus		0.006	0.0046	0.0007
Toxoplasma gondii	AtPH1 family protein	0.0083	0.0087	0.5014
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.006	0.0046	0.0044
Brugia malayi	Uncoordinated protein 104	0.0083	0.0087	0.0077
Echinococcus multilocularis	activated cdc42 kinase 1	0.006	0.0046	0.0044
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0087	0.0095	0.0319
Echinococcus granulosus	kinase suppressor of Ras 1	0.006	0.0046	0.0044
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.006	0.0046	0.0044
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus granulosus	integrin linked protein kinase	0.006	0.0046	0.0044
Loa Loa (eye worm)	cytohesin 3	0.0083	0.0087	0.0087
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Brugia malayi	regulator of G-protein signaling egl-10	0.0901	0.1568	0.156
Plasmodium vivax	PH domain containing protein	0.0083	0.0087	0.5014
Loa Loa (eye worm)	TK protein kinase	0.006	0.0046	0.0046
Echinococcus granulosus	oxysterol binding protein 1	0.0083	0.0087	0.0092
Entamoeba histolytica	protein kinase domain containing protein	0.0231	0.0355	0.2028
Loa Loa (eye worm)	TK protein kinase	0.006	0.0046	0.0046
Onchocerca volvulus		0.006	0.0046	0.0007
Echinococcus granulosus	roundabout 2	0.0139	0.0189	0.0215
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0083	0.0087	0.007
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0083	0.0087	0.0266
Onchocerca volvulus		0.0083	0.0087	0.0268
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.006	0.0046	0.0044
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0105	0.0127	1
Brugia malayi	SH2 domain containing protein	0.006	0.0046	0.0037
Entamoeba histolytica	hypothetical protein	0.017	0.0246	0.131
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0046	0.0264
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0065	0.0055	0.0054
Brugia malayi	PH domain containing protein	0.0083	0.0087	0.0077
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0195	0.0289	0.0289
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.006	0.0046	0.0044
Schistosoma mansoni	zinc finger protein	0.0083	0.0087	0.007
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0083	0.0087	0.5014
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0083	0.0087	0.5014
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0083	0.0087	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Loa Loa (eye worm)	TK protein kinase	0.006	0.0046	0.0046
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.006	0.0046	0.0007
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.006	0.0046	0.0044
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.006	0.0046	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Schistosoma mansoni	hypothetical protein	0.0083	0.0087	0.007
Echinococcus multilocularis	tyrosine protein kinase csk	0.006	0.0046	0.0044
Loa Loa (eye worm)	RGC/RGC protein kinase	0.006	0.0046	0.0046
Echinococcus granulosus	tyrosine protein kinase ABL1	0.006	0.0046	0.0044
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.006	0.0046	0.0044
Schistosoma mansoni	hypothetical protein	0.006	0.0046	0.003
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Echinococcus multilocularis	tyrosine protein kinase csk	0.006	0.0046	0.0044
Brugia malayi	Cadps2 protein	0.0083	0.0087	0.0077
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0105	0.0127	0.053
Loa Loa (eye worm)	AUR protein kinase	0.0087	0.0095	0.0095
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.006	0.0046	0.0264
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.006	0.0046	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0046	0.0264
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0105	0.0127	1
Brugia malayi	Cytohesin 3	0.0083	0.0087	0.0077
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.006	0.0046	0.0046
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.006	0.0046	0.003
Schistosoma mansoni	protein kinase	0.0083	0.0086	0.007
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0083	0.0087	0.007
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0083	0.0087	0.0092
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.006	0.0046	0.0044
Brugia malayi	hypothetical protein	0.0901	0.1568	0.156
Echinococcus granulosus	pleckstrin y domain containing family A	0.0083	0.0087	0.0092
Echinococcus granulosus	ephrin type A receptor 4 A	0.006	0.0046	0.0044
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Trichomonas vaginalis	centaurin alpha, putative	0.0083	0.0087	0.0523
Toxoplasma gondii	aurora kinase	0.0087	0.0095	0.6017
Schistosoma mansoni	hypothetical protein	0.0083	0.0087	0.007
Schistosoma mansoni	protein kinase	0.0087	0.0095	0.0078
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Brugia malayi	PH domain containing protein	0.0083	0.0087	0.0077
