Detailed information for compound 1384204

Basic information

Technical information
  • TDR Targets ID: 1384204
  • Name: ethyl 6-methyl-2-[[2-[(5-methyl-1,3,4-thiadia zol-2-yl)sulfanyl]acetyl]amino]-4,5,6,7-tetra hydro-1-benzothiophene-3-carboxylate
  • MW: 411.562 | Formula: C17H21N3O3S3
  • H donors: 1 H acceptors: 4 LogP: 4.96 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(NC(=O)CSc2nnc(s2)C)sc2c1CCC(C2)C
  • InChi: 1S/C17H21N3O3S3/c1-4-23-16(22)14-11-6-5-9(2)7-12(11)26-15(14)18-13(21)8-24-17-20-19-10(3)25-17/h9H,4-8H2,1-3H3,(H,18,21)
  • InChiKey: PLRIAWZANVGSRK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 6-methyl-2-[[2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylate
  • 6-methyl-2-[[2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-1-oxoethyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid ethyl ester
  • 6-methyl-2-[[2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]acetyl]amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid ethyl ester
  • ethyl 6-methyl-2-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanoylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
  • BAS 02052682
  • ChemDiv1_018508
  • 6-Methyl-2-[2-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanyl)-acetylamino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester
  • EU-0071751
  • MLS000527446
  • SMR000117920

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0699 0.5047
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.043 0.3006
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0044 0.0043
Trypanosoma brucei protein kinase, putative 0.0056 0.0699 0.5047
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0573 0.0571
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.043 0.3006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0322 0.0771
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.093 0.1326
Brugia malayi Pre-SET motif family protein 0.003 0.0304 0.0728
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0344 0.0822
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0552 0.055
Brugia malayi beta-lactamase family protein 0.0071 0.093 0.223
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0769 0.1085
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0344 0.0906
Loa Loa (eye worm) oxidoreductase 0.0013 0.0044 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4151 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0699 0.5047
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0103 0.0532
Trichomonas vaginalis esterase, putative 0.0071 0.093 0.2044
Echinococcus multilocularis geminin 0.0671 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0103 0.0532
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0103 0.0532
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.043 0.3006
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0304 0.1032
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0106 0.0278
Brugia malayi CXXC zinc finger family protein 0.0028 0.0278 0.0666
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0013 0.0044 0.0086
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0013 0.0044 0.0043
Chlamydia trachomatis pyruvate kinase 0.0032 0.0344 0.1148
Schistosoma mansoni nuclear hormone receptor 0.002 0.0151 0.0148
Brugia malayi MH2 domain containing protein 0.001 0.0003 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0552 0.055
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0699 0.0698
Brugia malayi beta-lactamase 0.0071 0.093 0.223
Loa Loa (eye worm) hypothetical protein 0.0071 0.093 0.2227
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0552 0.1324
Echinococcus multilocularis GPCR, family 2 0.0031 0.0322 0.032
Echinococcus granulosus pyruvate kinase 0.0032 0.0344 0.0343
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0769 0.0767
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4151 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0251 0.1653
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0103 0.0532
Echinococcus granulosus smad 0.001 0.0003 0.0001
Trypanosoma brucei unspecified product 0.0026 0.0251 0.1653
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.043 0.0577
Loa Loa (eye worm) hypothetical protein 0.0286 0.4173 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0044 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.093 0.6799
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0151 0.0148
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0344 0.1186
Schistosoma mansoni pyruvate kinase 0.0032 0.0344 0.0341
Plasmodium falciparum glutathione reductase 0.0047 0.0573 0.2055
Echinococcus multilocularis pyruvate kinase 0.0017 0.0106 0.0104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.043 0.3006
Schistosoma mansoni cpg binding protein 0.0028 0.0278 0.0275
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0151 0.0362
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0864 0.207
Brugia malayi Thioredoxin reductase 0.0047 0.0573 0.1372
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0044 0.0043
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0344 0.2359
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0044 0.0043
Entamoeba histolytica hypothetical protein 0.0036 0.0401 0.0868
Brugia malayi hypothetical protein 0.001 0.0011 0.0027
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1331 0.3189
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0103 0.0532
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0044 0.0043
Onchocerca volvulus 0.0071 0.093 0.2676
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0185 0.2658 1
Brugia malayi nuclear hormone receptor 0.002 0.0151 0.0362
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1353 0.3087
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1953 0.7315
Schistosoma mansoni hypothetical protein 0.0036 0.0401 0.0398
Echinococcus multilocularis cpg binding protein 0.003 0.0302 0.03
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0013 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0023
Echinococcus granulosus pyruvate kinase 0.0032 0.0344 0.0343
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.043 0.0428
Loa Loa (eye worm) glutathione reductase 0.0047 0.0573 0.1368
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0344 0.1148
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0003 0.0003
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0344 0.1186
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0421 0.0784
Schistosoma mansoni cpg binding protein 0.003 0.0302 0.0299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0151 0.0358
Trichomonas vaginalis hypothetical protein 0.0185 0.2658 0.6312
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4151 1
Loa Loa (eye worm) Smad1 0.001 0.0003 0.0003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2932 0.7025
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.043 0.103
Brugia malayi Smad1 0.001 0.0003 0.0007
Echinococcus granulosus pyruvate kinase 0.0017 0.0106 0.0104
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1353 0.3087
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.093 0.1326
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.83 0.8299
