Detailed information for compound 1386706

Basic information

Technical information
  • TDR Targets ID: 1386706
  • Name: [4-(8-ethoxy-1,3-dimethyl-4-oxocyclohepta[c]f uran-6-yl)-2-methoxyphenyl] 2-chlorobenzoate
  • MW: 478.921 | Formula: C27H23ClO6
  • H donors: 0 H acceptors: 2 LogP: 5.83 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(cc(=O)c2c1c(C)oc2C)c1ccc(c(c1)OC)OC(=O)c1ccccc1Cl
  • InChi: 1S/C27H23ClO6/c1-5-32-24-14-18(12-21(29)25-15(2)33-16(3)26(24)25)17-10-11-22(23(13-17)31-4)34-27(30)19-8-6-7-9-20(19)28/h6-14H,5H2,1-4H3
  • InChiKey: GADATMKMPUQMCH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-(8-ethoxy-1,3-dimethyl-4-oxo-cyclohepta[c]furan-6-yl)-2-methoxy-phenyl] 2-chlorobenzoate
  • 2-chlorobenzoic acid [4-(8-ethoxy-1,3-dimethyl-4-oxo-6-cyclohepta[c]furanyl)-2-methoxyphenyl] ester
  • 2-chlorobenzoic acid [4-(8-ethoxy-4-keto-1,3-dimethyl-cyclohepta[c]furan-6-yl)-2-methoxy-phenyl] ester
  • D313-0009
  • NCGC00118383-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.007 0.1259 0.1259
Schistosoma mansoni amine GPCR 0.007 0.1259 0.1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.007 0.1259 0.1259
Onchocerca volvulus 0.0049 0.0539 0.0081
Echinococcus granulosus thyrotropin releasing hormone receptor 0.007 0.1259 0.1259
Echinococcus granulosus g-protein coupled receptor 0.007 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Schistosoma mansoni glutaminase 0.0281 0.8298 1
Brugia malayi follicle stimulating hormone receptor 0.007 0.1259 0.097
Echinococcus granulosus G protein coupled receptor 139 0.007 0.1259 0.1259
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Schistosoma mansoni biogenic amine receptor 0.007 0.1259 0.1
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Schistosoma mansoni tar DNA-binding protein 0.0124 0.3053 0.3294
Brugia malayi putative neuropeptide receptor NPR1 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Schistosoma mansoni neuropeptide receptor 0.007 0.1259 0.1
Brugia malayi G-protein coupled receptor 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.1259 0.1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.007 0.1259 0.1032
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.1259 0.1259
Brugia malayi Trypsin family protein 0.0274 0.8053 0.9401
Echinococcus multilocularis neuropeptide FF receptor 2 0.007 0.1259 0.1259
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0539 0.0079
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.1259 0.1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.1259 0.1
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.3053 0.3196
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.1259 0.1259
Echinococcus multilocularis fmrfamide receptor 0.007 0.1259 0.1259
Echinococcus multilocularis g-protein coupled receptor 0.007 0.1259 0.1259
Schistosoma mansoni hypothetical protein 0.007 0.1259 0.1
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Onchocerca volvulus 0.007 0.1259 0.1032
Schistosoma mansoni adenoreceptor 0.007 0.1259 0.1
Echinococcus granulosus sex peptide receptor 0.007 0.1259 0.1259
Schistosoma mansoni alpha-1 adrenergic receptor 0.007 0.1259 0.1
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.1259 0.1259
Echinococcus multilocularis g protein coupled receptor 0.007 0.1259 0.1259
Echinococcus multilocularis tissue type plasminogen activator 0.0047 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Brugia malayi AKH receptor 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.1259 0.1259
Schistosoma mansoni amine GPCR 0.007 0.1259 0.1
Echinococcus multilocularis G-protein coupled receptor, putative 0.007 0.1259 0.1259
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.007 0.1259 0.1
Brugia malayi Dopamine receptor protein 1 0.007 0.1259 0.097
Brugia malayi glutaminase DH11.1 0.0281 0.8298 0.9704
Schistosoma mansoni neuropeptide receptor 0.007 0.1259 0.1
Leishmania major hypothetical protein, conserved 0.0047 0.0478 0.5
Schistosoma mansoni opsin-like receptor 0.007 0.1259 0.1
Echinococcus granulosus somatostatin receptor 0.007 0.1259 0.1259
Echinococcus granulosus g protein coupled receptor 0.007 0.1259 0.1259
Echinococcus multilocularis neuropeptide receptor A26 0.007 0.1259 0.1259
Loa Loa (eye worm) glutaminase 2 0.0281 0.8298 0.9704
