Detailed information for compound 1386758

Basic information

Technical information
  • TDR Targets ID: 1386758
  • Name: methyl 4-(4-chlorophenyl)-4-oxo-2-(4-propan-2 -ylphenyl)butanoate
  • MW: 344.832 | Formula: C20H21ClO3
  • H donors: 0 H acceptors: 2 LogP: 4.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C(c1ccc(cc1)C(C)C)CC(=O)c1ccc(cc1)Cl
  • InChi: 1S/C20H21ClO3/c1-13(2)14-4-6-15(7-5-14)18(20(23)24-3)12-19(22)16-8-10-17(21)11-9-16/h4-11,13,18H,12H2,1-3H3
  • InChiKey: RGPWQHRBJXQEEG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 4-(4-chlorophenyl)-2-(4-isopropylphenyl)-4-oxo-butanoate
  • 4-(4-chlorophenyl)-2-(4-isopropylphenyl)-4-oxobutanoic acid methyl ester
  • 4-(4-chlorophenyl)-2-(4-isopropylphenyl)-4-keto-butyric acid methyl ester
  • Oprea1_120166
  • 7J-578S
  • MLS000325882
  • SMR000170016
  • methyl 4-(4-chlorophenyl)-2-(4-isopropylphenyl)-4-oxobutanoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0097 0.0442 0.0442
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0579 0.4533 0.4533
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0061 0.0141 0.0147
Brugia malayi Muscleblind-like protein 0.018 0.1151 1
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0511 0.3957 0.3957
Loa Loa (eye worm) hypothetical protein 0.018 0.1151 0.5223
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.011 0.0278
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0061 0.0141 0.0141
Trichomonas vaginalis DNA polymerase II, putative 0.0097 0.0442 0.1117
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0061 0.0141 0.0356
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1224 1 1
Brugia malayi DNA polymerase delta catalytic subunit 0.0061 0.0141 0.1224
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0061 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0511 0.3957 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.1151 0.2909
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0178 0.0449
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0063 0.0154 1
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0097 0.0442 0.0442
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0097 0.0442 0.1117
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0222 0.15 0.3791
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.011 0.0278
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0061 0.0141 0.0356
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.1546 0.3907
Schistosoma mansoni hypothetical protein 0.035 0.259 0.6546
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0132 0.06
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0061 0.0141 0.1224
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0061 0.0141 0.0356
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0172 0.1081 0.1081
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0 0.5
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0222 0.15 0.3791
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0061 0.0141 0.0147
Toxoplasma gondii DNA polymerase 0.0061 0.0141 0.1088
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0061 0.0141 0.0356
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0511 0.3957 0.3957
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0061 0.0141 0.0356
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.011 0.05
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0132 0.1149
Brugia malayi mbt repeat family protein 0.0058 0.011 0.0957
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0305 0.2204 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0178 0.1544
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0132 0.1149
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0083 0.0325 0.0822
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0511 0.3957 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0511 0.3957 0.3957
Giardia lamblia DNA polymerase alpha subunit A 0.0188 0.1212 0.2807
Entamoeba histolytica hypothetical protein, conserved 0.0511 0.3957 1
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0061 0.0141 0.0356
Loa Loa (eye worm) hypothetical protein 0.0058 0.011 0.05
Loa Loa (eye worm) hypothetical protein 0.0066 0.0178 0.0807
Loa Loa (eye worm) hypothetical protein 0.006 0.0132 0.06
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.011 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0511 0.3957 1
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0222 0.15 0.3791
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0097 0.0442 0.0442
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0172 0.1081 0.1081
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.011 0.0278
Loa Loa (eye worm) hypothetical protein 0.018 0.1151 0.5223
Plasmodium vivax DNA polymerase alpha, putative 0.018 0.1146 1
Brugia malayi DNA polymerase alpha catalytic subunit 0.018 0.1146 0.9952
Entamoeba histolytica DNA repair and recombination protein, putative 0.0511 0.3957 1
Echinococcus multilocularis muscleblind protein 0.018 0.1151 0.2909
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0061 0.0141 0.0141
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0061 0.0141 0.0141
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0511 0.3957 0.3957
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0061 0.0141 0.0141
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0061 0.0141 0.0356
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0061 0.0141 0.0356
Giardia lamblia Rrm3p helicase 0.0511 0.3957 1
Loa Loa (eye worm) MBCTL1 0.0066 0.0178 0.0807
Onchocerca volvulus DNA polymerase homolog 0.0061 0.0141 0.0147
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.021 0.14 0.14
Brugia malayi mbt repeat family protein 0.0058 0.011 0.0957
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0511 0.3957 0.3957
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0579 0.4533 0.4533
Mycobacterium tuberculosis Conserved hypothetical protein 0.0645 0.5088 0.5
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0511 0.3957 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0178 0.0449
Toxoplasma gondii hypothetical protein 0.0197 0.1296 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.1546 0.3907
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0178 0.0449
Echinococcus granulosus muscleblind protein 0.018 0.1151 0.2909
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0061 0.0141 0.0141
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0511 0.3957 0.3957
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.011 0.0278
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0061 0.0141 0.0141
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1224 1 1
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0061 0.0141 0.0639
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0061 0.0141 0.0356
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0061 0.0141 0.0356
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0178 0.0449
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0061 0.0141 0.0356
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0061 0.0141 0.0141
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.018 0.1146 0.8841
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0172 0.1081 0.1081
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0063 0.0154 0.0389
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0579 0.4533 0.4533
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0061 0.0141 0.0356
Mycobacterium ulcerans hypothetical protein 0.0645 0.5088 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.2204 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1224 1 1
Toxoplasma gondii DNA polymerase family B protein 0.0061 0.0141 0.1088
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0178 0.0449
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.011 0.0278
Brugia malayi DNA polymerase family B containing protein 0.0061 0.0141 0.1224
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0172 0.1081 0.1081
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0061 0.0141 0.0356
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0511 0.3957 0.3957
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.011 0.0278

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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