Detailed information for compound 138450

Basic information

Technical information
  • TDR Targets ID: 138450
  • Name: 1-[4-(8-chloro-5,11-dihydro-[1]benzothiepino[ 4,3-b]pyridin-11-yl)piperazin-1-yl]-2-piperid in-4-ylethanone
  • MW: 457.031 | Formula: C24H29ClN4OS
  • H donors: 1 H acceptors: 2 LogP: 2.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)SCc1c(C2N2CCN(CC2)C(=O)CC2CCNCC2)nccc1
  • InChi: 1S/C24H29ClN4OS/c25-19-3-4-20-21(15-19)31-16-18-2-1-7-27-23(18)24(20)29-12-10-28(11-13-29)22(30)14-17-5-8-26-9-6-17/h1-4,7,15,17,24,26H,5-6,8-14,16H2
  • InChiKey: URIAEERZIAFNMX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[4-(8-chloro-5,11-dihydro-[1]benzothiepino[4,3-b]pyridin-11-yl)piperazin-1-yl]-2-(4-piperidyl)ethanone
  • 1-[4-(8-chloro-5,11-dihydro-[1]benzothiepino[4,3-b]pyridin-11-yl)-1-piperazinyl]-2-(4-piperidinyl)ethanone
  • 1-[4-(8-chloro-5,11-dihydro-[1]benzothiepino[4,3-b]pyridin-11-yl)piperazin-1-yl]-2-piperidin-4-yl-ethanone
  • 1-[4-(8-chloro-5,11-dihydro-[1]benzothiepino[4,3-b]pyridin-11-yl)piperazino]-2-(4-piperidyl)ethanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens farnesyltransferase, CAAX box, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium knowlesi protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Neospora caninum hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium falciparum protein farnesyltransferase subunit alpha Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium vivax prenyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Babesia bovis protein prenyltransferase alpha subunit repeat domain containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma mansoni protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium hominis farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Schistosoma japonicum ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Theileria parva hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Echinococcus granulosus protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium berghei protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Giardia lamblia Rab geranylgeranyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium parvum farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0172 0.0237
Trypanosoma brucei hypothetical protein, conserved 0.0177 0.1444 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0253 0.1556
Schistosoma mansoni lipoxygenase 0.0114 0.0882 0.1213
Echinococcus granulosus orexin receptor type 2 0.0034 0.0161 0.0222
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.0161 0.0222
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.0161 0.0222
Toxoplasma gondii ABC1 family protein 0.0177 0.1444 0.979
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0274 0.2312 0.318
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0561 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0128 0.0227
Brugia malayi RNA, U transporter 1 0.0171 0.1391 0.2461
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0148 0.0204
Echinococcus granulosus g protein coupled receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.018 0.0248
Echinococcus multilocularis importin subunit beta 1 0.006 0.0396 0.0545
Brugia malayi ecdysteroid receptor 0.0334 0.2851 0.5043
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.055 0.3773
Echinococcus multilocularis cpg binding protein 0.0063 0.0424 0.0583
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0368 0.2505
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0396 0.2702
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0305 0.2067
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0128 0.0177
Schistosoma mansoni opsin-like receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.005 0.0305 0.188
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0391 0.0538
Echinococcus granulosus 7TM GPCR rhodopsin 0.0034 0.0161 0.0222
Echinococcus granulosus chromobox protein 1 0.0071 0.0496 0.0683
Echinococcus multilocularis geminin 0.017 0.1383 0.1903
Echinococcus multilocularis dnaJ subfamily B 0.0826 0.727 1
Plasmodium vivax flap endonuclease 1, putative 0.0051 0.0314 0.1936
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0128 0.0227
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0391 0.0806
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0855 0.5621
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0318 0.0438
Brugia malayi nuclear hormone receptor 0.003 0.0128 0.0227
Onchocerca volvulus 0.005 0.0309 0.0437
Loa Loa (eye worm) hypothetical protein 0.003 0.0128 0.0227
Schistosoma mansoni inositol monophosphatase 0.0077 0.055 0.0756
Leishmania major trypanothione reductase 0.0049 0.0294 0.1951
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0049
Brugia malayi TAR-binding protein 0.0061 0.0407 0.072
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0084 0.0533
Echinococcus granulosus G protein coupled receptor 139 0.0034 0.0161 0.0222
Echinococcus granulosus serotonin receptor 0.0034 0.0161 0.0222
Entamoeba histolytica Flap nuclease, putative 0.0051 0.0314 0.0999
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0274 0.2312 0.4089
Echinococcus multilocularis G protein coupled receptor 139 0.0034 0.0161 0.0222
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0084 0.0533
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0143 0.1138 0.1753
Echinococcus multilocularis musashi 0.0027 0.01 0.0138
Onchocerca volvulus 0.0177 0.1444 0.2205
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0034 0.0161 0.0285
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0128 0.0227
Echinococcus granulosus dro:myosuppressin receptor 0.0034 0.0161 0.0222
Onchocerca volvulus 0.0034 0.0161 0.0208
Loa Loa (eye worm) hypothetical protein 0.0079 0.0561 0.0993
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0128 0.0177
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0161 0.0222
Brugia malayi intermediate filament protein 0.0027 0.01 0.0178
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0034 0.0161 0.0222
Mycobacterium ulcerans lipase LipD 0.0177 0.1444 0.3022
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.011 0.0159
Loa Loa (eye worm) hypothetical protein 0.0193 0.1586 0.2806
Onchocerca volvulus 0.0735 0.6452 1
Mycobacterium ulcerans beta-lactamase 0.0177 0.1444 0.3022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0079 0.011
Echinococcus multilocularis lamin dm0 0.0027 0.01 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.011 0.0159
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.055 0.3773
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.055 0.3694
