Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | signal transducer and activator of transcription 3 (acute-phase response factor) | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | notch | 0.0057 | 0.0547 | 0.0547 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0057 | 0.0547 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | protein jagged 1 | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | Peroxidasin | 0.0284 | 1 | 1 |
Schistosoma mansoni | notch | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0695 | 0.0695 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0284 | 1 | 1 |
Echinococcus granulosus | notch | 0.0057 | 0.0547 | 0.0547 |
Onchocerca volvulus | 0.0284 | 1 | 1 | |
Brugia malayi | EGF-like domain containing protein | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | EGF-like domain containing protein | 0.0057 | 0.0547 | 0.0547 |
Echinococcus granulosus | protein jagged 1 | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | notch | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0695 | 0.0695 |
Schistosoma mansoni | notch | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | notch | 0.0057 | 0.0547 | 0.0547 |
Echinococcus granulosus | protein jagged 2 | 0.0057 | 0.0547 | 0.0547 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0057 | 0.0547 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0695 | 0.0157 |
Echinococcus granulosus | peroxidasin | 0.0284 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | EGF-like domain containing protein | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | peroxidasin | 0.0284 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0057 | 0.0547 | 0.0547 |
Onchocerca volvulus | Peroxidase homolog | 0.0284 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0057 | 0.0547 | 0.0547 |
Echinococcus granulosus | protein jagged 2 | 0.0057 | 0.0547 | 0.0547 |
Loa Loa (eye worm) | STAT protein | 0.0191 | 0.6107 | 0.5882 |
Brugia malayi | notch-like transmembrane receptor | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0057 | 0.0547 | 0.0547 |
Echinococcus granulosus | fibropellin Ia | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | Animal haem peroxidase family protein | 0.0284 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | cell polarity protein | 0.0057 | 0.0547 | 0.0547 |
Echinococcus granulosus | neural cadherin | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | Animal haem peroxidase family protein | 0.0284 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0284 | 1 | 1 |
Schistosoma mansoni | slit | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0057 | 0.0547 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Echinococcus granulosus | delta-like protein 1 | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | Animal haem peroxidase family protein | 0.0284 | 1 | 1 |
Brugia malayi | Delta serrate ligand family protein | 0.0057 | 0.0547 | 0.0547 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0547 | 0.0547 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0057 | 0.0547 | 0.0547 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0057 | 0.0547 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0057 | 0.0547 | 0.0547 |
Echinococcus multilocularis | slit 2 protein | 0.0057 | 0.0547 | 0.0547 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0547 | 0.0547 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0057 | 0.0547 | 0.0547 |
Echinococcus multilocularis | fibropellin Ia | 0.0057 | 0.0547 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Echinococcus multilocularis | notch | 0.0057 | 0.0547 | 0.0547 |
Echinococcus multilocularis | neural cadherin | 0.0057 | 0.0547 | 0.0547 |
Onchocerca volvulus | Peroxidasin homolog | 0.0284 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0057 | 0.0547 | 0.0547 |
Onchocerca volvulus | Dual oxidase homolog | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0057 | 0.0547 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0547 | 0.0547 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0284 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0284 | 1 | 1 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | Blistered cuticle protein 3 | 0.0284 | 1 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0057 | 0.0547 | 0.0547 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | notch | 0.0057 | 0.0547 | 0.0547 |
Schistosoma mansoni | peroxidasin | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0284 | 1 | 1 |
Schistosoma mansoni | septate junction protein | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | EGF-like domain containing protein | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0057 | 0.0547 | 0.0547 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | STAT protein, DNA binding domain containing protein | 0.0191 | 0.6107 | 0.6107 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0057 | 0.0547 | 0.0547 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | EGF-like domain containing protein | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | Muscle positioning protein 4 | 0.0057 | 0.0547 | 0.0547 |
Brugia malayi | Cadherin domain containing protein | 0.0057 | 0.0547 | 0.0547 |
Giardia lamblia | High cysteine protein | 0.0057 | 0.0547 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0695 | 0.0157 |
Onchocerca volvulus | 0.0284 | 1 | 1 | |
Onchocerca volvulus | Peroxidase homolog | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0057 | 0.0547 | 0.0547 |
Onchocerca volvulus | 0.0284 | 1 | 1 | |
Echinococcus multilocularis | peroxidasin | 0.0284 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.35 um | PUBCHEM_BIOASSAY: Dose response cell-based assay to measure STAT3 inhibition. (Class of assay: confirmatory) [Related pubchem assays: 920, 1317, 1265, 1308, 862 ] | ChEMBL. | No reference |
IC50 (functional) | > 55.7 um | PUBCHEM_BIOASSAY: Dose response counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure STAT1 inhibition. (Class of assay: confirmatory) [Related pubchem assays: 920, 1317, 1265, 1308, 862 ] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5733 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.