Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0014 | 0.1265 | 0.1446 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.1265 | 0.1265 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5609 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4331 | 0.7332 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.042 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4619 | 0.4619 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0839 | 0.0607 |
Brugia malayi | hypothetical protein | 0.003 | 0.3713 | 0.6041 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3713 | 0.8229 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.3713 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8854 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.5609 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5609 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3713 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.3713 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.4331 | 0.5 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4619 | 0.8051 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4619 | 0.8051 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5609 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0531 | 0.0531 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.5609 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.5609 | 0.5609 |
Brugia malayi | hypothetical protein | 0.0043 | 0.5609 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.3713 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.3713 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.042 | 0.5 |
Brugia malayi | hypothetical protein | 0.002 | 0.214 | 0.2757 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3713 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4619 | 0.4619 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.3713 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.5609 | 0.5609 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4331 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0839 | 0.0607 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0014 | 0.1265 | 0.1446 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.042 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.5609 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.042 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4331 | 0.4331 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3078 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.