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0642 0.5618 0.9939
Loa Loa (eye worm) hypothetical protein 0.003 0.0128 0.0227
Schistosoma mansoni hypothetical protein 0.0019 0.0028 0.0038
Schistosoma mansoni hypothetical protein 0.0031 0.0136 0.0187
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0646 0.5653 1
Onchocerca volvulus 0.0034 0.0161 0.0208
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0084 0.0485
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0561 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0128 0.0227
Onchocerca volvulus 0.0177 0.1444 0.2205
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Brugia malayi MH2 domain containing protein 0.0477 0.4139 0.7323
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.0161 0.0222
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0655 0.0902
Echinococcus granulosus protein prenyltransferase alpha subunit 0.005 0.0305 0.0419
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni hypothetical protein 0.0826 0.727 1
Brugia malayi Bromodomain containing protein 0.0079 0.0562 0.0994
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.0161 0.0285
Schistosoma mansoni lamin 0.0027 0.01 0.0138
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0561 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.1444 0.2555
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0034 0.0161 0.0285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.055 0.3773
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0318 0.0438
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0034 0.0161 0.0222
Brugia malayi MH1 domain containing protein 0.0018 0.0018 0.0031
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0028 0.0038
Mycobacterium ulcerans hypothetical protein 0.0177 0.1444 0.3022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.018 0.1475 1
Schistosoma mansoni ap endonuclease 0.0057 0.0368 0.0506
Loa Loa (eye worm) hypothetical protein 0.0177 0.1444 0.2555
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0016 0.0022
Brugia malayi steroid hormone receptor 0.003 0.0128 0.0227
Onchocerca volvulus Huntingtin homolog 0.0122 0.0948 0.1433
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0034 0.0161 0.0222
Brugia malayi SET domain containing protein 0.0016 0.0003 0.0005
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0439 0.0604
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0034 0.0161 0.0285
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0084 0.0485
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0034 0.0161 0.0222
Schistosoma mansoni biogenic amine receptor 0.0034 0.0161 0.0222
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0396 0.2702
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0034 0.0161 0.0222
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.005 0.0305 0.2067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0966 0.0959
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0161 0.0222
Brugia malayi Serotonin receptor 0.0034 0.0161 0.0285
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.005 0.0305 0.188
Schistosoma mansoni ran 0.0044 0.0253 0.0349
Loa Loa (eye worm) RNA binding protein 0.0061 0.0407 0.072
Brugia malayi G-protein coupled receptor 0.0034 0.0161 0.0285
Brugia malayi beta-lactamase family protein 0.0177 0.1444 0.2555
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.005 0.0305 0.0419
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0439 0.0777
Echinococcus granulosus intermediate filament protein 0.0027 0.01 0.0138
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0242 0.0334
Giardia lamblia Rab geranylgeranyltransferase 0.0193 0.1586 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0079 0.011
Schistosoma mansoni aldehyde dehydrogenase 0.018 0.1475 0.2029
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0177 0.1444 0.1986
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0368 0.1382
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0136 0.0241
Onchocerca volvulus 0.0058 0.0377 0.0543
Echinococcus granulosus RUN 0.0019 0.0028 0.0038
Schistosoma mansoni thyroid hormone receptor 0.003 0.0128 0.0177
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0177 0.1444 0.1437
Schistosoma mansoni chromobox protein 0.0071 0.0496 0.0683
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0177 0.1444 0.1437
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0741 0.1311
Echinococcus multilocularis serotonin receptor 0.0034 0.0161 0.0222
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0424 0.0583
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0128 0.0177
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0051 0.0314 0.2083
Leishmania major hypothetical protein, conserved 0.0177 0.1444 0.979
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0161 0.0222
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0034 0.0161 0.0285
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.0161 0.0222
Leishmania major protein farnesyltransferase alpha subunit, putative 0.005 0.0305 0.2023
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1475 0.3087
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0368 0.6505
Brugia malayi beta-lactamase 0.0177 0.1444 0.2555
Brugia malayi hypothetical protein 0.0034 0.0161 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0215 0.0321
Schistosoma mansoni smad1 5 8 and 0.0033 0.0148 0.0204
Mycobacterium leprae conserved hypothetical protein 0.0177 0.1444 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0034 0.0161 0.0222
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0368 0.0757
Loa Loa (eye worm) hypothetical protein 0.0067 0.0461 0.0816
Schistosoma mansoni polycystin 1-related 0.0019 0.0028 0.0038
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.0161 0.0222
Brugia malayi G-protein coupled receptor 0.0034 0.0161 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.0851 0.1171
Onchocerca volvulus 0.0034 0.0161 0.0208
Schistosoma mansoni hypothetical protein 0.0642 0.5618 0.7728
Trichomonas vaginalis penicillin-binding protein, putative 0.0177 0.1444 0.2228
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0034 0.0161 0.0285
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0242 0.0364
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0561 0.3435
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0318 0.1629
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0193 0.1586 0.2449
Onchocerca volvulus 0.0105 0.0802 0.1205
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0069 0.0477 0.047
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0161 0.0222
