Detailed information for compound 1386564

Basic information

Technical information
  • TDR Targets ID: 1386564
  • Name: 1-(2-chlorophenothiazin-10-yl)-2-(5,6-dimethy lthieno[3,2-e]pyrimidin-4-yl)sulfanylethanone
  • MW: 470.03 | Formula: C22H16ClN3OS3
  • H donors: 0 H acceptors: 3 LogP: 6.58 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)N(C(=O)CSc1ncnc3c1c(C)c(s3)C)c1c(S2)cccc1
  • InChi: 1S/C22H16ClN3OS3/c1-12-13(2)29-22-20(12)21(24-11-25-22)28-10-19(27)26-15-5-3-4-6-17(15)30-18-8-7-14(23)9-16(18)26/h3-9,11H,10H2,1-2H3
  • InChiKey: RZZKYAKZVHKKAE-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-(2-chlorophenothiazin-10-yl)-2-(5,6-dimethylthieno[3,2-e]pyrimidin-4-yl)sulfanyl-ethanone
  • 1-(2-chloro-10-phenothiazinyl)-2-[(5,6-dimethyl-4-thieno[3,2-e]pyrimidinyl)thio]ethanone
  • 1-(2-chlorophenothiazin-10-yl)-2-[(5,6-dimethylthieno[3,2-e]pyrimidin-4-yl)thio]ethanone
  • Oprea1_532833
  • 1-(2-Chloro-phenothiazin-10-yl)-2-(5,6-dimethyl-thieno[2,3-d]pyrimidin-4-ylsulfanyl)-ethanone
  • MLS000564612
  • SMR000177300
  • Oprea1_620072
  • BAS 02054255
  • AG-690/40751541

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Subtilase family protein 0.0029 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Loa Loa (eye worm) proprotein convertase 2 0.0163 0.2131 0.2131
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0604 0.7098
Entamoeba histolytica cysteine proteinase, putative 0.002 0 0.5
Echinococcus multilocularis membrane bound transcription factor site 1 0.0029 0.0138 0.0172
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0133 0.169 0.2836
Echinococcus multilocularis Furin 1 0.0163 0.2131 0.2661
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0163 0.2131 0.3575
Trypanosoma cruzi subtilisin peptidase 0.0029 0.0138 0.162
Loa Loa (eye worm) hypothetical protein 0.027 0.3738 0.3738
Loa Loa (eye worm) subtilase 0.0029 0.0138 0.0138
Schistosoma mansoni site-1 peptidase (S08 family) 0.0029 0.0138 0.0138
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0029 0.0138 0.5
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0029 0.0138 0.5
Echinococcus granulosus Furin 1 0.0163 0.2131 0.2131
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.169 0.2836
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.169 0.2836
Loa Loa (eye worm) hypothetical protein 0.0029 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.169 0.2836
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.085 1
Toxoplasma gondii subtilisin SUB5 0.0029 0.0138 1
Giardia lamblia High cysteine membrane protein Group 2 0.0256 0.3526 1
Echinococcus multilocularis neuroendocrine convertase 2 0.0433 0.6172 0.7708
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.085 1
Plasmodium falciparum subtilisin-like protease 3 0.0029 0.0138 1
Leishmania major cathepsin L-like protease 0.0077 0.085 1
Toxoplasma gondii subtilisin SUB11 0.0029 0.0138 1
Echinococcus granulosus membrane bound transcription factor site 1 0.0029 0.0138 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.085 1
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0029 0.0138 0.162
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0133 0.169 0.2836
Plasmodium vivax subtilisin-like protease 2, putative 0.0029 0.0138 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0163 0.2131 0.3575
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0029 0.0138 0.0138
Echinococcus multilocularis 0.0555 0.8007 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.085 1
Echinococcus granulosus furin 0.0688 1 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0688 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.085 1
Brugia malayi neuroendocrine convertase 1 precursor 0.0433 0.6172 0.6172
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Plasmodium vivax subtilisin-like protease 1 0.0029 0.0138 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0029 0.0138 0.0138
Plasmodium falciparum subtilisin-like protease 2 0.0029 0.0138 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.169 0.2836
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0029 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.169 0.2836
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0138 0.0231
Echinococcus granulosus neuroendocrine convertase 2 0.0433 0.6172 0.6172
Schistosoma mansoni hypothetical protein 0.0133 0.169 0.169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0163 0.2131 0.3575
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0029 0.0138 0.5
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0029 0.0138 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0138 0.0231
Entamoeba histolytica cysteine proteinase, putative 0.002 0 0.5
Plasmodium falciparum subtilisin-like protease 1 0.0029 0.0138 1
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0163 0.2131 0.2131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.085 1
Toxoplasma gondii subtilisin SUB7 0.0029 0.0138 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0163 0.2131 0.3575
Toxoplasma gondii subtilisin SUB9 0.0029 0.0138 1
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0418 0.5959 0.7442
Entamoeba histolytica cysteine protease, putative 0.002 0 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.085 1
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.169 0.2836
Loa Loa (eye worm) hypothetical protein 0.0688 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.085 1
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.169 0.2836
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0138 0.0231
Toxoplasma gondii subtilisin SUB4 0.0029 0.0138 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Brugia malayi celfurPC protein 0.0555 0.8007 0.8007
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.169 0.2836
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0029 0.0138 0.5
Mycobacterium leprae Possible secreted protease 0.0029 0.0138 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.169 0.2836
Toxoplasma gondii subtilisin SUB8 0.0029 0.0138 1
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0029 0.0138 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.085 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.085 1
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.169 0.2836
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0418 0.5959 0.5959
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.075 0.8824
Toxoplasma gondii subtilisin SUB1 0.0029 0.0138 1
Onchocerca volvulus 0.0029 0.0138 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Leishmania major subtilisin-like serine peptidase 0.0029 0.0138 0.162
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0029 0.0138 0.0172
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.5959 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.085 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Brugia malayi proprotein convertase 2 0.0433 0.6172 0.6172
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0029 0.0138 0.5
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0133 0.169 0.2836
Loa Loa (eye worm) endoprotease bli-4 0.0688 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0163 0.2131 0.3575
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Leishmania major cathepsin L-like protease 0.0077 0.085 1
Toxoplasma gondii subtilisin SUB2 0.0029 0.0138 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0133 0.169 0.2836
Toxoplasma gondii subtilisin SUB6 0.0029 0.0138 1
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0029 0.0138 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.5959 1
Trichomonas vaginalis hypothetical protein 0.0133 0.169 0.2836
Leishmania major cathepsin L-like protease 0.0077 0.085 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0138 0.0231
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0029 0.0138 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.085 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0138 0.0231
Plasmodium vivax subtilisin-like serine protease, putative 0.0029 0.0138 1
Toxoplasma gondii subtilisin SUB12 0.0029 0.0138 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0029 0.0138 0.162
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0029 0.0138 0.0231
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0029 0.0138 0.0138
Toxoplasma gondii subtilisin SUB10 0.0029 0.0138 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.085 1
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0029 0.0138 0.0138
Schistosoma mansoni furin-1 (S08 family) 0.0299 0.4179 0.4179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.085 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.085 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0029 0.0138 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0163 0.2131 0.3575
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0029 0.0138 0.162

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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