Detailed information for compound 1388568

Basic information

Technical information
  • TDR Targets ID: 1388568
  • Name: N-[2-(3,4-dichlorophenyl)-1,3-benzoxazol-5-yl ]-2H-1,2,4-triazole-3-carboxamide
  • MW: 374.181 | Formula: C16H9Cl2N5O2
  • H donors: 2 H acceptors: 4 LogP: 3.91 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1n[nH]cn1)Nc1ccc2c(c1)nc(o2)c1ccc(c(c1)Cl)Cl
  • InChi: 1S/C16H9Cl2N5O2/c17-10-3-1-8(5-11(10)18)16-22-12-6-9(2-4-13(12)25-16)21-15(24)14-19-7-20-23-14/h1-7H,(H,21,24)(H,19,20,23)
  • InChiKey: YXYZRZKHFQPXTH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000121241
  • BAS 07603005
  • ZINC00810486
  • 1H-[1,2,4]Triazole-3-carboxylic acid [2-(3,4-dichloro-phenyl)-benzooxazol-5-yl]-amide
  • MLS000528766

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0338
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0045 0.0223 0.0512
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.044 0.4363 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0148 0.1299 0.8956
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Loa Loa (eye worm) hypothetical protein 0.0054 0.0322 0.0738
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0147 0.0338
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0056 0.0128
Schistosoma mansoni hypothetical protein 0.0049 0.0271 0.062
Brugia malayi Cytochrome P450 family protein 0.0052 0.0302 0.0692
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Trypanosoma cruzi cysteine peptidase, putative 0.0148 0.1299 0.2979
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1019 0.2336
Schistosoma mansoni cathepsin F (C01 family) 0.0148 0.1299 0.2979
Echinococcus granulosus cathepsin l1 0.0103 0.0832 0.1908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0082 0.0614 0.172
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0128
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0168 0.0471
Echinococcus multilocularis cathepsin L 0.0082 0.0614 0.0614
Echinococcus multilocularis cathepsin b 0.044 0.4363 0.4363
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.4363 1
Trypanosoma cruzi cysteine proteinase, putative 0.0082 0.0614 0.1408
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0037 0.0147 0.0338
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0168 0.0386
Giardia lamblia Cathepsin B precursor 0.0162 0.1451 1
Onchocerca volvulus Cathepsin F homolog 0.0148 0.1299 0.9965
Trypanosoma cruzi cysteine proteinase, putative 0.0082 0.0614 0.1408
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0178 0.1228
Schistosoma mansoni hypothetical protein 0.0205 0.1897 0.4348
Leishmania major cysteine peptidase A (CPA) 0.0148 0.1299 0.3638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0338
Loa Loa (eye worm) cysteine protease 0.0148 0.1299 0.2979
Brugia malayi Cathepsin L-like precursor 0.0148 0.1299 0.2979
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0056 0.0315
Plasmodium vivax vivapain-3 0.0082 0.0614 0.4054
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0056 0.5
Brugia malayi fibroinase precursor 0.0037 0.0147 0.0338
Brugia malayi cathepsin B-like cysteine proteinase 0.044 0.4363 1
Schistosoma mansoni cathepsin F (C01 family) 0.0103 0.0832 0.1908
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0147 0.0338
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1 0.7695
Giardia lamblia Cathepsin L-like protease 0.0037 0.0147 0.1015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0148 0.1299 0.8956
Trypanosoma cruzi cysteine protease, putative 0.0082 0.0614 0.1408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0148 0.1299 0.8956
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0148 0.1299 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0103 0.0832 0.5737
Brugia malayi Papain family cysteine protease containing protein 0.0082 0.0614 0.1408
Entamoeba histolytica cysteine proteinase 1, putative 0.0082 0.0614 0.4728
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0056 0.0128
Entamoeba histolytica cysteine proteinase, putative 0.0082 0.0614 0.4728
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0147 0.1015
Schistosoma mansoni cathepsin F (C01 family) 0.0148 0.1299 0.2979
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1 0.2292
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0037 0.0147 0.1015
Echinococcus granulosus Protein patched homolog 1 0.0051 0.029 0.0665
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0147 0.0734
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0056 0.0315
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1 0.1
Loa Loa (eye worm) cathepsin B 0.0162 0.1451 0.3326
Brugia malayi cathepsin L-like cysteine proteinase 0.0037 0.0147 0.0338
Loa Loa (eye worm) hypothetical protein 0.0045 0.0223 0.0512
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0499 0.0499
Echinococcus granulosus expressed protein 0.004 0.0178 0.0408
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0178 0.0408
Entamoeba histolytica cysteine proteinase, putative 0.0082 0.0614 0.4728
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0499 0.1144
Plasmodium vivax unspecified product 0.0082 0.0614 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0082 0.0614 0.1408
Brugia malayi Papain family cysteine protease containing protein 0.0082 0.0614 0.1408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0147 0.1015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0056 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0147 0.1015
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0037 0.0147 0.1015
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1562 0.4373
Entamoeba histolytica cysteine protease, putative 0.0037 0.0147 0.1134
Brugia malayi CHE-14 protein 0.0051 0.029 0.0665
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0148 0.1299 0.1299
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0056 0.0156
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.0147 0.0338
Schistosoma mansoni patched 1 0.0051 0.029 0.0665
Entamoeba histolytica cysteine proteinase, putative 0.0082 0.0614 0.4728
Giardia lamblia Cathepsin L-like protease 0.0037 0.0147 0.1015
Brugia malayi Cathepsin L-like precursor 0.0148 0.1299 0.2979
Echinococcus multilocularis cathepsin L 0.0037 0.0147 0.0147
Loa Loa (eye worm) ctsf protein 0.0148 0.1299 0.2979
