Detailed information for compound 1387178

Basic information

Technical information
  • TDR Targets ID: 1387178
  • Name: 3-methyl-N-[4-(tetrazol-1-yl)phenyl]-1-benzof uran-2-carboxamide
  • MW: 319.317 | Formula: C17H13N5O2
  • H donors: 1 H acceptors: 4 LogP: 3.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1oc2c(c1C)cccc2)Nc1ccc(cc1)n1cnnn1
  • InChi: 1S/C17H13N5O2/c1-11-14-4-2-3-5-15(14)24-16(11)17(23)19-12-6-8-13(9-7-12)22-10-18-20-21-22/h2-10H,1H3,(H,19,23)
  • InChiKey: UFNWNQKMTUROKZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-methyl-N-[4-(tetrazol-1-yl)phenyl]benzofuran-2-carboxamide
  • 3-methyl-N-[4-(1-tetrazolyl)phenyl]-2-benzofurancarboxamide
  • 3-methyl-N-[4-(1,2,3,4-tetrazol-1-yl)phenyl]-1-benzofuran-2-carboxamide
  • ZINC00414660
  • Oprea1_057239
  • 3-Methyl-benzofuran-2-carboxylic acid (4-tetrazol-1-yl-phenyl)-amide
  • MLS000068640
  • SMR000003826
  • Oprea1_086770
  • ASN 04935965

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 2, group E, member 3 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens peroxisome proliferator-activated receptor gamma No references
Homo sapiens nuclear receptor corepressor 2 Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus nuclear receptor co repressor related ncor Get druggable targets OG5_131772 All targets in OG5_131772
Echinococcus multilocularis nuclear receptor co repressor related (ncor) Get druggable targets OG5_131772 All targets in OG5_131772
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi photoreceptor-specific nuclear receptor Get druggable targets OG5_135311 All targets in OG5_135311
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135311 All targets in OG5_135311
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Echinococcus granulosus ecdysone induced protein 78C peroxisome proliferator-activated receptor gamma 477 aa 447 aa 28.2 %
Brugia malayi Nuclear hormone receptor family member nhr-49 nuclear receptor subfamily 2, group E, member 3 410 aa 384 aa 28.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G protein coupled receptor 139 0.0117 0.3111 0.3111
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0117 0.3111 0.5259
Echinococcus granulosus neuropeptides capa receptor 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0079
Schistosoma mansoni amine GPCR 0.0117 0.3111 0.5259
Schistosoma mansoni neuropeptide receptor 0.0117 0.3111 0.5259
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0815 0.0815
Echinococcus granulosus 7TM GPCR rhodopsin 0.0117 0.3111 0.3111
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0079
Brugia malayi larval opioid receptor 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus granulosus g protein coupled receptor 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis fmrfamide receptor 0.0117 0.3111 0.3111
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Brugia malayi neuropeptide F receptor 0.0117 0.3111 0.3396
Echinococcus multilocularis neuropeptides capa receptor 0.0117 0.3111 0.3111
Echinococcus multilocularis neuropeptide FF receptor 2 0.0117 0.3111 0.3111
Onchocerca volvulus 0.0117 0.3111 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0073 0.0073
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0074 0.1749 1
Echinococcus multilocularis neuropeptides capa receptor 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis neuropeptide receptor A26 0.0117 0.3111 0.3111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.3111 0.5259
Echinococcus granulosus geminin 0.0205 0.5916 0.5916
Brugia malayi Dopamine receptor protein 1 0.0117 0.3111 0.3396
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0117 0.3111 0.3111
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0073 0.0123
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0117 0.3111 0.5259
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0815 0.0815
Echinococcus granulosus neuropeptide Y receptor 0.0117 0.3111 0.3111
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0073 0.0079
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0073 0.0079
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0117 0.3111 0.3111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.3111 0.5259
Schistosoma mansoni coup transcription factor 0.0021 0.0073 0.0123
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0815 0.1378
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0073 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.3111 0.5259
Onchocerca volvulus 0.0117 0.3111 1
Echinococcus granulosus somatostatin receptor 0.0117 0.3111 0.3111
Echinococcus granulosus g protein coupled receptor 0.0117 0.3111 0.3111
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0073 0.0123
Brugia malayi G-protein coupled receptor 0.0117 0.3111 0.3396
Echinococcus granulosus biogenic amine 5HT receptor 0.0117 0.3111 0.3111
Brugia malayi Tachykinin-like peptides receptor 99D 0.0117 0.3111 0.3396
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0 0.5
Echinococcus multilocularis somatostatin receptor 0.0117 0.3111 0.3111
Onchocerca volvulus Neuropeptide F receptor homolog 0.0117 0.3111 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0117 0.3111 0.3111
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0073 0.0123
Schistosoma mansoni hypothetical protein 0.0117 0.3111 0.5259
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus granulosus neuropeptide receptor A26 0.0117 0.3111 0.3111
Echinococcus granulosus tachykinin peptides receptor 99D 0.0117 0.3111 0.3111
Brugia malayi G protein-coupled receptor F59B2.13 0.0117 0.3111 0.3396
Schistosoma mansoni hypothetical protein 0.0205 0.5916 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.1749 0.1749