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0013 0.0044 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0251 0.1653
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.043 0.0428
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0769 0.2805
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0421 0.0916
Echinococcus granulosus FTZ F1 alpha 0.002 0.0151 0.0149
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0421 0.0563
Loa Loa (eye worm) hypothetical protein 0.0032 0.0344 0.0822
Brugia malayi MAP kinase sur-1 0.0056 0.0699 0.1675
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0151 0.0149
Brugia malayi hypothetical protein 0.0146 0.2068 0.4955
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0003 0.0001
Onchocerca volvulus 0.0071 0.093 0.2676
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.043 0.3006
Schistosoma mansoni hypothetical protein 0.0067 0.0864 0.0861
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0699 0.1472
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0075
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0103 0.0268
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0344 0.2359
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0151 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1353 0.3087
Schistosoma mansoni thyroid hormone receptor 0.002 0.0151 0.0148
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0103 0.0268
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.093 0.2227
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0044 0.0043
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0013 0.0044 0.0102
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.1675 0.244
Echinococcus multilocularis Smad4 0.001 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.0036 0.0401 0.0868
Loa Loa (eye worm) hypothetical protein 0.0031 0.0322 0.0767
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0103 0.0268
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0151 0.0149
Brugia malayi hypothetical protein 0.0286 0.4173 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0011 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1353 0.135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0103 0.0532
Plasmodium falciparum thioredoxin reductase 0.0047 0.0573 0.2055
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0358
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.6729 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0151 0.0148
Plasmodium vivax glutathione reductase, putative 0.0047 0.0573 0.2055
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0103 0.0532
Echinococcus multilocularis pyruvate kinase 0.0026 0.0241 0.024
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0358
Schistosoma mansoni kinase 0.0051 0.062 0.0617
Mycobacterium ulcerans hypothetical protein 0.0071 0.093 0.3419
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0151 0.0362
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0033 0.003
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0103 0.0226
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2035 0.4874
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.043 0.3006
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0003 0.0003
Leishmania major pyruvate kinase 0.0032 0.0344 0.2359
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0003 0.0001
Trypanosoma brucei oxidoreductase-like protein 0.0013 0.0044 0.0086
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.043 0.3006
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.043 0.3006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4151 1
Schistosoma mansoni hypothetical protein 0.0671 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0103 0.0532
Plasmodium falciparum thioredoxin reductase 0.0016 0.0103 0.0268
Leishmania major oxidoreductase-like protein 0.0013 0.0044 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0151 0.0149
Loa Loa (eye worm) retinol dehydrogenase 12 0.0013 0.0044 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4151 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0013 0.0044 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.06 0.1227
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0011 0.0008
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.043 0.3006
Leishmania major DNA polymerase kappa, putative 0.0038 0.043 0.3006
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.043 0.3006
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.06 0.1227
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.093 0.2044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0151 0.0362
Loa Loa (eye worm) hypothetical protein 0.0071 0.093 0.2227
Schistosoma mansoni hypothetical protein 0.0671 1 1
Echinococcus granulosus dna polymerase kappa 0.0038 0.043 0.0428
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.093 0.0928
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0151 0.0362
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0304 0.0301
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0421 0.0941
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0103 0.0268
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0151 0.0149
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0344 0.0596
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0013 0.0044 0.0043
Leishmania major hypothetical protein, conserved 0.0071 0.093 0.6799
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0013 0.0044 0.0043
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0304 0.0302
Plasmodium vivax SET domain protein, putative 0.003 0.0304 0.1032
Echinococcus multilocularis dna polymerase kappa 0.0038 0.043 0.0428
Brugia malayi hypothetical protein 0.0036 0.0401 0.096
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0103 0.0268
Schistosoma mansoni coup transcription factor 0.002 0.0151 0.0148
Toxoplasma gondii thioredoxin reductase 0.0047 0.0573 0.2055
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0401 0.0398
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0322 0.032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0151 0.0362
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0044 0.0043
Brugia malayi nuclear receptor NHR-88 0.002 0.0151 0.0362
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0699 0.0698
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0421 0.2937
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0344 0.2359
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0151 0.0362
Schistosoma mansoni hypothetical protein 0.0031 0.0322 0.0319
Giardia lamblia Pyruvate kinase 0.0032 0.0344 0.0756
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0699 0.0698
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.1492 0.2166
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0699 0.0696
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.043 0.3006
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0044 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0151 0.0362
Echinococcus granulosus cpg binding protein 0.003 0.0302 0.03
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.093 0.1326
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0011 0.0027
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0106 0.0278
Onchocerca volvulus 0.002 0.0151 0.0322
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0151 0.0148