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0134	0.018	0.0164
Schistosoma mansoni	dynamin	0.0083	0.0087	0.007
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Loa Loa (eye worm)	hypothetical protein	0.0134	0.018	0.018
Schistosoma mansoni	nephrin	0.0139	0.0189	0.0173
Loa Loa (eye worm)	hypothetical protein	0.017	0.0246	0.0246
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Loa Loa (eye worm)	rho-GTPase-activating	0.0083	0.0087	0.0087
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0083	0.0086	0.4986
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0901	0.1568	1
Brugia malayi	Guanylyl cyclase protein 23	0.006	0.0046	0.0037
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0083	0.0087	0.0266
Echinococcus multilocularis	beta adrenergic receptor kinase	0.4258	0.765	0.9141
Echinococcus granulosus	fibroblast growth factor receptor 4	0.006	0.0046	0.0044
Brugia malayi	MH2 domain containing protein	0.0144	0.0198	0.0189
Brugia malayi	PH domain containing protein	0.0083	0.0087	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0083	0.0087	0.0092
Schistosoma mansoni	regulator of G protein signaling	0.0901	0.1568	0.1555
Brugia malayi	Variant SH3 domain containing protein	0.0083	0.0087	0.0077
Echinococcus granulosus	plexin a4	0.1087	0.1905	0.2268
Echinococcus granulosus	activated cdc42 kinase 1	0.006	0.0046	0.0044
Schistosoma mansoni	glutaminase	0.033	0.0535	0.0519
Brugia malayi	PH domain containing protein	0.0083	0.0087	0.0077
Echinococcus multilocularis	cytohesin 1	0.0083	0.0087	0.0092
Echinococcus multilocularis	kinase suppressor of Ras 1	0.006	0.0046	0.0044
Echinococcus multilocularis	transcription factor collier	0.017	0.0246	0.0282
Trichomonas vaginalis	STE family protein kinase	0.006	0.0046	0.0264
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0083	0.0087	0.0092
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0105	0.0127	0.053
Echinococcus granulosus	tyrosine protein kinase Fyn	0.006	0.0046	0.0044
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0095	0.0574
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.5555	1	1
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0087	0.0095	0.0319
Schistosoma mansoni	serine/threonine protein kinase	0.0087	0.0095	0.0078
Trichomonas vaginalis	AGC family protein kinase	0.006	0.0046	0.0264
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0046	0.0264
Echinococcus granulosus	Pleckstrin y	0.0083	0.0087	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Entamoeba histolytica	hypothetical protein	0.017	0.0246	0.131
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0083	0.0087	0.0523
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.006	0.0046	0.0044
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Schistosoma mansoni	goodpasture antigen-binding protein	0.0083	0.0087	0.007
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0105	0.0127	1
Onchocerca volvulus		0.0083	0.0087	0.0268
Echinococcus multilocularis	Pleckstrin y	0.0083	0.0087	0.0092
Echinococcus granulosus	calcium dependent secretion activator 1	0.0083	0.0087	0.0092
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Echinococcus multilocularis	regulator of G protein signaling 7	0.0901	0.1568	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0134	0.018	0.018
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.4258	0.765	0.765
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trypanosoma cruzi	PH domain containing protein, putative	0.0083	0.0087	0.5014
Echinococcus granulosus	tyrosine protein kinase shark	0.006	0.0046	0.0044
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0083	0.0087	0.0092
Trypanosoma cruzi	aurora B kinase, putative	0.0087	0.0095	0.6017
Leishmania major	protein kinase, putative	0.0105	0.0127	1
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Echinococcus multilocularis	regulator of G protein signaling 3	0.0901	0.1568	0.1865
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Onchocerca volvulus		0.006	0.0046	0.0007
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Echinococcus granulosus	oxysterol binding protein 9	0.0083	0.0087	0.0092
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0105	0.0127	0.053
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0083	0.0087	0.5014
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0087	0.0095	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Echinococcus granulosus	exocyst complex component 2	0.017	0.0246	0.0282
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Schistosoma mansoni	vav2	0.0083	0.0087	0.007
Brugia malayi	C-terminal src kinase protein 1	0.006	0.0046	0.0037
Echinococcus granulosus	GRB2 associated binding protein 3	0.0083	0.0087	0.0092
