Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidine kinase | 0.0237 | 0.5908 | 0.6548 |
Onchocerca volvulus | 0.0052 | 0.006 | 0.5 | |
Mycobacterium tuberculosis | Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) | 0.0052 | 0.006 | 0.5 |
Echinococcus multilocularis | concentrative Na+ nucleoside cotransporter | 0.0335 | 0.8991 | 1 |
Echinococcus granulosus | solute carrier family 28 | 0.0335 | 0.8991 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0243 | 0.6094 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0243 | 0.6094 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0243 | 0.6094 | 1 |
Mycobacterium leprae | PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) | 0.0052 | 0.006 | 0.5 |
Echinococcus granulosus | concentrative Na nucleoside cotransporter | 0.0335 | 0.8991 | 1 |
Leishmania major | thymidine kinase, putative | 0.0243 | 0.6094 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0243 | 0.6094 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0243 | 0.6094 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.3626 | 0.3993 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.2284 | 0.2491 |
Echinococcus granulosus | thymidine kinase | 0.0237 | 0.5908 | 0.6548 |
Giardia lamblia | Thymidine kinase | 0.0243 | 0.6094 | 0.607 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.031 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0243 | 0.6094 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.2596 | 0.4393 |
Echinococcus granulosus | Na+ dependent nucleoside transporter | 0.0335 | 0.8991 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.3626 | 0.6137 |
Echinococcus multilocularis | thymidine kinase | 0.0237 | 0.5908 | 0.6548 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.2596 | 0.4393 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.031 | 0.5 |
Echinococcus multilocularis | sodium:nucleoside cotransporter 2 | 0.0218 | 0.531 | 0.5878 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0237 | 0.5908 | 0.6548 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0237 | 0.5908 | 0.6548 |
Schistosoma mansoni | thymidine kinase | 0.0237 | 0.5908 | 1 |
Mycobacterium ulcerans | cytidine deaminase | 0.0052 | 0.006 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.2596 | 0.2839 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.031 | 1 |
Toxoplasma gondii | cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein | 0.0052 | 0.006 | 0.5 |
Echinococcus granulosus | thymidine kinase | 0.0237 | 0.5908 | 0.6548 |
Echinococcus multilocularis | solute carrier family 28 | 0.0335 | 0.8991 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.2284 | 0.3866 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.2284 | 0.2491 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0243 | 0.6094 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.031 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.3626 | 0.6137 |
Onchocerca volvulus | 0.0052 | 0.006 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0165 | 0.3626 | 0.3993 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.