TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 306.187 | Formula: C16H13Cl2NO
H donors: 1 H acceptors: 2 LogP: 4.38 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C(c1nccc2c1cccc2)O.Cl
InChi: 1S/C16H12ClNO.ClH/c17-13-7-5-12(6-8-13)16(19)15-14-4-2-1-3-11(14)9-10-18-15;/h1-10,16,19H;1H
InChiKey: NMEANLMGZAMLQY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Treponema pallidum	fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Giardia lamblia	Fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium ulcerans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	26.9 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.5 %
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.8 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0034	0.018	0.0129
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0034	0.018	0.0333
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0171	0.3244	0.4308
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7292	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0048	0.0495	0.0424
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0034	0.018	0.0247
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0034	0.018	0.0333
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0171	0.3244	0.4448
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7292	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0501	0.1346
Giardia lamblia	Proteasome subunit beta type 2	0.0082	0.1266	0.1527
Echinococcus granulosus	plexin a4	0.013	0.2334	0.2758
Brugia malayi	proteasome subunit alpha type 2	0.0034	0.018	0.0106
Echinococcus granulosus	proteasome prosome macropain	0.0171	0.3244	0.3868
Echinococcus multilocularis	netrin receptor unc 5	0.0048	0.0495	0.0514
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0034	0.018	0.0333
Onchocerca volvulus		0.0046	0.0456	0.2109
Schistosoma mansoni	hypothetical protein	0.0046	0.0456	0.1205
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0034	0.018	0.0333
Brugia malayi	hypothetical protein	0.0046	0.0456	0.0385
Echinococcus granulosus	proteasome subunit alpha type 6	0.0034	0.018	0.0129
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0034	0.018	0.0333
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0034	0.018	0.0333
Brugia malayi	TAR-binding protein	0.0071	0.1002	0.0934
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1002	0.2926
Leishmania major	proteasome beta 5 subunit, putative	0.0171	0.3244	1
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0133	0.2393	0.3282
Brugia malayi	20S proteasome alpha5 subunit	0.0034	0.018	0.0106
Loa Loa (eye worm)	RNA binding protein	0.0071	0.1002	0.2926
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0456	0.1205
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0171	0.3244	0.9911
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0171	0.3244	0.9911
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0133	0.2393	0.283
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0034	0.018	0.0129
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0034	0.018	0.0247
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0034	0.018	0.0333
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0082	0.1266	0.1455
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0034	0.018	0.0333
Echinococcus multilocularis	tar DNA binding protein	0.0071	0.1002	0.1132
Loa Loa (eye worm)	plexin A	0.013	0.2334	0.7131
Loa Loa (eye worm)	sema domain-containing protein	0.0046	0.0456	0.1205
Brugia malayi	proteasome subunit beta type 2	0.0082	0.1266	0.1201
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0082	0.1266	0.3546
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0397	0.8268	1
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0034	0.018	0.0247
Brugia malayi	proteasome subunit alpha type 4	0.0034	0.018	0.0106
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0034	0.018	0.0129
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0445	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0495	0.1328
Echinococcus granulosus	proteasome subunit beta type 6	0.0034	0.018	0.0129
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0133	0.2393	0.3112
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7292	1
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0034	0.018	0.0129
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0048	0.0495	0.1328
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0034	0.018	0.0247
Schistosoma mansoni	plexin	0.0064	0.0859	0.2477
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0034	0.018	0.0129
Leishmania major	proteasome beta 2 subunit, putative	0.0082	0.1266	0.3546
Brugia malayi	proteasome subunit beta type 3	0.0034	0.018	0.0106
Giardia lamblia	Fructose-bisphosphate aldolase	0.0353	0.7292	1
Echinococcus granulosus	semaphorin 1A	0.0046	0.0456	0.0466
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0048	0.0495	0.0514
Onchocerca volvulus	Notchless protein homolog	0.0034	0.018	0.0583
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7292	1
Schistosoma mansoni	netrin receptor unc5	0.0048	0.0495	0.1328
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0445	0.0374
Brugia malayi	plexin A	0.013	0.2334	0.2277
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7292	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0353	0.7292	0.5
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0082	0.1266	0.3761