Entamoeba histolytica	hypothetical protein	0.0105	0.0127	0.053
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus granulosus	protein kinase	0.006	0.0046	0.0044
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Onchocerca volvulus		0.006	0.0046	0.0007
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0083	0.0087	0.0092
Echinococcus multilocularis	tyrosine protein kinase HCK	0.006	0.0046	0.0044
Echinococcus multilocularis	exocyst complex component 2	0.017	0.0246	0.0282
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Onchocerca volvulus		0.006	0.0046	0.0007
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0105	0.0127	1
Brugia malayi	MAX-1A	0.0083	0.0087	0.0077
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.006	0.0046	0.003
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Brugia malayi	integrin-linked kinase	0.006	0.0046	0.0037
Echinococcus multilocularis	axis inhibition protein axin	0.0901	0.1568	0.1865
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.4655	0.8368	0.8368
Mycobacterium ulcerans	glutaminase	0.033	0.0535	0.5
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Entamoeba histolytica	protein kinase , putative	0.0087	0.0095	0.0319
Schistosoma mansoni	myotubularin-related protein	0.0083	0.0087	0.007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.006	0.0046	0.0037
Echinococcus multilocularis	insulin receptor	0.006	0.0046	0.0044
Onchocerca volvulus	Putative zinc finger protein	0.0083	0.0087	0.0268
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.006	0.0046	0.0044
Trichomonas vaginalis	CAMK family protein kinase	0.006	0.0046	0.0264
Echinococcus granulosus	c src tyrosine kinase	0.006	0.0046	0.0044
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.4655	0.8368	1
Loa Loa (eye worm)	sema domain-containing protein	0.0389	0.0641	0.0641
Echinococcus granulosus	aurora kinase A	0.0087	0.0095	0.0102
Brugia malayi	bone morphogenetic protein type 1 receptor	0.006	0.0046	0.0037
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Echinococcus granulosus	semaphorin 5B	0.0389	0.0641	0.0756
Echinococcus granulosus	retinal guanylyl cyclase 2	0.006	0.0046	0.0044
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.017	0.0246	0.0246
Trypanosoma brucei	PH domain containing protein, putative	0.0083	0.0087	0.5014
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Schistosoma mansoni	syntrophin	0.0083	0.0087	0.007
Entamoeba histolytica	PH domain containing protein	0.0083	0.0087	0.0266
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.017	0.0246	0.1539
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0083	0.0087	0.0523
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Echinococcus granulosus	G protein coupled receptor kinase 1	0.3357	0.6019	0.7189
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0083	0.0087	0.0092
Echinococcus granulosus	natriuretic peptide receptor 1	0.006	0.0046	0.0044
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0083	0.0087	0.0077
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.006	0.0046	0.0044
Onchocerca volvulus		0.006	0.0046	0.0007
Echinococcus granulosus	twitchin	0.0157	0.022	0.0252
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Onchocerca volvulus		0.006	0.0046	0.0007
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0083	0.0087	0.0092
Echinococcus granulosus	raf serine:threonine protein kinase	0.006	0.0046	0.0044
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Onchocerca volvulus		0.006	0.0046	0.0007
Echinococcus multilocularis	axis inhibition protein axin	0.0901	0.1568	0.1865
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.006	0.0046	0.0046
Echinococcus multilocularis	tyrosine protein kinase Srms	0.006	0.0046	0.0044
Loa Loa (eye worm)	TK/DDR protein kinase	0.006	0.0046	0.0046
Brugia malayi	TBC domain containing protein	0.0083	0.0087	0.0077
Loa Loa (eye worm)	uncoordinated protein 104	0.0083	0.0087	0.0087
Loa Loa (eye worm)	TK protein kinase	0.006	0.0046	0.0046
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0083	0.0087	0.5014
Schistosoma mansoni	serine/threonine RGC	0.006	0.0046	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0901	0.1568	0.1568
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trichomonas vaginalis	protein transport protein sec7, putative	0.0083	0.0087	0.0523
Echinococcus multilocularis	tyrosine protein kinase Abl	0.006	0.0046	0.0044
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus granulosus	Rho GTPase activating protein 24	0.0083	0.0087	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0083	0.0087	0.0266
Brugia malayi	hypothetical protein	0.006	0.0046	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0083	0.0087	0.0523
