TDR Targets

Basic information

Technical information

TDR Targets ID: 138576
Name: 1-[4-(3-bromo-8-chloro-5H-[1]benzoxepino[4,3- b]pyridin-11-ylidene)piperidin-1-yl]-2-(1-oxi dopyridin-1-ium-4-yl)ethanone
MW: 526.81 | Formula: C25H21BrClN3O3
H donors: 0 H acceptors: 3 LogP: 2.59 Rotable bonds: 3
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc2c(c1)OCc1c(C2=C2CCN(CC2)C(=O)Cc2cc[n+](cc2)[O-])ncc(c1)Br
InChi: 1S/C25H21BrClN3O3/c26-19-12-18-15-33-22-13-20(27)1-2-21(22)24(25(18)28-14-19)17-5-7-29(8-6-17)23(31)11-16-3-9-30(32)10-4-16/h1-4,9-10,12-14H,5-8,11,15H2
InChiKey: ZRMWHAYAESKTOA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[4-(3-bromo-8-chloro-5H-[1]benzoxepino[4,3-b]pyridin-11-ylidene)-1-piperidyl]-2-(1-oxidopyridin-1-ium-4-yl)ethanone
1-[4-(3-bromo-8-chloro-5H-[1]benzoxepino[4,3-b]pyridin-11-ylidene)-1-piperidinyl]-2-(1-oxido-4-pyridin-1-iumyl)ethanone
1-[4-(3-bromo-8-chloro-5H-[1]benzoxepino[4,3-b]pyridin-11-ylidene)piperidin-1-yl]-2-(1-oxidanidylpyridin-1-ium-4-yl)ethanone
1-[4-(3-bromo-8-chloro-5H-[1]benzoxepino[4,3-b]pyridin-11-ylidene)piperidino]-2-(1-oxidopyridin-1-ium-4-yl)ethanone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	farnesyltransferase, CAAX box, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium berghei	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium parvum	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Giardia lamblia	Rab geranylgeranyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium hominis	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Theileria parva	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus granulosus	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium vivax	prenyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Babesia bovis	protein prenyltransferase alpha subunit repeat domain containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma mansoni	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium knowlesi	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium falciparum	protein farnesyltransferase subunit alpha	Get druggable targets OG5_128459	All targets in OG5_128459
Neospora caninum	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	UPL-1	0.0095	0.0228	0.1098
Mycobacterium leprae	probable uridine phosphorylase	0.0095	0.0228	0.0006
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0457	0.1911	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0073	0.0089
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0127	0.0377	0.1972
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0127	0.0377	0.1972
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0107	0.0285	0.0348
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	0.0457	0.1911	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Brugia malayi	amidase	0.0185	0.0649	0.0792
Mycobacterium tuberculosis	Possible conserved membrane protein	0.0093	0.0222	0.0066
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.005	0.002	0.0265
Giardia lamblia	Rab geranylgeranyltransferase	0.0193	0.0683	0.3506
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0193	0.0683	0.9869
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0246	0.0929	0.3783
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0457	0.1911	1
Brugia malayi	hypothetical protein	0.0046	0.0002	0.0002
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Onchocerca volvulus		0.0061	0.0073	0.0381
Onchocerca volvulus		0.0107	0.0285	0.149
Plasmodium falciparum	plasmepsin II	0.0195	0.0692	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.005	0.002	0.0075
Plasmodium falciparum	plasmepsin IV	0.0195	0.0692	1
Toxoplasma gondii	hypothetical protein	0.005	0.002	0.0265
Onchocerca volvulus	Phospholipase A2 homolog	0.0047	0.0007	0.0039
Echinococcus granulosus	methylthioadenosine phosphorylase	0.0095	0.0228	0.1131
Mycobacterium ulcerans	bifunctional Mta/Sah nucleosidase Mtn	0.0095	0.0228	0.0072
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Echinococcus multilocularis	S formylglutathione hydrolase	0.0093	0.0222	0.1101
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0127	0.0377	0.1972
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0095	0.0228	0.5817
Onchocerca volvulus		0.0046	0.0002	0.001
Brugia malayi	hypothetical protein	0.0061	0.0073	0.0089
Mycobacterium tuberculosis	Probable conserved exported protein	0.0093	0.0222	0.0066
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0193	0.0683	0.0834
Leishmania major	nucleoside phosphorylase-like protein	0.0095	0.0228	0.5817
