Detailed information for compound 1386665

Basic information

Technical information
  • TDR Targets ID: 1386665
  • Name: 5-(2,5-dichlorothiophen-3-yl)-1-(4-methoxyphe nyl)pyrazole
  • MW: 325.213 | Formula: C14H10Cl2N2OS
  • H donors: 0 H acceptors: 1 LogP: 5.13 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1nccc1c1cc(sc1Cl)Cl
  • InChi: 1S/C14H10Cl2N2OS/c1-19-10-4-2-9(3-5-10)18-12(6-7-17-18)11-8-13(15)20-14(11)16/h2-8H,1H3
  • InChiKey: AJMQYOIFCCXFMW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(2,5-dichloro-3-thienyl)-1-(4-methoxyphenyl)pyrazole
  • 4N-746
  • 4-[5-(2,5-dichloro-3-thienyl)-1H-pyrazol-1-yl]phenyl methyl ether
  • MLS000540562
  • SMR000125820
  • ZINC01389732

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0036 0.0329 0.0848
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.0045 0.0067
Plasmodium falciparum peptide deformylase 0.0674 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0068 0.0165
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0061 0.0711 0.1244
Mycobacterium tuberculosis Probable reductase 0.0087 0.1098 0.1079
Loa Loa (eye worm) glutathione reductase 0.0038 0.0357 0.1207
Echinococcus multilocularis histone deacetylase 3 0.0061 0.0711 0.2415
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0707 0.1876
Onchocerca volvulus 0.0239 0.3399 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.3294 0.3281
Loa Loa (eye worm) histone deacetylase 7A 0.0018 0.0045 0.0152
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0365 0.1204
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.1098 0.1079
Trypanosoma brucei Peptide deformylase 2 0.0257 0.3679 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0329 0.0309
Plasmodium falciparum glutathione reductase 0.0038 0.0357 0.0337
Plasmodium vivax SET domain protein, putative 0.003 0.0235 0.0215
Schistosoma mansoni histone deacetylase hda2 0.0018 0.0045 0.0086
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0068 0.0229
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0329 0.0309
Brugia malayi Pre-SET motif family protein 0.003 0.0235 0.0795
Trichomonas vaginalis histone deacetylase, putative 0.0061 0.0711 0.1244
Trypanosoma brucei trypanothione reductase 0.0038 0.0357 0.092
Echinococcus granulosus lamin dm0 0.0027 0.0191 0.0597
Schistosoma mansoni histone deacetylase 1 2 3 0.0018 0.0045 0.0086
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0403 0.1361
Echinococcus granulosus histone deacetylase 3 0.0061 0.0711 0.2415
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0692 0.2337
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0438 0.1458
Trypanosoma cruzi histone deacetylase 1, putative 0.0061 0.0711 0.1888
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0329 0.0309
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0357 0.092
Echinococcus multilocularis histone deacetylase 1 0.0061 0.0711 0.2415
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0707 0.24
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.0229
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0478 0.16
Trypanosoma brucei histone deacetylase 2 0.0018 0.0045 0.0067
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0191 0.0646
Trypanosoma cruzi Peptide deformylase 2, putative 0.0257 0.3679 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.1098 0.1079
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0707 0.24
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.0045 0.0067
Echinococcus multilocularis histone deacetylase 6 0.0018 0.0045 0.0086
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0674 1 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0257 0.3679 1
Brugia malayi histone deacetylase 11 0.0018 0.0045 0.0152
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0329 0.108
Echinococcus granulosus histone deacetylase 1 0.0061 0.0711 0.2415
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0478 0.16
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.1113
Echinococcus granulosus intermediate filament protein 0.0027 0.0191 0.0597
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.1113
Trypanosoma brucei Polypeptide deformylase 1 0.0257 0.3679 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0191 0.0646
Plasmodium vivax glutathione reductase, putative 0.0038 0.0357 0.0337
Trypanosoma brucei histone deacetylase 4 0.0018 0.0045 0.0067
Onchocerca volvulus Huntingtin homolog 0.0124 0.1651 0.4789
Schistosoma mansoni hypothetical protein 0.0019 0.0068 0.0165
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0235 0.0215
Treponema pallidum polypeptide deformylase (def) 0.0674 1 0.5
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0329 0.0309
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0235 0.0751
Echinococcus granulosus histone deacetylase 7 0.0018 0.0045 0.0086
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0329 0.0844
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0021 0.007
Loa Loa (eye worm) hypothetical protein 0.0061 0.0711 0.2403
Plasmodium vivax peptide deformylase, putative 0.0674 1 1
Echinococcus granulosus geminin 0.0205 0.2881 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0235 0.0751
Loa Loa (eye worm) histone deacetylase 1 0.0061 0.0711 0.2403
Leishmania major histone deacetylase, putative 0.0018 0.0045 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0478 0.16
Loa Loa (eye worm) histone deacetylase 0.0018 0.0045 0.0152
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.1113
