TDR Targets

Basic information

Technical information

TDR Targets ID: 138576
Name: 1-[4-(3-bromo-8-chloro-5H-[1]benzoxepino[4,3- b]pyridin-11-ylidene)piperidin-1-yl]-2-(1-oxi dopyridin-1-ium-4-yl)ethanone
MW: 526.81 | Formula: C25H21BrClN3O3
H donors: 0 H acceptors: 3 LogP: 2.59 Rotable bonds: 3
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc2c(c1)OCc1c(C2=C2CCN(CC2)C(=O)Cc2cc[n+](cc2)[O-])ncc(c1)Br
InChi: 1S/C25H21BrClN3O3/c26-19-12-18-15-33-22-13-20(27)1-2-21(22)24(25(18)28-14-19)17-5-7-29(8-6-17)23(31)11-16-3-9-30(32)10-4-16/h1-4,9-10,12-14H,5-8,11,15H2
InChiKey: ZRMWHAYAESKTOA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[4-(3-bromo-8-chloro-5H-[1]benzoxepino[4,3-b]pyridin-11-ylidene)-1-piperidyl]-2-(1-oxidopyridin-1-ium-4-yl)ethanone
1-[4-(3-bromo-8-chloro-5H-[1]benzoxepino[4,3-b]pyridin-11-ylidene)-1-piperidinyl]-2-(1-oxido-4-pyridin-1-iumyl)ethanone
1-[4-(3-bromo-8-chloro-5H-[1]benzoxepino[4,3-b]pyridin-11-ylidene)piperidin-1-yl]-2-(1-oxidanidylpyridin-1-ium-4-yl)ethanone
1-[4-(3-bromo-8-chloro-5H-[1]benzoxepino[4,3-b]pyridin-11-ylidene)piperidino]-2-(1-oxidopyridin-1-ium-4-yl)ethanone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	farnesyltransferase, CAAX box, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium knowlesi	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Babesia bovis	protein prenyltransferase alpha subunit repeat domain containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Schistosoma mansoni	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	Get druggable targets OG5_128459	All targets in OG5_128459
Giardia lamblia	Rab geranylgeranyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Theileria parva	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Candida albicans	alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p)	Get druggable targets OG5_128459	All targets in OG5_128459
Neospora caninum	hypothetical protein	Get druggable targets OG5_128459	All targets in OG5_128459
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium berghei	protein farnesyltransferase subunit alpha, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium parvum	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium vivax	prenyltransferase alpha subunit, putative	Get druggable targets OG5_128459	All targets in OG5_128459
Plasmodium falciparum	protein farnesyltransferase subunit alpha	Get druggable targets OG5_128459	All targets in OG5_128459
Cryptosporidium hominis	farnesyltransferase	Get druggable targets OG5_128459	All targets in OG5_128459

