Detailed information for compound 138577

Basic information

Technical information
  • TDR Targets ID: 138577
  • Name: ethyl 4-(butylamino)-1-(2-chloro-2-phenylethy l)pyrazolo[3,4-b]pyridine-5-carboxylate
  • MW: 400.902 | Formula: C21H25ClN4O2
  • H donors: 1 H acceptors: 3 LogP: 4.89 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNc1c(cnc2c1cnn2CC(c1ccccc1)Cl)C(=O)OCC
  • InChi: 1S/C21H25ClN4O2/c1-3-5-11-23-19-16-13-25-26(14-18(22)15-9-7-6-8-10-15)20(16)24-12-17(19)21(27)28-4-2/h6-10,12-13,18H,3-5,11,14H2,1-2H3,(H,23,24)
  • InChiKey: SGBZEJRVXGMMLP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl 4-(butylamino)-1-(2-chloro-2-phenyl-ethyl)pyrazolo[3,4-b]pyridine-5-carboxylate
  • 4-(butylamino)-1-(2-chloro-2-phenylethyl)-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester
  • 4-(butylamino)-1-(2-chloro-2-phenyl-ethyl)pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester
  • ethyl 4-butylamino-1-(2-chloro-2-phenylethyl)pyrazolo[4,5-e]pyridine-5-carboxylate
  • ethyl 4-butylamino-1-(2-chloro-2-phenyl-ethyl)pyrazolo[4,5-e]pyridine-5-carboxylate
  • 4-butylamino-1-(2-chloro-2-phenylethyl)-5-pyrazolo[4,5-e]pyridinecarboxylic acid ethyl ester
  • 4-butylamino-1-(2-chloro-2-phenyl-ethyl)pyrazolo[4,5-e]pyridine-5-carboxylic acid ethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 314 aa 21.7 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 311 aa 21.9 %
Echinococcus multilocularis allatostatin A receptor Adenosine A1 receptor   326 aa 306 aa 26.1 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 331 aa 25.7 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.3 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 312 aa 22.1 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 311 aa 21.9 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 326 aa 20.2 %
Echinococcus granulosus allatostatin A receptor Adenosine A1 receptor   326 aa 304 aa 25.3 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 277 aa 23.8 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 296 aa 22.6 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A1 receptor   326 aa 318 aa 22.3 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 315 aa 23.8 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 312 aa 24.0 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 307 aa 21.2 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 301 aa 25.6 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.003 0.0323
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1096
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0211 0.3047
Leishmania major methylthioadenosine phosphorylase, putative 0.0035 0.0116 0.1735
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0038 0.013 0.0226
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0025 0.0073 0.2029
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0038 0.013 0.0226
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0105 0.0441 0.7038
Loa Loa (eye worm) cytochrome P450 family protein 0.0076 0.0306 0.0555
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.003 0.0036
Onchocerca volvulus 0.007 0.0278 0.3722
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.003 0.0054
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0038 0.013 0.1957
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0035 0.0116 0.1234
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0441 0.4447
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0105 0.0441 0.7038
Trypanosoma cruzi Biotin--acetyl-CoA-carboxylase ligase, putative 0.004 0.0143 0.2164
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0221 0.098 0.098
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.003 0.0204
Mycobacterium tuberculosis Hypothetical protein 0.0035 0.0116 0.0201
Mycobacterium leprae probable uridine phosphorylase 0.0035 0.0116 0.0201
Brugia malayi aspartic protease BmAsp-1, identical 0.0052 0.0198 0.0342
Brugia malayi Cytochrome P450 family protein 0.0076 0.0306 0.0538
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0105 0.0441 0.7038
Echinococcus granulosus purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Giardia lamblia UPL-1 0.0035 0.0116 0.1234
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.003 0.003
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0025 0.0073 0.0654
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0233 0.042
Loa Loa (eye worm) uridine phosphorylase 0.0035 0.0116 0.0211
Plasmodium vivax plasmepsin V, putative 0.0052 0.0198 0.1938
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.003 0.0323
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0233 0.3633
Schistosoma mansoni ap endonuclease 0.0079 0.0322 0.0313
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0038 0.013 0.0226
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0035 0.0116 0.1735
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0035 0.0116 0.1115
Loa Loa (eye worm) hypothetical protein 0.007 0.0278 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.0623 0.6318
Brugia malayi hypothetical protein 0.0052 0.0198 0.0342
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0217 0.0208
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.003 0.0204
Brugia malayi Pepsin A precursor 0.0052 0.0198 0.0342
Echinococcus multilocularis purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0221 0.098 0.178
Mycobacterium ulcerans peptide amidase, GatA 0.0025 0.0073 0.012
Plasmodium falciparum esterase, putative 0.0144 0.0623 0.6318
Loa Loa (eye worm) cytochrome P450 family protein 0.0076 0.0306 0.0555
