Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | oxidoreductase | 0.0442 | 0.7237 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0442 | 0.7237 | 0.5 |
Trypanosoma cruzi | aldo-keto reductase | 0.0442 | 0.7237 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0442 | 0.7237 | 0.7237 |
Giardia lamblia | Aldose reductase | 0.0442 | 0.7237 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0442 | 0.7237 | 0.7237 |
Onchocerca volvulus | 0.0442 | 0.7237 | 0.5 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0442 | 0.7237 | 0.5 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.049 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.049 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.049 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.049 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0442 | 0.7237 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0442 | 0.7237 | 0.7237 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0442 | 0.7237 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0442 | 0.7237 | 0.7237 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0442 | 0.7237 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0442 | 0.7237 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0442 | 0.7237 | 0.7237 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0442 | 0.7237 | 0.7237 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0442 | 0.7237 | 0.5 |
Onchocerca volvulus | 0.0442 | 0.7237 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0442 | 0.7237 | 0.7237 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0442 | 0.7237 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0442 | 0.7237 | 0.7237 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.049 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0442 | 0.7237 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0442 | 0.7237 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0442 | 0.7237 | 0.7237 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0442 | 0.7237 | 0.7237 |
Leishmania major | prostaglandin f synthase, putative | 0.0442 | 0.7237 | 0.5 |
Onchocerca volvulus | 0.0442 | 0.7237 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0442 | 0.7237 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0442 | 0.7237 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0442 | 0.7237 | 0.7237 |
Echinococcus granulosus | solute carrier family 5 | 0.049 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0442 | 0.7237 | 0.7237 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 0.7237 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0442 | 0.7237 | 0.7237 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0442 | 0.7237 | 0.7237 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0442 | 0.7237 | 0.7237 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.049 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0442 | 0.7237 | 0.7237 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0442 | 0.7237 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0442 | 0.7237 | 0.7237 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0442 | 0.7237 | 0.7237 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0442 | 0.7237 | 0.7237 |
Echinococcus granulosus | hypothetical protein | 0.0442 | 0.7237 | 0.7237 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0442 | 0.7237 | 0.7237 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0442 | 0.7237 | 0.7237 |
Schistosoma mansoni | inositol transporter | 0.049 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0442 | 0.7237 | 0.7237 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0442 | 0.7237 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0442 | 0.7237 | 0.5 |
Onchocerca volvulus | 0.0442 | 0.7237 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Onchocerca volvulus | 0.0442 | 0.7237 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.0442 | 0.7237 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0442 | 0.7237 | 0.7237 |
Leishmania major | aldo-keto reductase-like protein | 0.0442 | 0.7237 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0442 | 0.7237 | 0.7237 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0442 | 0.7237 | 0.7237 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0442 | 0.7237 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0442 | 0.7237 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.0442 | 0.7237 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0442 | 0.7237 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0442 | 0.7237 | 0.7237 |
Onchocerca volvulus | 0.0442 | 0.7237 | 0.5 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0442 | 0.7237 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0442 | 0.7237 | 0.7237 |
Giardia lamblia | Aldose reductase | 0.0442 | 0.7237 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0442 | 0.7237 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.