Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.095 | 0.095 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2844 | 0.7321 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2844 | 0.2844 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0568 | 0.1461 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2844 | 0.7321 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.051 | 0.1313 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0568 | 0.1461 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0568 | 0.0568 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.3885 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2844 | 0.2844 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.051 | 0.051 |
Echinococcus granulosus | muscleblind protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1732 | 0.1732 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2844 | 0.2844 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.138 | 0.138 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.138 | 0.3552 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0568 | 0.0568 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.051 | 0.051 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2844 | 0.2844 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2844 | 0.2844 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.051 | 0.051 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.138 | 0.138 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0568 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.138 | 0.3552 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0568 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2844 | 0.7321 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.138 | 0.3552 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0568 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.5517 | 0.5517 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.138 | 0.138 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2844 | 0.2844 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0568 | 0.0568 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.138 | 0.138 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2844 | 0.2844 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.138 | 0.138 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2844 | 0.7321 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.5517 | 0.5517 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.138 | 0.138 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.051 | 0.1313 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.2582 | 0.2582 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.095 | 0.095 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.5517 | 0.5517 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2844 | 0.7321 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0568 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.051 | 0.051 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2844 | 0.2844 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (binding) | 15.8489 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.