Detailed information for compound 138636

Basic information

Technical information
  • TDR Targets ID: 138636
  • Name: 2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-tetraz ol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetr ahydrophthalazin-1-one
  • MW: 584.708 | Formula: C33H40N6O4
  • H donors: 1 H acceptors: 4 LogP: 6.22 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1OCCCCOc1ccc(cc1)c1n[nH]nn1)C1=NN(C2CCCCCC2)C(=O)C2C1CC=CC2
  • InChi: 1S/C33H40N6O4/c1-41-29-19-16-24(31-27-12-6-7-13-28(27)33(40)39(36-31)25-10-4-2-3-5-11-25)22-30(29)43-21-9-8-20-42-26-17-14-23(15-18-26)32-34-37-38-35-32/h6-7,14-19,22,25,27-28H,2-5,8-13,20-21H2,1H3,(H,34,35,37,38)
  • InChiKey: DNDNLFXKQSTINI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-cycloheptyl-4-[4-methoxy-3-[4-[4-(2H-1,2,3,4-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4a,5,8,8a-tetrahydrophthalazin-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4C, cAMP-specific References
Homo sapiens phosphodiesterase 4D, cAMP-specific Starlite/ChEMBL References
Homo sapiens phosphodiesterase 3B, cGMP-inhibited References
Homo sapiens phosphodiesterase 3A, cGMP-inhibited Starlite/ChEMBL References
Trypanosoma brucei cAMP-specific phosphodiesterase Starlite/ChEMBL References
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative References
Homo sapiens phosphodiesterase 4A, cAMP-specific References
Homo sapiens phosphodiesterase 4B, cAMP-specific References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma congolense cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum expressed protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_132613 All targets in OG5_132613
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania infantum cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma congolense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania braziliensis cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania donovani cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Candida albicans similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Trypanosoma cruzi cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei cAMP-specific phosphodiesterase Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trypanosoma brucei gambiense cAMP-specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative Get druggable targets OG5_127318 All targets in OG5_127318
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127318 All targets in OG5_127318
Leishmania mexicana cAMP specific phosphodiesterase, putative Get druggable targets OG5_127318 All targets in OG5_127318
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0151 0.034 0.0715
Leishmania major importin beta-1 subunit, putative 0.0121 0.0219 0.087
Brugia malayi RNA, U transporter 1 0.0424 0.1445 0.1469
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.034 0.1767
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0087 0.0082 0.0083
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.031 0.0984 0.0984
Trypanosoma brucei hypothetical protein, conserved 0.0179 0.0454 0.2352
Brugia malayi RNA binding protein 0.0135 0.0278 0.0283
Echinococcus multilocularis sodium and chloride dependent glycine 0.0169 0.0415 0.0422
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1666 0.8985
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0525 0.1852 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0151 0.034 0.0346
Trypanosoma cruzi hypothetical protein, conserved 0.0179 0.0454 0.2352
Brugia malayi TAR-binding protein 0.0135 0.0278 0.0283
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0418 0.1422 0.1445
Schistosoma mansoni importin beta-1 0.0149 0.0333 0.0333
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0478 0.1666 0.1666
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0097 0.0123 0.0125
Loa Loa (eye worm) hypothetical protein 0.2498 0.9836 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0184 0.0188
Mycobacterium leprae conserved hypothetical protein 0.0151 0.034 0.1772
Mycobacterium tuberculosis Conserved protein 0.0151 0.034 0.0715
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.0278 0.0283
Brugia malayi beta-lactamase family protein 0.0151 0.034 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0454 0.2388
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0179 0.0454 0.4127
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0225 0.0641 0.3403
Loa Loa (eye worm) hypothetical protein 0.0211 0.0582 0.0592
Echinococcus multilocularis protein dispatched 1 0.0098 0.0126 0.0128
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0248 0.0735 0.4124
Schistosoma mansoni hypothetical protein 0.0083 0.0064 0.0064
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0179 0.0454 0.2388
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.0313 0.0318
Schistosoma mansoni hypothetical protein 0.0144 0.0313 0.0313
Echinococcus granulosus snurportin 1 0.1591 0.6167 0.627
Echinococcus multilocularis Niemann Pick C1 protein 0.0285 0.0884 0.0899
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0179 0.0454 0.2388
Plasmodium falciparum phosphodiesterase delta, putative 0.0179 0.0454 0.4127
Loa Loa (eye worm) hypothetical protein 0.0169 0.0415 0.0422