Schistosoma mansoni microtubule-associated protein tau 0.0711 0.6232 0.8572
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Toxoplasma gondii hypothetical protein 0.0027 0.0099 0.0621
Brugia malayi hypothetical protein 0.0034 0.0161 0.0285
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0368 0.0651
Brugia malayi beta-lactamase family protein 0.0177 0.1444 0.2555
Brugia malayi Tachykinin-like peptides receptor 99D 0.0034 0.0161 0.0285
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.055 0.0841
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Schistosoma mansoni hypothetical protein 0.0067 0.0461 0.0634
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0079 0.011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0172 0.0237
Brugia malayi hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0034 0.0161 0.0222
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0697 0.0959
Plasmodium falciparum thioredoxin reductase 0.0049 0.0294 0.1813
Loa Loa (eye worm) nuclear factor I 0.0018 0.0018 0.0031
Loa Loa (eye worm) hypothetical protein 0.0177 0.1444 0.2555
Brugia malayi G protein-coupled receptor 0.0034 0.0161 0.0285
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0461 0.0816
Onchocerca volvulus 0.0034 0.0161 0.0208
Brugia malayi CXXC zinc finger family protein 0.0058 0.0377 0.0667
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0193 0.1586 0.2182
Echinococcus granulosus geminin 0.017 0.1383 0.1903
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.0149
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0439 0.3004
Brugia malayi Dopamine receptor protein 2 0.0034 0.0161 0.0285
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0079 0.011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0243
Loa Loa (eye worm) Smad1 0.0033 0.0148 0.0262
Loa Loa (eye worm) hypothetical protein 0.0334 0.2851 0.5043
Onchocerca volvulus 0.0031 0.0137 0.0171
Leishmania major importin beta-1 subunit, putative 0.0049 0.0294 0.1949
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0161 0.0222
Schistosoma mansoni aldehyde dehydrogenase 0.018 0.1475 0.2029
Schistosoma mansoni bromodomain containing protein 0.0067 0.0456 0.0628
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.0161 0.0222
Schistosoma mansoni rab6-interacting 0.0019 0.0028 0.0038
Schistosoma mansoni smad1 5 8 and 0.0033 0.0148 0.0204
Echinococcus multilocularis neuropeptide receptor 0.0034 0.0161 0.0222
Onchocerca volvulus 0.0027 0.01 0.0113
Loa Loa (eye worm) hypothetical protein 0.004 0.0215 0.038
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0391 0.0806
Schistosoma mansoni hypothetical protein 0.017 0.1383 0.1903
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0128 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0105 0.0802 0.1103
Schistosoma mansoni chromobox protein 0.0071 0.0496 0.0683
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0034 0.0161 0.0222
Onchocerca volvulus 0.0034 0.0161 0.0208
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0128 0.0177
Entamoeba histolytica hypothetical protein 0.0049 0.0294 0.086
Echinococcus multilocularis flap endonuclease 1 0.0051 0.0314 0.0431
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Mycobacterium tuberculosis Probable esterase LipL 0.0177 0.1444 0.1437
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0161 0.0222
Mycobacterium tuberculosis Probable lipase LipD 0.0177 0.1444 0.1437
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0294 0.0444
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0263 0.2211 0.3912
Schistosoma mansoni ran 0.0044 0.0253 0.0349
Echinococcus multilocularis somatostatin receptor 0.0034 0.0161 0.0222
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0294 0.1813
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0309 0.0546
Brugia malayi Bromodomain containing protein 0.0038 0.0201 0.0356
Onchocerca volvulus 0.0027 0.01 0.0113
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0294 0.052
Schistosoma mansoni hypothetical protein 0.017 0.1383 0.1903
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.001 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0161 0.0222
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0128 0.0177
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0034 0.0161 0.0222
Echinococcus granulosus neuropeptide receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni lamin 0.0027 0.01 0.0138
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.005 0.0305 0.0419
Loa Loa (eye worm) hypothetical protein 0.0027 0.0096 0.017
Trichomonas vaginalis inositol monophosphatase, putative 0.0077 0.055 0.0841
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.2074 0.2852
Schistosoma mansoni cpg binding protein 0.0063 0.0424 0.0583
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0161 0.0222
Brugia malayi sulfakinin receptor protein 0.0034 0.0161 0.0285
Schistosoma mansoni myosin xvIII 0.0034 0.0161 0.0222
Entamoeba histolytica Ran family GTPase 0.0044 0.0253 0.0574
Schistosoma mansoni cpg binding protein 0.0058 0.0377 0.0518
Brugia malayi hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0128 0.0177
Plasmodium falciparum importin beta, putative 0.006 0.0396 0.2458
Loa Loa (eye worm) melatonin receptor type 1A 0.0034 0.0161 0.0285
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.0161 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0177 0.1444 1
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0396 0.2645
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0028 0.0125
Echinococcus granulosus somatostatin receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.005 0.0305 0.0539
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0128 0.0177
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0136 0.0241
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0294 0.0405
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0128 0.0177
Echinococcus multilocularis zinc finger protein 0.0023 0.0062 0.0086
Echinococcus multilocularis Smad4 0.0033 0.0148 0.0204
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0407 0.056
Schistosoma mansoni hypothetical protein 0.005 0.0309 0.0424
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0008 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0177 0.1444 0.1437
Plasmodium vivax SET domain protein, putative 0.0094 0.0697 0.4368
Brugia malayi hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni importin beta-1 0.006 0.0396 0.0545
Loa Loa (eye worm) hypothetical protein 0.0177 0.1444 0.2555
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.0161 0.0222
Schistosoma mansoni hypothetical protein 0.0034 0.0161 0.0222