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Entamoeba histolytica	PH domain containing protein	0.0083	0.0087	0.0266
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus granulosus	regulator of G protein signaling 3	0.0901	0.1568	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Brugia malayi	Tyrosine-protein kinase abl-1	0.006	0.0046	0.0037
Loa Loa (eye worm)	TK/EGFR protein kinase	0.006	0.0046	0.0046
Trichomonas vaginalis	protein tyrosine kinase, putative	0.006	0.0046	0.0264
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0083	0.0087	0.0523
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Echinococcus granulosus	Regulator of G protein signaling 20	0.0901	0.1568	0.1865
Echinococcus granulosus	tyrosine protein kinase csk	0.006	0.0046	0.0044
Echinococcus multilocularis	neuroglian	0.0134	0.018	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0389	0.0641	0.0641
Schistosoma mansoni	plexin	0.0527	0.0892	0.0877
Onchocerca volvulus		0.0083	0.0087	0.0268
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.006	0.0046	0.0044
Loa Loa (eye worm)	syntrophin-1	0.0083	0.0087	0.0087
Trypanosoma cruzi	Protein kinase B	0.0105	0.0127	1
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Loa Loa (eye worm)	protein kinase domain-containing protein	0.006	0.0046	0.0046
Schistosoma mansoni	vesicular amine transporter	0.0137	0.0185	0.0169
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0105	0.0127	0.0127
Trichomonas vaginalis	AGC family protein kinase	0.0087	0.0095	0.0574
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0046	0.003
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Echinococcus multilocularis	tumor protein p63	0.0408	0.0676	0.0797
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0083	0.0087	0.0087
Trypanosoma cruzi	NIMA-related kinase, putative	0.0105	0.0127	1
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Onchocerca volvulus		0.006	0.0046	0.0007
Echinococcus multilocularis	protein kinase	0.006	0.0046	0.0044
Loa Loa (eye worm)	serine/threonine protein kinase	0.006	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0389	0.0641	0.0641
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.1568	1
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0105	0.0127	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.018	0.018
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.1568	1
Echinococcus multilocularis	protein kinase	0.006	0.0046	0.0044
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.006	0.0046	0.0044
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Entamoeba histolytica	PH domain containing protein	0.0083	0.0087	0.0266
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0083	0.0087	0.0266
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.006	0.0046	0.0037
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0083	0.0087	0.0092
Loa Loa (eye worm)	RGC/RGC protein kinase	0.006	0.0046	0.0046
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0083	0.0087	0.0087
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Schistosoma mansoni	protein kinase	0.0083	0.0086	0.007
Entamoeba histolytica	protein kinase, putative	0.0087	0.0095	0.0319
Schistosoma mansoni	protein kinase	0.006	0.0046	0.003
Schistosoma mansoni	rho gtpase activating protein	0.0083	0.0087	0.007
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0083	0.0087	0.0077
Brugia malayi	serine/threonine protein kinase 6	0.0087	0.0095	0.0085
Brugia malayi	Sema domain containing protein	0.0389	0.0641	0.0632
Entamoeba histolytica	hypothetical protein	0.0901	0.1568	1
Schistosoma mansoni	protein kinase	0.006	0.0046	0.003
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0198	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Echinococcus granulosus	tyrosine protein kinase HCK	0.006	0.0046	0.0044
Leishmania major	hypothetical protein, conserved	0.0083	0.0087	0.5014
Echinococcus multilocularis	tyrosine protein kinase pr2	0.006	0.0046	0.0044
Trypanosoma cruzi	NIMA-related kinase, putative	0.0105	0.0127	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0105	0.0127	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.006	0.0046	0.0046
Entamoeba histolytica	protein kinase, putative	0.0105	0.0127	0.053
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.006	0.0046	0.0044
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0083	0.0087	0.0266
Brugia malayi	Protein kinase domain containing protein	0.0303	0.0485	0.0476
Echinococcus granulosus	regulator of G protein signaling 7	0.0901	0.1568	0.1865
Trichomonas vaginalis	centaurin/arf, putative	0.0083	0.0087	0.0523
Loa Loa (eye worm)	sema domain-containing protein	0.0389	0.0641	0.0641
Brugia malayi	Syntrophin-1	0.0083	0.0087	0.0077
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus multilocularis	dynamin 1	0.0083	0.0087	0.0092