Echinococcus multilocularis lamin dm0 0.0028 0.0085 0.0085
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0211 0.3047
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0217 0.0391
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0121 0.0518 0.0925
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.003 0.0204
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0167 0.0731 1
Onchocerca volvulus 0.0052 0.0198 0.2607
Schistosoma mansoni cpg binding protein 0.0031 0.0099 0.0089
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.003 0.0323
Schistosoma mansoni lamin 0.0028 0.0085 0.0075
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.003 0.0323
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0038 0.013 0.0226
Mycobacterium leprae POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS 0.0029 0.0088 0.0148
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0322 0.3221
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0018 0.0018
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.003 0.0204
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0038 0.013 0.0226
Loa Loa (eye worm) hypothetical protein 0.0279 0.1248 0.2268
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0038 0.013 0.0226
Plasmodium falciparum plasmepsin VI 0.0221 0.098 1
Plasmodium falciparum plasmepsin V 0.0052 0.0198 0.1938
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0038 0.013 0.1957
Plasmodium falciparum plasmepsin IX 0.0052 0.0198 0.1938
Trypanosoma cruzi monoglyceride lipase, putative 0.0144 0.0623 1
Schistosoma mansoni amidase 0.021 0.0931 0.0921
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0038 0.013 0.0226
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0038 0.013 0.0226
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0167 0.0731 1
Toxoplasma gondii phosphorylase family protein 0.0035 0.0116 0.1096
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0167 0.0731 0.1312
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0105 0.0441 0.7038
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0025 0.0073 0.0073
Mycobacterium ulcerans hypothetical protein 0.0049 0.0183 0.0327
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0025 0.0073 0.012
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.003 0.0036
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1096
Onchocerca volvulus 0.0016 0.003 0.0275
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0038 0.013 0.1957
Onchocerca volvulus 0.0026 0.0074 0.0888
Mycobacterium ulcerans hypothetical protein 0.0049 0.0183 0.0327
Echinococcus multilocularis uridine phosphorylase 1 0.0035 0.0116 0.0116
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.003 0.0323
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.003 0.0204
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0167 0.0731 0.7433
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0026 0.0074 0.1044
Echinococcus granulosus cpg binding protein 0.0033 0.0107 0.0107
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.003 0.0323
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0026 0.0074 0.0074
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0233 0.2295
Onchocerca volvulus 0.0121 0.0518 0.7051
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0038 0.013 0.0226
Loa Loa (eye worm) hypothetical protein 0.007 0.0278 0.0506
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0217 0.0391
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0028 0.0085 0.0154
Echinococcus multilocularis fatty acid amide hydrolase 1 0.021 0.0931 0.0931
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0198 0.0188
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0038 0.013 0.1957
Loa Loa (eye worm) hypothetical protein 0.007 0.0278 0.0506
Loa Loa (eye worm) aspartyl protease 6 0.0052 0.0198 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0074 0.066
Echinococcus granulosus lamin dm0 0.0028 0.0085 0.0085
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.003 0.0323
Loa Loa (eye worm) biotin protein ligase 1 0.004 0.0143 0.0259
Echinococcus multilocularis synaptic glycoprotein sc2 0.0026 0.0074 0.0074
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0025 0.0073 0.0073
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0221 0.098 0.098
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0025 0.0073 0.012
Brugia malayi Cytochrome P450 family protein 0.0038 0.013 0.0218
Echinococcus multilocularis synaptojanin 1 0.0016 0.003 0.003
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.003 0.0036
Schistosoma mansoni synaptojanin 0.0016 0.003 0.002
Plasmodium vivax biotin--[acetyl-CoA-carboxylase] synthetase, putative 0.004 0.0143 0.1367
Plasmodium vivax aspartyl proteinase, putative 0.0052 0.0198 0.1938
Brugia malayi Amidase family protein 0.0025 0.0073 0.0115
Giardia lamblia Synaptic glycoprotein SC2 0.0026 0.0074 0.063
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0052 0.0198 0.036
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.003 0.0036
Trypanosoma cruzi amidase, putative 0.0025 0.0073 0.1034
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0079 0.0322 0.0322
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0038 0.013 0.0226
Schistosoma mansoni hypothetical protein 0.0038 0.013 0.012
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0049 0.0183 0.0327
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.003 0.0204
Giardia lamblia Kinase, CMGC MAPK 0.0105 0.0441 0.5869
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.003 0.0204
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.003 0.0323
