Detailed information for compound 1385117

Basic information

Technical information
  • TDR Targets ID: 1385117
  • Name: 2-(2-bromophenyl)-5-[(2-fluorophenyl)sulfanyl methyl]-1,3,4-oxadiazole
  • MW: 365.22 | Formula: C15H10BrFN2OS
  • H donors: 0 H acceptors: 2 LogP: 4.25 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccccc1SCc1nnc(o1)c1ccccc1Br
  • InChi: 1S/C15H10BrFN2OS/c16-11-6-2-1-5-10(11)15-19-18-14(20-15)9-21-13-8-4-3-7-12(13)17/h1-8H,9H2
  • InChiKey: VHCBXAVMJMRNJM-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(2-bromophenyl)-5-[[(2-fluorophenyl)thio]methyl]-1,3,4-oxadiazole
  • ZINC03473413
  • MLS000770941
  • SMR000375893
  • T5452649

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SUMO1/sentrin specific peptidase 7 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens v-rel avian reticuloendotheliosis viral oncogene homolog A No references
Homo sapiens caspase 3, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens SUMO/sentrin specific peptidase family member 8 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens SUMO1/sentrin specific peptidase 6 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_129942 All targets in OG5_129942
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis sentrin specific protease 7 Get druggable targets OG5_131076 All targets in OG5_131076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_131076 All targets in OG5_131076
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis sentrin specific protease 8 Get druggable targets OG5_129942 All targets in OG5_129942
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_129942 All targets in OG5_129942
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_129942 All targets in OG5_129942
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis Sentrin-specific protease, putative Get druggable targets OG5_129942 All targets in OG5_129942
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_131076 All targets in OG5_131076
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus sentrin specific protease 7 Get druggable targets OG5_131076 All targets in OG5_131076
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus sentrin specific protease 8 Get druggable targets OG5_129942 All targets in OG5_129942
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) Ulp1 protease Get druggable targets OG5_129942 All targets in OG5_129942
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K08596 sentrin-specific protease 7, putative Get druggable targets OG5_131076 All targets in OG5_131076
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_129942 All targets in OG5_129942
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_131076 All targets in OG5_131076
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_129942 All targets in OG5_129942
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K08597 sentrin-specific protease 8, putative Get druggable targets OG5_129942 All targets in OG5_129942
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_131076 All targets in OG5_131076
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Brugia malayi Cell death protein 3 precursor caspase 3, apoptosis-related cysteine peptidase 277 aa 253 aa 38.7 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Plasmodium falciparum sentrin-specific protease 1 SUMO/sentrin specific peptidase family member 8 212 aa 197 aa 23.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Peptide deformylase 2, putative 0.1318 0.3791 1
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0053 0.0077
Giardia lamblia Sentrin specific protease, putative 0.0047 0.0096 0.1462
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0028 0.0154
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0028 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0053 0.1081
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0292 1
Schistosoma mansoni kinase 0.0058 0.0129 0.2263
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0135 0.1544
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0084 0.1479
Echinococcus multilocularis caspase 2 0.0032 0.0053 0.0191
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0044 0.0021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0044 0.0294
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0192 0.0445
Trypanosoma cruzi hypothetical protein 0.0111 0.0284 0.0689
Trichomonas vaginalis Sentrin-specific protease, putative 0.0111 0.0284 0.9704
Schistosoma mansoni survival motor neuron protein 0.0058 0.013 0.2277
Brugia malayi PXA domain containing protein 0.0023 0.0028 0.0154
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0292 0.2297
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0029 0.0168
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0053 0.0029
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0022 0.0003
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0029 0.0168
Brugia malayi hypothetical protein 0.0023 0.0028 0.0154
Trypanosoma cruzi metacaspase, putative 0.0032 0.0053 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0292 1
Mycobacterium ulcerans hypothetical protein 0.0022 0.0025 0.0002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0088
Mycobacterium tuberculosis Conserved protein 0.0022 0.0025 0.0006
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0292 0.3565
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0028 0.0098
Brugia malayi beta-lactamase family protein 0.0022 0.0025 0.0115
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0111 0.0284 0.9704
Echinococcus granulosus expressed protein 0.0451 0.1271 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0115
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0053 0.1081
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0028 0.0154
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0022 0.0025 0.0115
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0028 0.0485
Schistosoma mansoni hypothetical protein 0.0049 0.0103 0.1814
Brugia malayi PXA domain containing protein 0.0023 0.0028 0.0154
Schistosoma mansoni patched 1 0.0051 0.0109 0.1908
Loa Loa (eye worm) hypothetical protein 0.0041 0.008 0.0829
