Detailed information for compound 1386704

Basic information

Technical information
  • TDR Targets ID: 1386704
  • Name: 2-(6-chloro-4-methyl-2-oxochromen-7-yl)oxy-N- [4-(morpholin-4-ylmethyl)phenyl]acetamide
  • MW: 442.892 | Formula: C23H23ClN2O5
  • H donors: 1 H acceptors: 2 LogP: 2.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)CN1CCOCC1)COc1cc2oc(=O)cc(c2cc1Cl)C
  • InChi: 1S/C23H23ClN2O5/c1-15-10-23(28)31-20-12-21(19(24)11-18(15)20)30-14-22(27)25-17-4-2-16(3-5-17)13-26-6-8-29-9-7-26/h2-5,10-12H,6-9,13-14H2,1H3,(H,25,27)
  • InChiKey: GJJUSTPRUVDKEA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(6-chloro-4-methyl-2-oxo-chromen-7-yl)oxy-N-[4-(morpholinomethyl)phenyl]acetamide
  • 2-[(6-chloro-4-methyl-2-oxo-7-chromenyl)oxy]-N-[4-(morpholinomethyl)phenyl]acetamide
  • 2-(6-chloro-2-keto-4-methyl-chromen-7-yl)oxy-N-[4-(morpholinomethyl)phenyl]acetamide
  • 2-(6-chloro-4-methyl-2-oxo-chromen-7-yl)oxy-N-[4-(morpholin-4-ylmethyl)phenyl]ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi G-protein coupled receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Brugia malayi sulfakinin receptor protein 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0687 0.1669 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0022 0.0022
Schistosoma mansoni transient receptor potential channel 4 0.0099 0.0218 0.0218
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.4064 1 1
Schistosoma mansoni neuropeptide receptor 0.0046 0.0087 0.0087
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.0087 0.0087
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0022 0.0022
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.0087 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0038 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0046 0.0087 0.0522
Schistosoma mansoni acetylcholinesterase 0.0687 0.1669 0.1669
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0087 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0687 0.1669 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.0087 0.0087
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0136 0.0136
Brugia malayi hypothetical protein 0.0017 0.0015 0.0015
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0087 0.0087
Brugia malayi hypothetical protein 0.0046 0.0087 0.0087
Brugia malayi hypothetical protein 0.0046 0.0087 0.0087
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0099 0.0218 0.0218
Echinococcus multilocularis somatostatin receptor 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0046 0.0087 0.0522
Onchocerca volvulus 0.0687 0.1669 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) carboxylesterase 0.0687 0.1669 0.1669
Schistosoma mansoni opsin-like receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0046 0.0087 0.0087
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.0087 0.0087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0123 0.0123
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0046 0.0087 0.0087
Brugia malayi putative neuropeptide receptor 0.0046 0.0087 0.0087
Brugia malayi G protein-coupled receptor 0.0046 0.0087 0.0087
Echinococcus granulosus dnaJ subfamily B 0.0416 0.1001 0.1001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0687 0.1669 0.1669
Echinococcus granulosus acetylcholinesterase 0.4064 1 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0001 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Brugia malayi Carboxylesterase family protein 0.0687 0.1669 0.1669
Echinococcus multilocularis serotonin receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0087 0.0087
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0022
Schistosoma mansoni biogenic amine receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Brugia malayi hypothetical protein 0.0687 0.1669 0.1669
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0046 0.0087 0.0522
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.0087 0.0087
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0087 0.0087
Echinococcus granulosus g protein coupled receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0087 0.0087
Brugia malayi Dopamine receptor 0.0046 0.0087 0.0087
Mycobacterium ulcerans carboxylesterase, LipT 0.0687 0.1669 0.5
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0065 0.0065
Trichomonas vaginalis spcc417.12 protein, putative 0.0687 0.1669 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0033 0.0057 0.0057
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0076 0.0076
Brugia malayi ORL1-like opioid receptor 0.0046 0.0087 0.0087
Brugia malayi Carboxylesterase family protein 0.0687 0.1669 0.1669
Onchocerca volvulus 0.0046 0.0087 0.0522
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.006 0.0123 0.0123
Echinococcus granulosus neuropeptide s receptor 0.0046 0.0087 0.0087
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.0087 0.0087
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.0087 0.0087
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0166 0.0383 0.0383
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0001 0.0001
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0073 0.0156 0.0156
Echinococcus multilocularis acetylcholinesterase 0.4064 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.0087 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0087 0.0087
Brugia malayi hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0001 0.0001
Echinococcus multilocularis sex peptide receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0687 0.1669 0.1669
Brugia malayi hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0687 0.1669 0.1669
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0046 0.0087 0.0522
Brugia malayi neuropeptide F receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0087 0.0087
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0087 0.0087
Schistosoma mansoni transient receptor potential channel 0.0099 0.0218 0.0218
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0022 0.0022
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0001 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) carboxylesterase 0.0687 0.1669 0.1669
Onchocerca volvulus 0.0046 0.0087 0.0522
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.0087 0.0087
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0087 0.0087
Schistosoma mansoni gliotactin 0.0687 0.1669 0.1669
Schistosoma mansoni hypothetical protein 0.0046 0.0087 0.0087
