Detailed information for compound 1387943

Basic information

Technical information
  • TDR Targets ID: 1387943
  • Name: 2-chloro-4-methyl-N-(2-morpholin-4-ylethyl)be nzamide
  • MW: 282.766 | Formula: C14H19ClN2O2
  • H donors: 1 H acceptors: 1 LogP: 1.86 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)Cl)C(=O)NCCN1CCOCC1
  • InChi: 1S/C14H19ClN2O2/c1-11-2-3-12(13(15)10-11)14(18)16-4-5-17-6-8-19-9-7-17/h2-3,10H,4-9H2,1H3,(H,16,18)
  • InChiKey: VXLOCUJBFKOMFC-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-chloro-4-methyl-N-(2-morpholinoethyl)benzamide
  • MLS001205219
  • SMR000523531
  • BAS 06108146
  • 2-Chloro-4-methyl-N-(2-morpholin-4-yl-ethyl)-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei proteasome alpha 7 subunit 0.0066 0.0496 0.0576
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0066 0.0496 0.0576
Brugia malayi proteasome subunit alpha type 3 0.0066 0.0496 0.0704
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0262 0.391 0.7384
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0066 0.0496 0.0576
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0337 0.5223 0.5053
Echinococcus granulosus Proteasome subunit alpha type 7 0.0066 0.0496 0.0496
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0066 0.0496 0.0576
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0066 0.0496 0.0576
Onchocerca volvulus 0.0603 0.9859 1
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0162 0.2172 0.2331
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0066 0.0496 0.0576
Loa Loa (eye worm) hypothetical protein 0.0172 0.2332 0.3111
Trypanosoma cruzi 20S proteasome subunit 0.0162 0.2172 0.3918
Loa Loa (eye worm) hypothetical protein 0.0059 0.037 0.0239
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0066 0.0496 0.0576
Echinococcus multilocularis netrin receptor unc 5 0.0059 0.037 0.037
Echinococcus granulosus histone lysine methyltransferase setb 0.0167 0.2259 0.2259
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0066 0.0496 0.0331
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0337 0.5223 1
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0066 0.0496 0.0576
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0066 0.0496 0.0576
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0066 0.0496 0.0576
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0066 0.0496 0.0576
Plasmodium falciparum proteasome subunit beta type-5 0.0337 0.5223 1
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0066 0.0496 0.0576
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0262 0.391 0.4406
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0337 0.5223 1
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0066 0.0496 0.0576
Plasmodium vivax proteasome subunit beta type-7, putative 0.0066 0.0496 0.0576
Echinococcus multilocularis proteasome subunit beta type 7 0.0066 0.0496 0.0496
Toxoplasma gondii proteasome subunit beta type, putative 0.0337 0.5223 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0167 0.2259 0.2435
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0066 0.0496 0.0576
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0066 0.0496 0.0576
Leishmania major proteasome alpha 2 subunit, putative 0.0066 0.0496 0.0576
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0066 0.0496 0.0576
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0066 0.0496 0.0423
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0262 0.391 0.391
Loa Loa (eye worm) hypothetical protein 0.0352 0.5472 0.7707
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0066 0.0496 0.0576
Schistosoma mansoni ankyrin 23/unc44 0.0059 0.037 0.0181
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0066 0.0496 0.0576
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0066 0.0496 0.0576
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0218 0.0218
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0066 0.0496 0.0496
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0066 0.0496 0.0496
Giardia lamblia Proteasome subunit beta type 1 0.0262 0.391 0.7224
Brugia malayi Proteasome A-type and B-type family protein 0.0066 0.0496 0.0704
Echinococcus granulosus proteasome subunit beta type 6 0.0066 0.0496 0.0496
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0066 0.0496 0.0496
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0066 0.0496 0.0576
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0337 0.5223 0.5972
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0066 0.0496 0.0576
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0066 0.0496 0.0576
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0066 0.0496 0.0576
Schistosoma mansoni hypothetical protein 0.0059 0.037 0.0181
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0232 0.0016
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0066 0.0496 0.0423
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0066 0.0496 0.5
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0162 0.2172 0.1792
Brugia malayi Immunoglobulin I-set domain containing protein 0.0059 0.037 0.0526
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0066 0.0496 0.0496
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0066 0.0496 0.0576
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.006 0.0379 0.0192
Echinococcus multilocularis Ankyrin 0.006 0.0379 0.0379
Leishmania major proteasome alpha 7 subunit, putative 0.0066 0.0496 0.0576
Schistosoma mansoni single-minded 0.0051 0.0232 0.0016
Loa Loa (eye worm) proteasome subunit beta type 2 0.0162 0.2172 0.2876
Leishmania major proteasome beta 5 subunit, putative 0.0337 0.5223 1
Toxoplasma gondii heat shock protein hslv, putative 0.0066 0.0496 0.0576
Leishmania major proteasome alpha 1 subunit, putative 0.0066 0.0496 0.0576
Toxoplasma gondii proteasome subunit 0.0066 0.0496 0.0576
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0066 0.0496 0.0331
Brugia malayi proteasome subunit alpha type 4 0.0066 0.0496 0.0704
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0337 0.5223 1
Brugia malayi Proteasome A-type and B-type family protein 0.0337 0.5223 0.742
Brugia malayi hypothetical protein 0.0172 0.2332 0.3313
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0066 0.0496 0.0576