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0053 0.1081
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0096 0.1266
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0063 0.0038
Trypanosoma brucei metacaspase MCA3 0.0032 0.0053 0.0077
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.3454 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.079 0.6221
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0029 0.0168
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0044 0.0024
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0292 0.3565
Brugia malayi Bromodomain containing protein 0.0035 0.0063 0.0606
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0192 0.0445
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0154
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0192 0.2276
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0044 0.0021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0088
Echinococcus multilocularis caspase 0.012 0.0309 0.11
Trypanosoma cruzi Peptide deformylase 2, putative 0.1318 0.3791 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0063 0.0223
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0028 0.0112
Plasmodium falciparum peptide deformylase 0.3454 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0022 0.0025 0.0006
Plasmodium vivax sentrin-specific protease 2, putative 0.0047 0.0096 0.0074
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0306 0.3746
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0192 0.0445
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0096 0.2678
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0053 0.0029
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0049 0.0024
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0111 0.0284 0.4732
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.079 0.2816
Mycobacterium tuberculosis Probable esterase LipL 0.0022 0.0025 0.0006
Loa Loa (eye worm) hypothetical protein 0.006 0.0136 0.155
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0053 0.1081
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0016 0.0123
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.021 0.0569 1
Echinococcus granulosus caspase 3 0.0088 0.0216 0.1697
Echinococcus granulosus Ankyrin 0.0038 0.0072 0.0565
Echinococcus granulosus caspase 2 0.0032 0.0053 0.0421
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0084 0.1479
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0044 0.0021
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0084 0.03
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0044 0.0024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0022 0.0025 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0112
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0096 0.1039
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0292 0.104
Echinococcus multilocularis peregrin 0.0035 0.0063 0.0223
Brugia malayi Uncoordinated protein 44 0.0038 0.0071 0.0718
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0112
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0292 0.4878
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0028 0.0098
Leishmania major metacaspase, putative 0.0032 0.0053 0.0077
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0379 0.4695
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0053 0.1081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0022 0.0025 0.0432
Loa Loa (eye worm) hypothetical protein 0.0062 0.0142 0.163
Echinococcus granulosus caspase 0.012 0.0309 0.243
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0028 0.0154
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0088
Plasmodium falciparum phd finger protein, putative 0.0035 0.0063 0.004
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0192 0.2276
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0028 0.0154
Echinococcus granulosus GPCR family 2 0.0019 0.0016 0.0123
Entamoeba histolytica hypothetical protein 0.0043 0.0087 0.1089
Toxoplasma gondii hypothetical protein 0.3454 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0049 0.0026
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0028 0.0154
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0047 0.0096 0.1689
Brugia malayi Death domain containing protein 0.0038 0.0071 0.0718
Brugia malayi hypothetical protein 0.003 0.0049 0.0427
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0192 0.3373
Brugia malayi beta-lactamase 0.0022 0.0025 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0112
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0094 0.0743
Echinococcus multilocularis expressed conserved protein 0.0112 0.0285 0.1015
Schistosoma mansoni hypothetical protein 0.0019 0.0016 0.0275
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0154
Mycobacterium ulcerans beta-lactamase 0.0022 0.0025 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0112
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.012 0.0309 0.243
Schistosoma mansoni hypothetical protein 0.0038 0.0071 0.1253
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2807 1
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0103 0.0366
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0063 0.0038
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0049 0.0064
Echinococcus granulosus death domain containing protein 0.0038 0.0071 0.0561
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0044 0.0021
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0049 0.0026
Brugia malayi Cell death protein 3 precursor 0.0032 0.0053 0.0488
Brugia malayi hypothetical protein 0.0043 0.0087 0.0915
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0063 0.0493
Brugia malayi hypothetical protein 0.0023 0.0028 0.0154
Schistosoma mansoni netrin receptor unc5 0.0038 0.0071 0.1253
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0374 0.1046 0.3727
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.3454 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0044 0.0021
Schistosoma mansoni hypothetical protein 0.0205 0.0555 0.975
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0053 0.1081
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0115