Echinococcus granulosus peptide allatostatin:somatostatin 0.0117 0.3111 0.3111
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0117 0.3111 0.3111
Echinococcus granulosus biogenic amine 5HT receptor 0.0117 0.3111 0.3111
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0815 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.3111 0.5259
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0073 0.0079
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0117 0.3111 0.3111
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0117 0.3111 0.5259
Loa Loa (eye worm) G-protein coupled receptor 0.0117 0.3111 0.3396
Echinococcus multilocularis g protein coupled receptor 0.0117 0.3111 0.3111
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0117 0.3111 0.5259
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0815 0.0815
Echinococcus multilocularis sex peptide receptor 0.0117 0.3111 0.3111
Schistosoma mansoni growth hormone secretagogue receptor 0.0117 0.3111 0.5259
Brugia malayi follicle stimulating hormone receptor 0.0117 0.3111 0.3396
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0073 0.0073
Brugia malayi Melatonin receptor type 1A 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Onchocerca volvulus 0.0117 0.3111 1
Onchocerca volvulus 0.0117 0.3111 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0117 0.3111 0.3396
Loa Loa (eye worm) TYRA-2 protein 0.0117 0.3111 0.3396
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0073 0.0079
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0815 1
Brugia malayi G protein-coupled receptor 0.0117 0.3111 0.3396
Schistosoma mansoni hypothetical protein 0.0117 0.3111 0.5259
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Schistosoma mansoni biogenic amine (5HT) receptor 0.0117 0.3111 0.5259
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0073 0.0123
Schistosoma mansoni neuropeptide F-like receptor 0.0117 0.3111 0.5259
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0073 0.0073
Onchocerca volvulus 0.0117 0.3111 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0815 0.5
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0073 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.3111 0.5259
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0117 0.3111 0.3396
Onchocerca volvulus 0.0117 0.3111 1
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0333 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0117 0.3111 0.3111
Schistosoma mansoni histamine h1 receptor 0.0117 0.3111 0.5259
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0073 0.0123
Schistosoma mansoni neuropeptide receptor 0.0117 0.3111 0.5259
Schistosoma mansoni biogenic amine receptor 0.0117 0.3111 0.5259
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus granulosus neuropeptide s receptor 0.0117 0.3111 0.3111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0073 0.0079
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.1749 0.5
Brugia malayi hypothetical protein 0.0117 0.3111 0.3396
Brugia malayi putative neuropeptide receptor NPR1 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Onchocerca volvulus 0.0117 0.3111 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0073 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.3111 0.5259
Onchocerca volvulus 0.0117 0.3111 1
Schistosoma mansoni amine GPCR 0.0117 0.3111 0.5259
Echinococcus granulosus neuropeptide Y receptor 0.0117 0.3111 0.3111
Brugia malayi ecdysteroid receptor 0.0021 0.0073 0.0079
Echinococcus granulosus alpha 1A adrenergic receptor 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0073 0.0073
Echinococcus granulosus tm gpcr rhodopsin 0.0117 0.3111 0.3111
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0073 0.0079
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0815 0.089
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis allatostatin A receptor 0.0117 0.3111 0.3111
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Onchocerca volvulus 0.0117 0.3111 1
Brugia malayi Dopamine receptor protein 2 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0073 0.0079
Echinococcus multilocularis G-protein coupled receptor, putative 0.0117 0.3111 0.3111
Loa Loa (eye worm) neuropeptide F receptor 0.0117 0.3111 0.3396
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0815 0.1378
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus granulosus neuropeptide receptor 0.0117 0.3111 0.3111
Echinococcus granulosus fmrfamide receptor 0.0117 0.3111 0.3111
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0074 0.1749 0.2957
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0815 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0117 0.3111 0.5259
Schistosoma mansoni biogenic amine receptor 0.0117 0.3111 0.5259
Schistosoma mansoni amine GPCR 0.0117 0.3111 0.5259
Schistosoma mansoni biogenic amine receptor 0.0117 0.3111 0.5259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.3111 0.5259
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0117 0.3111 0.5259
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0117 0.3111 0.3396
Brugia malayi photoreceptor-specific nuclear receptor 0.0306 0.9162 1
Brugia malayi Serotonin receptor 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0073 0.0073
Echinococcus multilocularis g-protein coupled receptor 0.0117 0.3111 0.3111
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0117 0.3111 0.3111
Brugia malayi AKH receptor 0.0117 0.3111 0.3396
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0117 0.3111 0.5259
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Brugia malayi sulfakinin receptor protein 0.0117 0.3111 0.3396
