Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.4591 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.3289 | 0.3289 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.4591 | 0.4591 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4591 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.4591 | 0.4591 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.3289 | 0.3289 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1767 | 0.1767 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1767 | 0.3848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4591 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.4591 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.1767 | 0.1767 |
Brugia malayi | RNA binding protein | 0.0073 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4591 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.