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0053 0.0031
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0053 0.1081
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0115
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0063 0.11
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0022 0.0025 0.0432
Giardia lamblia Kinase, PLK 0.0114 0.0292 1
Echinococcus granulosus expressed conserved protein 0.0112 0.0285 0.2243
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0124 0.3736
Brugia malayi hypothetical protein 0.002 0.0017 0.0023
Plasmodium falciparum sentrin-specific protease 1 0.0047 0.0096 0.0074
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0084 0.0663
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0454 0.1618
Loa Loa (eye worm) hypothetical protein 0.003 0.0049 0.0427
Mycobacterium tuberculosis Probable lipase LipD 0.0022 0.0025 0.0006
Trypanosoma cruzi metacaspase, putative 0.0032 0.0053 0.0077
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0028 0.0485
Trypanosoma brucei polo-like protein kinase 0.0114 0.0292 0.071
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0306 0.109
Brugia malayi PHD-finger family protein 0.0035 0.0063 0.0606
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0124 0.3736
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0111 0.0284 0.9704
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0028 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0025 0.0002
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0047 0.0096 0.019
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0044 0.0021
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0022 0.0025 0.0115
Mycobacterium ulcerans lipase LipD 0.0022 0.0025 0.0002
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0306 0.2408
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0096 0.2678
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0053 0.1081
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0096 0.1039
Plasmodium vivax metacaspase 1, putative 0.0032 0.0053 0.0031
Echinococcus granulosus sentrin specific protease 7 0.021 0.0569 0.4481
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0111 0.0284 0.9704
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0044 0.0294
Leishmania major hypothetical protein, conserved 0.003 0.0049 0.0064
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0029 0.0504
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0071 0.0718
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0028 0.0485
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0096 0.2678
Echinococcus multilocularis netrin receptor unc 5 0.0038 0.0071 0.0254
Echinococcus multilocularis protein patched 0.0051 0.0109 0.0387
Trypanosoma brucei metacaspase MCA2 0.0032 0.0053 0.0077
Brugia malayi MH2 domain containing protein 0.0144 0.0379 0.4695
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0103 0.0809
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0028 0.0154
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0096 0.2678
Brugia malayi jmjC domain containing protein 0.0115 0.0295 0.3612
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0227 0.398
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0016 0.0123
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0053 0.0077
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0047 0.0096 0.2678
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0192 0.1511
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0038 0.0071 0.0254
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0292 0.071
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0488
Schistosoma mansoni hypothetical protein 0.0049 0.0103 0.1814
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0063 0.004
Echinococcus granulosus sentrin specific protease 8 0.0111 0.0284 0.2235
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.1318 0.3791 1
Onchocerca volvulus 0.0047 0.0096 0.2678
Trypanosoma brucei metacaspase 0.0032 0.0053 0.0077
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0087 0.0309
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0029 0.0504
Entamoeba histolytica hypothetical protein 0.0043 0.0087 0.1089
Echinococcus granulosus netrin receptor unc 5 0.0038 0.0071 0.0561
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0454 0.3575
Echinococcus granulosus geminin 0.0205 0.0555 0.4369
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0028 0.0485
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.036
Plasmodium falciparum metacaspase 1 0.0032 0.0053 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0154
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0028 0.0217
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.1039
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0028 0.0098
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0053 0.1081
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0292 1
Mycobacterium ulcerans esterase/lipase LipP 0.0022 0.0025 0.0002
Loa Loa (eye worm) hypothetical protein 0.0051 0.0109 0.12
Echinococcus multilocularis sentrin specific protease 1 0.0047 0.0096 0.0343
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0094 0.0336
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0096 0.1039
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0718
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0295 0.1053
Echinococcus granulosus sentrin specific protease 1 0.0047 0.0096 0.0757
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0724
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0295 0.2326
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0112
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0047 0.0096 0.0074
Plasmodium vivax peptide deformylase, putative 0.3454 1 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0044 0.036
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0028 0.0485
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0088
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0022 0.0025 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0016 0.0056
Brugia malayi beta-lactamase family protein 0.0022 0.0025 0.0115
Onchocerca volvulus Netrin receptor homolog 0.0038 0.0071 0.1749