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.0161 0.0222
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0048 0.0066
Brugia malayi MH2 domain containing protein 0.0033 0.0148 0.0262
Trichomonas vaginalis glutaminase, putative 0.0547 0.4759 0.7374
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0561 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0128 0.0157
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) hypothetical protein 0.0247 0.2074 0.3668
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Brugia malayi hypothetical protein 0.0034 0.0161 0.0285
Loa Loa (eye worm) hypothetical protein 0.0111 0.0851 0.1506
Onchocerca volvulus 0.0034 0.0161 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0128 0.0227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0008 0.0011
Plasmodium vivax glutathione reductase, putative 0.0049 0.0294 0.1813
Brugia malayi Heterochromatin protein 1 0.0071 0.0496 0.0878
Brugia malayi glutaminase DH11.1 0.0547 0.4759 0.842
Brugia malayi putative neuropeptide receptor 0.0034 0.0161 0.0285
Echinococcus multilocularis snurportin 1 0.0642 0.5618 0.7728
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0128 0.0157
Toxoplasma gondii exonuclease III APE 0.0057 0.0368 0.2453
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0077 0.055 0.9798
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0016 0.0022
Loa Loa (eye worm) flap endonuclease-1 0.0051 0.0314 0.0555
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0128 0.0177
Schistosoma mansoni Smad4 0.0033 0.0148 0.0204
Echinococcus multilocularis neuropeptide s receptor 0.0034 0.0161 0.0222
Onchocerca volvulus 0.0034 0.0161 0.0208
Echinococcus multilocularis chromobox protein 1 0.0071 0.0496 0.0683
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Brugia malayi Pre-SET motif family protein 0.0646 0.5653 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.0161 0.0222
Echinococcus multilocularis lamin 0.0027 0.01 0.0138
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0194 0.0266
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0089 0.0123
Loa Loa (eye worm) hypothetical protein 0.003 0.0128 0.0227
Mycobacterium leprae Probable lipase LipE 0.0177 0.1444 1
Leishmania major GTP-binding protein, putative 0.0044 0.0253 0.1674
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0028 0.0049
Schistosoma mansoni neuropeptide receptor 0.0034 0.0161 0.0222
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0561 0.377
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0193 0.1586 1
Echinococcus granulosus lamin dm0 0.0027 0.01 0.0138
Loa Loa (eye worm) hypothetical protein 0.0177 0.1444 0.2555
Echinococcus multilocularis fmrfamide receptor 0.0034 0.0161 0.0222
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0318 0.031
Echinococcus multilocularis G-protein coupled receptor, putative 0.0034 0.0161 0.0222
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0034 0.0161 0.0285
Brugia malayi hypothetical protein 0.0122 0.0948 0.1677
Echinococcus multilocularis beta LACTamase domain containing family member 0.0177 0.1444 0.1986
Echinococcus granulosus FTZ F1 alpha 0.003 0.0128 0.0177
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0034 0.0161 0.0222
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0148 0.0204
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0368 0.2505
Loa Loa (eye worm) hypothetical protein 0.0177 0.1444 0.2555
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0128 0.0227
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0439 0.1888
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.0161 0.0222
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0439 0.0777
Echinococcus granulosus beta LACTamase domain containing family member 0.0177 0.1444 0.1986
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0161 0.0222
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0966 0.0959
Echinococcus granulosus neuropeptide FF receptor 2 0.0034 0.0161 0.0222
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0294 0.0405
Echinococcus granulosus allatostatin A receptor 0.0034 0.0161 0.0222
Mycobacterium tuberculosis Conserved protein 0.0177 0.1444 0.1437
Loa Loa (eye worm) glutaminase 0.0547 0.4759 0.842
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0253 0.0349
Brugia malayi hypothetical protein 0.0019 0.0028 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0161 0.0222
Echinococcus granulosus peptide allatostatin:somatostatin 0.0034 0.0161 0.0222
Schistosoma mansoni loxhd1 0.0019 0.0028 0.0038
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0028 0.0125
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0193 0.1586 0.2182
Mycobacterium tuberculosis Conserved protein 0.0177 0.1444 0.1437
Loa Loa (eye worm) hypothetical protein 0.0041 0.0223 0.0395
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0069 0.0477 0.2811
Mycobacterium tuberculosis Probable hydrolase 0.0177 0.1444 0.1437
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus granulosus dnaJ subfamily B 0.0826 0.727 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0128 0.0227
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0034 0.0161 0.0285
Schistosoma mansoni amine GPCR 0.0034 0.0161 0.0222
Echinococcus granulosus hypothetical protein 0.0034 0.0161 0.0222
Echinococcus multilocularis neuropeptide receptor A26 0.0034 0.0161 0.0222
Trichomonas vaginalis ran, putative 0.0044 0.0253 0.0381
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0034 0.0161 0.0285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0051 0.0314 0.2128
Mycobacterium tuberculosis Conserved protein 0.0177 0.1444 0.1437
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0089 0.0123
Echinococcus granulosus chromobox protein 1 0.0071 0.0496 0.0683
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0084 0.0533
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) MH2 domain-containing protein 0.0477 0.4139 0.7323
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0136 0.0187
Toxoplasma gondii hypothetical protein 0.0143 0.1138 0.7702
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0136 0.0187
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.005 0.0305 0.0419
Brugia malayi Doublecortin family protein 0.0019 0.0028 0.0049
Brugia malayi hypothetical protein 0.0025 0.0084 0.0149
Brugia malayi neuropeptide F receptor 0.0034 0.0161 0.0285
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0034 0.0161 0.0222
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0128 0.0177
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus multilocularis smad 0.0033 0.0148 0.0204
