Detailed information for compound 1388036

Basic information

Technical information
  • TDR Targets ID: 1388036
  • Name: (5E)-5-[(3-imidazol-1-ylpropylamino)methylide ne]-1-(4-methoxyphenyl)-1,3-diazinane-2,4,6-t rione
  • MW: 369.375 | Formula: C18H19N5O4
  • H donors: 2 H acceptors: 4 LogP: 1.44 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1C(=O)NC(=O)/C(=C\NCCCn2ccnc2)/C1=O
  • InChi: 1S/C18H19N5O4/c1-27-14-5-3-13(4-6-14)23-17(25)15(16(24)21-18(23)26)11-19-7-2-9-22-10-8-20-12-22/h3-6,8,10-12,19H,2,7,9H2,1H3,(H,21,24,26)/b15-11+
  • InChiKey: CCUKQRDKNLDDIF-RVDMUPIBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(3-imidazol-1-ylpropylamino)methylidene]-1-(4-methoxyphenyl)-1,3-diazinane-2,4,6-trione
  • (5E)-5-[(3-imidazol-1-ylpropylamino)methylene]-1-(4-methoxyphenyl)hexahydropyrimidine-2,4,6-trione
  • 5-[(3-imidazol-1-ylpropylamino)methylene]-1-(4-methoxyphenyl)hexahydropyrimidine-2,4,6-trione
  • (5E)-5-[[3-(1-imidazolyl)propylamino]methylene]-1-(4-methoxyphenyl)hexahydropyrimidine-2,4,6-trione
  • 5-[[3-(1-imidazolyl)propylamino]methylene]-1-(4-methoxyphenyl)hexahydropyrimidine-2,4,6-trione
  • (5E)-5-[(3-imidazol-1-ylpropylamino)methylene]-1-(4-methoxyphenyl)barbituric acid
  • 5-[(3-imidazol-1-ylpropylamino)methylene]-1-(4-methoxyphenyl)barbituric acid
  • STOCK2S-54608
  • 5-[1-(3-Imidazol-1-yl-propylamino)-meth-(E)-ylidene]-1-(4-methoxy-phenyl)-pyrimidine-2,4,6-trione
  • MLS000556546
  • SMR000147863

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0024 0.0059 0.0046
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.1298 0.1291
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0008
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0008
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0253 0.0246
Schistosoma mansoni zinc finger protein 0.0018 0.0028 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Loa Loa (eye worm) hypothetical protein 0.0046 0.02 0.0193
Schistosoma mansoni hypothetical protein 0.0181 0.1037 0.1025
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0052
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.0059 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.2219 0.416
Schistosoma mansoni hypothetical protein 0.0437 0.2626 0.2616
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0872 0.5323 0.5317
Brugia malayi Bromodomain containing protein 0.0092 0.0486 0.0486
Schistosoma mansoni site-1 peptidase (S08 family) 0.0082 0.0423 0.0409
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0624 0.1157
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Trypanosoma brucei subtilisin peptidase 0.0082 0.0423 0.6627
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0054 0.004
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0422 0.2532 0.4749
Loa Loa (eye worm) hypothetical protein 0.1626 1 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0253 0.3787
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0041 0.0027
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0093 0.0079
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0008
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0093 0.0079
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.008 0.1267
Schistosoma mansoni tyrosine kinase 0.0264 0.1553 0.1542
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.2219 0.416
Giardia lamblia High cysteine membrane protein Group 2 0.0418 0.2507 0.9898
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0008
Brugia malayi hypothetical protein 0.0027 0.008 0.008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0103 0.0096
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0008
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.007 0.1159
Brugia malayi chromobox protein homolog 3 0.0042 0.0172 0.0172
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0253 0.024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.007 0.0289
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0045 0.0038
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0192 0.0345
Toxoplasma gondii subtilisin SUB12 0.0097 0.0517 1
Leishmania major hypothetical protein, conserved 0.0027 0.008 0.0883
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0191 0.0177
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Onchocerca volvulus 0.0254 0.1489 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0082 0.0423 1
Leishmania major hypothetical protein, conserved 0.0024 0.0059 0.0535
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0063
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0023
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0054 0.0439
Echinococcus multilocularis membrane bound transcription factor site 1 0.0082 0.0423 0.0531
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0082 0.0423 0.0423
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Loa Loa (eye worm) subtilase 0.0082 0.0423 0.0415
Schistosoma mansoni furin-1 (S08 family) 0.0836 0.51 0.5093
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0068 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0423 0.0779
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.2219 0.416
Onchocerca volvulus 0.0033 0.0116 0.0732
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Echinococcus multilocularis microtubule associated protein 2 0.0738 0.4491 0.5811
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0253 0.046
Echinococcus granulosus epidermal growth factor receptor 0.0264 0.1553 0.1542
Echinococcus multilocularis snurportin 1 0.0329 0.1955 0.2519
Plasmodium vivax importin-beta 2, putative 0.0031 0.0104 0.1881
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0032 0.0044
Leishmania major importin beta-1 subunit, putative 0.0025 0.0068 0.0679
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0872 0.5323 0.6891
Loa Loa (eye worm) hypothetical protein 0.0042 0.0172 0.0164
Echinococcus multilocularis chromobox protein 1 0.0075 0.0375 0.0469
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.008 0.0883
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0371 0.0464
Onchocerca volvulus 0.0045 0.0191 0.1237
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0041 0.0035
Toxoplasma gondii kringle domain-containing protein 0.0024 0.0059 0.1016