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0109 0.0855
Schistosoma mansoni caspase-7 (C14 family) 0.012 0.0309 0.5423
Echinococcus multilocularis expressed protein 0.0451 0.1271 0.4527
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0135 0.1544
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0044 0.005
Schistosoma mansoni caspase-3 (C14 family) 0.012 0.0309 0.5423
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0087 0.1521
Schistosoma mansoni hypothetical protein 0.0049 0.0103 0.1814
Plasmodium falciparum metacaspase-like protein 0.0032 0.0053 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0049 0.0026
Trypanosoma brucei Peptide deformylase 2 0.1318 0.3791 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0084 0.0884
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0049 0.0064
Echinococcus multilocularis geminin 0.0205 0.0555 0.1978
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0096 0.0072
Treponema pallidum polypeptide deformylase (def) 0.3454 1 0.5
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0044 0.036
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0096 0.0072
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0022 0.0025 0.0006
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0047 0.0096 0.1689
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0292 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0096 0.1266
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0063 0.0606
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0096 0.1266
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0096 0.1266
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0044 0.0294
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0053 0.1081
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0087 0.0682
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0311 0.5466
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.11
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.1318 0.3791 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0053 0.1081
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.036
Schistosoma mansoni hypothetical protein 0.0019 0.0016 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0109 0.3143
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0044 0.0021
Entamoeba histolytica hypothetical protein 0.0043 0.0087 0.1089
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0053 0.1081
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0044 0.005
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0028 0.0485
Schistosoma mansoni hypothetical protein 0.0049 0.0103 0.1814
Mycobacterium tuberculosis Conserved protein 0.0022 0.0025 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0053 0.1081
Brugia malayi hypothetical protein 0.0286 0.079 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0154
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0044 0.005
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0028 0.0485
Mycobacterium tuberculosis Conserved protein 0.0022 0.0025 0.0006
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0038 0.0072 0.126
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.0071 0.0718
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0028 0.0217
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.008 0.0829
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0038 0.0071 0.0561
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.1039
Schistosoma mansoni ankyrin 23/unc44 0.0038 0.0071 0.1253
Echinococcus granulosus caspase 8 0.0032 0.0053 0.0421
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0053 0.1081
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0053 0.0029
Echinococcus granulosus expressed conserved protein 0.0163 0.0434 0.3412
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0096 0.0072
Onchocerca volvulus 0.0029 0.0044 0.0709
Onchocerca volvulus Cell death protein 3 homolog 0.0032 0.0053 0.1081
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0044 0.0019
Mycobacterium tuberculosis Probable lipase LipE 0.0022 0.0025 0.0006
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0044 0.0019
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0028 0.0485
Brugia malayi jmjC domain containing protein 0.0043 0.0084 0.0884
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0292 0.071
Loa Loa (eye worm) beta-lactamase 0.0022 0.0025 0.0115
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0096 0.2678
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0292 0.071
Echinococcus granulosus peregrin 0.0035 0.0063 0.0493
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0044 0.036
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0292 0.5126
Echinococcus granulosus beta LACTamase domain containing family member 0.0022 0.0025 0.0194
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0028 0.0217
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0096 0.2678
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0292 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0115
Leishmania major polypeptide deformylase-like protein, putative 0.1318 0.3791 1
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0028 0.0217
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0029 0.0226
Trypanosoma brucei metacaspase 5, putative 0.0032 0.0053 0.0077
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0172 0.2013
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.1039
Echinococcus multilocularis sentrin specific protease 7 0.021 0.0569 0.2029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0115
Trypanosoma cruzi metacaspase, putative 0.0032 0.0053 0.0077
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0028 0.0217
Schistosoma mansoni hypothetical protein 0.0205 0.0555 0.975
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0016 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0292 1
Brugia malayi Protein kinase domain containing protein 0.0039 0.0072 0.0732
Schistosoma mansoni hypothetical protein 0.0058 0.013 0.2277
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0096 0.2678
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0028 0.0485