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0066 0.0496 0.0576
Brugia malayi proteasome subunit alpha type 6 0.0066 0.0496 0.0704
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0066 0.0496 0.0576
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0167 0.2259 0.2259
Echinococcus multilocularis proteasome subunit alpha type 6 0.0066 0.0496 0.0496
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0066 0.0496 0.0331
Brugia malayi Thioredoxin reductase 0.005 0.0207 0.0294
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0066 0.0496 0.0576
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0066 0.0496 0.0331
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0066 0.0496 0.0423
Trypanosoma brucei proteasome beta 6 subunit 0.0262 0.391 0.7384
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0066 0.0496 0.0576
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0066 0.0496 0.0496
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0066 0.0496 0.0576
Echinococcus multilocularis proteasome (prosome, macropain) 0.0337 0.5223 0.5223
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0059 0.037 0.0239
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0167 0.2259 0.2259
Brugia malayi Pre-SET motif family protein 0.0442 0.7039 1
Toxoplasma gondii peptidase, T1 family protein 0.0066 0.0496 0.0576
Plasmodium vivax proteasome subunit beta type-5, putative 0.0337 0.5223 1
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0066 0.0496 0.0496
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0066 0.0496 0.0576
Echinococcus granulosus death domain containing protein 0.0059 0.037 0.037
Onchocerca volvulus Netrin receptor homolog 0.0059 0.037 0.0376
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0066 0.0496 0.0331
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0162 0.2172 0.3918
Brugia malayi proteasome subunit alpha type 1 0.0066 0.0496 0.0704
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0066 0.0496 0.0576
Echinococcus granulosus proteasome subunit beta t family 0.0066 0.0496 0.0496
Toxoplasma gondii proteasome beta subunit 0.0066 0.0496 0.0576
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0162 0.2172 0.2172
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0066 0.0496 0.0576
Loa Loa (eye worm) proteasome subunit beta type 3 0.0066 0.0496 0.0423
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0066 0.0496 0.0576
Loa Loa (eye worm) hypothetical protein 0.006 0.0379 0.0252
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0066 0.0496 0.0576
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0066 0.0496 0.0576
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0066 0.0496 0.0331
Loa Loa (eye worm) proteasome subunit beta type 1 0.0262 0.391 0.5421
Brugia malayi hypoxia-induced factor 1 0.0158 0.21 0.2984
Plasmodium vivax SET domain protein, putative 0.0167 0.2259 0.4091
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0066 0.0496 0.0576
Brugia malayi Protein kinase domain containing protein 0.0059 0.037 0.0526
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0612 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0161 0.2152 0.2152
Echinococcus granulosus subfamily T1A non peptidase ue 0.0066 0.0496 0.0496
Leishmania major proteasome beta 2 subunit, putative 0.0066 0.0496 0.0576
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0066 0.0496 0.0576
Trypanosoma brucei proteasome beta 7 subunit 0.0066 0.0496 0.0576
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0066 0.0496 0.0576
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0337 0.5223 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0066 0.0496 0.0576
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0262 0.391 0.7384
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0066 0.0496 0.0576
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0066 0.0496 0.0496
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0066 0.0496 0.0331
Plasmodium vivax proteasome subunit beta type-1, putative 0.0262 0.391 0.7384
Brugia malayi glutathione reductase 0.005 0.0207 0.0294
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0066 0.0496 0.0576
Echinococcus granulosus proteasome subunit alpha type 2 0.0066 0.0496 0.0496
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0066 0.0496 0.0576
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0066 0.0496 0.0576
Plasmodium vivax proteasome subunit beta type-3, putative 0.0066 0.0496 0.0576
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0066 0.0496 0.0576
Schistosoma mansoni netrin receptor unc5 0.0059 0.037 0.0181
Leishmania major proteasome alpha 1 subunit, putative 0.0066 0.0496 0.0576
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0337 0.5223 1
Trichomonas vaginalis set domain proteins, putative 0.0603 0.9851 1
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0337 0.5223 1
Loa Loa (eye worm) hypothetical protein 0.0364 0.5679 0.8009
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0066 0.0496 0.0331
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0262 0.391 0.7384
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0066 0.0496 0.0576
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0066 0.0496 0.0576
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0066 0.0496 0.0423
Loa Loa (eye worm) hypoxia-induced factor 1 0.0158 0.21 0.2772
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0066 0.0496 0.0423
Plasmodium falciparum proteasome subunit beta type-4 0.0066 0.0496 0.0576
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0066 0.0496 0.0423
Brugia malayi Proteasome A-type and B-type family protein 0.0066 0.0496 0.0704
Plasmodium vivax proteasome subunit beta type-2, putative 0.0162 0.2172 0.3918
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0167 0.2259 0.2435
Brugia malayi proteasome subunit alpha type 2 0.0066 0.0496 0.0704
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0066 0.0496 0.0576
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0066 0.0496 0.0576
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0262 0.391 0.7384
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0066 0.0496 0.0331