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0082	0.1266	0.3546
Giardia lamblia	Proteasome subunit beta type 1	0.0133	0.2393	0.3112
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0133	0.2393	0.7316
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0034	0.018	0.0333
Echinococcus multilocularis	semaphorin 5B	0.0046	0.0456	0.0466
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0082	0.1266	0.3761
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0034	0.018	0.0247
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0082	0.1266	0.3546
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0397	0.8268	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0859	0.2477
Brugia malayi	RNA recognition motif domain containing protein	0.0071	0.1002	0.0934
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0034	0.018	0.0333
Schistosoma mansoni	ankyrin 23/unc44	0.0048	0.0495	0.1328
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0034	0.018	0.0129
Echinococcus multilocularis	proteasome subunit beta type 7	0.0034	0.018	0.0129
Brugia malayi	Uncoordinated protein 44	0.0048	0.0495	0.0424
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0034	0.018	0.0333
Echinococcus multilocularis	proteasome subunit beta type 6	0.0034	0.018	0.0129
Brugia malayi	Proteasome A-type and B-type family protein	0.0034	0.018	0.0106
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0034	0.018	0.0333
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0445	0.0453
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.7292	1
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0034	0.018	0.0247
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0034	0.018	0.0129
Brugia malayi	Proteasome A-type and B-type family protein	0.0171	0.3244	0.3193
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0034	0.018	0.0129
Mycobacterium ulcerans	proteasome PrcB	0.0171	0.3244	0.9911
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7292	1
Brugia malayi	RNA binding protein	0.0071	0.1002	0.0934
Schistosoma mansoni	plexin	0.011	0.1885	0.5713
Echinococcus granulosus	proteasome subunit beta type 7	0.0034	0.018	0.0129
Plasmodium falciparum	proteasome subunit beta type-5	0.0171	0.3244	1
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0034	0.018	0.0333
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1002	0.2926
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0034	0.018	0.0333
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0034	0.018	0.0247
Loa Loa (eye worm)	PAS-3 protein	0.0034	0.018	0.0333
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0133	0.2393	0.7224
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0133	0.2393	0.7224
Trypanosoma brucei	proteasome beta 6 subunit	0.0133	0.2393	0.7224
Brugia malayi	Death domain containing protein	0.0048	0.0495	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0456	0.1205
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0034	0.018	0.0247
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0048	0.0495	0.0514
Echinococcus multilocularis	Ankyrin	0.0048	0.0501	0.0521
Brugia malayi	proteasome subunit alpha type 1	0.0034	0.018	0.0106
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0445	0.1171
Echinococcus granulosus	proteasome subunit beta t family	0.0034	0.018	0.0129
Brugia malayi	proteasome subunit beta type 1	0.0133	0.2393	0.2336
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0034	0.018	0.0333
Loa Loa (eye worm)	hypothetical protein	0.011	0.1885	0.5713
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0034	0.018	0.0333
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0667	0.0597
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0171	0.3244	1
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1002	0.2926
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0034	0.018	0.0129
Brugia malayi	Proteasome A-type and B-type family protein	0.0034	0.018	0.0106
Loa Loa (eye worm)	sema domain-containing protein	0.0046	0.0456	0.1205
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0034	0.018	0.0247
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0034	0.018	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0276	0.0203
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0034	0.018	0.0247
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7292	1
Echinococcus granulosus	Ankyrin	0.0048	0.0501	0.0521
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0048	0.0501	0.1346
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0667	0.187
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0456	0.1205
Schistosoma mansoni	hypothetical protein	0.0038	0.0276	0.0636
Onchocerca volvulus	Netrin receptor homolog	0.0048	0.0495	0.2324
Schistosoma mansoni	hypothetical protein	0.0048	0.0495	0.1328
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0034	0.018	0.0247
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0034	0.018	0.0333
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0034	0.018	0.0129
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.3271	1
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0034	0.018	0.0247
Echinococcus granulosus	netrin receptor unc 5	0.0048	0.0495	0.0514
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0071	0.1002	0.2926
Toxoplasma gondii	proteasome subunit beta type, putative	0.0171	0.3244	1
