Detailed information for compound 1387326

Basic information

Technical information
  • TDR Targets ID: 1387326
  • Name: (5E)-1-(4-methylphenyl)-5-[(pyridin-2-ylmethy lamino)methylidene]-2-sulfanylidene-1,3-diazi nane-4,6-dione
  • MW: 352.41 | Formula: C18H16N4O2S
  • H donors: 2 H acceptors: 3 LogP: 2.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)N1C(=S)NC(=O)/C(=C\NCc2ccccn2)/C1=O
  • InChi: 1S/C18H16N4O2S/c1-12-5-7-14(8-6-12)22-17(24)15(16(23)21-18(22)25)11-19-10-13-4-2-3-9-20-13/h2-9,11,19H,10H2,1H3,(H,21,23,25)/b15-11+
  • InChiKey: KBJUYKXHZKNDOT-RVDMUPIBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-methylphenyl)-5-[(pyridin-2-ylmethylamino)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
  • (5E)-1-(4-methylphenyl)-5-[(2-pyridylmethylamino)methylene]-2-thioxo-hexahydropyrimidine-4,6-dione
  • 1-(4-methylphenyl)-5-[(2-pyridylmethylamino)methylene]-2-thioxo-hexahydropyrimidine-4,6-dione
  • (5E)-1-(4-methylphenyl)-5-[(2-pyridylmethylamino)methylene]-2-thioxohexahydropyrimidine-4,6-dione
  • 1-(4-methylphenyl)-5-[(2-pyridylmethylamino)methylene]-2-thioxohexahydropyrimidine-4,6-dione
  • 1-(4-methylphenyl)-5-[(2-pyridylmethylamino)methylene]-2-thioxo-hexahydropyrimidine-4,6-quinone
  • (5E)-1-(4-methylphenyl)-5-[(2-pyridylmethylamino)methylene]-2-thioxo-hexahydropyrimidine-4,6-quinone
  • 5-[1-[(Pyridin-2-ylmethyl)-amino]-meth-(E)-ylidene]-2-thioxo-1-p-tolyl-dihydro-pyrimidine-4,6-dione
  • MLS000333735
  • SMR000437851