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0246	0.0929	0.3783
Mycobacterium ulcerans	hypothetical protein	0.0093	0.0222	0.0066
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0193	0.0683	0.3531
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0107	0.0285	0.0348
Brugia malayi	hypothetical protein	0.0046	0.0002	0.0002
Loa Loa (eye worm)	uridine phosphorylase	0.0095	0.0228	0.0278
Plasmodium falciparum	purine nucleoside phosphorylase	0.0095	0.0228	0.3272
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0193	0.0683	0.2779
Mycobacterium ulcerans	hypothetical protein	0.0093	0.0222	0.0066
Mycobacterium ulcerans	hypothetical protein	0.0093	0.0222	0.0066
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0193	0.0683	0.3531
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.005	0.002	0.0038
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0095	0.0228	0.0921
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0193	0.0683	0.9869
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0002	0.0002
Mycobacterium ulcerans	secreted antigen 85-A FbpA	0.0093	0.0222	0.0066
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0195	0.0692	0.3622
Onchocerca volvulus		0.0107	0.0285	0.149
Onchocerca volvulus	Phospholipase A2 homolog	0.0047	0.0007	0.0039
Toxoplasma gondii	hypothetical protein	0.0143	0.0451	0.6508
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0457	0.1911	1
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0061	0.0073	0.0089
Brugia malayi	hypothetical protein	0.0061	0.0073	0.0089
Plasmodium vivax	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.3272
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0002	0.0002
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.3204
Plasmodium falciparum	plasmepsin VI	0.0195	0.0692	1
Toxoplasma gondii	Purine nucleoside phosphorylase	0.0095	0.0228	0.3272
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0007	0.0009
Onchocerca volvulus		0.0046	0.0002	0.001
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Mycobacterium ulcerans	5'-methylthioadenosine phosphorylase	0.0095	0.0228	0.0072
Echinococcus granulosus	methylthioadenosine phosphorylase	0.0095	0.0228	0.1131
Onchocerca volvulus		0.0107	0.0285	0.149
Echinococcus granulosus	uridine phosphorylase 1	0.0095	0.0228	0.1131
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0193	0.0683	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0225	0.083	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0649	0.0792
Echinococcus granulosus	microsomal triglyceride transfer protein large	0.0225	0.083	0.4306
Echinococcus multilocularis	uridine phosphorylase 1	0.0095	0.0228	0.1131
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0093	0.0222	0.0066
Loa Loa (eye worm)	esterase D	0.0093	0.0222	0.0271
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	0.0457	0.1911	1
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0046	0.0002	0.0002
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0046	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0379	0.0463
Mycobacterium tuberculosis	Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind	0.0093	0.0222	0.0066
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Brugia malayi	MTAP	0.0095	0.0228	0.0278
Onchocerca volvulus	Apolipophorins homolog	0.0127	0.0379	0.1985
Mycobacterium tuberculosis	Possible conserved membrane protein	0.0093	0.0222	0.0066
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.005	0.002	0.0108
Brugia malayi	amidase	0.0185	0.0649	0.0792
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0195	0.0692	0.3579
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Leishmania major	nucleoside phosphorylase-like protein	0.0095	0.0228	0.5817
Schistosoma mansoni	cathepsin D (A01 family)	0.0574	0.2454	1
Toxoplasma gondii	hypothetical protein	0.005	0.002	0.0265
Trypanosoma brucei	uridine phosphorylase	0.0095	0.0228	0.5817
Plasmodium falciparum	lysophospholipase, putative	0.0127	0.0377	0.5434
Onchocerca volvulus		0.0107	0.0285	0.149
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0095	0.0228	0.5817
Onchocerca volvulus		0.0107	0.0285	0.149
Mycobacterium ulcerans	lysophospholipase	0.0127	0.0377	0.0223
Mycobacterium tuberculosis	Conserved protein	0.0093	0.0222	0.0066
Mycobacterium ulcerans	bifunctional Mta/Sah nucleosidase Mtn	0.0095	0.0228	0.0072
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.005	0.002	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0228	0.1191
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0095	0.0228	0.5817
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0061	0.0073	0.0089
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	0.0457	0.1911	0.2334
Trypanosoma cruzi	monoglyceride lipase, putative	0.0127	0.0377	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0285	0.0348
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0193	0.0683	0.3575
Mycobacterium tuberculosis	Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular	0.0093	0.0222	0.0066
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.005	0.002	0.0265
Brugia malayi	aspartic protease BmAsp-1, identical	0.0046	0.0002	0.0002
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0127	0.0377	0.5431
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0363	0.1472	0.7684
Leishmania major	monoglyceride lipase, putative	0.0127	0.0377	1