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0.0044 0.0086
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0103 0.0171
Loa Loa (eye worm) hypothetical protein 0.0071 0.093 0.2227
Leishmania major trypanothione reductase 0.0047 0.0573 0.4087
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0699 0.2538
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0421 0.144
Echinococcus multilocularis pyruvate kinase 0.0017 0.0106 0.0104
Echinococcus granulosus pyruvate kinase 0.0017 0.0106 0.0104
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0322 0.032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0151 0.0362
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0251 0.1653
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.1353 0.3242
Brugia malayi glutathione reductase 0.0047 0.0573 0.1372
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.043 0.3006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.093 0.0929
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0013 0.0044 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0552 0.0551
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0769 0.5579
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1353 1
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.093 0.2044
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.4151 1
Toxoplasma gondii exonuclease III APE 0.0037 0.0421 0.1477
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0421 0.1008
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0044 0.0043
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0151 0.0149
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0278 0.0662
Echinococcus granulosus dna polymerase eta 0.0038 0.043 0.0428
Leishmania major DNA polymerase eta, putative 0.0038 0.043 0.3006
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0013 0.0044 0.0086
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.093 0.0928
Trypanosoma brucei pteridine reductase 1 0.0013 0.0044 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0103 0.0532
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0151 0.0149
Loa Loa (eye worm) hypothetical protein 0.0067 0.0864 0.2067
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0699 0.1472
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0044 0.0043
Brugia malayi ecdysteroid receptor 0.002 0.0151 0.0362
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0573 0.079
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0013 0.0044 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0304 0.0301
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.093 0.2044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0151 0.0358
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4151 1
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0013 0.0044 0.0043
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0003 0.0001
Schistosoma mansoni dihydropteridine reductase 0.0013 0.0044 0.0041
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.1675 0.6239
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0344 0.1186
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0151 0.0322
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0344 0.0906
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0103 0.0532
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0151 0.0149
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0421 0.0784
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0013 0.0044 0.0043
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0421 0.0419
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0278 0.0277
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0044 0.0043
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0151 0.0362
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0103 0.0268
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0699 0.5047
Trypanosoma brucei trypanothione reductase 0.0047 0.0573 0.4087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0151 0.0362
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0185 0.2658 1
Mycobacterium ulcerans lipase LipD 0.0071 0.093 0.3419
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0044 0.0043
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0106 0.0278
Plasmodium falciparum enoyl-acyl carrier reductase 0.0185 0.2658 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.093 0.2044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0322 0.032
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1353 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0304 0.0301
Onchocerca volvulus 0.0058 0.0735 0.2087
Brugia malayi steroid hormone receptor 0.002 0.0151 0.0362
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0358
Echinococcus multilocularis dna polymerase eta 0.0038 0.043 0.0428
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0196 0.037
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.1492 0.2166
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0151 0.0149
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0146 0.2068 0.4953
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0103 0.0532
Trichomonas vaginalis set domain proteins, putative 0.0232 0.3356 0.8036
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0151 0.0148
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0151 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1353 0.3087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0151 0.0362
Schistosoma mansoni ap endonuclease 0.0037 0.0421 0.0418
Echinococcus granulosus pyruvate kinase 0.0017 0.0106 0.0104
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0044 0.0043
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0322 0.0767
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.093 0.6799
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0103 0.0248
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0573 0.2055
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0103 0.0532
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0044 0.0043
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0013 0.0044 0.0043
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0044 0.0043
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.043 0.103
Echinococcus multilocularis pyruvate kinase 0.0032 0.0344 0.0343
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0103 0.0268
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0421 0.0784
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.043 0.3006
Entamoeba histolytica hypothetical protein 0.0036 0.0401 0.0868
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0044 0.0043
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0769 0.0766
Echinococcus multilocularis pyruvate kinase 0.0032 0.0344 0.0343
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.1492 0.554
Schistosoma mansoni hypothetical protein 0.0031 0.0322 0.0319
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0185 0.2658 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0344 0.0825
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0044 0.0043
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.043 0.0427
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.043 0.3006