Toxoplasma gondii	aspartyl protease ASP1	0.0195	0.0692	1
Treponema pallidum	biotin--acetyl-CoA-carboxylase ligase	0.0162	0.0538	1
Plasmodium falciparum	lysophospholipase, putative	0.0127	0.0377	0.5434
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0457	0.1911	1
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.005	0.002	0.0265
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0095	0.0228	0.0921
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0046	0.0002	0.0002
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0457	0.1911	1
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	0.0457	0.1911	1
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0195	0.0692	0.3579
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.3204
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0095	0.0228	0.0921
Plasmodium vivax	plasmepsin IV, putative	0.0195	0.0692	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0127	0.0377	0.1972
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0073	0.0089
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0061	0.0073	0.0089
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0193	0.0683	0.3575
Mycobacterium ulcerans	secreted antigen 85-C FbpC	0.22	1	1
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.005	0.002	0.0038
Onchocerca volvulus		0.005	0.002	0.0105
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0246	0.0929	0.3783
Plasmodium falciparum	esterase, putative	0.0127	0.0377	0.5434
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0185	0.0649	0.3349
Toxoplasma gondii	phosphorylase family protein	0.0095	0.0228	0.3272
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0095	0.0228	0.5817
Loa Loa (eye worm)	hypothetical protein	0.0225	0.083	0.1014
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0195	0.0692	0.3622
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0195	0.0692	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0073	0.0089
Trichomonas vaginalis	conserved hypothetical protein	0.0127	0.0377	0.1972
Plasmodium vivax	PST-A protein	0.0127	0.0377	0.5434
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0127	0.0377	0.5431
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.005	0.002	0.0038
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0185	0.0649	0.3349
Brugia malayi	MTAP	0.0095	0.0228	0.0278
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0095	0.0228	0.5817
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0379	0.0463
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.005	0.002	0.0038
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0107	0.0285	0.0348
Echinococcus granulosus	uridine phosphorylase 1	0.0095	0.0228	0.1131
Mycobacterium tuberculosis	Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase	0.0095	0.0228	0.0072
Trypanosoma brucei	monoglyceride lipase, putative	0.0127	0.0377	1
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0193	0.0683	0.0834
Onchocerca volvulus		0.0107	0.0285	0.149
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.3204
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0195	0.0692	0.0845
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0061	0.0073	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0363	0.1472	0.1797
Entamoeba histolytica	MTA/SAH nucleosidase, putative	0.0095	0.0228	0.3204
Toxoplasma gondii	phosphorylase family protein	0.0095	0.0228	0.3272
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	0.0457	0.1911	0.1782
Plasmodium falciparum	lysophospholipase, putative	0.0127	0.0377	0.5434
Mycobacterium ulcerans	hypothetical protein	0.0093	0.0222	0.0066
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0095	0.0228	0.5817
Mycobacterium tuberculosis	Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A)	0.0093	0.0222	0.0066
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0193	0.0683	1
Echinococcus multilocularis	microsomal triglyceride transfer protein large	0.0225	0.083	0.4306
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0002	0.0002
Trypanosoma cruzi	monoglyceride lipase, putative	0.0127	0.0377	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0007	0.0009
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0195	0.0692	0.2816
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0193	0.0683	0.9869
Leishmania major	monoglyceride lipase, putative	0.0127	0.0377	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0649	0.0792
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0127	0.0377	0.1972
Mycobacterium tuberculosis	Possible lysophospholipase	0.0127	0.0377	0.0223