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.006	0.0046	0.0007
Schistosoma mansoni	ephrin receptor	0.006	0.0046	0.003
Brugia malayi	probable spectrin beta chain	0.0083	0.0087	0.0077
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0105	0.0127	1
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0083	0.0087	0.0266
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0901	0.1568	0.1555
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0083	0.0087	0.0266
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.006	0.0046	0.0264
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0083	0.0087	0.0092
Brugia malayi	plexin A	0.1087	0.1905	0.1898
Trypanosoma cruzi	PH domain containing protein, putative	0.0083	0.0087	0.5014
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Brugia malayi	protein-tyrosine kinase	0.006	0.0046	0.0037
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Loa Loa (eye worm)	hypothetical protein	0.006	0.0045	0.0045
Entamoeba histolytica	hypothetical protein	0.0083	0.0087	0.0266
Brugia malayi	Plexin repeat family protein	0.0916	0.1597	0.1589
Leishmania major	protein kinase, putative	0.0105	0.0127	1
Onchocerca volvulus		0.0083	0.0087	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0901	0.1568	0.1568
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0087	0.0095	0.0102
Echinococcus multilocularis	Pleckstrin y	0.0083	0.0087	0.0092
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0087	0.0095	0.6017
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0083	0.0087	0.0092
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.006	0.0046	0.0044
Echinococcus multilocularis	hypothetical protein	0.0389	0.0641	0.0756
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.006	0.0046	0.0044
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0901	0.1568	0.1865
Echinococcus multilocularis	plexin a4	0.1087	0.1905	0.2268
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.006	0.0046	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Echinococcus multilocularis	semaphorin 5B	0.0389	0.0641	0.0756
Echinococcus granulosus	axis inhibition protein axin	0.0901	0.1568	0.1865
Schistosoma mansoni	protein kinase	0.006	0.0046	0.003
Echinococcus multilocularis	roundabout 2	0.0139	0.0189	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0527	0.0892	0.0892
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0901	0.1568	0.1865
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0105	0.0127	0.053
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Echinococcus granulosus	activated cdc42 kinase 1	0.006	0.0046	0.0044
Echinococcus multilocularis	oxysterol binding protein 1	0.0083	0.0087	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0189	0.0189
Onchocerca volvulus		0.0083	0.0087	0.0268
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0105	0.0127	1
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus granulosus	DCC interacting protein 13 beta	0.0083	0.0087	0.0092
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Echinococcus multilocularis	protein tyrosine kinase	0.006	0.0046	0.0044
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Onchocerca volvulus	outspread protein homolog	0.0083	0.0087	0.0268
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0105	0.0127	1
Loa Loa (eye worm)	RGS-3 protein	0.0901	0.1568	0.1568
Entamoeba histolytica	p21-activated kinase	0.0105	0.0127	0.053
Plasmodium falciparum	PH domain-containing protein, putative	0.0083	0.0087	0.5014
Echinococcus granulosus	Immunoglobulin	0.0134	0.018	0.0204
Trypanosoma cruzi	hypothetical protein	0.0083	0.0087	0.5014
Entamoeba histolytica	protein kinase, putative	0.0105	0.0127	0.053
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0083	0.0087	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Echinococcus multilocularis	c src tyrosine kinase	0.006	0.0046	0.0044
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Schistosoma mansoni	zinc finger protein	0.0083	0.0087	0.007
Loa Loa (eye worm)	hypothetical protein	0.017	0.0246	0.0246
Schistosoma mansoni	goodpasture antigen-binding protein	0.0083	0.0087	0.007
Brugia malayi	regulator of G-protein signaling rgs-7	0.0901	0.1568	0.156
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0901	0.1568	0.156
Entamoeba histolytica	protein kinase domain containing protein	0.0087	0.0095	0.0319
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Echinococcus granulosus	oxysterol binding protein 3	0.0083	0.0087	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.006	0.0046	0.0264
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Trypanosoma cruzi	PH domain containing protein, putative	0.0083	0.0087	0.5014