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0117 0.3111 0.3111
Brugia malayi hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis geminin 0.0205 0.5916 0.5916
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Brugia malayi hypothetical protein 0.0117 0.3111 0.3396
Brugia malayi hypothetical protein 0.0117 0.3111 0.3396
Echinococcus granulosus dro:myosuppressin receptor 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0073 0.0073
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0073 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.3111 0.5259
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0815 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Onchocerca volvulus 0.0117 0.3111 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0073 0.0073
Schistosoma mansoni amine GPCR 0.0117 0.3111 0.5259
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0117 0.3111 0.3111
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0117 0.3111 0.5259
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Brugia malayi hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis neuropeptide receptor 0.0117 0.3111 0.3111
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0073 0.0079
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0117 0.3111 0.3111
Onchocerca volvulus 0.0117 0.3111 1
Brugia malayi hypothetical protein 0.0117 0.3111 0.3396
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0815 0.0815
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0117 0.3111 0.3111
Onchocerca volvulus 0.0117 0.3111 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0117 0.3111 0.3111
Echinococcus granulosus g protein coupled receptor 0.0117 0.3111 0.3111
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0815 0.5
Echinococcus granulosus orexin receptor type 2 0.0117 0.3111 0.3111
Brugia malayi Serotonin receptor 0.0117 0.3111 0.3396
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0117 0.3111 0.5259
Schistosoma mansoni adenoreceptor 0.0117 0.3111 0.5259
Echinococcus granulosus hypothetical protein 0.0117 0.3111 0.3111
Echinococcus multilocularis serotonin receptor 0.0117 0.3111 0.3111
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0117 0.3111 0.3396
Echinococcus granulosus neuropeptide FF receptor 2 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.1749 0.1749
Loa Loa (eye worm) hypothetical protein 0.0045 0.0815 0.089
Brugia malayi hypothetical protein 0.0117 0.3111 0.3396
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0073 0.0079
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0073 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0073 0.0123
Echinococcus multilocularis neuropeptide receptor 0.0117 0.3111 0.3111
Echinococcus multilocularis neuropeptide Y receptor 0.0117 0.3111 0.3111
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0815 1
Schistosoma mansoni myosin xvIII 0.0117 0.3111 0.5259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0073 0.0123
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0117 0.3111 0.5259
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0815 0.4662
Schistosoma mansoni neuropeptide receptor 0.0117 0.3111 0.5259
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0073 0.0123
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0073 0.0073
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0117 0.3111 0.3396
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0073 0.0073
Schistosoma mansoni biogenic amine (5HT) receptor 0.0117 0.3111 0.5259
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0079
Schistosoma mansoni hypothetical protein 0.0117 0.3111 0.5259
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.1452 0.1585
Echinococcus multilocularis dro:myosuppressin receptor 0.0117 0.3111 0.3111
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Brugia malayi hypothetical protein 0.0117 0.3111 0.3396
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0073 0.0079
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Onchocerca volvulus 0.0117 0.3111 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0073 0.0079
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0073 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Brugia malayi ORL1-like opioid receptor 0.0117 0.3111 0.3396
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0117 0.3111 0.3111
Brugia malayi neuropeptide F receptor 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0306 0.9162 1
Echinococcus granulosus serotonin receptor 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus granulosus rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0117 0.3111 0.3396
Echinococcus multilocularis neuropeptide s receptor 0.0117 0.3111 0.3111
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0117 0.3111 0.5259
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0073 0.0073
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0117 0.3111 0.3111
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0073 0.0079
Schistosoma mansoni opsin-like receptor 0.0117 0.3111 0.5259
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0073 0.0073
Schistosoma mansoni neuropeptide f receptor 76f 0.0117 0.3111 0.5259
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Schistosoma mansoni neuropeptide receptor 0.0117 0.3111 0.5259
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0117 0.3111 0.3111
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0074 0.1749 0.1909
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0073 0.0079
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0073 0.0079
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0117 0.3111 1