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0054 0.0046
Echinococcus multilocularis neuroendocrine convertase 2 0.1258 0.7719 1
Brugia malayi RNA, U transporter 1 0.0088 0.0457 0.0457
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0172 0.111
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0253 0.3787
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0253 0.4819
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0115 0.0624 0.0792
Loa Loa (eye worm) endoprotease bli-4 0.1626 1 1
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0372 0.2219 0.416
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0032 0.0044
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0115 0.0132
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.007 0.1014
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0133 0.0735 0.0723
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0093 0.0102
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.0059 0.0739
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0082 0.0423 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0012 0.0006
Schistosoma mansoni hypothetical protein 0.0018 0.0028 0.0014
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0504 0.3042 0.5708
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0082 0.0423 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.2219 0.416
Schistosoma mansoni kinase 0.0058 0.0276 0.0262
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.007 0.1014
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0059 0.0535
Trichomonas vaginalis hypothetical protein 0.0372 0.2219 0.416
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0063
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0243 0.0297
Schistosoma mansoni rotamase 0.0036 0.0134 0.0121
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0253 0.024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0324 0.0311
Brugia malayi Subtilase family protein 0.0082 0.0423 0.0423
Echinococcus granulosus chromobox protein 1 0.0075 0.0375 0.0362
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0115 0.0624 1
Echinococcus granulosus microtubule associated protein 2 0.0738 0.4491 0.4483
Brugia malayi celfurPC protein 0.1254 0.7694 0.7694
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0624 0.0611
Loa Loa (eye worm) hypothetical protein 0.0085 0.0443 0.0435
Brugia malayi MAP kinase sur-1 0.0055 0.0253 0.0253
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0375 0.069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Echinococcus granulosus cpg binding protein 0.0035 0.0129 0.0115
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0253 0.0805
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0243 0.0229
Brugia malayi Pre-SET motif family protein 0.0223 0.1298 0.1298
Echinococcus granulosus Furin 1 0.0504 0.3042 0.3032
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0032 0.0044
Schistosoma mansoni chromobox protein 0.0075 0.0375 0.0362
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.007 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0423 0.0779
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0423 0.0779
Loa Loa (eye worm) hypothetical protein 0.0053 0.0243 0.0236
Echinococcus multilocularis expressed protein 0.0036 0.0134 0.0157
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0129 0.2387
Onchocerca volvulus 0.0024 0.0059 0.035
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0129 0.1326
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0624 1
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.2219 0.416
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0133 0.0735 0.1368
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0082 0.0423 0.6627
Trichomonas vaginalis rotamase, putative 0.0036 0.0134 0.0237
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0375 0.0368
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Echinococcus granulosus chromobox protein 1 0.0075 0.0375 0.0362
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0032 0.0044
Echinococcus multilocularis cpg binding protein 0.0035 0.0129 0.0149
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0082 0.0423 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.007 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0423 0.0779
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0504 0.3042 0.5708
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0068 0.0679
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0104 0.0117
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0104 0.009
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0054 0.0593
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0192 0.0345
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0624 0.1157
Echinococcus granulosus neuroendocrine convertase 2 0.1258 0.7719 0.7716
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.2219 0.416
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0253 0.0311
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.008 0.0883
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0253 0.3787
Schistosoma mansoni cpg binding protein 0.0035 0.0129 0.0115
Brugia malayi AMP-binding enzyme family protein 0.0025 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0096 0.0165
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0054 0.0593
Loa Loa (eye worm) hypothetical protein 0.0049 0.0218 0.0211
Toxoplasma gondii subtilisin SUB8 0.0082 0.0423 0.8141
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0253 0.3787
Brugia malayi AMP-binding enzyme family protein 0.0025 0.007 0.007
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0082 0.0423 0.6627
Brugia malayi CHD4 protein 0.0016 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0172 0.0308
Plasmodium vivax SET domain protein, putative 0.0033 0.0115 0.216
Schistosoma mansoni cpg binding protein 0.0035 0.0129 0.0115
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0008
Toxoplasma gondii subtilisin SUB7 0.0082 0.0423 0.8141
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0104 0.1895
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0504 0.3042 0.5708