Toxoplasma gondii	protein kinase domain-containing protein	0.0105	0.0127	1
Schistosoma mansoni	ephrin receptor	0.0065	0.0055	0.0039
Loa Loa (eye worm)	TK/CSK protein kinase	0.006	0.0046	0.0046
Echinococcus multilocularis	tyrosine protein kinase	0.006	0.0046	0.0044
Entamoeba histolytica	hypothetical protein	0.017	0.0246	0.131
Loa Loa (eye worm)	Plekhf2 protein	0.0083	0.0087	0.0087
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0083	0.0086	0.0092
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0065	0.0055	0.0054
Echinococcus granulosus	receptor type guanylyl cyclase	0.006	0.0046	0.0044
Entamoeba histolytica	hypothetical protein	0.0901	0.1568	1
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0083	0.0087	0.0092
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0083	0.0087	0.0092
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0083	0.0087	0.0087
Schistosoma mansoni	protein kinase	0.0083	0.0086	0.007
Loa Loa (eye worm)	hypothetical protein	0.006	0.0046	0.0046
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0083	0.0086	0.0092
Loa Loa (eye worm)	plexin A	0.1087	0.1905	0.1905
Echinococcus granulosus	insulin receptor	0.006	0.0046	0.0044
Schistosoma mansoni	hypothetical protein	0.017	0.0246	0.023
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0105	0.0127	0.078
Loa Loa (eye worm)	hypothetical protein	0.0134	0.018	0.018
Brugia malayi	Dynamin	0.0083	0.0087	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0916	0.1597	0.1597
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.006	0.0046	0.003
Echinococcus multilocularis	tyrosine kinase	0.006	0.0046	0.0044
Schistosoma mansoni	serine/threonine protein kinase	0.5555	1	1
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Loa Loa (eye worm)	RGC/RGC protein kinase	0.006	0.0046	0.0046
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0083	0.0087	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Loa Loa (eye worm)	hypothetical protein	0.0901	0.1568	0.1568
Schistosoma mansoni	protein kinase	0.006	0.0046	0.003
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0087	0.0095	0.6017
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.006	0.0046	0.0044
Entamoeba histolytica	protein kinase, putative	0.0105	0.0127	0.053
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0087	0.0523
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Echinococcus granulosus	dynamin 1	0.0083	0.0087	0.0092
Schistosoma mansoni	oxysterol-binding protein 1	0.0083	0.0087	0.007
Entamoeba histolytica	tyrosin kinase, putative	0.0231	0.0355	0.2028
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0901	0.1568	0.1865
Schistosoma mansoni	regulator of G protein signaling	0.0901	0.1568	0.1555
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.006	0.0046	0.0046
Echinococcus granulosus	Pleckstrin y	0.0083	0.0087	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0087	0.0087
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Brugia malayi	ephrin receptor 1 precursor	0.006	0.0046	0.0037
Echinococcus granulosus	tyrosine protein kinase Fyn	0.006	0.0046	0.0044
Loa Loa (eye worm)	TK protein kinase	0.006	0.0046	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0901	0.1568	1
Trichomonas vaginalis	conserved hypothetical protein	0.017	0.0246	0.1539
Echinococcus multilocularis	Immunoglobulin	0.0134	0.018	0.0204
Echinococcus multilocularis	myotubularin protein 13	0.0083	0.0087	0.0092
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.006	0.0046	0.0044
Trichomonas vaginalis	AGC family protein kinase	0.0105	0.0127	0.078
Loa Loa (eye worm)	PXA domain-containing protein	0.0901	0.1568	0.1568
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0083	0.0087	0.0266
Brugia malayi	Protein kinase domain containing protein	0.0105	0.0127	0.0117
Trichomonas vaginalis	TKL family protein kinase	0.006	0.0046	0.0264
Brugia malayi	Protein kinase domain containing protein	0.006	0.0046	0.0037
Schistosoma mansoni	tyrosine kinase	0.006	0.0046	0.003
Schistosoma mansoni	hypothetical protein	0.0527	0.0892	0.0877
Echinococcus multilocularis	activin receptor type	0.0083	0.0086	0.0092
Echinococcus multilocularis	beta 1 syntrophin	0.0083	0.0087	0.0092
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.006	0.0046	0.0044
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.006	0.0046	0.0046
Brugia malayi	PXA domain containing protein	0.0901	0.1568	0.156
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0083	0.0087	0.0092
Loa Loa (eye worm)	TK/FER protein kinase	0.006	0.0046	0.0046

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.0032 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 125.8925 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1533883

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1384118