Leishmania major hypothetical protein, conserved 0.0179 0.0454 0.2352
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Mycobacterium tuberculosis Probable reductase 0.0201 0.0544 0.1292
Echinococcus granulosus tar DNA binding protein 0.0135 0.0278 0.0283
Loa Loa (eye worm) hypothetical protein 0.0112 0.0184 0.0188
Trypanosoma brucei hypothetical protein, conserved 0.0151 0.034 0.1631
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.034 0.1767
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0525 0.1852 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0151 0.034 0.1767
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0523 0.1847 0.1878
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.031 0.0984 0.4609
Schistosoma mansoni patched 1 0.0086 0.0077 0.0077
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0179 0.0454 0.2352
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0179 0.0454 0.2352
Brugia malayi Protein kinase domain containing protein 0.2498 0.9836 1
Trichomonas vaginalis conserved hypothetical protein 0.03 0.0942 0.5046
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.034 0.1631
Mycobacterium tuberculosis Probable lipase LipD 0.0151 0.034 0.0715
Schistosoma mansoni hypothetical protein 0.0083 0.0064 0.0064
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.2498 0.9836 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0151 0.034 0.0346
Echinococcus multilocularis expressed conserved protein 0.0187 0.0489 0.0497
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0478 0.1666 1
Trypanosoma cruzi hypothetical protein, conserved 0.0179 0.0454 0.2352
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.031 0.0984 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0121 0.0219 0.087
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0179 0.0454 0.2352
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0181 0.0463 0.1062
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0454 0.2388
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0523 0.1847 0.1878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0523 0.1847 0.1847
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0201 0.0544 0.1292
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0179 0.0454 0.2352
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0478 0.1666 1
Mycobacterium tuberculosis Conserved protein 0.0151 0.034 0.0715
Trypanosoma cruzi trypanothione reductase, putative 0.0088 0.0087 0.0035
Loa Loa (eye worm) hypothetical protein 0.0391 0.1314 0.1336
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0314 0.1 0.5361
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.02 0.0538 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0224 0.0635 0.1548
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0392 0.1317 0.1339
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Plasmodium falciparum phosphodiesterase gamma, putative 0.0179 0.0454 0.4127
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.04 0.1348 0.137
Trichomonas vaginalis conserved hypothetical protein 0.0135 0.0276 0.1421
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0525 0.1852 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0151 0.034 0.0715
Toxoplasma gondii ABC1 family protein 0.0151 0.034 0.1319
Echinococcus multilocularis geminin 0.0735 0.2705 0.275
Echinococcus granulosus thioredoxin glutathione reductase 0.0089 0.0089 0.0091
Leishmania major trypanothione reductase 0.0088 0.0087 0.0035
Loa Loa (eye worm) hypothetical protein 0.0151 0.034 0.0346
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0151 0.034 0.0346
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0478 0.1666 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0523 0.1847 0.1878
Schistosoma mansoni hypothetical protein 0.0083 0.0064 0.0064
Loa Loa (eye worm) glutathione reductase 0.0088 0.0087 0.0089
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0478 0.1666 0.8985
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0121 0.0219 0.111
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Echinococcus multilocularis tar DNA binding protein 0.0135 0.0278 0.0283
Brugia malayi Calcitonin receptor-like protein seb-1 0.0211 0.0582 0.0592
Loa Loa (eye worm) hypothetical protein 0.0149 0.0333 0.0339
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1666 0.8985
Loa Loa (eye worm) beta-lactamase 0.0151 0.034 0.0346
Toxoplasma gondii hypothetical protein 0.0135 0.0276 0.0995
Trichomonas vaginalis conserved hypothetical protein 0.0525 0.1852 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.04 0.1348 0.137
Brugia malayi Thioredoxin reductase 0.0088 0.0087 0.0089
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0248 0.0735 0.0747
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.031 0.0984 0.1001
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0201 0.0544 0.1292
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0179 0.0454 0.2388
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0179 0.0454 0.0454
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1666 0.8985
Leishmania major hypothetical protein, conserved 0.0151 0.034 0.1631
Brugia malayi Importin beta-1 subunit 0.0149 0.0333 0.0339
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0278 0.0278