Loa Loa (eye worm) hypothetical protein 0.0286 0.079 1
Trypanosoma brucei Polypeptide deformylase 1 0.1318 0.3791 1
Loa Loa (eye worm) Ulp1 protease 0.0111 0.0284 0.3463
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0154
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0028 0.0217
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0606
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0028 0.0217
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0192 0.0684
Schistosoma mansoni hypothetical protein 0.0019 0.0016 0.0275
Echinococcus granulosus nuclear factor of activated T cells 5 0.0374 0.1046 0.8233
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0028 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0028 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0029 0.0504
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0028 0.0485
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.021 0.0569 1
Onchocerca volvulus Alhambra homolog 0.0035 0.0063 0.1424
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0379 0.4695
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0109 0.0855
Schistosoma mansoni hypothetical protein 0.0019 0.0016 0.0275
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.012 0.0309 0.11
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0154
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0109 0.0387
Plasmodium vivax sentrin-specific protease 1, putative 0.0047 0.0096 0.0074
Echinococcus multilocularis beta LACTamase domain containing family member 0.0022 0.0025 0.0088
Trypanosoma brucei Metacaspase-4 0.0032 0.0053 0.0077
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0111 0.0284 0.3463
Echinococcus multilocularis caspase 3 0.0088 0.0216 0.0768
Schistosoma mansoni hypothetical protein 0.0043 0.0087 0.1521
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0029 0.0102
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0028 0.0098
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0028 0.0154
Trypanosoma cruzi metacaspase, putative 0.0032 0.0053 0.0077
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0028 0.0098
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.013 0.1471
Loa Loa (eye worm) Ulp1 protease 0.0047 0.0096 0.1039
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0028 0.0485
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0306 0.5137
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0488
Onchocerca volvulus 0.0058 0.013 0.3929
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0047 0.0096 0.019
Echinococcus multilocularis expressed conserved protein 0.0163 0.0434 0.1545
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0292 1
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0028 0.0217
Mycobacterium ulcerans hypothetical protein 0.0029 0.0044 0.0021
Entamoeba histolytica hypothetical protein 0.0043 0.0087 0.1089
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0047 0.0096 0.019
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0047 0.0096 0.0074
Schistosoma mansoni hypothetical protein 0.0041 0.008 0.1404
Trypanosoma brucei SUMO1/Ulp2, putative 0.0047 0.0096 0.019
Echinococcus multilocularis caspase 8 0.0032 0.0053 0.0191
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0053 0.1081
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0109 0.12
Echinococcus multilocularis GPCR, family 2 0.0019 0.0016 0.0056
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.0053 0.0939
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0053 0.0939
Loa Loa (eye worm) hypothetical protein 0.0119 0.0306 0.3746
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0111 0.0284 0.4988
Echinococcus multilocularis protein dispatched 1 0.0058 0.013 0.0462
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0141 0.0371 0.0353
Mycobacterium ulcerans peptide deformylase 0.3454 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0292 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0028 0.0098
Echinococcus multilocularis Ankyrin 0.0038 0.0072 0.0256
Mycobacterium tuberculosis Probable hydrolase 0.0022 0.0025 0.0006
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0049 0.0064
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0135 0.1544
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0028 0.0098
Echinococcus multilocularis sentrin specific protease 8 0.0111 0.0284 0.1012
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0192 0.0445
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.3454 1 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.0135 0.1544
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0192 0.3035
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.0053 0.0488
Brugia malayi CHE-14 protein 0.0051 0.0109 0.12

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.818 um PUBCHEM_BIOASSAY: Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response. (Class of assay: confirmatory) [Related pubchem assays: 1239 ] ChEMBL. No reference
IC50 (functional) = 6.47 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID434973, AID434986] ChEMBL. No reference
IC50 (functional) = 12.1 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2575, AID2582, AID2599] ChEMBL. No reference
IC50 (functional) = 14.7 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2575, AID2582, AID434986] ChEMBL. No reference
IC50 (functional) = 17.1 uM PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2599, AID434973, AID489001] ChEMBL. No reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.9528 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.636 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 1.636 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0588 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 2.3778 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 3.3587 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: Confirmation Assay for Identification of Novel General Anesthetics. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2323, AID2385, AID485281] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 70.7946 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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