Giardia lamblia	UPL-1	0.0095	0.0228	0.1098
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0107	0.0285	0.0348
Onchocerca volvulus		0.005	0.002	0.0105
Onchocerca volvulus		0.0107	0.0285	0.149
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0127	0.0377	0.0159
Mycobacterium ulcerans	hypothetical protein	0.0093	0.0222	0.0066
Echinococcus multilocularis	methylthioadenosine phosphorylase	0.0095	0.0228	0.1131
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0061	0.0073	0.0089
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0195	0.0692	0.0845
Echinococcus multilocularis	hormone sensitive lipase	0.0246	0.0929	0.4828
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0457	0.1911	1
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0193	0.0683	0.0834
Brugia malayi	Pepsin A precursor	0.0046	0.0002	0.0002
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.005	0.002	0.0038
Schistosoma mansoni	hypothetical protein	0.0225	0.083	0.3378
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0185	0.0649	0.3349
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.005	0.002	0.0265
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Plasmodium vivax	plasmepsin IV, putative	0.0195	0.0692	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0692	0.0845
Schistosoma mansoni	uridine phosphorylase	0.0095	0.0228	0.0921
Brugia malayi	uridine phosphorylase family protein	0.0095	0.0228	0.0278
Onchocerca volvulus		0.0046	0.0002	0.001
Loa Loa (eye worm)	S-methyl-5'-thioadenosine phosphorylase MTAP	0.0095	0.0228	0.0278
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.005	0.002	0.0075
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	0.0457	0.1911	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0185	0.0649	0.3349
Plasmodium falciparum	lysophospholipase, putative	0.0127	0.0377	0.5434
Plasmodium falciparum	esterase, putative	0.0127	0.0377	0.5434
Schistosoma mansoni	purine nucleoside phosphorylase	0.0457	0.1911	0.7787
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0127	0.0377	0.1972
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0095	0.0228	0.5817
Toxoplasma gondii	phosphorylase family protein	0.0095	0.0228	0.3272
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0127	0.0377	0.1972
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0073	0.0089
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.0228	0.1191
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0073	0.0089
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0457	0.1911	1
Onchocerca volvulus		0.0061	0.0073	0.0381
Echinococcus granulosus	Lipid transport protein N terminal	0.0127	0.0379	0.1931
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0127	0.0377	0.1972
Trichomonas vaginalis	conserved hypothetical protein	0.0127	0.0377	0.1972
Mycobacterium ulcerans	secreted Mpt51/Mpb51 antigen protein FbpD	0.0093	0.0222	0.0066
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0095	0.0228	0.0921
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Plasmodium vivax	PST-A protein	0.0127	0.0377	0.5434
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0095	0.0228	0.0072
Entamoeba histolytica	hypothetical protein	0.0095	0.0228	0.3204
Entamoeba histolytica	endo-1,4-beta-xylanase, putative	0.0093	0.0222	0.3117
Schistosoma mansoni	amidase	0.0185	0.0649	0.2638
Echinococcus multilocularis	microsomal triglyceride transfer protein large	0.0225	0.083	0.4306
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0246	0.0929	0.3783
Mycobacterium leprae	probable uridine phosphorylase	0.0095	0.0228	0.0006
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0185	0.0649	0.3349
Mycobacterium ulcerans	secreted antigen 85-B FbpB	0.0093	0.0222	0.0066
Schistosoma mansoni	biotin-protein ligase	0.0048	0.0013	0.0045
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.0683	0.3575
Mycobacterium ulcerans	secreted antigen 85-C FbpC	0.22	1	1
Plasmodium falciparum	lysophospholipase, putative	0.0127	0.0377	0.5434
Trypanosoma brucei	monoglyceride lipase, putative	0.0127	0.0377	1
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.3204
Brugia malayi	Angiotensin-converting enzyme family protein	0.181	0.8189	1
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0127	0.0377	0.1972
Onchocerca volvulus	Phospholipase A2 homolog	0.0047	0.0007	0.0039
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0195	0.0692	1
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0095	0.0228	0.5817
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	0.0457	0.1911	0.1782
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.181	0.8189	1
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0193	0.0683	1
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0127	0.0377	0.1972
Brugia malayi	Phospholipase A2 family protein	0.0047	0.0007	0.0009
Mycobacterium tuberculosis	Possible lysophospholipase	0.0127	0.0377	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0683	0.0834
Leishmania major	methylthioadenosine phosphorylase, putative	0.0095	0.0228	0.5817
Mycobacterium tuberculosis	Hypothetical protein	0.0095	0.0228	0.0072
Brugia malayi	Esterase D	0.0093	0.0222	0.0271
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0107	0.0285	0.0348
Echinococcus granulosus	hormone sensitive lipase	0.0246	0.0929	0.4828
Loa Loa (eye worm)	hypothetical protein	0.0246	0.0929	0.1135