Mycobacterium tuberculosis Probable dehydrogenase 0.0201 0.0544 0.1292
Echinococcus multilocularis Niemann Pick C1 protein 0.02 0.0538 0.0547
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0151 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0151 0.034 0.0346
Entamoeba histolytica hypothetical protein 0.0121 0.0219 0.3023
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0314 0.1 0.5361
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.031 0.0984 0.1001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Echinococcus multilocularis sodium and chloride dependent glycine 0.0169 0.0415 0.0422
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0179 0.0454 0.0462
Echinococcus granulosus Niemann Pick C1 protein 0.02 0.0538 0.0547
Mycobacterium leprae Probable lipase LipE 0.0151 0.034 0.1772
Plasmodium falciparum importin beta, putative 0.0149 0.0333 0.279
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0211 0.0582 0.0592
Trypanosoma brucei trypanothione reductase 0.0088 0.0087 0.0035
Trypanosoma brucei importin beta-1 subunit, putative 0.0149 0.0333 0.159
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Leishmania major cAMP-specific phosphodiesterase, putative 0.0179 0.0454 0.2352
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0523 0.1847 0.1847
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Brugia malayi beta-lactamase 0.0151 0.034 0.0346
Trypanosoma brucei importin beta-1 subunit, putative 0.0149 0.0333 0.159
Schistosoma mansoni sodium/chloride dependent transporter 0.0169 0.0415 0.0415
Loa Loa (eye worm) TAR-binding protein 0.0135 0.0278 0.0283
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0211 0.0582 0.0592
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0077 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0523 0.1847 0.1847
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0224 0.0635 0.1548
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0097 0.0123 0.0125
Leishmania major hypothetical protein, conserved 0.0179 0.0454 0.2352
Schistosoma mansoni chromobox protein 0.007 0.0015 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0179 0.0454 0.2352
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0248 0.0735 0.3336
Echinococcus granulosus geminin 0.0735 0.2705 0.275
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Mycobacterium tuberculosis Probable oxidoreductase 0.0224 0.0635 0.1548
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0571 0.2041 1
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0278 0.0278
Mycobacterium tuberculosis Probable lipase LipE 0.0151 0.034 0.0715
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Onchocerca volvulus 0.0151 0.034 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0248 0.0735 0.4124
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0248 0.0735 0.4124
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0077 0.0334
Plasmodium vivax importin-beta 2, putative 0.0149 0.0333 0.3854
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0151 0.034 0.3407
Schistosoma mansoni ran 0.0087 0.0082 0.0082
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0571 0.2041 0.2041
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.04 0.1348 0.1348
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0151 0.034 0.0715
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.057 0.2037 0.2071
Toxoplasma gondii GAF domain-containing protein 0.0135 0.0276 0.0995
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0179 0.0454 0.0454
Plasmodium vivax phosphodiesterase gamma, putative 0.0179 0.0454 0.5701
Plasmodium vivax hypothetical protein, conserved 0.0151 0.034 0.3955
Loa Loa (eye worm) hypothetical protein 0.0151 0.034 0.0346
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0179 0.0454 0.0454
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0201 0.0544 0.7467
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1678 0.6517 0.6626
Giardia lamblia Hypothetical protein 0.0179 0.0454 0.1902
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Schistosoma mansoni ran 0.0087 0.0082 0.0082
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0179 0.0454 0.0454
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0248 0.0735 0.0747
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0478 0.1666 0.8985
Toxoplasma gondii hypothetical protein 0.03 0.0942 0.4394
Giardia lamblia hypothetical protein 0.0179 0.0454 0.1902
Trypanosoma cruzi hypothetical protein, conserved 0.0179 0.0454 0.2352
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0633 0.2293 0.2331
Onchocerca volvulus 0.0151 0.034 0.5
Loa Loa (eye worm) hypothetical protein 0.0105 0.0155 0.0157
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0571 0.2041 0.2075
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.1591 0.6167 0.627
Loa Loa (eye worm) hypothetical protein 0.0571 0.2041 0.2075
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0314 0.1 0.5361
Toxoplasma gondii HEAT repeat-containing protein 0.0149 0.0333 0.1286
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0179 0.0454 0.2388
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0278 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.0179 0.0454 0.2352
Brugia malayi beta-lactamase family protein 0.0151 0.034 0.0346
