Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.3387 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.3387 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.3387 | 0.3387 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.3387 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.3387 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.3387 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 1 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.3387 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.3387 | 0.3387 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 1 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.3387 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.3387 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.3387 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.3387 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.3387 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.3387 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.3387 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.3387 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.3387 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.3387 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.3387 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.9466 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.