Mycobacterium tuberculosis Conserved protein 0.0036 0.0329 0.0309
Schistosoma mansoni lamin 0.0027 0.0191 0.0597
Loa Loa (eye worm) hypothetical protein 0.0027 0.0191 0.0646
Schistosoma mansoni hypothetical protein 0.0205 0.2881 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0329 0.0309
Giardia lamblia Histone deacetylase 0.0061 0.0711 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0152
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0068 0.0165
Trichomonas vaginalis histone deacetylase, putative 0.0061 0.0711 0.1244
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0021 0.007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.1098 0.1079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0235 0.0751
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0357 0.0337
Echinococcus granulosus lamin 0.0027 0.0191 0.0597
Brugia malayi histone deacetylase 3 (HD3) 0.0061 0.0711 0.2403
Brugia malayi Histone deacetylase family protein 0.0018 0.0045 0.0152
Schistosoma mansoni hypothetical protein 0.0205 0.2881 1
Schistosoma mansoni hypothetical protein 0.0041 0.0403 0.1337
Echinococcus multilocularis histone deacetylase 6 0.0018 0.0045 0.0086
Onchocerca volvulus 0.0182 0.2545 0.7453
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0478 0.1616
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.1113
Plasmodium vivax histone deacetylase, putative 0.0018 0.0045 0.0025
Echinococcus multilocularis histone deacetylase 7 0.0018 0.0045 0.0086
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0674 1 0.5
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.1245 0.1227
Mycobacterium tuberculosis Conserved protein 0.0036 0.0329 0.0309
Onchocerca volvulus 0.003 0.0235 0.0567
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0068 0.0165
Trypanosoma brucei histone deacetylase 3 0.0018 0.0045 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0478 0.16
Loa Loa (eye worm) hypothetical protein 0.0027 0.0184 0.0621
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0707 0.0391
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0219 0.0692
Toxoplasma gondii ABC1 family protein 0.0036 0.0329 0.0309
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0707 0.0688
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0707 0.0391
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0068 0.0165
Echinococcus granulosus GPCR family 2 0.0019 0.0068 0.0165
Echinococcus granulosus histone deacetylase 8 0.0018 0.0045 0.0086
Schistosoma mansoni hypothetical protein 0.0043 0.0438 0.1458
Onchocerca volvulus 0.0027 0.0191 0.0436
Toxoplasma gondii histone deacetylase HDAC4 0.0018 0.0045 0.0025
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0235 0.0751
Schistosoma mansoni histone deacetylase 0.0061 0.0711 0.2415
Schistosoma mansoni hypothetical protein 0.0019 0.0068 0.0165
Brugia malayi Histone deacetylase family protein 0.0018 0.0045 0.0152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0478 0.16
Brugia malayi isocitrate dehydrogenase 0.0016 0.0021 0.007
Brugia malayi intermediate filament protein 0.0027 0.0191 0.0646
Toxoplasma gondii hypothetical protein 0.0674 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0329 0.108
Loa Loa (eye worm) hypothetical protein 0.0182 0.2545 0.8599
Loa Loa (eye worm) hypothetical protein 0.0124 0.1651 0.558
Trypanosoma brucei histone deacetylase, putative 0.0018 0.0045 0.0067
Loa Loa (eye worm) hypothetical protein 0.0124 0.1651 0.558
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.0045 0.0067
Echinococcus granulosus histone deacetylase 6 0.0018 0.0045 0.0086
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0061 0.0711 0.1244
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.0045 0.0067
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0357 0.1207
Leishmania major hypothetical protein, conserved 0.0036 0.0329 0.0844
Echinococcus multilocularis GPCR, family 2 0.0019 0.0068 0.0165
Echinococcus multilocularis geminin 0.0205 0.2881 1
Brugia malayi Histone deacetylase 1 0.0061 0.0711 0.2403
Leishmania major polypeptide deformylase-like protein, putative 0.0257 0.3679 1
Trichomonas vaginalis histone deacetylase, putative 0.0061 0.0711 0.1244
Brugia malayi glutathione reductase 0.0038 0.0357 0.1207
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.0045 0.0067
Plasmodium falciparum histone deacetylase 1 0.0061 0.0711 0.0692
Schistosoma mansoni histone deacetylase 0.0061 0.0711 0.2415
Schistosoma mansoni hypothetical protein 0.0019 0.0068 0.0165
Echinococcus granulosus histone deacetylase 6 0.0018 0.0045 0.0086
Trichomonas vaginalis set domain proteins, putative 0.0239 0.3399 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0329 0.1113
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0329 0.0309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0707 0.0391
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0068 0.0229
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0257 0.3679 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0191 0.0646
Brugia malayi hypothetical protein 0.0043 0.0438 0.1479
Echinococcus multilocularis histone deacetylase 0.0018 0.0045 0.0086
Toxoplasma gondii histone deacetylase HDAC5 0.0018 0.0045 0.0025
Brugia malayi Pre-SET motif family protein 0.021 0.296 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0357 0.0337
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.1098 0.1079