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0079 0.011
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni zinc finger protein 0.0023 0.0062 0.0086
Echinococcus granulosus tar DNA binding protein 0.0061 0.0407 0.056
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0128 0.0177
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni biogenic amine receptor 0.0034 0.0161 0.0222
Echinococcus granulosus 7tm_1 domain containing protein 0.0034 0.0161 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0128 0.0227
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0016 0.0022
Toxoplasma gondii thioredoxin reductase 0.0049 0.0294 0.1951
Echinococcus granulosus neuropeptide receptor 0.0034 0.0161 0.0222
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0128 0.0177
Schistosoma mansoni thyroid hormone receptor 0.003 0.0128 0.0177
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0148 0.0204
Trichomonas vaginalis flap endonuclease-1, putative 0.0051 0.0314 0.0474
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1475 0.3087
Brugia malayi CHD4 protein 0.0017 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni hypothetical protein 0.0034 0.0161 0.0222
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0128 0.0227
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0561 0.1164
Brugia malayi Dopamine receptor 0.0034 0.0161 0.0285
Plasmodium falciparum flap endonuclease 1 0.0051 0.0314 0.1936
Onchocerca volvulus 0.0034 0.0161 0.0208
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0089 0.0123
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0028 0.0038
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0034 0.0161 0.0208
Loa Loa (eye worm) hypothetical protein 0.006 0.0396 0.0701
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0128 0.0227
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0128 0.0227
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.055 0.0841
Onchocerca volvulus 0.0034 0.0161 0.0208
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0161 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0305 0.2067
Brugia malayi ORL1-like opioid receptor 0.0034 0.0161 0.0285
Schistosoma mansoni glutaminase 0.0547 0.4759 0.6547
Schistosoma mansoni hypothetical protein 0.0031 0.0136 0.0187
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0253 0.1556
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0128 0.0227
Brugia malayi Importin beta-1 subunit 0.006 0.0396 0.0701
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0099 0.1647
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.0161 0.0222
Onchocerca volvulus 0.0034 0.0161 0.0208
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0049
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0015 0.0027
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus multilocularis neuropeptide FF receptor 2 0.0034 0.0161 0.0222
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0882 0.1213
Trichomonas vaginalis D-aminoacylase, putative 0.0177 0.1444 0.2228
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0368 0.228
Echinococcus granulosus lamin 0.0027 0.01 0.0138
Onchocerca volvulus 0.003 0.0128 0.0157
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0439 0.3004
Brugia malayi AKH receptor 0.0034 0.0161 0.0285
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0148 0.0204
Mycobacterium ulcerans glutaminase 0.0547 0.4759 1
Echinococcus granulosus inositol monophosphatase 1 0.0077 0.055 0.0756
Brugia malayi hypothetical protein 0.0034 0.0161 0.0285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Onchocerca volvulus 0.0034 0.0161 0.0208
Schistosoma mansoni opsin-like receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0894 0.6042
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0034 0.0161 0.0222
Echinococcus granulosus fmrfamide receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) hypothetical protein 0.003 0.0128 0.0227
Echinococcus multilocularis fmrfamide receptor 0.0034 0.0161 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0128 0.0227
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.01 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0128 0.0227
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0741 0.1311
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0377 0.0667
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0355 0.0628
Onchocerca volvulus 0.0034 0.0161 0.0208
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.0161 0.0222
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0128 0.0177
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.005 0.0305 0.0419
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0177 0.1444 0.2555
Trichomonas vaginalis esterase, putative 0.0177 0.1444 0.2228
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0128 0.0177
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0496 0.0758
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0042 0.0075
Echinococcus granulosus cpg binding protein 0.0063 0.0424 0.0583
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0855 0.0848
Onchocerca volvulus 0.005 0.0305 0.0431
Brugia malayi hypothetical protein 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.005 0.0305 0.0936
Brugia malayi larval opioid receptor 0.0034 0.0161 0.0285
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0274 0.2312 0.318
Brugia malayi Serotonin receptor 0.0034 0.0161 0.0285
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0496 0.0878
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0128 0.0227
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0424 0.0583
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0034 0.0161 0.0222
Brugia malayi PHD-finger family protein 0.0028 0.011 0.0195
Loa Loa (eye worm) hypothetical protein 0.0122 0.0948 0.1677
Brugia malayi Probable ClpP-like protease 0.0079 0.0561 0.0993
Trichomonas vaginalis D-aminoacylase, putative 0.0177 0.1444 0.2228
Loa Loa (eye worm) hypothetical protein 0.003 0.0128 0.0227
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0253 0.0448
Echinococcus multilocularis orexin receptor type 2 0.0034 0.0161 0.0222
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0128 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Schistosoma mansoni inositol monophosphatase 0.0077 0.055 0.0756
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0561 0.1164
Loa Loa (eye worm) inositol-1 0.0077 0.055 0.0973
Loa Loa (eye worm) hypothetical protein 0.0122 0.0948 0.1677
Schistosoma mansoni hypothetical protein 0.0034 0.0161 0.0222
Echinococcus granulosus Smad4 0.0033 0.0148 0.0204
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.0991 0.1363