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.0087 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0087 0.0087
Schistosoma mansoni amine GPCR 0.0046 0.0087 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0046 0.0087 0.0522
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.0087 0.0087
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.0087 0.0522
Echinococcus granulosus serotonin receptor 0.0046 0.0087 0.0087
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.0087 0.0087
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0087 0.0087
Schistosoma mansoni opsin-like receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis carboxylesterase 5A 0.4064 1 1
Brugia malayi RE15519p 0.0046 0.0087 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Echinococcus granulosus GPCR family 2 0.0019 0.0022 0.0022
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0687 0.1669 0.1669
Brugia malayi Serotonin receptor 0.0046 0.0087 0.0087
Echinococcus granulosus somatostatin receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0687 0.1669 0.1669
Schistosoma mansoni myosin xvIII 0.0046 0.0087 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.0087 0.0087
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0137 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0687 0.1669 0.1669
Echinococcus granulosus acetylcholinesterase 0.4064 1 1
Loa Loa (eye worm) hypothetical protein 0.0687 0.1669 0.1669
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.0087 0.0087
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0087 0.0087
Echinococcus granulosus g protein coupled receptor 0.0046 0.0087 0.0087
Brugia malayi Cache domain containing protein 0.0073 0.0156 0.0156
Loa Loa (eye worm) carboxylesterase 0.4064 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0087 0.0087
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0046 0.0087 0.0522
Echinococcus granulosus neuroligin 0.0687 0.1669 0.1669
Echinococcus multilocularis serotonin receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0087 0.0087
Echinococcus granulosus sex peptide receptor 0.0046 0.0087 0.0087
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.0087 0.0087
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.0087 0.0087
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.0087 0.0087
Echinococcus granulosus BC026374 protein S09 family 0.0687 0.1669 0.1669
Echinococcus granulosus para nitrobenzyl esterase 0.0687 0.1669 0.1669
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.0087 0.0087
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.0087 0.0087
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0046 0.0087 0.0087
Brugia malayi hypothetical protein 0.0046 0.0087 0.0087
Schistosoma mansoni cpg binding protein 0.0037 0.0065 0.0065
Brugia malayi Dopamine receptor protein 2 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0046 0.0087 0.0522
Brugia malayi Dopamine receptor protein 1 0.0046 0.0087 0.0087
Echinococcus granulosus transient receptor potential gamma protein 0.0099 0.0218 0.0218
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0062 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0076
Echinococcus multilocularis neuroligin 0.0687 0.1669 0.1669
Echinococcus granulosus neuropeptide receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.0087 0.0087
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.0087 0.0087
Echinococcus granulosus orexin receptor type 2 0.0046 0.0087 0.0087
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0022 0.0022
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0087 0.0087
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0046 0.0087 0.0522
Echinococcus granulosus carboxylesterase 5A 0.4064 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.0087 0.0087
Schistosoma mansoni transient receptor potential channel 0.0065 0.0136 0.0136
Schistosoma mansoni amine GPCR 0.0046 0.0087 0.0087
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.021 0.021
Onchocerca volvulus 0.0687 0.1669 1
Leishmania major hypothetical protein, conserved 0.0026 0.0038 0.5
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0038 0.5
Brugia malayi Serotonin receptor 0.0046 0.0087 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0087 0.0087
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0003 0.0003
Brugia malayi AKH receptor 0.0046 0.0087 0.0087
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.0087 0.0087
Echinococcus multilocularis acetylcholinesterase 0.4064 1 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0687 0.1669 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0041 0.0076 0.0076
Loa Loa (eye worm) acetylcholinesterase 1 0.4064 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.0087 0.0087
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.0087 0.0087
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.0087 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.0087 0.0087
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Echinococcus multilocularis orexin receptor type 2 0.0046 0.0087 0.0087
Brugia malayi hypothetical protein 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0046 0.0087 0.0522
Schistosoma mansoni amine GPCR 0.0046 0.0087 0.0087
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0022 0.0022
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0046 0.0087 0.0522
Echinococcus granulosus g-protein coupled receptor 0.0046 0.0087 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0087 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Brugia malayi hypothetical protein 0.0046 0.0087 0.0087
Brugia malayi larval opioid receptor 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0046 0.0087 0.0522
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0038 0.5
Onchocerca volvulus 0.0046 0.0087 0.0522
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0136 0.0136
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.1001 0.1001
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0364 0.0874 0.0874
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0038 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0038 0.5
Echinococcus granulosus voltage dependent calcium channel subunit 0.0364 0.0874 0.0874
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.0087 0.0087
Brugia malayi Carboxylesterase family protein 0.4064 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0687 0.1669 0.1669