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0082 0.0423 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.008 0.1422
Loa Loa (eye worm) hypothetical protein 0.0033 0.0116 0.0108
Onchocerca volvulus 0.0051 0.0226 0.1476
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.2219 0.416
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.003 0.0161
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0253 0.3787
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0266 0.0485
Mycobacterium leprae Possible secreted protease 0.0082 0.0423 1
Leishmania major subtilisin-like serine peptidase 0.0082 0.0423 0.6627
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0624 1
Brugia malayi Bromodomain containing protein 0.0046 0.02 0.02
Toxoplasma gondii subtilisin SUB9 0.0082 0.0423 0.8141
Echinococcus granulosus furin 0.1626 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.2219 0.416
Echinococcus multilocularis Furin 1 0.0504 0.3042 0.393
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0023
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0063
Toxoplasma gondii subtilisin SUB11 0.0082 0.0423 0.8141
Schistosoma mansoni bromodomain containing protein 0.0078 0.0398 0.0385
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0059 0.0052
Toxoplasma gondii subtilisin SUB2 0.0082 0.0423 0.8141
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0082 0.0423 1
Schistosoma mansoni zinc finger protein 0.0025 0.007 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0423 0.0779
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0253 0.046
Trichomonas vaginalis set domain proteins, putative 0.0254 0.1489 0.2785
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Echinococcus multilocularis epidermal growth factor receptor 0.0264 0.1553 0.1998
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0023
Entamoeba histolytica hypothetical protein 0.0025 0.0068 0.0251
Toxoplasma gondii subtilisin SUB10 0.0082 0.0423 0.8141
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.007 0.1014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0872 0.5323 1
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0082 0.0423 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0129 0.1707
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0243 0.0229
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0031 0.0104 0.0097
Brugia malayi Importin beta-1 subunit 0.0031 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0082 0.0423 0.0415
Schistosoma mansoni chromobox protein 0.0075 0.0375 0.0362
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0054 0.0439
Trypanosoma brucei polo-like protein kinase 0.0115 0.0624 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0054 0.0904
Brugia malayi neuroendocrine convertase 1 precursor 0.1577 0.9696 0.9696
Trypanosoma brucei protein kinase, putative 0.0055 0.0253 0.3787
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0082 0.0423 1
Toxoplasma gondii subtilisin SUB6 0.0082 0.0423 0.8141
Echinococcus granulosus expressed protein 0.0036 0.0134 0.0121
Echinococcus multilocularis dnaJ subfamily B 0.0437 0.2626 0.3391
Brugia malayi hypothetical protein 0.0017 0.0021 0.0021
Schistosoma mansoni ran 0.0023 0.0054 0.004
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0129 0.1707
Brugia malayi Heterochromatin protein 1 0.0075 0.0375 0.0375
Brugia malayi serine/threonine-protein kinase plk-2 0.0115 0.0624 0.0624
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0253 0.0311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0082 0.0423 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0253 0.024
Trichomonas vaginalis rotamase, putative 0.0035 0.0129 0.0227
Brugia malayi Protein kinase domain containing protein 0.0024 0.0059 0.0059
Onchocerca volvulus 0.0031 0.0103 0.0647
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Echinococcus granulosus zinc finger protein 0.0025 0.007 0.0057
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.007 0.0289
Echinococcus granulosus membrane bound transcription factor site 1 0.0082 0.0423 0.0409
Echinococcus granulosus importin subunit beta 1 0.0031 0.0104 0.0091
Echinococcus multilocularis zinc finger protein 0.0025 0.007 0.0074
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.003 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0134 0.0237
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0134 0.0134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.007 0.1159
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0299 0.5715
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0266 0.0485
Toxoplasma gondii subtilisin SUB1 0.0082 0.0423 0.8141
Mycobacterium ulcerans hypothetical protein 0.0025 0.007 0.1014
Schistosoma mansoni hypothetical protein 0.0329 0.1955 0.1944
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0068 0.0112
Brugia malayi Pre-SET motif family protein 0.0033 0.0115 0.0115
Echinococcus multilocularis chromobox protein 1 0.0075 0.0375 0.0469
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0129 0.1707
Entamoeba histolytica serine/threonine protein kinase, putative 0.0115 0.0624 1
Plasmodium vivax subtilisin-like protease 1 0.0082 0.0423 1
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0067 0.006
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.007 0.1014
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0134 0.0127
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.007 0.1014
Onchocerca volvulus Serine\/threonine kinase homolog 0.0115 0.0624 0.416
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.2219 0.416
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0624 0.1157
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0253 0.046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0032 0.0044
Schistosoma mansoni hypothetical protein 0.0025 0.0067 0.0054
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0082 0.0423 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.007 0.1014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0172 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.2219 0.416
Schistosoma mansoni site-1 peptidase (S08 family) 0.0082 0.0423 0.0409
Giardia lamblia Kinase, PLK 0.0115 0.0624 0.2299
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0624 0.1157