Loa Loa (eye worm) hypothetical protein 0.0418 0.1422 0.1445
Brugia malayi CHE-14 protein 0.0086 0.0077 0.0078
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0077 0.0078
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0478 0.1666 0.8985
Loa Loa (eye worm) hypothetical protein 0.0151 0.034 0.0346
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0571 0.2041 0.2075
Loa Loa (eye worm) hypothetical protein 0.1179 0.45 0.4574
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.057 0.2037 0.2071
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0478 0.1666 0.8985
Echinococcus multilocularis thioredoxin glutathione reductase 0.0089 0.0089 0.0091
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0179 0.0454 0.4127
Loa Loa (eye worm) PDE1B protein 0.04 0.1348 0.137
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.2498 0.9836 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0169 0.0415 0.0422
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0181 0.0463 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.057 0.2037 0.2071
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0077 0.0078
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0135 0.0276 0.0535
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0151 0.034 0.0715
Mycobacterium ulcerans esterase/lipase LipP 0.0151 0.034 0.3407
Trichomonas vaginalis ran, putative 0.0087 0.0082 0.036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0523 0.1847 0.1878
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.0278 0.0283
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0087 0.0082 0.0083
Schistosoma mansoni hypothetical protein 0.0083 0.0064 0.0064
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0015 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0151 0.034 0.1767
Loa Loa (eye worm) thioredoxin reductase 0.0088 0.0087 0.0089
Loa Loa (eye worm) hypothetical protein 0.0112 0.0184 0.0188
Plasmodium falciparum glutathione reductase 0.0088 0.0087 0.0062
Loa Loa (eye worm) hypothetical protein 0.02 0.0538 0.0547
Trichomonas vaginalis penicillin-binding protein, putative 0.0151 0.034 0.1767
Echinococcus multilocularis snurportin 1 0.1591 0.6167 0.627
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0478 0.1666 0.8985
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0179 0.0454 0.5701
Trichomonas vaginalis conserved hypothetical protein 0.03 0.0942 0.5046
Mycobacterium ulcerans hypothetical protein 0.0151 0.034 0.3407
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0392 0.1317 0.1339
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0224 0.0635 1
Loa Loa (eye worm) hypothetical protein 0.1 0.3776 0.3839
Plasmodium vivax thioredoxin reductase, putative 0.0088 0.0087 0.0086
Echinococcus granulosus Niemann Pick C1 protein 0.0285 0.0884 0.0899
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0291 0.0908 0.0923
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Echinococcus granulosus expressed conserved protein 0.0187 0.0489 0.0497
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0278 0.0278
Brugia malayi SET domain containing protein 0.0097 0.0123 0.0125
Echinococcus multilocularis importin subunit beta 1 0.0149 0.0333 0.0339
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0478 0.1666 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Schistosoma mansoni chromobox protein 0.007 0.0015 0.0015
Loa Loa (eye worm) TKL/MLK/LZK protein kinase 0.2498 0.9836 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0392 0.1317 0.1339
Loa Loa (eye worm) hypothetical protein 0.0086 0.0077 0.0078
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.04 0.1348 0.137
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0571 0.2041 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0478 0.1666 0.1694
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0344 0.112 0.6013
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0571 0.2041 0.2075
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0121 0.0219 0.111
Brugia malayi glutathione reductase 0.0088 0.0087 0.0089
Echinococcus granulosus importin subunit beta 1 0.0149 0.0333 0.0339
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0179 0.0454 0.0454
Trichomonas vaginalis importin beta-1, putative 0.0121 0.0219 0.111
Schistosoma mansoni hypothetical protein 0.0735 0.2705 0.2705
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0169 0.0415 0.0422
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0291 0.0908 0.0923
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Echinococcus multilocularis protein patched 0.0086 0.0077 0.0078
Echinococcus granulosus sodium and chloride dependent glycine 0.0169 0.0415 0.0422
Mycobacterium ulcerans beta-lactamase 0.0151 0.034 0.3407
Schistosoma mansoni hypothetical protein 0.0735 0.2705 0.2705
Schistosoma mansoni enhancer of zeste ezh 0.0097 0.0123 0.0123
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0203 0.055 0.055
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.034 0.1631
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0201 0.0544 0.1292
Loa Loa (eye worm) hypothetical protein 0.0169 0.0415 0.0422
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0087 0.0082 0.0083
Toxoplasma gondii hypothetical protein 0.0135 0.0276 0.0995