Mycobacterium leprae SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR 0.0049 0.0183 0.0327
Entamoeba histolytica hypothetical protein 0.0035 0.0116 0.1459
Mycobacterium ulcerans hypothetical protein 0.0026 0.0074 0.0121
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.003 0.0323
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.003 0.0323
Plasmodium falciparum plasmepsin VII 0.0052 0.0198 0.1938
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0016 0.003 0.0323
Trypanosoma cruzi cytochrome P450, putative 0.0076 0.0306 0.4825
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0038 0.013 0.0226
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1459
Wolbachia endosymbiont of Brugia malayi biotin-(acetyl-CoA carboxylase) ligase 0.004 0.0143 0.4245
Echinococcus multilocularis purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Plasmodium vivax aspartyl protease, putative 0.0052 0.0198 0.1938
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0233 0.0223
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0161
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0149
Mycobacterium ulcerans secreted antigen 85-B FbpB 0.0049 0.0183 0.0327
Plasmodium falciparum polyprenol reductase, putative 0.0026 0.0074 0.066
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1459
Schistosoma mansoni microtubule-associated protein tau 0.2168 1 1
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.0623 0.6318
Leishmania major biotin/lipoate protein ligase-like protein 0.004 0.0143 0.2164
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0026 0.0074 0.066
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0211 0.3047
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0038 0.013 0.0226
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0025 0.0073 0.3162
Loa Loa (eye worm) hypothetical protein 0.0052 0.0196 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0116 0.1096
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0198 0.0188
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0038 0.013 0.0226
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0198 0.0188
Plasmodium vivax polyprenol reductase, putative 0.0026 0.0074 0.066
Echinococcus multilocularis purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0233 0.042
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.003 0.003
Toxoplasma gondii cytochrome p450 superfamily protein 0.0038 0.013 0.1237
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0025 0.0073 0.012
Echinococcus granulosus dnaJ subfamily B 0.0439 0.1988 0.1988
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0144 0.0623 0.6318
Echinococcus multilocularis purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0054
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.003 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.003 0.0323
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.003 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0054
Brugia malayi MAP kinase sur-1 0.0105 0.0441 0.0785
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.003 0.0204
Echinococcus granulosus purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Brugia malayi amidase 0.021 0.0931 0.1675
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0035 0.0116 0.1735
Echinococcus granulosus synaptojanin 1 0.0016 0.003 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0233 0.0223
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.003 0.0204
Mycobacterium leprae Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0049 0.0183 0.0327
Brugia malayi hypothetical protein 0.0244 0.1084 0.1956
Schistosoma mansoni synaptojanin 0.0016 0.003 0.002
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0038 0.013 0.0226
Brugia malayi putative amidase 0.0025 0.0073 0.0115
Echinococcus multilocularis purine nucleoside phosphorylase 0.0133 0.057 0.057
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.013 0.0236
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0038 0.013 0.0226
Onchocerca volvulus 0.0031 0.0099 0.1228
Plasmodium vivax exodeoxyribonuclease III, putative 0.0016 0.003 0.0204
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0026 0.0074 0.0064
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.003 0.0323
Echinococcus granulosus mitogen activated protein kinase 0.0105 0.0441 0.0441
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0133 0.057 0.057
Plasmodium vivax hypothetical protein, conserved 0.0016 0.003 0.0204
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0026 0.0074 0.0116
Trypanosoma cruzi UDP-glucoronosyl and UDP-glucosyl transferase, putative 0.004 0.014 0.2122
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0035 0.0116 0.1735
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0035 0.0116 0.0116
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.003 0.0036
Onchocerca volvulus 0.0052 0.0196 0.2578
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0211 0.3047
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.003 0.0323
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.1988 0.1988
Plasmodium falciparum plasmepsin I 0.0221 0.098 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0144 0.0623 0.6318
Brugia malayi cytochrome P450 0.0038 0.013 0.0218
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0221 0.098 1
Mycobacterium tuberculosis Conserved protein 0.0049 0.0183 0.0327
Schistosoma mansoni biotin-protein ligase 0.0055 0.0211 0.0201
Brugia malayi CXXC zinc finger family protein 0.0031 0.0099 0.0161
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0211 0.3047
