Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0359 | 0.025 | 1 |
Echinococcus granulosus | adam 17 protease | 0.0199 | 0.0087 | 0.3473 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0359 | 0.025 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3795 | 0.3744 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3795 | 0.3744 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.9945 | 1 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3795 | 0.3744 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.9945 | 1 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.0181 | 0.0068 | 0.2739 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0219 | 0.0108 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.9945 | 1 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.9945 | 1 | 1 |
Plasmodium falciparum | peptide deformylase | 0.9945 | 1 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.014 | 0.0027 | 0.1666 |
Brugia malayi | Matrixin family protein | 0.0239 | 0.0128 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3795 | 0.3744 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.9945 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0219 | 0.0108 | 0.3807 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3795 | 0.3744 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0239 | 0.0128 | 0.4569 |
Plasmodium vivax | peptide deformylase, putative | 0.9945 | 1 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3795 | 0.3744 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.9945 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0219 | 0.0108 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0271 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3795 | 0.3744 | 0.5 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0181 | 0.0068 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 30.1313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.