Trichomonas vaginalis histone deacetylase, putative 0.0061 0.0711 0.1244
Entamoeba histolytica histone deacetylase, putative 0.0061 0.0711 1
Schistosoma mansoni histone deacetylase 4 5 0.0018 0.0045 0.0086
Toxoplasma gondii histone deacetylase HDAC2 0.0061 0.0711 0.0692
Leishmania major trypanothione reductase 0.0038 0.0357 0.092
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0329 0.108
Plasmodium falciparum thioredoxin reductase 0.0038 0.0357 0.0337
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0707 0.24
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0692 0.2337
Leishmania major histone deacetylase, putative 0.0061 0.0711 0.1888
Echinococcus multilocularis lamin dm0 0.0027 0.0191 0.0597
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0329 0.0309
Toxoplasma gondii thioredoxin reductase 0.0038 0.0357 0.0337
Toxoplasma gondii histone deacetylase HDAC3 0.0061 0.0711 0.0692
Onchocerca volvulus 0.0036 0.0329 0.0848
Echinococcus multilocularis histone deacetylase 8 0.0018 0.0045 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0235 0.0751
Trypanosoma cruzi histone deacetylase 1, putative 0.0061 0.0711 0.1888
Plasmodium vivax histone deacetylase, putative 0.0018 0.0045 0.0025
Brugia malayi beta-lactamase family protein 0.0036 0.0329 0.1113
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0438 0.1458
Echinococcus multilocularis musashi 0.0027 0.0191 0.0597
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.296 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.1245 0.1227
Brugia malayi hypothetical protein 0.0124 0.1651 0.558
Schistosoma mansoni histone deacetylase 4 5 0.0018 0.0045 0.0086
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.1098 0.1079
Brugia malayi beta-lactamase 0.0036 0.0329 0.1113
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.1113
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0235 0.0751
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0329 0.1113
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0329 0.0309
Onchocerca volvulus 0.0027 0.0191 0.0436
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0707 0.0688
Loa Loa (eye worm) hypothetical protein 0.006 0.0692 0.2337
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0235 0.0751
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0478 0.1616
Echinococcus granulosus histone deacetylase 6 0.0018 0.0045 0.0086
Toxoplasma gondii histone deacetylase HDAC1 0.0018 0.0045 0.0025
Brugia malayi beta-lactamase family protein 0.0036 0.0329 0.1113
Brugia malayi histone deacetylase 1 (HD1) 0.0061 0.0711 0.2403
Brugia malayi hypothetical protein 0.0182 0.2545 0.8599
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0707 0.24
Plasmodium falciparum histone deacetylase, putative 0.0018 0.0045 0.0025
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0365 0.1204
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.1245 0.0947
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0329 0.1113
Loa Loa (eye worm) hypothetical protein 0.003 0.0235 0.0795
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0068 0.0165
Loa Loa (eye worm) histone deacetylase 3 0.0061 0.0711 0.2403
Plasmodium falciparum histone deacetylase 2 0.0018 0.0045 0.0025
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0329 0.108
Schistosoma mansoni lamin 0.0027 0.0191 0.0597
Echinococcus granulosus histone deacetylase 0.0018 0.0045 0.0086
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0438 0.1458
Trypanosoma brucei histone deacetylase 1 0.0061 0.0711 0.1888
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0478 0.16
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0674 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0403 0.1361
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0478 0.16
Onchocerca volvulus 0.0036 0.0329 0.0848
Echinococcus multilocularis histone deacetylase 6 0.0018 0.0045 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0329 0.0844
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0061 0.0711 0.1244
Trichomonas vaginalis histone deacetylase, putative 0.0061 0.0711 0.1244
Schistosoma mansoni histone deacetylase hda2 0.0018 0.0045 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0329 0.0844
Loa Loa (eye worm) hypothetical protein 0.0036 0.0329 0.1113
Leishmania major histone deacetylase, putative 0.0018 0.0045 0.0067
Plasmodium vivax histone deacetylase 1, putative 0.0061 0.0711 0.0692
Loa Loa (eye worm) histone deacetylase 11 0.0018 0.0045 0.0152
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0692 0.2337
Leishmania major histone deacetylase, putative 0.0061 0.0711 0.1888
Trypanosoma cruzi Peptide deformylase 2, putative 0.0257 0.3679 1
Brugia malayi Thioredoxin reductase 0.0038 0.0357 0.1207
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.1098 0.0795
Mycobacterium ulcerans peptide deformylase 0.0674 1 1
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0329 0.0309
Echinococcus multilocularis lamin 0.0027 0.0191 0.0597
Trichomonas vaginalis histone deacetylase, putative 0.0061 0.0711 0.1244
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0068 0.0229
Plasmodium vivax histone deacetylase 2, putative 0.0018 0.0045 0.0025
Schistosoma mansoni intermediate filament proteins 0.0027 0.0191 0.0597
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.1245 0.1227
Onchocerca volvulus Huntingtin homolog 0.0124 0.1651 0.4789

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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