Loa Loa (eye worm) glutathione reductase 0.0049 0.0294 0.052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0274 0.2312 0.318
Giardia lamblia Flap structure-specific endonuclease 0.0051 0.0314 0.1936
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0128 0.0177
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0368 0.2453
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0368 0.0558
Brugia malayi Thioredoxin reductase 0.0049 0.0294 0.052
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0294 0.0286
Loa Loa (eye worm) beta-lactamase 0.0177 0.1444 0.2555
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0177 0.1444 0.1986
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0407 0.072
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0274 0.2312 0.4089
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0966 0.0959
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0274 0.2312 0.318
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.0161 0.0222
Brugia malayi hypothetical protein 0.0034 0.0161 0.0285
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0148 0.0262
Onchocerca volvulus 0.0034 0.0161 0.0208
Echinococcus granulosus GPCR family 2 0.0031 0.0136 0.0187
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0193 0.1586 0.2449
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0368 0.0558
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0128 0.0227
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0128 0.0177
Brugia malayi hypothetical protein 0.0035 0.0172 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0274 0.2312 0.318
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0161 0.0222
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0215 0.0291
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.7018 0.9654
Brugia malayi putative neuropeptide receptor NPR1 0.0034 0.0161 0.0285
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0128 0.0177
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.0161 0.0285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0161 0.0222
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0016 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0128 0.0227
Plasmodium vivax importin-beta 2, putative 0.006 0.0396 0.2458
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.005 0.0305 0.2067
Echinococcus granulosus smad 0.0033 0.0148 0.0204
Echinococcus multilocularis neuropeptide receptor 0.0034 0.0161 0.0222
Trichomonas vaginalis D-aminoacylase, putative 0.0177 0.1444 0.2228
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0274 0.2312 0.318
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0253 0.171
Echinococcus granulosus histone lysine methyltransferase setb 0.0111 0.0851 0.1171
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0391 0.0538
Brugia malayi hypothetical protein 0.0247 0.2074 0.3668
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Onchocerca volvulus 0.0034 0.0161 0.0208
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0128 0.0177
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0561 0.0772
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0028 0.0038
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0391 0.2612
Schistosoma mansoni smad1 5 8 and 0.0033 0.0148 0.0204
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0194 0.0266
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0561 0.377
Brugia malayi MH2 domain containing protein 0.0033 0.0148 0.0262
Echinococcus multilocularis dro:myosuppressin receptor 0.0034 0.0161 0.0222
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0161 0.0222
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0128 0.0177
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0855 0.0848
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0561 0.0772
Echinococcus granulosus g protein coupled receptor 0.0034 0.0161 0.0222
Echinococcus multilocularis allatostatin A receptor 0.0034 0.0161 0.0222
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0172 0.0237
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0561 0.0772
Schistosoma mansoni biogenic amine receptor 0.0034 0.0161 0.0222
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0148 0.0204
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0079 0.011
Brugia malayi MH1 domain containing protein 0.0033 0.0148 0.0262
Echinococcus granulosus alpha 1A adrenergic receptor 0.0034 0.0161 0.0222
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0077 0.055 0.3694
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0128 0.0177
Brugia malayi GnHR receptor homolog 0.0034 0.0161 0.0285
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0407 0.056
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0242 0.0364
Schistosoma mansoni hypothetical protein 0.0021 0.0042 0.0058
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0855 0.0848
Trypanosoma brucei trypanothione reductase 0.0049 0.0294 0.1992
Brugia malayi G protein-coupled receptor F59B2.13 0.0034 0.0161 0.0285
Schistosoma mansoni hypothetical protein 0.0035 0.0172 0.0237
Loa Loa (eye worm) glutaminase 2 0.0547 0.4759 0.842
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0161 0.0222
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0193 0.1586 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus multilocularis microtubule associated protein 2 0.0711 0.6232 0.8572
Schistosoma mansoni hypothetical protein 0.0031 0.0136 0.0187
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Mycobacterium ulcerans aldehyde dehydrogenase 0.018 0.1475 0.3087
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0128 0.0177
Echinococcus granulosus importin subunit beta 1 0.006 0.0396 0.0545
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0128 0.0177
Schistosoma mansoni nuclear hormone receptor 0.003 0.0128 0.0177
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0161 0.0222
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0294 0.1992
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0008 0.0011
Schistosoma mansoni neuropeptide receptor 0.0034 0.0161 0.0222
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0253 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0128 0.0227
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0193 0.1586 0.2182
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0136 0.0187
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0368 0.228
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0294 0.0444
Echinococcus granulosus g-protein coupled receptor 0.0034 0.0161 0.0222
Echinococcus granulosus sex peptide receptor 0.0034 0.0161 0.0222