Loa Loa (eye worm)	aspartyl protease 6	0.0046	0.0002	0.0002
Plasmodium falciparum	plasmepsin VI	0.0195	0.0692	1
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.181	0.8189	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.005	0.002	0.0038
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0093	0.0222	0.0066
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0457	0.1911	1
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Mycobacterium ulcerans	hypothetical protein	0.0093	0.0222	0.0066
Echinococcus granulosus	microsomal triglyceride transfer protein large	0.0225	0.083	0.4306
Mycobacterium tuberculosis	Conserved protein	0.0093	0.0222	0.0066
Loa Loa (eye worm)	S-methyl-5'-thioadenosine phosphorylase MTAP	0.0095	0.0228	0.0278
Brugia malayi	Angiotensin-converting enzyme family protein	0.181	0.8189	1
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0228	0.1191
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.0683	0.3575
Schistosoma mansoni	uridine phosphorylase	0.0095	0.0228	0.0921
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0095	0.0228	0.1098
Mycobacterium ulcerans	secreted antigen 85-A FbpA	0.0093	0.0222	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0683	0.0834
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0195	0.0692	0.3579
Mycobacterium ulcerans	hypothetical protein	0.0127	0.0377	0.0223
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0127	0.0377	0.5431
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.005	0.002	0.0025
Mycobacterium ulcerans	bifunctional protein BirA	0.0151	0.0491	0.0339
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0061	0.0073	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0002	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0127	0.0377	0.1972
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.005	0.002	0.0025
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	0.0457	0.1911	0.2334
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0363	0.1472	0.7684
Schistosoma mansoni	hypothetical protein	0.0225	0.083	0.3378
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.3204
Echinococcus multilocularis	uridine phosphorylase 1	0.0095	0.0228	0.1131
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0061	0.0073	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0246	0.0929	0.1135
Schistosoma mansoni	cathepsin D (A01 family)	0.0574	0.2454	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Mycobacterium tuberculosis	Hypothetical protein	0.0095	0.0228	0.0072
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0107	0.0285	0.0348
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0095	0.0228	0.5817
Loa Loa (eye worm)	uridine phosphorylase	0.0095	0.0228	0.0278
Schistosoma mansoni	purine nucleoside phosphorylase	0.0457	0.1911	0.7787
Toxoplasma gondii	hypothetical protein	0.0143	0.0451	0.6508
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0143	0.0451	0.236
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.0683	0.3575
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0193	0.0683	0.2779
Toxoplasma gondii	Purine nucleoside phosphorylase	0.0095	0.0228	0.3272
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0095	0.0228	0.0072
Onchocerca volvulus		0.0107	0.0285	0.149
Plasmodium falciparum	lysophospholipase, putative	0.0127	0.0377	0.5434
Echinococcus multilocularis	Lipid transport protein, N terminal	0.0127	0.0379	0.1931
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	0.0363	0.1472	0.7684
Brugia malayi	Esterase D	0.0093	0.0222	0.0271
Mycobacterium ulcerans	hypothetical protein	0.0093	0.0222	0.0066
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0095	0.0228	0.0921
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.3204
Mycobacterium ulcerans	purine nucleoside phosphorylase	0.0457	0.1911	0.1782
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0457	0.1911	1
Echinococcus granulosus	S formylglutathione hydrolase	0.0093	0.0222	0.1101
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0185	0.0649	0.3349
Plasmodium falciparum	purine nucleoside phosphorylase	0.0095	0.0228	0.3272
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0127	0.0377	0.1972
Brugia malayi	Pepsin A precursor	0.0046	0.0002	0.0002
Onchocerca volvulus		0.0061	0.0073	0.0381
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	0.0457	0.1911	0.1728
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0095	0.0228	0.1098
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	0.0457	0.1911	1