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0279 0.1248 0.124
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0025 0.0073 0.0561
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0026 0.0074 0.066
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0026 0.0074 0.1044
Echinococcus granulosus purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.02 0.0363
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0026 0.0074 0.066
Onchocerca volvulus 0.005 0.0186 0.2442
Loa Loa (eye worm) hypothetical protein 0.0052 0.0198 0.036
Toxoplasma gondii exonuclease III APE 0.0079 0.0322 0.3221
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0038 0.013 0.0226
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.003 0.0323
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1096
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.003 0.0323
Echinococcus granulosus 5'partial|biotin protein ligase 0.0029 0.0088 0.0088
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0079 0.0322 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0038 0.013 0.0226
Schistosoma mansoni hypothetical protein 0.005 0.0186 0.0176
Schistosoma mansoni cathepsin D (A01 family) 0.0652 0.2975 0.2968
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0026 0.0074 0.0745
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0025 0.0027
Brugia malayi intermediate filament protein 0.0028 0.0085 0.0136
Onchocerca volvulus 0.0121 0.0518 0.7051
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.007 0.0278 0.0488
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0026 0.0074 0.066
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0105 0.0441 0.0802
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0279 0.1248 0.124
Treponema pallidum pfs protein (pfs) 0.0035 0.0116 0.1115
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0054
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0217 0.0377
Brugia malayi CCR4 0.0016 0.003 0.0036
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0016 0.003 0.0204
Plasmodium falciparum biotin--acetyl-CoA-carboxylase, putative 0.004 0.0143 0.1367
Loa Loa (eye worm) hypothetical protein 0.007 0.0278 0.0506
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.003 0.003
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0038 0.013 0.0226
Echinococcus granulosus fatty acid amide hydrolase 1 0.0025 0.0073 0.0073
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.003 0.0204
Mycobacterium tuberculosis Possible lysophospholipase 0.0144 0.0623 0.1157
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0025 0.0073 0.012
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.003 0.0054
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0038 0.013 0.0226
Echinococcus multilocularis 0.0038 0.013 0.013
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1096
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0279 0.1248 0.124
Leishmania major hypothetical protein, conserved 0.0016 0.003 0.0323
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.1084 0.1084
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0144 0.0623 0.6318
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0026 0.0074 0.1044
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.1155 0.5306 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0221 0.098 0.178
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0038 0.013 0.0226
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0079 0.0322 0.4173
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.003 0.0323
Echinococcus multilocularis biotin protein ligase 0.004 0.0143 0.0143
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.003 0.0323
Echinococcus multilocularis fatty acid amide hydrolase 1 0.021 0.0931 0.0931
Brugia malayi Synaptic glycoprotein SC2 0.0026 0.0074 0.0116
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0026 0.0074 0.066
Mycobacterium ulcerans amidase 0.0025 0.0073 0.012
Leishmania major hypothetical protein, conserved 0.0025 0.0073 0.1034
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0038 0.013 0.0226
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0038 0.013 0.0226
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0078 0.081
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0038 0.013 0.0226
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0026 0.0074 0.066
Echinococcus granulosus synaptic glycoprotein sc2 0.0026 0.0074 0.0074
Onchocerca volvulus 0.0121 0.0518 0.7051
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.007 0.0278 0.0488
Loa Loa (eye worm) hypothetical protein 0.0244 0.1084 0.197
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0035 0.0116 0.1735
Schistosoma mansoni cript-related 0.0016 0.003 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0054
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.003 0.002
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0025 0.0073 0.012
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0018 0.0018
Schistosoma mansoni cathepsin D (A01 family) 0.0652 0.2975 0.2968
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0026 0.0074 0.0064
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0221 0.098 1
Trypanosoma cruzi amidase, putative 0.0025 0.0073 0.1034
Echinococcus multilocularis S formylglutathione hydrolase 0.0049 0.0183 0.0183
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0076 0.0306 0.0558
Leishmania major monoglyceride lipase, putative 0.0144 0.0623 1
Leishmania major cytochrome p450-like protein 0.0038 0.013 0.1957
Chlamydia trachomatis AMP nucleosidase 0.0035 0.0116 0.5303