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0561 0.3504
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.0851 0.1171
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0882 0.1213
Loa Loa (eye worm) TYRA-2 protein 0.0034 0.0161 0.0285
Brugia malayi Smad1 0.0033 0.0148 0.0262
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0253 0.1556
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0407 0.056
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0215 0.0321
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0028 0.0038
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.0178
Giardia lamblia Rab geranylgeranyltransferase 0.005 0.0305 0.188
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0031
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.001 0.0014
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0294 0.1991
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0128 0.0227
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0318 0.031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0161 0.0222
Mycobacterium ulcerans esterase/lipase LipP 0.0177 0.1444 0.3022
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0407 0.056
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.001 0.0014
Toxoplasma gondii hypothetical protein 0.005 0.0305 0.2023
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.01 0.0178
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0099 0.0577
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0407 0.056
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0028 0.0038
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0966 0.6449
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0084 0.0522
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0177 0.1444 0.3022
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0193 0.1586 0.2806
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0407 0.072
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0368 0.036
Echinococcus multilocularis RUN 0.0019 0.0028 0.0038
Brugia malayi neuropeptide F receptor 0.0034 0.0161 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0128 0.0227
Brugia malayi hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni adenoreceptor 0.0034 0.0161 0.0222
Brugia malayi Pre-SET motif family protein 0.0094 0.0697 0.1234
Echinococcus granulosus g protein coupled receptor 0.0034 0.0161 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0128 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0128 0.0227
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.005 0.0305 0.0461
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0048 0.0085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0274 0.2312 0.318
Schistosoma mansoni amine GPCR 0.0034 0.0161 0.0222
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0028 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0024 0.0025
Schistosoma mansoni intermediate filament proteins 0.0027 0.01 0.0138
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0077 0.055 0.267
Brugia malayi Inositol-1 0.0077 0.055 0.0973
Brugia malayi Dopamine receptor protein 1 0.0034 0.0161 0.0285
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0368 0.6505
Onchocerca volvulus 0.0034 0.0161 0.0208
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0561 0.3504
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0294 0.0444
Schistosoma mansoni amine GPCR 0.0034 0.0161 0.0222
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0034 0.0161 0.0222
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0439 0.294
Schistosoma mansoni hypothetical protein 0.0031 0.0136 0.0187
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0193 0.1586 0.2449
Schistosoma mansoni flap endonuclease-1 0.0046 0.027 0.0371
Schistosoma mansoni opsin-like receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) hypothetical protein 0.0099 0.0741 0.1311
Loa Loa (eye worm) hypothetical protein 0.0046 0.027 0.0478
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0034 0.0161 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.0177 0.1444 1
Onchocerca volvulus Bile acid receptor homolog 0.0334 0.2851 0.4394
Loa Loa (eye worm) hypothetical protein 0.0071 0.0494 0.0873
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0008 0.0014
Schistosoma mansoni growth hormone secretagogue receptor 0.0034 0.0161 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0128 0.0227
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0051 0.0314 0.2128
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0253 0.1674
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.018 0.1475 0.1468
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0128 0.0227
Brugia malayi nuclear receptor NHR-88 0.003 0.0128 0.0227
Echinococcus granulosus neuropeptide s receptor 0.0034 0.0161 0.0222
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0368 0.2505
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0161 0.0222
Schistosoma mansoni alpha-1 adrenergic receptor 0.0034 0.0161 0.0222
Echinococcus granulosus tachykinin peptides receptor 99D 0.0034 0.0161 0.0222
Schistosoma mansoni ap endonuclease 0.0057 0.0368 0.0506
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0136 0.0241
Schistosoma mansoni hypothetical protein 0.0034 0.0161 0.0222
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0079 0.011
Onchocerca volvulus Huntingtin homolog 0.0122 0.0948 0.1433
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni neuropeptide f receptor 76f 0.0034 0.0161 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0128 0.0227
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0368 0.228
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.018 0.1475 0.2029
Brugia malayi MH1 domain containing protein 0.0018 0.0018 0.0031
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.018 0.0248
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0439 0.0604
Brugia malayi Flap endonuclease-1 0.0051 0.0314 0.0555
Brugia malayi RE15519p 0.0034 0.0161 0.0285
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0034 0.0161 0.0285
Trichomonas vaginalis set domain proteins, putative 0.0735 0.6452 1
Brugia malayi Melatonin receptor type 1A 0.0034 0.0161 0.0285
Schistosoma mansoni lipoxygenase 0.008 0.0573 0.0789
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0496 0.0758
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.2074 0.2852
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0111 0.0851 0.1171
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0084 0.0485
Schistosoma mansoni coup transcription factor 0.003 0.0128 0.0177
Schistosoma mansoni survival motor neuron protein 0.005 0.0309 0.0424