Echinococcus granulosus sex peptide receptor 0.0117 0.3111 0.3111
Echinococcus granulosus allatostatin A receptor 0.0117 0.3111 0.3111
Onchocerca volvulus 0.0117 0.3111 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0079
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0117 0.3111 0.3111
Loa Loa (eye worm) G-protein coupled receptor 0.0117 0.3111 0.3396
Echinococcus multilocularis serotonin receptor 0.0117 0.3111 0.3111
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0073 0.0123
Echinococcus granulosus neuropeptides capa receptor 0.0117 0.3111 0.3111
Echinococcus multilocularis g protein coupled receptor 0.0117 0.3111 0.3111
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0815 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0073 0.0079
Echinococcus multilocularis orexin receptor type 2 0.0117 0.3111 0.3111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0073 0.0079
Echinococcus granulosus G protein coupled receptor 139 0.0117 0.3111 0.3111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0073 0.0079
Brugia malayi steroid hormone receptor 0.0021 0.0073 0.0079
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0073 0.0123
Brugia malayi hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Onchocerca volvulus 0.0117 0.3111 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0073 0.0079
Echinococcus granulosus g-protein coupled receptor 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0079
Brugia malayi hypothetical protein 0.0117 0.3111 0.3396
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0117 0.3111 0.3111
Schistosoma mansoni amine GPCR 0.0117 0.3111 0.5259
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0079
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0073 0.0123
Brugia malayi Dopamine receptor 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Brugia malayi putative neuropeptide receptor 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Schistosoma mansoni hypothetical protein 0.0205 0.5916 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Brugia malayi G-protein coupled receptor 0.0117 0.3111 0.3396
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Echinococcus multilocularis fmrfamide receptor 0.0117 0.3111 0.3111
Echinococcus granulosus tm gpcr rhodopsin 0.0117 0.3111 0.3111
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.1749 0.5
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0815 0.0815
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0815 0.0815
Schistosoma mansoni opsin-like receptor 0.0117 0.3111 0.5259
Loa Loa (eye worm) melatonin receptor type 1A 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Schistosoma mansoni opsin-like receptor 0.0117 0.3111 0.5259
Brugia malayi nuclear hormone receptor 0.0021 0.0073 0.0079
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0117 0.3111 0.3111
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0117 0.3111 0.3111
Onchocerca volvulus 0.0117 0.3111 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0073 0.0123
Onchocerca volvulus 0.0117 0.3111 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0117 0.3111 0.5259
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0073 0.0079
Brugia malayi RE15519p 0.0117 0.3111 0.3396
Loa Loa (eye worm) hypothetical protein 0.0117 0.3111 0.3396
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0073 0.0073
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0117 0.3111 0.5259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0117 0.3111 0.3111
Echinococcus granulosus tm gpcr rhodopsin 0.0117 0.3111 0.3111
Brugia malayi GnHR receptor homolog 0.0117 0.3111 0.3396
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0073 0.0073
Echinococcus multilocularis g protein coupled receptor 0.0117 0.3111 0.3111
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0073 0.0073
Schistosoma mansoni neuropeptide F-like receptor 0.0117 0.3111 0.5259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0117 0.3111 0.5259
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0074 0.1749 1
Echinococcus granulosus neuropeptide receptor 0.0117 0.3111 0.3111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0073 0.0073
Loa Loa (eye worm) neuropeptide F receptor 0.0117 0.3111 0.3396
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0117 0.3111 0.5259
Schistosoma mansoni alpha-1 adrenergic receptor 0.0117 0.3111 0.5259

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 7.48 um PUBCHEM_BIOASSAY: Counterscreen for NR2E3 inverse agonists: TR-FRET-based biochemical high throughput dose response assay to identify inverse agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2). (Class of assay: confirmatory) [Related pubchem assays: 2379 (Confirmation (NR2E3 agonists in quadruplicate)), 2759 (Dose response counterscreen (PPARg and NCOR2 interaction agonists in triplicate)), 2758 (Dose response (NR2E3 agonists in quadruplicate)), 2325 (Summary (NR2E3 agonists)), 2300 (Primary screen (NR2E3 agonists in singlicate))] ChEMBL. No reference
IC50 (functional) = 8.458 um PUBCHEM_BIOASSAY: TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists. (Class of assay: confirmatory) [Related pubchem assays: 2379 (Confirmation (NR2E3 agonists in quadruplicate)), 2759 (Dose response counterscreen (PPARg and NCOR2 interaction agonists in triplicate)), 2758 (Dose response (NR2E3 agonists in quadruplicate)), 2325 (Summary (NR2E3 agonists)), 2300 (Primary screen (NR2E3 agonists in singlicate))] ChEMBL. No reference
IC50 (functional) 78.545 uM PubChem BioAssay. Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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