Loa Loa (eye worm) proprotein convertase 2 0.0504 0.3042 0.3037
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0082 0.0423 1
Giardia lamblia Furin precursor putative serine protease 0.0422 0.2532 1
Leishmania major GTP-binding protein, putative 0.0023 0.0054 0.0439
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0872 0.5323 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.1955 0.1949
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0104 0.1286
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0096 0.0165
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0624 0.1157
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0041 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0624 0.1157
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0243 0.0229
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0014 0.0006
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0082 0.0423 0.6627
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0115 0.0624 0.0616
Plasmodium falciparum subtilisin-like protease 3 0.0082 0.0423 1
Brugia malayi CXXC zinc finger family protein 0.0031 0.0103 0.0103
Plasmodium falciparum subtilisin-like protease 1 0.0082 0.0423 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0182 0.0219
Schistosoma mansoni importin beta-1 0.0031 0.0104 0.0091
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0253 0.046
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0226 0.0409
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0023
Echinococcus multilocularis geminin 0.0181 0.1037 0.1328
Brugia malayi Kringle domain containing protein 0.0024 0.0059 0.0059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0032 0.0044
Echinococcus granulosus snurportin 1 0.0329 0.1955 0.1944
Plasmodium falciparum subtilisin-like protease 2 0.0082 0.0423 1
Schistosoma mansoni cpg binding protein 0.0031 0.0103 0.009
Loa Loa (eye worm) hypothetical protein 0.0369 0.2203 0.2197
Toxoplasma gondii subtilisin SUB5 0.0082 0.0423 0.8141
Echinococcus granulosus dnaJ subfamily B 0.0437 0.2626 0.2616
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0068 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.2219 0.416
Plasmodium falciparum importin beta, putative 0.0031 0.0104 0.1881
Plasmodium vivax subtilisin-like protease 2, putative 0.0082 0.0423 1
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0082 0.0423 0.0423
Schistosoma mansoni hypothetical protein 0.0181 0.1037 0.1025
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.008 0.1267
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.008 0.0883
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0504 0.3042 0.5708
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0104 0.1286
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0129 0.1707
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0504 0.3042 0.5708
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0115 0.0624 0.0611
Loa Loa (eye worm) hypothetical protein 0.0804 0.4903 0.4899
Toxoplasma gondii subtilisin SUB4 0.0082 0.0423 0.8141
Loa Loa (eye worm) hypothetical protein 0.0053 0.0243 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0115 0.0102
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0624 0.1157
Onchocerca volvulus 0.0025 0.007 0.0422
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.007 0.0716
Schistosoma mansoni hypothetical protein 0.0372 0.2219 0.2209
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0054 0.0052
Schistosoma mansoni ran 0.0023 0.0054 0.004
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0025 0.007 0.007
Brugia malayi PHD-finger family protein 0.0032 0.011 0.011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0032 0.0044
Trichomonas vaginalis ran, putative 0.0023 0.0054 0.0085
Onchocerca volvulus 0.0082 0.0423 0.2802
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0371 0.0358
Trypanosoma cruzi subtilisin peptidase 0.0082 0.0423 0.6627
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0375 0.069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0504 0.3042 0.5708
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0253 0.3787
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0082 0.0423 0.0409
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0504 0.3042 0.3032
Loa Loa (eye worm) hypothetical protein 0.0027 0.008 0.0073
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0253 0.3787
Echinococcus granulosus geminin 0.0181 0.1037 0.1025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Schistosoma mansoni microtubule-associated protein tau 0.0738 0.4491 0.4483
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.007 0.0716
Loa Loa (eye worm) TK/EGFR protein kinase 0.0264 0.1553 0.1547
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0032 0.0044
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0115 0.2109
Brugia malayi PAN domain containing protein 0.0015 0.0008 0.0008
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.008 0.1267
Plasmodium vivax subtilisin-like serine protease, putative 0.0082 0.0423 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.0059 0.0739
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0023
Brugia malayi Furin-like cysteine rich region family protein 0.0264 0.1553 0.1553
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0422 0.2532 0.4749
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1626 1 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0192 0.1243
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0182 0.0169
Brugia malayi proprotein convertase 2 0.1258 0.7719 0.7719
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0012 0.0006
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0041 0.0027
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.007 0.1014
Echinococcus multilocularis 0.1254 0.7694 0.9967
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0054 0.0439
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0082 0.0423 0.6627
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0054 0.0054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0082 0.0423 0.0779

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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