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0103 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.043 0.3006
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0103 0.0226
Schistosoma mansoni cpg binding protein 0.003 0.0302 0.0299
Schistosoma mansoni pyruvate kinase 0.0017 0.0106 0.0103
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0358
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0344 0.0822
Schistosoma mansoni DNA polymerase eta 0.0038 0.043 0.0427
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0151 0.0148
Brugia malayi polk-prov protein 0.0012 0.0033 0.0079
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0421 0.1477
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0044 0.0043
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.1675 0.244
Trypanosoma brucei unspecified product 0.0026 0.0251 0.1653
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0044 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0151 0.0358
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.043 0.1511
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.093 0.2044
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0769 0.0768
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0151 0.0362
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.1353 1
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0699 0.1472
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0185 0.2658 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.1492 0.2166
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0151 0.0322
Schistosoma mansoni pyruvate kinase 0.0032 0.0344 0.0341
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0358
Brugia malayi MH1 domain containing protein 0.001 0.0003 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0151 0.0148
Schistosoma mansoni hypothetical protein 0.0031 0.0322 0.0319
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0103 0.0532
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.1353 0.1351
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4151 1
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0003 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0552 0.0551
Schistosoma mansoni thyroid hormone receptor 0.002 0.0151 0.0148
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1353 0.3087
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0151 0.0362
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.1353 0.1351
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0103 0.0268
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0421 0.2937
Mycobacterium tuberculosis Probable reductase 0.0108 0.1492 0.2166
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0151 0.0358
Plasmodium falciparum pyruvate kinase 0.0032 0.0344 0.1186
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0673 0.2437
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1331 0.3187
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0103 0.0532
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.043 0.0939
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0151 0.0149
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0304 0.0302
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.83 0.8299
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.093 0.0929
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0103 0.0226
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0421 0.0419
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0421 0.1005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0401 0.0399
Mycobacterium ulcerans oxidoreductase 0.0013 0.0044 0.0043
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0196 0.0466
Leishmania major pyruvate kinase 0.0032 0.0344 0.2359
Mycobacterium leprae Probable lipase LipE 0.0071 0.093 0.339
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0769 0.0767
Brugia malayi nuclear receptor RXR 0.001 0.0011 0.0027
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0185 0.2658 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0322 0.0771
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0151 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.043 0.3006
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0151 0.0148
Onchocerca volvulus 0.0232 0.3356 1
Schistosoma mansoni ap endonuclease 0.0037 0.0421 0.0418
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1331 0.3189
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1353 0.3087
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.093 0.223
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0344 0.0596
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0573 0.4087
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0421 0.1477
Onchocerca volvulus 0.0071 0.093 0.2676
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0151 0.0362
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0573 0.1368
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0044 0.0043
Mycobacterium ulcerans beta-lactamase 0.0071 0.093 0.3419
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0735 0.1762
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0421 0.1477
Giardia lamblia DINP protein human, muc B family 0.0038 0.043 0.0963
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0106
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0.0044 0.0086
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0103 0.0268
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0011 0.0008
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0699 0.5047
Onchocerca volvulus 0.003 0.0304 0.0784
Giardia lamblia Kinase, PLK 0.0099 0.1353 0.3205
Echinococcus granulosus GPCR family 2 0.0031 0.0322 0.032
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.4151 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.1353 0.3952
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0185 0.2658 1
Brugia malayi MH1 domain containing protein 0.001 0.0003 0.0007
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0344 0.0906
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0699 0.1618
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0151 0.0358
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.043 0.1511
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.1492 0.2166
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0044 0.0043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0151 0.0149
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0344 0.2359
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0151 0.0148
Schistosoma mansoni survival motor neuron protein 0.0058 0.0735 0.0733
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0358
Loa Loa (eye worm) hypothetical protein 0.0038 0.043 0.1026
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0011 0.0023
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.4173 0.4172
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.043 0.0807
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0151 0.0358
Giardia lamblia Pyruvate kinase 0.0017 0.0106 0.0177
Plasmodium vivax hypothetical protein, conserved 0.0071 0.093 0.3419
Mycobacterium tuberculosis Conserved protein 0.0071 0.093 0.1326
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0103 0.0102
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0401 0.0399
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0103 0.0102
