Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0145 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0145 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0145 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0145 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0145 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0145 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0145 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0145 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0145 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0145 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0145 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0145 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0145 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0145 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0145 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0145 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0145 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0145 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0145 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0145 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0145 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0145 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0145 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0145 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0145 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0145 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0145 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0145 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0145 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.