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0262 0.391 0.365
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0066 0.0496 0.0496
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0066 0.0496 0.0576
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0066 0.0496 0.0576
Echinococcus multilocularis proteasome subunit beta type 6 0.0066 0.0496 0.0496
Mycobacterium ulcerans proteasome PrcA 0.0066 0.0496 0.0949
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0066 0.0496 0.0331
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0066 0.0496 0.0331
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0066 0.0496 0.0423
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0066 0.0496 0.0576
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0167 0.2259 0.4091
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0066 0.0496 0.0423
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0066 0.0496 0.0576
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0066 0.0496 0.0496
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0162 0.2172 0.1792
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0066 0.0496 0.0576
Leishmania major proteasome alpha 7 subunit, putative 0.0066 0.0496 0.0576
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0066 0.0496 0.0496
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0066 0.0496 0.0331
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0442 0.7039 1
Brugia malayi SET domain containing protein 0.037 0.5786 0.822
Onchocerca volvulus 0.0531 0.8598 0.872
Leishmania major proteasome beta 7 subunit, putative 0.0066 0.0496 0.0576
Toxoplasma gondii proteasome subunit alpha type, putative 0.0066 0.0496 0.0576
Echinococcus granulosus proteasome subunit beta type 7 0.0066 0.0496 0.0496
Echinococcus multilocularis proteasome subunit alpha type 2 0.0066 0.0496 0.0496
Brugia malayi Proteasome subunit alpha type 1 0.0066 0.0496 0.0704
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0162 0.2172 0.3546
Echinococcus granulosus Proteasome subunit alpha beta 0.0066 0.0496 0.0496
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0066 0.0496 0.0576
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0531 0.8598 1
Giardia lamblia Proteasome subunit beta type 2 0.0162 0.2172 0.3546
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0218 0.0218
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0262 0.391 0.391
Mycobacterium ulcerans proteasome PrcB 0.0337 0.5223 1
Echinococcus granulosus proteasome prosome macropain 0.0337 0.5223 0.5223
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0066 0.0496 0.0423
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0162 0.2172 0.3918
Onchocerca volvulus Notchless protein homolog 0.0066 0.0496 0.0503
Brugia malayi Uncoordinated protein 44 0.0059 0.037 0.0526
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0066 0.0496 0.0331
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0162 0.2172 0.2331
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0066 0.0496 0.0496
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0337 0.5223 1
Toxoplasma gondii proteasome subunit alpha1, putative 0.0066 0.0496 0.0576
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0162 0.2172 0.3918
Brugia malayi 20S proteasome alpha5 subunit 0.0066 0.0496 0.0704
Echinococcus granulosus proteasome subunit alpha type 6 0.0066 0.0496 0.0496
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0066 0.0496 0.0576
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0167 0.2259 0.2435
Brugia malayi Pre-SET motif family protein 0.0167 0.2259 0.3209
Brugia malayi PAS domain containing protein 0.0051 0.0232 0.0329
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0059 0.037 0.037
Plasmodium vivax proteasome subunit beta type-4, putative 0.0066 0.0496 0.0576
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0066 0.0496 0.0331
Leishmania major proteasome beta 2 subunit, putative 0.0162 0.2172 0.3918
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0066 0.0496 0.0576
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0262 0.391 0.7384
Loa Loa (eye worm) hypothetical protein 0.0167 0.2259 0.3004
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0066 0.0496 0.0576
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0066 0.0496 0.0576
Brugia malayi Death domain containing protein 0.0059 0.037 0.0526
Brugia malayi proteasome subunit beta type 2 0.0162 0.2172 0.3085
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0066 0.0496 0.0576
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0066 0.0496 0.0576
Plasmodium vivax proteasome subunit beta type-6, putative 0.0066 0.0496 0.0576
Echinococcus granulosus Ankyrin 0.006 0.0379 0.0379
Brugia malayi Proteasome subunit alpha type 7-1 0.0066 0.0496 0.0704
Echinococcus granulosus netrin receptor unc 5 0.0059 0.037 0.037
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0066 0.0496 0.0576
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0162 0.2172 0.2172
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0059 0.037 0.037
Leishmania major proteasome alpha 3 subunit, putative 0.0066 0.0496 0.0576
Brugia malayi proteasome subunit beta type 3 0.0066 0.0496 0.0704
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0262 0.391 0.7224
Leishmania major proteasome beta-1 subunit, putative 0.0066 0.0496 0.0576
Loa Loa (eye worm) PAS-3 protein 0.0066 0.0496 0.0423
Brugia malayi Proteasome A-type and B-type family protein 0.0066 0.0496 0.0704
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0066 0.0496 0.0576
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0066 0.0496 0.0576
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0066 0.0496 0.0496
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0066 0.0496 0.0331
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0066 0.0496 0.0576
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0337 0.5223 0.7342
Brugia malayi proteasome subunit beta type 1 0.0262 0.391 0.5555
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0162 0.2172 0.3918
Leishmania major proteasome beta 3 subunit, putative 0.0066 0.0496 0.0576

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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