Echinococcus multilocularis purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Mycobacterium leprae Conserved hypothetical protein 0.0038 0.013 0.0226
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0026 0.0074 0.0745
Echinococcus granulosus purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0038 0.013 0.0226
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0033
Schistosoma mansoni fatty-acid amide hydrolase 0.0025 0.0073 0.0063
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0078 0.081
Mycobacterium ulcerans lysophospholipase 0.0144 0.0623 0.1157
Schistosoma mansoni methylthioadenosine phosphorylase 0.0035 0.0116 0.0106
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0025 0.0073 0.0073
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1096
Plasmodium falciparum plasmepsin III 0.0052 0.0198 0.1938
Mycobacterium ulcerans bifunctional protein BirA 0.0172 0.0752 0.14
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.003 0.0323
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0221 0.098 0.0971
Mycobacterium ulcerans secreted antigen 85-A FbpA 0.0049 0.0183 0.0327
Echinococcus granulosus N terminal of biotin protein ligase 0.0055 0.0211 0.0211
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0217 0.3383
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0016 0.003 0.0323
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.003 0.0054
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.1155 0.5306 1
Echinococcus granulosus octanoyltransferase mitochondrial 0.0012 0.001 0.001
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0085 0.0136
Loa Loa (eye worm) CYP4Cod1 0.0076 0.0306 0.0555
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0211 0.3047
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.003 0.0275
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0105 0.0441 0.7038
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0211 0.3047
Leishmania major hypothetical protein, conserved 0.0016 0.003 0.0323
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.003 0.0054
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.003 0.0204
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0025 0.0073 0.012
Schistosoma mansoni cpg binding protein 0.0033 0.0107 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0116 0.1096
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0025 0.0073 0.1034
Echinococcus multilocularis biotin protein ligase 0.004 0.0143 0.0143
Leishmania major hypothetical protein, conserved 0.0016 0.003 0.0323
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0322 0.3221
Treponema pallidum biotin--acetyl-CoA-carboxylase ligase 0.0183 0.0806 1
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0035 0.0116 0.1459
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0217 0.0391
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0035 0.0116 0.0201
Echinococcus granulosus purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Echinococcus multilocularis hormone sensitive lipase 0.0279 0.1248 0.1248
Trypanosoma brucei uridine phosphorylase 0.0035 0.0116 0.1735
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0167 0.0731 0.1361
Schistosoma mansoni memapsin-2 (A01 family) 0.0052 0.0198 0.0188
Brugia malayi Amidase family protein 0.0025 0.0073 0.0115
Onchocerca volvulus 0.0121 0.0518 0.7051
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0026 0.0074 0.1044
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0049 0.0183 0.0327
Schistosoma mansoni survival motor neuron protein 0.005 0.0186 0.0176
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0025 0.0045
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0079 0.0322 0.4934
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.003 0.003
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0026 0.0074 0.066
Brugia malayi Esterase D 0.0049 0.0183 0.0315
Trypanosoma cruzi cytochrome P450, putative 0.0076 0.0306 0.4825
Onchocerca volvulus 0.0028 0.0085 0.1034
Schistosoma mansoni fatty-acid amide hydrolase 0.021 0.0931 0.0921
Echinococcus granulosus S formylglutathione hydrolase 0.0049 0.0183 0.0183
Plasmodium falciparum biotin protein ligase, putative 0.004 0.0143 0.1367
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0038 0.013 0.0226
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0016 0.003 0.0323
Trypanosoma brucei protein kinase, putative 0.0105 0.0441 0.7038
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1459
Treponema pallidum exodeoxyribonuclease (exoA) 0.0079 0.0322 0.3771
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.003 0.003
Trypanosoma cruzi Biotin--acetyl-CoA-carboxylase ligase, putative 0.004 0.0143 0.2164
Mycobacterium ulcerans secreted Mpt51/Mpb51 antigen protein FbpD 0.0049 0.0183 0.0327
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0025 0.0073 0.0654
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0079 0.0322 0.059
Schistosoma mansoni uridine phosphorylase 0.0035 0.0116 0.0106
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0026 0.0074 0.066
Schistosoma mansoni ap endonuclease 0.0079 0.0322 0.0313
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0085 0.0154
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0038 0.013 0.0226
Brugia malayi LBP/BPI 0.0052 0.0196 0.0338
Plasmodium falciparum plasmepsin VIII, putative 0.0052 0.0198 0.1938
Loa Loa (eye worm) hypothetical protein 0.0133 0.057 0.1036
Echinococcus multilocularis octanoyltransferase, mitochondrial 0.0012 0.001 0.001
Plasmodium falciparum lysophospholipase, putative 0.0144 0.0623 0.6318
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0121 0.0518 0.0925