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.1259 0.1259
Brugia malayi RNA binding protein 0.0124 0.3053 0.3196
Brugia malayi Dopamine receptor 0.007 0.1259 0.097
Onchocerca volvulus 0.007 0.1259 0.1032
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.1259 0.097
Schistosoma mansoni peptide (allatostatin)-like receptor 0.007 0.1259 0.1
Echinococcus granulosus neuropeptides capa receptor 0.007 0.1259 0.1259
Echinococcus granulosus neuropeptides capa receptor 0.007 0.1259 0.1259
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.007 0.1259 0.097
Echinococcus granulosus neuropeptide s receptor 0.007 0.1259 0.1259
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.007 0.1259 0.1
Echinococcus granulosus neuropeptide Y receptor 0.007 0.1259 0.1259
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0274 0.8053 0.9687
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus multilocularis tachykinin peptides receptor 99D 0.007 0.1259 0.1259
Echinococcus granulosus neuropeptide FF receptor 2 0.007 0.1259 0.1259
Schistosoma mansoni histamine h1 receptor 0.007 0.1259 0.1
Toxoplasma gondii kringle domain-containing protein 0.0047 0.0478 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.007 0.1259 0.097
Schistosoma mansoni biogenic amine receptor 0.007 0.1259 0.1
Echinococcus granulosus tar DNA binding protein 0.0124 0.3053 0.3053
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus multilocularis neuropeptide receptor 0.007 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Schistosoma mansoni hypothetical protein 0.007 0.1259 0.1
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Brugia malayi Serotonin receptor 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus multilocularis g protein coupled receptor 0.007 0.1259 0.1259
Echinococcus granulosus g protein coupled receptor 0.007 0.1259 0.1259
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0478 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.1259 0.1
Echinococcus granulosus peptide allatostatin:somatostatin 0.007 0.1259 0.1259
Schistosoma mansoni amine GPCR 0.007 0.1259 0.1
Echinococcus granulosus neuropeptide Y receptor 0.007 0.1259 0.1259
Onchocerca volvulus 0.007 0.1259 0.1032
Echinococcus granulosus orexin receptor type 2 0.007 0.1259 0.1259
Echinococcus multilocularis dro:myosuppressin receptor 0.007 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.0274 0.8053 0.9401
Onchocerca volvulus Neuropeptide F receptor homolog 0.007 0.1259 0.1032
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.1259 0.1
Brugia malayi neuropeptide F receptor 0.007 0.1259 0.097
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.0049 0.0539 0.0076
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.1259 0.1
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.3053 0.3196
Echinococcus multilocularis neuropeptide s receptor 0.007 0.1259 0.1259
Echinococcus granulosus hypothetical protein 0.007 0.1259 0.1259
Brugia malayi Serotonin/octopamine receptor family protein 7 0.007 0.1259 0.097
Brugia malayi hypothetical protein 0.007 0.1259 0.097
Echinococcus multilocularis serotonin receptor 0.007 0.1259 0.1259
Echinococcus multilocularis tumor protein p63 0.0332 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.1259 0.1
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.1259 0.1259
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.1259 0.1259
Schistosoma mansoni opsin-like receptor 0.007 0.1259 0.1
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.1259 0.097
Echinococcus multilocularis serotonin receptor 0.007 0.1259 0.1259
Echinococcus granulosus serotonin receptor 0.007 0.1259 0.1259
Echinococcus granulosus g protein coupled receptor 0.007 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.1259 0.1259
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.1259 0.1259
Brugia malayi hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.1259 0.1259
Schistosoma mansoni opsin-like receptor 0.007 0.1259 0.1
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.1259 0.1
Onchocerca volvulus 0.007 0.1259 0.1032
Schistosoma mansoni tar DNA-binding protein 0.0124 0.3053 0.3294
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.007 0.1259 0.097
Brugia malayi neuropeptide F receptor 0.007 0.1259 0.097