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0769 0.2805
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0769 0.2805
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.093 0.3419
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.093 0.1326
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0103 0.01
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0151 0.0149
Brugia malayi beta-lactamase family protein 0.0071 0.093 0.223
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0044 0.0043
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0103 0.0532
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.4173 0.4172
Schistosoma mansoni hypothetical protein 0.0399 0.5884 0.5883
Loa Loa (eye worm) hypothetical protein 0.0071 0.093 0.2227
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.1353 0.3187
Onchocerca volvulus 0.0028 0.0278 0.0705
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.1492 0.2166
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0044 0.0043
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.093 0.1326
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0304 0.0301
Echinococcus granulosus neuropeptide s receptor 0.0558 0.83 0.8299
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0013 0.0044 0.0041
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0573 0.0571
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.043 0.0807
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0699 0.5047
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.043 0.0577
Toxoplasma gondii ABC1 family protein 0.0071 0.093 0.3419
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0344 0.0822
Plasmodium falciparum glutathione reductase 0.0016 0.0103 0.0268
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2035 0.4874
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0011 0.0009
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0699 0.0698
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0466
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.043 0.3006
Brugia malayi Pre-SET motif family protein 0.0203 0.2932 0.7026
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.093 0.3419
Echinococcus granulosus Smad4 0.001 0.0003 0.0001
Echinococcus multilocularis pyruvate kinase 0.0017 0.0106 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.043 0.3006
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0151 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0151 0.0362
Loa Loa (eye worm) beta-lactamase 0.0071 0.093 0.2227
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0013 0.0044 0.0086
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.093 0.1326
Trypanosoma brucei unspecified product 0.0038 0.043 0.3006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.043 0.3006
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.5884 0.5884
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.4151 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0151 0.0149
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.4151 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0044 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1353 0.3087
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0013 0.0044 0.0043
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0769 0.0768
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0151 0.0362
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0037 0.0089
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0699 0.5047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0421 0.2937
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0151 0.0149
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.093 0.6799
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0699 0.1472
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0011 0.0009
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.1675 0.244
Loa Loa (eye worm) hypothetical protein 0.0071 0.093 0.2227
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0106
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0185 0.2658 0.391
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4151 1
Leishmania major pteridine reductase 1 0.0013 0.0044 0.0086
Echinococcus multilocularis smad 0.001 0.0003 0.0001
Mycobacterium tuberculosis Conserved protein 0.0071 0.093 0.1326
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0013 0.0044 0.0043
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0304 0.0302
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.093 0.1326
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0421 0.2937
Brugia malayi MH2 domain containing protein 0.0144 0.2035 0.4876
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0044 0.0043
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.043 0.1026
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.043 0.0427
Mycobacterium leprae conserved hypothetical protein 0.0071 0.093 0.339
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0003 0.0007
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1953 0.7303
Loa Loa (eye worm) hypothetical protein 0.0098 0.1331 0.3187
Onchocerca volvulus 0.0146 0.2068 0.6111
Mycobacterium tuberculosis Conserved protein 0.0071 0.093 0.1326
Loa Loa (eye worm) hypothetical protein 0.0071 0.093 0.2227
Loa Loa (eye worm) hypothetical protein 0.003 0.0304 0.0724
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0358
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0151 0.0148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0552 0.0551
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0769 0.2805
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0151 0.0149
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0151 0.0149
Entamoeba histolytica hypothetical protein 0.0036 0.0401 0.0868
Trypanosoma brucei polo-like protein kinase 0.0099 0.1353 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0699 0.5047
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.83 0.8299
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.043 0.3006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0552 0.132
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0103 0.0532
Schistosoma mansoni hypothetical protein 0.0031 0.0322 0.0319
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0344 0.0825
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0103 0.0532
Brugia malayi MH2 domain containing protein 0.001 0.0003 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0552 0.055
Schistosoma mansoni hypothetical protein 0.0058 0.0735 0.0733
Echinococcus granulosus dnaJ subfamily B 0.0399 0.5884 0.5884
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0023
Brugia malayi hypothetical protein 0.001 0.0011 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0151 0.0358
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0037 0.0089
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1953 0.2856
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0552 0.0551
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0344 0.0449
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0699 0.1672
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.1353 0.3239

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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