Brugia malayi MTAP 0.0035 0.0116 0.0194
Plasmodium falciparum lysophospholipase, putative 0.0144 0.0623 0.6318
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0441 0.0432
Loa Loa (eye worm) hypothetical protein 0.007 0.0278 0.0506
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0211 0.3047
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.003 0.0204
Trypanosoma brucei monoglyceride lipase, putative 0.0144 0.0623 1
Mycobacterium tuberculosis Probable conserved exported protein 0.0049 0.0183 0.0327
Loa Loa (eye worm) amidase 0.0025 0.0073 0.0133
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0198 0.0188
Schistosoma mansoni cpg binding protein 0.0033 0.0107 0.0097
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.002
Brugia malayi Cytochrome P450 family protein 0.0038 0.013 0.0218
Trypanosoma brucei Biotin--acetyl-CoA-carboxylase ligase, putative 0.004 0.0143 0.2164
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0134
Mycobacterium ulcerans amidase 0.0025 0.0073 0.012
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1198 0.5504 1
Brugia malayi hypothetical protein 0.007 0.0278 0.0488
Plasmodium falciparum plasmepsin X 0.0052 0.0198 0.1938
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0167 0.0731 0.1361
Onchocerca volvulus 0.0121 0.0518 0.7051
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1096
Brugia malayi Angiotensin-converting enzyme family protein 0.1198 0.5504 1
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0026 0.0074 0.0074
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0198 0.0188
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0079 0.0322 0.5098
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0035 0.0116 0.1234
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.003 0.0323
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1096
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0079 0.0322 0.059
Echinococcus granulosus methylthioadenosine phosphorylase 0.0035 0.0116 0.0116
Mycobacterium ulcerans amidase 0.0025 0.0073 0.012
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0079 0.0322 0.0586
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.003 0.0204
Echinococcus granulosus fatty acid amide hydrolase 1 0.021 0.0931 0.0931
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.003 0.003
Echinococcus granulosus uridine phosphorylase 1 0.0035 0.0116 0.0116
Echinococcus granulosus purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.003 0.0054
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.003 0.0036
Chlamydia trachomatis hypothetical protein 0.0055 0.0211 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0028
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0322 0.3221
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.007 0.0278 0.0506
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.003 0.0204
Echinococcus granulosus cytochrome P450 2K1 0.0038 0.013 0.013
Mycobacterium tuberculosis Possible conserved membrane protein 0.0049 0.0183 0.0327
Entamoeba histolytica hypothetical protein 0.0026 0.0074 0.0745
Mycobacterium ulcerans hypothetical protein 0.0049 0.0183 0.0327
Mycobacterium ulcerans hypothetical protein 0.0049 0.0183 0.0327
Echinococcus granulosus fatty acid amide hydrolase 1 0.021 0.0931 0.0931
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0121 0.0518 0.0942
Echinococcus multilocularis musashi 0.0028 0.0085 0.0085
Onchocerca volvulus 0.0016 0.003 0.0275
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0026 0.0074 0.066
Onchocerca volvulus 0.007 0.0278 0.3722
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0099 0.0179
Toxoplasma gondii Purine nucleoside phosphorylase 0.0035 0.0116 0.1096
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0038 0.013 0.0226
Loa Loa (eye worm) hypothetical protein 0.0052 0.0196 0.0356
Leishmania major cytochrome p450-like protein 0.0076 0.0306 0.4825
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0105 0.0441 0.7038
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0079 0.0322 0.5098
Trypanosoma brucei cytochrome P450, putative 0.0076 0.0306 0.4825
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0441 0.4447
Schistosoma mansoni hypothetical protein 0.0439 0.1988 0.198
Loa Loa (eye worm) esterase D 0.0049 0.0183 0.0333
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0025 0.0073 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0233 0.042
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0035 0.0116 0.1735
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0026 0.0074 0.1044
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0038 0.013 0.0226
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.003 0.0204
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0035 0.0116 0.1735
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.003 0.0323
Echinococcus multilocularis lamin 0.0028 0.0085 0.0085
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0144 0.0623 0.6318
Onchocerca volvulus 0.0121 0.0518 0.7051
Brugia malayi aspartic protease BmAsp-2, identical 0.0052 0.0198 0.0342
Plasmodium falciparum plasmepsin II 0.0221 0.098 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0018
Brugia malayi biotin--acetyl-CoA-carboxylase ligase family protein 0.004 0.0143 0.0241
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0026 0.0074 0.066
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0144 0.0623 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0038 0.013 0.0226
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0144 0.0623 1
Plasmodium falciparum plasmepsin IV 0.0221 0.098 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0132 0.0239
