Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0511 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.2006 | 0.742 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1469 | 0.4753 |
Schistosoma mansoni | lamin | 0.0033 | 0.1469 | 0.1654 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.63 | 0.63 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0511 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0511 | 0.0511 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.1469 | 0.1654 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0511 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.63 | 0.63 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2525 | 0.3479 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2525 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.63 | 1 |
Onchocerca volvulus | 0.0033 | 0.1469 | 0.5 | |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0511 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2525 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2525 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2525 | 0.2525 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.2006 | 0.2582 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1469 | 0.1469 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.2006 | 0.2582 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0511 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1469 | 0.4753 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2525 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.1469 | 0.4753 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0511 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1469 | 0.1469 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0511 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0511 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2525 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.2006 | 0.2006 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0511 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.2006 | 0.2006 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.2006 | 0.742 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0511 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.2006 | 0.2582 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1469 | 0.4753 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0511 | 0.0511 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0511 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.2006 | 0.742 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.2006 | 0.742 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.2006 | 0.742 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1411 | 0.1411 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.2006 | 0.742 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1469 | 0.1469 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0511 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.2006 | 0.2582 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1469 | 0.4753 |
Onchocerca volvulus | 0.0033 | 0.1469 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2525 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1469 | 0.1469 |
Schistosoma mansoni | lamin | 0.0033 | 0.1469 | 0.1654 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2525 | 0.3479 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.2006 | 0.2006 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1469 | 0.1469 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0511 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1469 | 0.4753 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0511 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.2006 | 0.2006 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.892 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.724 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.695 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.295 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.093 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.067 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.9953 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.