Echinococcus multilocularis inositol monophosphatase 1 0.0077 0.055 0.0756
Echinococcus multilocularis serotonin receptor 0.0034 0.0161 0.0222
Loa Loa (eye worm) intermediate filament protein 0.0027 0.01 0.0178
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.005 0.0305 0.0539
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0697 0.47
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0741 0.1311
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.005 0.0305 0.2067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0161 0.0222
Trichomonas vaginalis penicillin-binding protein, putative 0.0177 0.1444 0.2228
Schistosoma mansoni neuropeptide receptor 0.0034 0.0161 0.0222
Plasmodium falciparum glutathione reductase 0.0049 0.0294 0.1813
Echinococcus granulosus microtubule associated protein 2 0.0711 0.6232 0.8572
Schistosoma mansoni rab6-interacting 0.0019 0.0028 0.0038
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0148 0.0262
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0193 0.1586 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0368 0.0506
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0016 0.0022
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0368 0.0506
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0407 0.056
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0391 0.0383
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0193 0.1586 0.2806
Schistosoma mansoni cpg binding protein 0.0063 0.0424 0.0583
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0048 0.0066
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0253 0.0448
Plasmodium vivax hypothetical protein, conserved 0.0177 0.1444 0.9099
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0177 0.1444 0.2555
Toxoplasma gondii aldehyde dehydrogenase 0.018 0.1475 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0161 0.0222
Echinococcus granulosus zinc finger protein 0.0023 0.0062 0.0086
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0161 0.0222
Schistosoma mansoni histamine h1 receptor 0.0034 0.0161 0.0222
Echinococcus multilocularis GPCR, family 2 0.0031 0.0136 0.0187
Echinococcus multilocularis g-protein coupled receptor 0.0034 0.0161 0.0222
Echinococcus granulosus neuropeptide receptor A26 0.0034 0.0161 0.0222
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0253 0.171
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0391 0.0692
Echinococcus multilocularis sex peptide receptor 0.0034 0.0161 0.0222
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.005 0.0305 0.2067
Mycobacterium tuberculosis Probable lipase LipE 0.0177 0.1444 0.1437
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0855 0.0848
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.0161 0.0222
Leishmania major hypothetical protein, conserved 0.0025 0.0084 0.0522
Schistosoma mansoni neuropeptide receptor 0.0034 0.0161 0.0222
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0099 0.0577
Brugia malayi chromobox protein homolog 3 0.004 0.0215 0.038
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0305 0.2067
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0008 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0128 0.0227
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0128 0.0177
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0407 0.072
Brugia malayi hypothetical protein 0.0019 0.0028 0.0049
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.001 0.0014
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0077 0.055 0.114
Loa Loa (eye worm) hypothetical protein 0.0031 0.0136 0.0241
Brugia malayi hypothetical protein 0.0034 0.0161 0.0285
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0855 0.0848
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.0161 0.0285
Echinococcus multilocularis chromobox protein 1 0.0071 0.0496 0.0683
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0285
Schistosoma mansoni amine GPCR 0.0034 0.0161 0.0222
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0063 0.0111
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0024 0.0025
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.018 0.1475 0.2029
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0439 0.3004
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0253 0.171
Onchocerca volvulus Neuropeptide F receptor homolog 0.0034 0.0161 0.0208
Schistosoma mansoni amine GPCR 0.0034 0.0161 0.0222
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0128 0.0177
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0051 0.0314 0.2083
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0008 0.0011
Brugia malayi MH1 domain containing protein 0.0033 0.0148 0.0262
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.005 0.0305 0.2067
Onchocerca volvulus 0.0034 0.0161 0.0208
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0136 0.0187
Brugia malayi follicle stimulating hormone receptor 0.0263 0.2211 0.3912
Schistosoma mansoni smad 0.0033 0.0148 0.0204
Echinococcus granulosus snurportin 1 0.0642 0.5618 0.7728
Mycobacterium tuberculosis Probable reductase 0.0111 0.0855 0.0848
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0034 0.0161 0.0222
Onchocerca volvulus 0.0177 0.1444 0.2205
Onchocerca volvulus 0.0034 0.0161 0.0208
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.0161 0.0285
Echinococcus granulosus flap endonuclease 1 0.0051 0.0314 0.0431
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0034 0.0161 0.0222
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0034 0.0161 0.0222
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0016 0.0022
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0439 0.0604
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0079 0.011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0368 0.0651
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0697 0.0959
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0391 0.0538
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.005 0.0305 0.2067
Loa Loa (eye worm) transcription factor SMAD2 0.0477 0.4139 0.7323
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.0161 0.0222
Brugia malayi RNA binding protein 0.0061 0.0407 0.072
Brugia malayi glutathione reductase 0.0049 0.0294 0.052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0202 0.0357

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.1 uM In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS. ChEMBL. 9873573
IC50 (binding) = 1.1 uM In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS. ChEMBL. 9873573

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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