Plasmodium falciparum DNase I-like protein, putative 0.0016 0.003 0.0204
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1459
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0038 0.013 0.1957
Loa Loa (eye worm) hypothetical protein 0.0052 0.0196 0.0356
Loa Loa (eye worm) hypothetical protein 0.021 0.0931 0.1691
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0016 0.003 0.0323
Brugia malayi Cytochrome P450 family protein 0.0076 0.0306 0.0538
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.003 0.0204
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0217 0.0217
Brugia malayi hypothetical protein 0.007 0.0278 0.0488
Leishmania major cytochrome p450-like protein 0.0038 0.013 0.1957
Echinococcus multilocularis purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0196 0.1916
Plasmodium vivax aspartyl protease, putative 0.0052 0.0198 0.1938
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0038 0.013 0.0226
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0259 0.0249
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.003 0.0204
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0052 0.0198 0.1938
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.003 0.003
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0144 0.0623 0.6318
Chlamydia trachomatis biotin synthetase 0.004 0.0143 0.6615
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0322 0.3221
Echinococcus granulosus hormone sensitive lipase 0.0279 0.1248 0.1248
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0026 0.0074 0.0745
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0025 0.0073 0.012
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0198 0.0188
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.1155 0.5306 1
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0049 0.0183 0.0327
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0035 0.0116 0.0201
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0038 0.013 0.0226
Echinococcus multilocularis mitogen activated protein kinase 0.0105 0.0441 0.0441
Schistosoma mansoni uridine phosphorylase 0.0035 0.0116 0.0106
Echinococcus multilocularis mitogen activated protein kinase 3 0.0105 0.0441 0.0441
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0198 0.0188
Schistosoma mansoni methylthioadenosine phosphorylase 0.0035 0.0116 0.0106
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.0254
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0052 0.0198 0.036
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.003 0.0054
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0105 0.0441 0.4447
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0441 0.4447
Treponema pallidum uridine phosphorylase (udp) 0.0035 0.0116 0.1115
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0079 0.0322 0.5098
Loa Loa (eye worm) hypothetical protein 0.0121 0.0518 0.0942
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0134
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0226 0.2229
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.003 0.0036
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.007 0.0278 0.0506
Mycobacterium ulcerans amidase 0.0025 0.0073 0.012
Echinococcus granulosus mitogen activated protein kinase 3 0.0105 0.0441 0.0441
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.003 0.003
Brugia malayi uridine phosphorylase family protein 0.0035 0.0116 0.0194
Echinococcus multilocularis purine nucleoside phosphorylase 0.0133 0.057 0.057
Toxoplasma gondii phosphorylase family protein 0.0035 0.0116 0.1096
Plasmodium falciparum purine nucleoside phosphorylase 0.0035 0.0116 0.1096
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0038 0.013 0.0226
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0038 0.013 0.0226
Onchocerca volvulus 0.0121 0.0518 0.7051
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0035 0.0116 0.0201
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0085 0.0154
Schistosoma mansoni intermediate filament proteins 0.0028 0.0085 0.0075
Leishmania major nucleoside phosphorylase-like protein 0.0035 0.0116 0.1735
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.003 0.0036
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0038 0.013 0.0226
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0038 0.013 0.0226
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.1084 0.1084
Brugia malayi exodeoxyribonuclease III family protein 0.0079 0.0322 0.0569
Mycobacterium tuberculosis Probable exported protein 0.0016 0.003 0.0037
Leishmania major pantothenate kinase subunit, putative 0.0016 0.003 0.0323
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.003 0.002
Plasmodium vivax aspartyl protease, putative 0.0052 0.0198 0.1938
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.003 0.0323
Echinococcus granulosus purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Echinococcus multilocularis cpg binding protein 0.0033 0.0107 0.0107
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.003 0.0323
Toxoplasma gondii aspartyl protease ASP3 0.0052 0.0198 0.1938
Mycobacterium ulcerans hypothetical protein 0.0144 0.0623 0.1157
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0105 0.0441 0.7038
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0038 0.013 0.0226
Onchocerca volvulus 0.0121 0.0518 0.7051
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0079 0.0322 0.0322
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1096
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0049 0.0183 0.0327