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0195	0.0692	0.2816
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0127	0.0377	0.5431
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	0.0457	0.1911	1
Loa Loa (eye worm)	aspartyl protease 6	0.0046	0.0002	0.0002
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0185	0.0649	0.3349
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0363	0.1472	0.7684
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0073	0.0089
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0457	0.1911	1
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0195	0.0692	0.3579
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.3204
Trichomonas vaginalis	conserved hypothetical protein	0.0127	0.0377	0.1972
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.005	0.002	0.0105
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Schistosoma mansoni	uridine phosphorylase	0.0095	0.0228	0.0921
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0095	0.0228	0.5817
Schistosoma mansoni	cathepsin D (A01 family)	0.0574	0.2454	1
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0095	0.0228	0.0921
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0061	0.0073	0.0089
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	0.0363	0.1472	0.7684
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.005	0.002	0.0025
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	0.0457	0.1911	0.1728
Echinococcus multilocularis	Lipid transport protein, N terminal	0.0127	0.0379	0.1931
Toxoplasma gondii	phosphorylase family protein	0.0095	0.0228	0.3272
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.1191
Chlamydia trachomatis	AMP nucleosidase	0.0095	0.0228	1
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.3204
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0107	0.0285	0.0348
Mycobacterium ulcerans	bifunctional protein BirA	0.0151	0.0491	0.0339
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0095	0.0228	0.1098
Mycobacterium tuberculosis	Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A)	0.0093	0.0222	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0007	0.0009
Mycobacterium ulcerans	purine nucleoside phosphorylase	0.0457	0.1911	0.1782
Onchocerca volvulus		0.0107	0.0285	0.149
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0193	0.0683	0.9869
Mycobacterium tuberculosis	Probable conserved exported protein	0.0093	0.0222	0.0066
Plasmodium falciparum	plasmepsin IV	0.0195	0.0692	1
Mycobacterium ulcerans	hypothetical protein	0.0127	0.0377	0.0223
Brugia malayi	hypothetical protein	0.0061	0.0073	0.0089
Mycobacterium tuberculosis	Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase	0.0095	0.0228	0.0072
Schistosoma mansoni	purine nucleoside phosphorylase	0.0457	0.1911	0.7787
Brugia malayi	aspartic protease BmAsp-2, identical	0.0046	0.0002	0.0002
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0095	0.0228	0.3204
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.005	0.002	0.0025
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0457	0.1911	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0073	0.0089
Brugia malayi	hypothetical protein	0.0046	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0073	0.0089
Entamoeba histolytica	MTA/SAH nucleosidase, putative	0.0095	0.0228	0.3204
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0127	0.0377	0.1972
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	0.0095	0.0228	0.5817
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.005	0.002	0.0038
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0457	0.1911	1
Plasmodium vivax	aspartyl proteinase, putative	0.0195	0.0692	1
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0246	0.0929	0.3783
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0095	0.0228	0.1098
Toxoplasma gondii	aspartyl protease ASP1	0.0195	0.0692	1
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0061	0.0073	0.0089
Echinococcus multilocularis	S formylglutathione hydrolase	0.0093	0.0222	0.1101
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0193	0.0683	0.3575
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0143	0.0451	0.236
Onchocerca volvulus		0.0061	0.0073	0.0381
Plasmodium falciparum	plasmepsin I	0.0195	0.0692	1
Onchocerca volvulus		0.0107	0.0285	0.149
Giardia lamblia	Rab geranylgeranyltransferase	0.0193	0.0683	0.3506
Schistosoma mansoni	fatty-acid amide hydrolase	0.0185	0.0649	0.2638
Mycobacterium tuberculosis	Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)	0.22	1	1
Onchocerca volvulus		0.0107	0.0285	0.149
Echinococcus granulosus	purine nucleoside phosphorylase	0.0457	0.1911	1
Trypanosoma brucei	monoglyceride lipase, putative	0.0127	0.0377	1
Plasmodium falciparum	plasmepsin II	0.0195	0.0692	1
Loa Loa (eye worm)	hypothetical protein	0.0363	0.1472	0.1797
Echinococcus granulosus	S formylglutathione hydrolase	0.0093	0.0222	0.1101
Treponema pallidum	biotin--acetyl-CoA-carboxylase ligase	0.0162	0.0538	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.11 uM	In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.	ChEMBL.	9873573
IC50 (binding)	= 0.11 uM	In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.	ChEMBL.	9873573

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

PubChem: 9849786

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 138576