Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1443 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0793 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0087 | 0.2472 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.0987 | 0.6841 |
Giardia lamblia | Telomerase catalytic subunit | 0.0087 | 0.2472 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0038 | 0.0874 | 0.1219 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0115 | 0.3389 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0087 | 0.2472 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0704 | 0.4882 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0155 | 0.1077 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0023 | 0.0383 | 0.2653 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0136 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0712 | 0.4931 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0704 | 0.0982 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0087 | 0.2472 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0704 | 0.4882 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0115 | 0.3389 | 1 |
Onchocerca volvulus | 0.0033 | 0.0704 | 0.0334 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0383 | 0.2653 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1443 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0704 | 0.0982 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0023 | 0.0383 | 0.2653 |
Mycobacterium leprae | HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE ACPS (HOLO-ACP SYNTHASE) (CoA:APO-[ACP]PANTETHEINEPHOSPHOTRANSFERASE) (CoA:APO-[ACYL-CARRIE | 0.0092 | 0.2649 | 1 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0115 | 0.3389 | 0.5 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0115 | 0.3389 | 0.5 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0115 | 0.3389 | 0.5 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0115 | 0.3389 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0704 | 0.4882 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0023 | 0.0383 | 0.2653 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0155 | 0.1077 |
Echinococcus granulosus | lamin | 0.0033 | 0.0704 | 0.4882 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0383 | 0.5 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0115 | 0.3389 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0685 | 0.4747 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0704 | 0.4882 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0087 | 0.2472 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1443 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0704 | 0.4882 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.0793 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0038 | 0.0874 | 0.6057 |
Schistosoma mansoni | lamin | 0.0033 | 0.0704 | 0.4882 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1443 | 0.2012 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1443 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0212 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0704 | 0.4882 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1443 | 1 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0023 | 0.0383 | 0.0534 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1443 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0038 | 0.0874 | 0.6057 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0212 | 0.1468 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.0987 | 0.6841 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1443 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0136 | 0.0943 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0704 | 0.4882 |
Brugia malayi | Telomerase reverse transcriptase | 0.0231 | 0.7171 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0087 | 0.2472 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0155 | 0.1077 |
Onchocerca volvulus | 0.0033 | 0.0704 | 0.0334 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0038 | 0.0874 | 0.6057 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0704 | 0.4882 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0704 | 0.4882 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1443 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.0704 | 0.4882 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0045 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.