Schistosoma mansoni amine GPCR 0.007 0.1259 0.1
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.1259 0.1259
Echinococcus granulosus tissue type plasminogen activator 0.0047 0.0478 0.0478
Brugia malayi TAR-binding protein 0.0124 0.3053 0.3196
Onchocerca volvulus 0.007 0.1259 0.1032
Brugia malayi hypothetical protein 0.007 0.1259 0.097
Brugia malayi hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus multilocularis biogenic amine (5HT) receptor 0.007 0.1259 0.1259
Echinococcus multilocularis g protein coupled receptor 0.007 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.1259 0.1259
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.007 0.1259 0.1259
Brugia malayi hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.0274 0.8053 0.9401
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus granulosus 7tm_1 domain containing protein 0.007 0.1259 0.1259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.1259 0.1
Brugia malayi G-protein coupled receptor 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Schistosoma mansoni myosin xvIII 0.007 0.1259 0.1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.007 0.1259 0.1
Echinococcus granulosus tachykinin peptides receptor 99D 0.007 0.1259 0.1259
Brugia malayi RE15519p 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.0288 0.8536 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.1259 0.1
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.1259 0.1259
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.007 0.1259 0.097
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.007 0.1259 0.1259
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0047 0.0478 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.007 0.1259 0.1259
Echinococcus granulosus 7TM GPCR rhodopsin 0.007 0.1259 0.1259
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.1259 0.1
Onchocerca volvulus 0.007 0.1259 0.1032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.1259 0.1259
Echinococcus multilocularis alpha 1A adrenergic receptor 0.007 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.007 0.1259 0.097
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Loa Loa (eye worm) RNA binding protein 0.0124 0.3053 0.3196
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.1259 0.1259
Onchocerca volvulus 0.007 0.1259 0.1032
Onchocerca volvulus 0.007 0.1259 0.1032
Echinococcus multilocularis orexin receptor type 2 0.007 0.1259 0.1259
Brugia malayi Dopamine receptor protein 2 0.007 0.1259 0.097
Brugia malayi larval opioid receptor 0.007 0.1259 0.097
Schistosoma mansoni neuropeptide f receptor 76f 0.007 0.1259 0.1
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.1259 0.1259
Brugia malayi Serotonin receptor 0.007 0.1259 0.097
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.1259 0.1259
Echinococcus granulosus dro:myosuppressin receptor 0.007 0.1259 0.1259
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.007 0.1259 0.1
Onchocerca volvulus 0.007 0.1259 0.1032
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus multilocularis allatostatin A receptor 0.007 0.1259 0.1259
Loa Loa (eye worm) follicle stimulating hormone receptor 0.007 0.1259 0.097
Loa Loa (eye worm) TAR-binding protein 0.0124 0.3053 0.3196
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.007 0.1259 0.1
Echinococcus multilocularis somatostatin receptor 0.007 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Schistosoma mansoni tar DNA-binding protein 0.0124 0.3053 0.3294
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.1259 0.1259
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.1259 0.1259
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Onchocerca volvulus 0.007 0.1259 0.1032
Schistosoma mansoni tar DNA-binding protein 0.0124 0.3053 0.3294
Onchocerca volvulus 0.007 0.1259 0.1032
Echinococcus multilocularis G protein coupled receptor 139 0.007 0.1259 0.1259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.1259 0.1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.1259 0.1
Brugia malayi putative neuropeptide receptor 0.007 0.1259 0.097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.1259 0.1
Echinococcus multilocularis fmrfamide receptor 0.007 0.1259 0.1259
Brugia malayi hypothetical protein 0.007 0.1259 0.097
Onchocerca volvulus 0.007 0.1259 0.1032