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.3398 0.3398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0151 0.8313 0.8313
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0151 0.8313 0.8357
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0071 0.2809 0.2809
Brugia malayi orphan nuclear receptor NR2E1 0.0071 0.2809 0.2809
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0151 0.8313 0.8313
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0151 0.8313 0.7963
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.2809 0.1651
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0071 0.2809 0.132
Echinococcus multilocularis ecdysone induced protein 78C 0.0151 0.8313 0.7963
Leishmania major hypothetical protein, conserved 0.003 0 0.5
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1158 1
Loa Loa (eye worm) hypothetical protein 0.008 0.3398 0.3398
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0151 0.8313 0.8313
Echinococcus multilocularis thyroid hormone receptor alpha 0.0151 0.8313 0.7963
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Loa Loa (eye worm) hypothetical protein 0.008 0.3398 0.3398
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.008 0.3398 0.2369
Echinococcus granulosus nuclear receptor nhr 48 0.0071 0.2809 0.1651
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1455 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0151 0.8313 0.7963
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0151 0.8313 0.8313
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.008 0.3398 0.2032
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0151 0.8313 0.8357
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0151 0.8313 0.8357
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0151 0.8313 0.8313
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0151 0.8313 0.8313
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0071 0.2809 0.132
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0151 0.8313 0.7963
Schistosoma mansoni nuclear hormone receptor 0.0071 0.2809 0.132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0151 0.8313 0.8313
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0151 0.8313 0.8313
Loa Loa (eye worm) hypothetical protein 0.0151 0.8313 0.8313
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1455 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0151 0.8313 0.8357
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Loa Loa (eye worm) hypothetical protein 0.0151 0.8313 0.8313
Schistosoma mansoni thyroid hormone receptor 0.0151 0.8313 0.7963
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1455 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0151 0.8313 0.8313
Brugia malayi nuclear hormone receptor family member nhr-6 0.0071 0.2809 0.2809
Schistosoma mansoni thyroid hormone receptor 0.0151 0.8313 0.7963
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0071 0.2809 0.132
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0071 0.2809 0.2809
Brugia malayi photoreceptor-specific nuclear receptor 0.0151 0.8313 0.8313
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 1 1
Brugia malayi hypothetical protein 0.008 0.3398 0.3398
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1715 0.1715
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0151 0.8313 0.7963
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0071 0.2809 0.132
Brugia malayi ecdysone receptor 0.0071 0.2809 0.2809
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0151 0.8313 0.8313
Loa Loa (eye worm) acetyltransferase 0.0175 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0071 0.2809 0.132
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Schistosoma mansoni nuclear hormone receptor 0.0071 0.2809 0.132
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 1 1
Schistosoma mansoni nuclear receptor 0.0071 0.2809 0.132
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1715 0.0317
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0151 0.8313 0.8313
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0071 0.2809 0.132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0151 0.8313 0.7963
Onchocerca volvulus 0.0151 0.8313 1
Brugia malayi hypothetical protein 0.008 0.3398 0.3398
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0151 0.8313 0.8357
Echinococcus granulosus ecdysone induced protein 78C 0.0151 0.8313 0.8357
Brugia malayi Nuclear hormone receptor E75 0.0071 0.2809 0.2809
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.008 0.3398 0.2032
Brugia malayi nuclear hormone receptor 0.0151 0.8313 0.8313
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0151 0.8313 0.7963
Echinococcus multilocularis nuclear receptor nhr 48 0.0071 0.2809 0.132
Brugia malayi nuclear receptor NHR-88 0.0151 0.8313 0.8313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.2809 0.132
Onchocerca volvulus Protein ultraspiracle homolog 0.0151 0.8313 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0151 0.8313 0.8313
Schistosoma mansoni zinc finger protein 0.0071 0.2809 0.132
Loa Loa (eye worm) hypothetical protein 0.0151 0.8313 0.8313
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.3398 0.3398
Loa Loa (eye worm) hypothetical protein 0.008 0.3398 0.3398
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1158 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0151 0.8313 0.8313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0151 0.8313 0.8313
Brugia malayi hypothetical protein 0.0071 0.2809 0.2809
Loa Loa (eye worm) DR-78 0.0071 0.2809 0.2809
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.008 0.3398 0.3398
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0151 0.8313 0.8313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1715 0.0317
Loa Loa (eye worm) hypothetical protein 0.0151 0.8313 0.8313
Schistosoma mansoni nuclear receptor 0.0071 0.2809 0.132
Echinococcus granulosus thyroid hormone receptor alpha 0.0071 0.2809 0.1651
Schistosoma mansoni nuclear hormone receptor 0.0151 0.8313 0.7963
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0151 0.8313 0.7963
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0071 0.2809 0.132
Schistosoma mansoni retinoic acid receptor RXR 0.0151 0.8313 0.7963
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0151 0.8313 0.7963
Brugia malayi Steroid receptor seven-up type 2 0.0151 0.8313 0.8313
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0 0.5
Brugia malayi steroid hormone receptor 0.0151 0.8313 0.8313
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0151 0.8313 0.8313
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.9661 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0 0.5
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1158 0.5
Loa Loa (eye worm) hypothetical protein 0.0151 0.8313 0.8313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0151 0.8313 0.8313
Loa Loa (eye worm) steroid hormone receptor 0.0151 0.8313 0.8313
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0151 0.8313 0.8313
Loa Loa (eye worm) hypothetical protein 0.0151 0.8313 0.8313
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1455 1
Echinococcus multilocularis FTZ F1 alpha 0.0151 0.8313 0.7963
Brugia malayi nuclear receptor NHR-88 0.0071 0.2809 0.2809
Brugia malayi conserved hypotetical protein 0.0071 0.2809 0.2809
Brugia malayi Nuclear hormone receptor-like 1 0.0151 0.8313 0.8313
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0151 0.8313 0.8313
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1455 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1715 0.1715
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0151 0.8313 0.7963
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0151 0.8313 0.8357
Echinococcus granulosus Nuclear hormone receptor HR96 0.0071 0.2809 0.1651
Schistosoma mansoni RAR-like nuclear receptor 0.0151 0.8313 0.7963
Brugia malayi Nuclear hormone receptor E75 0.0071 0.2809 0.2809
Schistosoma mansoni retinoid-x-receptor (RXR) 0.008 0.3398 0.2032
Schistosoma mansoni steroid hormone receptor ad4bp 0.0151 0.8313 0.7963
Brugia malayi nuclear receptor RXR 0.008 0.3398 0.3398
Brugia malayi nuclear hormone receptor 0.0071 0.2809 0.2809
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0151 0.8313 0.7963
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0151 0.8313 0.8313
Schistosoma mansoni coup transcription factor 0.0151 0.8313 0.7963
Brugia malayi ecdysteroid receptor 0.0151 0.8313 0.8313
Brugia malayi tailless protein 0.0071 0.2809 0.2809
Onchocerca volvulus Bile acid receptor homolog 0.0151 0.8313 1
Loa Loa (eye worm) hypothetical protein 0.008 0.3398 0.3398
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0151 0.8313 0.8357
Brugia malayi nuclear receptor RXR 0.0071 0.2809 0.2809
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0151 0.8313 0.7963
Loa Loa (eye worm) hypothetical protein 0.0151 0.8313 0.8313
Loa Loa (eye worm) hypothetical protein 0.008 0.3398 0.3398
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0 0.5
Echinococcus granulosus FTZ F1 alpha 0.0151 0.8313 0.8357
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0071 0.2809 0.1651
Loa Loa (eye worm) hypothetical protein 0.0151 0.8313 0.8313
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0151 0.8313 1
Brugia malayi hypothetical protein 0.0071 0.2809 0.2809
Brugia malayi nuclear receptor NHR-67 0.0071 0.2809 0.2809
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0151 0.8313 0.7963
Loa Loa (eye worm) hypothetical protein 0.0071 0.2809 0.2809
Loa Loa (eye worm) nuclear hormone receptor 0.0071 0.2809 0.2809
Echinococcus granulosus Nuclear hormone receptor HR96 0.0071 0.2809 0.1651
Brugia malayi nuclear hormone receptor family member odr-7 0.0071 0.2809 0.2809
Loa Loa (eye worm) nuclear receptor NHR-67 0.0071 0.2809 0.2809

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0336 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2079 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.3548 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.3973 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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