Echinococcus multilocularis transient receptor potential gamma protein 0.0099 0.0218 0.0218
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.0087 0.0087
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0687 0.1669 0.1669
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0038 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Echinococcus multilocularis cpg binding protein 0.0037 0.0065 0.0065
Schistosoma mansoni transient receptor potential channel 0.0065 0.0136 0.0136
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0087 0.0087
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0022 0.0022
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0065 0.0065
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis para nitrobenzyl esterase 0.0687 0.1669 0.1669
Brugia malayi GnHR receptor homolog 0.0046 0.0087 0.0087
Echinococcus multilocularis fmrfamide receptor 0.0046 0.0087 0.0087
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.0087 0.0087
Schistosoma mansoni adenoreceptor 0.0046 0.0087 0.0087
Schistosoma mansoni amine GPCR 0.0046 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0046 0.0087 0.0087
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis BC026374 protein (S09 family) 0.0687 0.1669 0.1669
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Brugia malayi Carboxylesterase family protein 0.0687 0.1669 0.1669
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0687 0.1669 0.1669
Schistosoma mansoni hypothetical protein 0.0086 0.0186 0.0186
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.0087 0.0087
Echinococcus granulosus g protein coupled receptor 0.0046 0.0087 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Schistosoma mansoni neuropeptide receptor 0.0046 0.0087 0.0087
Echinococcus granulosus hypothetical protein 0.0046 0.0087 0.0087
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.008 0.0172 0.0172
Onchocerca volvulus 0.0046 0.0087 0.0522
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Schistosoma mansoni neuropeptide receptor 0.0046 0.0087 0.0087
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.0087 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Schistosoma mansoni opsin-like receptor 0.0046 0.0087 0.0087
Echinococcus granulosus cpg binding protein 0.0037 0.0065 0.0065
Echinococcus granulosus neuropeptide receptor 0.0046 0.0087 0.0087
Schistosoma mansoni cpg binding protein 0.0035 0.006 0.006
Schistosoma mansoni biogenic amine receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0046 0.0087 0.0522
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0022
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0087 0.0087
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0159 0.0367 0.0367
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0087 0.0087
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.0087 0.0087
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.0087 0.0522
Onchocerca volvulus 0.0687 0.1669 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Brugia malayi hypothetical protein 0.0046 0.0087 0.0087
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.0087 0.0087
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0687 0.1669 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.0087 0.0087
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0046 0.0087 0.0522
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.0087 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.0087 0.0087
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0038
Brugia malayi Carboxylesterase family protein 0.0687 0.1669 0.1669
Schistosoma mansoni neuroligin 3 (S09 family) 0.0687 0.1669 0.1669
Echinococcus multilocularis g protein coupled receptor 0.0046 0.0087 0.0087
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.0087 0.0087
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0065 0.0065
Echinococcus multilocularis allatostatin A receptor 0.0046 0.0087 0.0087
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0035 0.006 0.0361
Brugia malayi follicle stimulating hormone receptor 0.0046 0.0087 0.0087
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0123 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0416 0.1001 0.1001
Schistosoma mansoni histamine h1 receptor 0.0046 0.0087 0.0087
Brugia malayi hypothetical protein 0.0046 0.0087 0.0087
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.0087 0.0087
Brugia malayi Melatonin receptor type 1A 0.0046 0.0087 0.0087
Brugia malayi G-protein coupled receptor 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Brugia malayi CXXC zinc finger family protein 0.0035 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Mycobacterium tuberculosis Carboxylesterase LipT 0.0687 0.1669 0.5
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0687 0.1669 0.1669
Loa Loa (eye worm) hypothetical protein 0.4064 1 1
Loa Loa (eye worm) hypothetical protein 0.0687 0.1669 0.1669
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.0087 0.0087
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.4064 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Echinococcus granulosus allatostatin A receptor 0.0046 0.0087 0.0087
Schistosoma mansoni cpg binding protein 0.0037 0.0065 0.0065
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0003 0.0003
Schistosoma mansoni neuropeptide receptor 0.0046 0.0087 0.0087
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.0087 0.0087
Echinococcus granulosus voltage dependent calcium channel subunit 0.0166 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0087 0.0087
Onchocerca volvulus 0.0687 0.1669 1
Brugia malayi hypothetical protein 0.0046 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0687 0.1669 0.1669
Brugia malayi neuropeptide F receptor 0.0046 0.0087 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.0087 0.0087
Echinococcus multilocularis neuropeptide receptor 0.0046 0.0087 0.0087
Schistosoma mansoni amine GPCR 0.0372 0.0892 0.0892
Brugia malayi hypothetical protein 0.0026 0.0038 0.0038
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.0087 0.0087
Echinococcus granulosus fmrfamide receptor 0.0046 0.0087 0.0087
Schistosoma mansoni biogenic amine receptor 0.0046 0.0087 0.0087
Schistosoma mansoni serine-rich repeat protein 0.0086 0.0186 0.0186

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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