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Schistosoma mansoni biogenic amine receptor 0.007 0.1259 0.1
Brugia malayi G protein-coupled receptor F59B2.13 0.007 0.1259 0.097
Onchocerca volvulus 0.0245 0.7094 0.8734
Mycobacterium ulcerans glutaminase 0.0281 0.8298 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.007 0.1259 0.1259
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.1259 0.1259
Brugia malayi hypothetical protein 0.007 0.1259 0.097
Echinococcus granulosus allatostatin A receptor 0.007 0.1259 0.1259
Schistosoma mansoni growth hormone secretagogue receptor 0.007 0.1259 0.1
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Schistosoma mansoni hypothetical protein 0.007 0.1259 0.1
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.1259 0.097
Onchocerca volvulus 0.007 0.1259 0.1032
Onchocerca volvulus 0.007 0.1259 0.1032
Echinococcus granulosus neuropeptide receptor A26 0.007 0.1259 0.1259
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.007 0.1259 0.1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.1259 0.1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.1259 0.1
Plasmodium falciparum cysteine repeat modular protein 1 0.0047 0.0478 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.007 0.1259 0.097
Echinococcus granulosus neuropeptide receptor 0.007 0.1259 0.1259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.1259 0.1
Echinococcus multilocularis sex peptide receptor 0.007 0.1259 0.1259
Loa Loa (eye worm) TYRA-2 protein 0.007 0.1259 0.097
Schistosoma mansoni hypothetical protein 0.007 0.1259 0.1
Onchocerca volvulus 0.007 0.1259 0.1032
Brugia malayi Melatonin receptor type 1A 0.007 0.1259 0.097
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.007 0.1259 0.1
Loa Loa (eye worm) glutaminase 0.0281 0.8298 0.9704
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.007 0.1259 0.097
Echinococcus granulosus neuropeptide receptor 0.007 0.1259 0.1259
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.007 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus granulosus fmrfamide receptor 0.007 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.007 0.1259 0.097
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.007 0.1259 0.1259
Schistosoma mansoni amine GPCR 0.007 0.1259 0.1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0274 0.8053 0.9687
Trichomonas vaginalis glutaminase, putative 0.0281 0.8298 0.5
Echinococcus multilocularis neuropeptide receptor 0.007 0.1259 0.1259
Onchocerca volvulus 0.007 0.1259 0.1032
Loa Loa (eye worm) melatonin receptor type 1A 0.007 0.1259 0.097
Schistosoma mansoni neuropeptide receptor 0.007 0.1259 0.1
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.1259 0.1259
Brugia malayi ORL1-like opioid receptor 0.007 0.1259 0.097
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.007 0.1259 0.1259
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.1259 0.1259
Brugia malayi sulfakinin receptor protein 0.0288 0.8536 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.1259 0.1259
Schistosoma mansoni neuropeptide receptor 0.007 0.1259 0.1
Echinococcus multilocularis tar DNA binding protein 0.0124 0.3053 0.3053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.1259 0.1
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.1259 0.1259
Onchocerca volvulus 0.007 0.1259 0.1032
Brugia malayi hypothetical protein 0.0288 0.8536 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.1259 0.1259
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.1259 0.1259
Brugia malayi GnHR receptor homolog 0.007 0.1259 0.097
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.007 0.1259 0.1259
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.1259 0.1259
Brugia malayi G protein-coupled receptor 0.007 0.1259 0.097
Brugia malayi hypothetical protein 0.007 0.1259 0.097
Brugia malayi hypothetical protein 0.007 0.1259 0.097
Brugia malayi Tachykinin-like peptides receptor 99D 0.007 0.1259 0.097
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.1259 0.1259
Schistosoma mansoni tar DNA-binding protein 0.0124 0.3053 0.3294
Onchocerca volvulus 0.0274 0.8053 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.007 0.1259 0.097

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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