Plasmodium vivax PST-A protein 0.0144 0.0623 0.6318
Mycobacterium tuberculosis Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas 0.0029 0.0088 0.0148
Echinococcus multilocularis microtubule associated protein 2 0.2168 1 1
Schistosoma mansoni nocturnin 0.0016 0.003 0.002
Trypanosoma brucei monoglyceride lipase, putative 0.0144 0.0623 1
Plasmodium falciparum lysophospholipase, putative 0.0144 0.0623 0.6318
Toxoplasma gondii aspartyl protease ASP1 0.0221 0.098 1
Schistosoma mansoni purine nucleoside phosphorylase 0.0167 0.0731 0.0722
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0144 0.0623 0.1157
Loa Loa (eye worm) cytochrome P450 0.0038 0.013 0.0236
Toxoplasma gondii aspartyl protease 0.0052 0.0198 0.1938
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0074 0.066
Schistosoma mansoni lamin 0.0028 0.0085 0.0075
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.007 0.0278 0.0488
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0016 0.003 0.0204
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0211 0.3047
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0052 0.0198 0.0188
Brugia malayi hypothetical protein 0.0052 0.0196 0.0338
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0035 0.0116 0.0211
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.003 0.0204
Mycobacterium leprae putative cytochrome p450 0.0038 0.013 0.0226
Entamoeba histolytica biotin--acetyl-CoA-carboxylase ligase, putative 0.004 0.0143 0.1902
Onchocerca volvulus 0.0028 0.0085 0.1034
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0028
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0035 0.0116 0.1459
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.003 0.0204
Schistosoma mansoni cytochrome P450 0.0038 0.013 0.012
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0026 0.0074 0.066
Brugia malayi Eukaryotic aspartyl protease family protein 0.0052 0.0198 0.0342
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0038 0.013 0.0226
Echinococcus multilocularis N terminal of biotin protein ligase 0.0055 0.0211 0.0211
Echinococcus granulosus lamin 0.0028 0.0085 0.0085
Brugia malayi hypothetical protein 0.0052 0.0198 0.0342
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0038 0.013 0.0226
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0026 0.0074 0.066
Plasmodium vivax aspartyl proteinase, putative 0.0221 0.098 1
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0121 0.0518 0.0925
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.003 0.0204
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0233 0.042
Loa Loa (eye worm) hypothetical protein 0.0052 0.0196 0.0356
Schistosoma mansoni biotin-protein ligase 0.004 0.0143 0.0133
Schistosoma mansoni methylthioadenosine phosphorylase 0.0035 0.0116 0.0106
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.003 0.003
Loa Loa (eye worm) amidase 0.0025 0.0073 0.0133
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0088 0.0161
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0026 0.0074 0.1044
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0441 0.4447
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0038 0.013 0.0226
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0186 0.032
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0049 0.0183 0.2585
Echinococcus granulosus intermediate filament protein 0.0028 0.0085 0.0085
Plasmodium vivax plasmepsin IV, putative 0.0221 0.098 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0134
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0025 0.0073 0.012
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0217 0.0217
Giardia lamblia Hypothetical protein 0.004 0.0143 0.1609
Onchocerca volvulus 0.0052 0.0198 0.2607
Mycobacterium ulcerans amidase 0.0025 0.0073 0.012
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0079 0.0322 0.5098
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0167 0.0731 0.1361
Echinococcus granulosus purine nucleoside phosphorylase 0.0167 0.0731 0.0731
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0038 0.013 0.0226
Schistosoma mansoni purine nucleoside phosphorylase 0.0167 0.0731 0.0722
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0116 0.0201
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0144 0.0623 0.6318

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 3 % Percent inhibition of specific [3H]-CGS-21,680 binding to adenosine A2A receptors in bovine cortical membranes at 10 microM concentration ChEMBL. 12383013
Inhibition (binding) = 3 % Percent inhibition of [3H]-CGS-21,680 binding to A2A adenosine receptor of bovine striatal membrane at 10 uM ChEMBL. 11549462
Inhibition (binding) = 3 % Percent inhibition of specific [3H]-CGS-21,680 binding to adenosine A2A receptors in bovine cortical membranes at 10 microM concentration ChEMBL. 12383013
Inhibition (binding) = 3 % Percent inhibition of [3H]-CGS-21,680 binding to A2A adenosine receptor of bovine striatal membrane at 10 uM ChEMBL. 11549462
Ki (binding) = 4100 nM Binding affinity to Adenosine A1 receptor in bovine cortical membranes by [3H]-N6-cyclohexyl adenosine displacement. ChEMBL. 12383013
Ki (binding) = 4100 nM Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membrane expressed as Ki ChEMBL. 11549462
Ki (binding) = 4100 nM Binding affinity to Adenosine A1 receptor in bovine cortical membranes by [3H]-N6-cyclohexyl adenosine displacement. ChEMBL. 12383013
Ki (binding) = 4100 nM Displacement of [3H]-CHA from Adenosine A1 receptor in bovine cortical membrane expressed as Ki ChEMBL. 11549462

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.