Onchocerca volvulus	Phospholipase A2 homolog	0.0047	0.0007	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0073	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0692	0.0845
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.005	0.002	0.0108
Plasmodium falciparum	plasmepsin I	0.0195	0.0692	1
Entamoeba histolytica	endo-1,4-beta-xylanase, putative	0.0093	0.0222	0.3117
Brugia malayi	uridine phosphorylase family protein	0.0095	0.0228	0.0278
Brugia malayi	Phospholipase A2 family protein	0.0047	0.0007	0.0009
Schistosoma mansoni	cathepsin D (A01 family)	0.0574	0.2454	1
Schistosoma mansoni	amidase	0.0185	0.0649	0.2638
Trypanosoma brucei	monoglyceride lipase, putative	0.0127	0.0377	1
Loa Loa (eye worm)	esterase D	0.0093	0.0222	0.0271
Entamoeba histolytica	hypothetical protein	0.0095	0.0228	0.3204
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0107	0.0285	0.0348
Echinococcus multilocularis	methylthioadenosine phosphorylase	0.0095	0.0228	0.1131
Onchocerca volvulus		0.0107	0.0285	0.149
Chlamydia trachomatis	AMP nucleosidase	0.0095	0.0228	1
Mycobacterium tuberculosis	Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind	0.0093	0.0222	0.0066
Brugia malayi	hypothetical protein	0.0046	0.0002	0.0002
Plasmodium vivax	aspartyl proteinase, putative	0.0195	0.0692	1
Mycobacterium ulcerans	lysophospholipase	0.0127	0.0377	0.0223
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0246	0.0929	0.3783
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Onchocerca volvulus		0.0046	0.0002	0.001
Onchocerca volvulus		0.0107	0.0285	0.149
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0061	0.0073	0.0089
Mycobacterium ulcerans	5'-methylthioadenosine phosphorylase	0.0095	0.0228	0.0072
Mycobacterium tuberculosis	Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)	0.22	1	1
Mycobacterium ulcerans	hypothetical protein	0.0093	0.0222	0.0066
Schistosoma mansoni	purine nucleoside phosphorylase	0.0457	0.1911	0.7787
Mycobacterium ulcerans	secreted antigen 85-B FbpB	0.0093	0.0222	0.0066
Echinococcus granulosus	hormone sensitive lipase	0.0246	0.0929	0.4828
Plasmodium vivax	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.3272
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0363	0.1472	0.7684
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.3204
Echinococcus granulosus	Lipid transport protein N terminal	0.0127	0.0379	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0007	0.0009
Onchocerca volvulus		0.0107	0.0285	0.149
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.005	0.002	0.0105
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0046	0.0002	0.0002
Leishmania major	methylthioadenosine phosphorylase, putative	0.0095	0.0228	0.5817
Onchocerca volvulus		0.0107	0.0285	0.149
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0228	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0073	0.0089
Brugia malayi	aspartic protease BmAsp-1, identical	0.0046	0.0002	0.0002
Onchocerca volvulus		0.0107	0.0285	0.149
Schistosoma mansoni	fatty-acid amide hydrolase	0.0185	0.0649	0.2638
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0193	0.0683	0.3531
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0193	0.0683	0.3531
Brugia malayi	hypothetical protein	0.0061	0.0073	0.0089
Schistosoma mansoni	uridine phosphorylase	0.0095	0.0228	0.0921
Trypanosoma brucei	uridine phosphorylase	0.0095	0.0228	0.5817
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	0.0095	0.0228	0.5817
Mycobacterium tuberculosis	Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular	0.0093	0.0222	0.0066
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Mycobacterium ulcerans	secreted Mpt51/Mpb51 antigen protein FbpD	0.0093	0.0222	0.0066
Brugia malayi	aspartic protease BmAsp-2, identical	0.0046	0.0002	0.0002
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0127	0.0377	0.0159
Onchocerca volvulus	Apolipophorins homolog	0.0127	0.0379	0.1985
Schistosoma mansoni	biotin-protein ligase	0.0048	0.0013	0.0045
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0185	0.0649	0.3349
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Echinococcus multilocularis	hormone sensitive lipase	0.0246	0.0929	0.4828
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0285	0.0348

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.11 uM	In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.	ChEMBL.	9873573
IC50 (binding)	= 0.11 uM	In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.	ChEMBL.	9873573

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 9849786

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 138576