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0082	0.1266	0.3546
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0667	0.0597
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0667	0.187
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0171	0.3244	1
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0495	0.0424
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0445	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0456	0.1205
Schistosoma mansoni	hypothetical protein	0.0064	0.0859	0.2477
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0171	0.3244	1
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0133	0.2393	0.7224
Brugia malayi	hypothetical protein	0.0046	0.0456	0.0385
Echinococcus multilocularis	plexin a4	0.013	0.2334	0.2758
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0445	0.1171
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0445	0.0453
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0034	0.018	0.0333
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0171	0.3244	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.3271	1
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0082	0.1266	0.1455
Echinococcus granulosus	Proteasome subunit alpha beta	0.0034	0.018	0.0129
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0133	0.2393	0.283
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1002	0.2926
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0034	0.018	0.0333
Schistosoma mansoni	hypothetical protein	0.0046	0.0456	0.1205
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0133	0.2393	0.7224
Brugia malayi	proteasome subunit alpha type 3	0.0034	0.018	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0456	0.1205
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0034	0.018	0.0247
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0034	0.018	0.0333
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.1002	0.2926
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0171	0.3244	0.3868
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0034	0.018	0.0247
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0034	0.018	0.0247
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0034	0.018	0.0129
Echinococcus granulosus	proteasome subunit alpha type 2	0.0034	0.018	0.0129
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0082	0.1266	0.1527
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0034	0.018	0.0129
Trypanosoma cruzi	20S proteasome subunit	0.0082	0.1266	0.3546
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0034	0.018	0.0333
Brugia malayi	Plexin repeat family protein	0.011	0.1885	0.1824
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0034	0.018	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0456	0.1205
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0133	0.2393	0.7316
Brugia malayi	Proteasome subunit alpha type 1	0.0034	0.018	0.0106
Echinococcus granulosus	semaphorin 5B	0.0046	0.0456	0.0466
Schistosoma mansoni	semaphorin 5-related	0.0046	0.0456	0.1205
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0082	0.1266	0.1736
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0171	0.3244	0.4308
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0034	0.018	0.0129
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0171	0.3244	1
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0034	0.018	0.0333
Brugia malayi	proteasome subunit alpha type 6	0.0034	0.018	0.0106
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0082	0.1266	0.3761
Onchocerca volvulus		0.011	0.1885	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.3271	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0276	0.0636
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.7292	1
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0034	0.018	0.0129
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0445	0.1171
Echinococcus granulosus	death domain containing protein	0.0048	0.0495	0.0514
Brugia malayi	Proteasome subunit alpha type 7-1	0.0034	0.018	0.0106
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.7292	1
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0034	0.018	0.0129
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0034	0.018	0.0333
Loa Loa (eye worm)	TAR-binding protein	0.0071	0.1002	0.2926
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0445	0.1171
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0082	0.1266	0.3546
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0133	0.2393	0.7224
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0082	0.1266	0.1527
Echinococcus granulosus	tar DNA binding protein	0.0071	0.1002	0.1132
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0133	0.2393	0.7224
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0034	0.018	0.0333
Brugia malayi	Sema domain containing protein	0.0046	0.0456	0.0385
Brugia malayi	Proteasome A-type and B-type family protein	0.0034	0.018	0.0106
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0171	0.3244	1
Echinococcus multilocularis	hypothetical protein	0.0046	0.0456	0.0466
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0034	0.018	0.0129
Brugia malayi	Sema domain containing protein	0.0046	0.0456	0.0385
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0034	0.018	0.0333

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1539324

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1387946