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Echinococcus granulosus sodium and chloride dependent glycine 0.0169 0.0415 0.0422
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0344 0.112 0.6013
Loa Loa (eye worm) SET domain-containing protein 0.0097 0.0123 0.0125
Toxoplasma gondii thioredoxin reductase 0.0088 0.0087 0.0029
Echinococcus multilocularis chromobox protein 1 0.007 0.0015 0.0016
Mycobacterium ulcerans lipase LipD 0.0151 0.034 0.3407
Loa Loa (eye worm) hypothetical protein 0.0291 0.0908 0.0923
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0344 0.112 0.6554
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0248 0.0735 0.3336
Brugia malayi Niemann-Pick C1 protein precursor 0.02 0.0538 0.0547
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0291 0.0908 0.0908
Plasmodium vivax hypothetical protein, conserved 0.0135 0.0276 0.2983
Trichomonas vaginalis conserved hypothetical protein 0.03 0.0942 0.5046
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Schistosoma mansoni sodium/chloride dependent transporter 0.0169 0.0415 0.0415
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0179 0.0454 0.2388
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0179 0.0454 0.5701
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1179 0.45 0.4574
Loa Loa (eye worm) hypothetical protein 0.0256 0.0768 0.0781
Trichomonas vaginalis esterase, putative 0.0151 0.034 0.1767
Schistosoma mansoni hypothetical protein 0.1591 0.6167 0.6167
Loa Loa (eye worm) RNA binding protein 0.0135 0.0278 0.0283
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0392 0.1317 0.1339
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0201 0.0544 0.1292
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0478 0.1666 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0963 0.3625 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0151 0.034 0.0346
Loa Loa (eye worm) hypothetical protein 0.2498 0.9836 1
Plasmodium falciparum GAF domain-related protein, putative 0.0135 0.0276 0.2159
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0077 0.0078
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0248 0.0735 0.4124
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0248 0.0735 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0478 0.1666 0.8985
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0523 0.1847 0.1878
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0179 0.0454 0.2388
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0225 0.0641 0.3403
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0633 0.2293 0.2331
Loa Loa (eye worm) hypothetical protein 0.0144 0.0313 0.0318
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0418 0.1422 0.1422
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0571 0.2041 0.2075
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0278 0.0278
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0179 0.0454 0.4127
Brugia malayi Heterochromatin protein 1 0.007 0.0015 0.0016
Plasmodium vivax glutathione reductase, putative 0.0088 0.0087 0.0086
Mycobacterium tuberculosis Probable esterase LipL 0.0151 0.034 0.0715
Mycobacterium tuberculosis Probable hydrolase 0.0151 0.034 0.0715
Loa Loa (eye worm) hypothetical protein 0.0151 0.034 0.0346
Echinococcus granulosus chromobox protein 1 0.007 0.0015 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0523 0.1847 0.1878
Loa Loa (eye worm) hypothetical protein 0.0151 0.034 0.0346
Echinococcus granulosus GTP binding nuclear protein Ran 0.0087 0.0082 0.0083
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0179 0.0454 0.1902
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0478 0.1666 0.8985
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0179 0.0454 0.2352
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0179 0.0454 0.2388
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0179 0.0454 0.2388
Plasmodium falciparum thioredoxin reductase 0.0088 0.0087 0.0062
Echinococcus granulosus chromobox protein 1 0.007 0.0015 0.0016
Onchocerca volvulus 0.0151 0.034 0.5
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0478 0.1666 0.1694
Echinococcus multilocularis chromobox protein 1 0.007 0.0015 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0179 0.0454 0.2352
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0151 0.034 0.034

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 5.5 Inhibitory activity of the against phosphodiesterase 3 (PDE3); No significant inhibitory activity at pIC50 ChEMBL. 11472206
IC50 (binding) = 9.2 Inhibition of phosphodiesterase 4 (PDE4) in human neutrophils ChEMBL. 11472206
IC50 (binding) = 0.004 uM Inhibition of Trypanosoma brucei TbrPDEB1 ChEMBL. 22963052
IC50 (functional) = 0.08 uM Antitrypanosomal activity against Trypanosoma brucei brucei ChEMBL. 22963052
Log IC50 (binding) < 5.5 Inhibitory activity of the against phosphodiesterase 3 (PDE3); No significant inhibitory activity at pIC50 ChEMBL. 11472206
Log IC50 (binding) = 9.2 Inhibition of phosphodiesterase 4 (PDE4) in human neutrophils ChEMBL. 11472206

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense 22963052

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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