Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.3175 | 0.3643 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.372 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.007 | 0.0325 | 0.0288 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0493 | 0.0457 |
Onchocerca volvulus | 0.007 | 0.0325 | 0.5 | |
Brugia malayi | RNA binding protein | 0.0076 | 0.0493 | 0.0457 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0493 | 0.0173 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.372 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0325 | 0.0288 |
Brugia malayi | Carboxylesterase family protein | 0.0417 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.8537 | 1 |
Onchocerca volvulus | 0.007 | 0.0325 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0493 | 0.0457 |
Brugia malayi | Carboxylesterase family protein | 0.007 | 0.0325 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0325 | 0.0288 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0493 | 0.0457 |
Onchocerca volvulus | 0.007 | 0.0325 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.007 | 0.0325 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0325 | 0.0288 |
Brugia malayi | hypothetical protein | 0.007 | 0.0325 | 0.0288 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0493 | 0.0173 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 0.8537 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0493 | 0.0173 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0493 | 0.0173 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0493 | 0.0173 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.007 | 0.0325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0325 | 0.0288 |
Brugia malayi | Carboxylesterase family protein | 0.007 | 0.0325 | 0.0288 |
Brugia malayi | Carboxylesterase family protein | 0.007 | 0.0325 | 0.0288 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0493 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0417 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0325 | 0.0288 |
Loa Loa (eye worm) | carboxylesterase | 0.0417 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0417 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0417 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.007 | 0.0325 | 0.0288 |
Onchocerca volvulus | 0.007 | 0.0325 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0417 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.8537 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0493 | 0.0173 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0493 | 0.0457 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0365 | 0.8537 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0417 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0417 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0493 | 0.0173 |
Echinococcus multilocularis | acetylcholinesterase | 0.0417 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.007 | 0.0325 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.007 | 0.0325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0325 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0325 | 0.0288 |
Echinococcus granulosus | acetylcholinesterase | 0.0417 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.