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Entamoeba histolytica cysteine protease, putative 0.0037 0.0147 0.1134
Giardia lamblia Cysteine protease 0.0037 0.0147 0.1015
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0147 0.1015
Schistosoma mansoni cathepsin s 0.0045 0.0223 0.0512
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0056 0.0315
Echinococcus multilocularis expressed protein 0.004 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0148 0.1304 0.2989
Brugia malayi Cathepsin L-like precursor 0.0103 0.0832 0.1908
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0147 0.1015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0147 0.0338
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0148 0.1299 0.3638
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0148 0.1299 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0148 0.1299 0.8956
Brugia malayi Cathepsin L-like precursor 0.0148 0.1299 0.2979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0037 0.0147 0.1015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0162 0.1451 0.3326
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0147 0.1015
Toxoplasma gondii hypothetical protein 0.0059 0.0372 0.172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0148 0.1299 0.3638
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0037 0.0147 0.0338
Mycobacterium ulcerans hypothetical protein 0.0192 0.1766 1
Giardia lamblia Cathepsin B precursor 0.0037 0.0147 0.1015
Loa Loa (eye worm) hypothetical protein 0.0062 0.041 0.094
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0147 0.0338
Brugia malayi cathepsin Z-like cysteine proteinase 0.0037 0.0147 0.0338
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0037 0.0147 0.1015
Plasmodium vivax vivapain-2 0.0148 0.1299 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1562 0.4373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0148 0.1299 0.3638
Trypanosoma cruzi cysteine peptidase, putative 0.0148 0.1299 0.2979
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0082 0.0614 0.1408
Brugia malayi cathepsin Z-like cysteine proteinase 0.0037 0.0147 0.0338
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3571 0.8187
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0162 0.1451 0.3326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Brugia malayi Cathepsin L-like precursor 0.0045 0.0223 0.0512
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1534 0.1534
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0056 0.0315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0147 0.1015
Brugia malayi Cathepsin L-like cysteine proteinase 0.0103 0.0832 0.1908
Onchocerca volvulus 0.0148 0.1299 0.9965
Giardia lamblia Cathepsin L precursor 0.0037 0.0147 0.1015
Entamoeba histolytica hypothetical protein 0.0043 0.0211 0.1621
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0056 0.0429
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.3571 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0037 0.0147 0.1015
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0056 0.0156
Giardia lamblia Hypothetical protein 0.0037 0.0147 0.1015
Entamoeba histolytica cysteine proteinase, putative 0.0103 0.0832 0.6406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Echinococcus granulosus dna polymerase eta 0.0054 0.0322 0.0738
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0148 0.1299 0.8956
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0338
Trypanosoma cruzi cysteine peptidase, putative 0.0148 0.1299 0.2979
Onchocerca volvulus 0.0148 0.1299 0.9965
Trichomonas vaginalis rotamase, putative 0.004 0.0178 0.1228
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.4363 1
Onchocerca volvulus 0.0148 0.1299 0.9965
Onchocerca volvulus 0.0148 0.1299 0.9965
Onchocerca volvulus Cathepsin L homolog 0.0148 0.1299 0.9965
Leishmania major cathepsin L-like protease 0.0148 0.1299 0.3638
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0147 0.0338
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0056 0.0429
Leishmania major DNA polymerase eta, putative 0.0038 0.0154 0.043
Plasmodium falciparum cysteine proteinase falcipain 1 0.0082 0.0614 0.4054
Echinococcus granulosus cathepsin L 0.0037 0.0147 0.0338
Brugia malayi Cathepsin L-like precursor 0.0148 0.1299 0.2979
Echinococcus granulosus cathepsin b 0.044 0.4363 1
Onchocerca volvulus Cathepsin L homolog 0.0148 0.1299 0.9965
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0148 0.1299 0.8956
Brugia malayi Cathepsin L-like precursor 0.0148 0.1299 0.2979
Entamoeba histolytica hypothetical protein 0.0043 0.0211 0.1621
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0211 0.0483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Loa Loa (eye worm) hypothetical protein 0.0148 0.1304 0.2989
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0293 0.0671
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0293 0.0671
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0082 0.0614 0.1408
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1 0.2292
Loa Loa (eye worm) hypothetical protein 0.0103 0.0832 0.1908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0148 0.1299 0.3638
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0037 0.0147 0.1015
Giardia lamblia Cathepsin L precursor 0.0037 0.0147 0.1015
Echinococcus granulosus cathepsin L cysteine protease 0.0082 0.0614 0.1408
Echinococcus granulosus cathepsin L cysteine proteinase 0.0148 0.1299 0.2979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0103 0.0832 0.5737
Giardia lamblia Cathepsin B precursor 0.0162 0.1451 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0148 0.1299 0.3638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0147 0.1015
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.029 0.029
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0148 0.1299 0.2979
Loa Loa (eye worm) hypothetical protein 0.0103 0.0832 0.1908
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0148 0.1299 0.3638
Brugia malayi Papain family cysteine protease containing protein 0.0148 0.1299 0.2979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0147 0.1015
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0056 0.0128
Echinococcus granulosus cathepsin b 0.044 0.4363 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0148 0.1299 0.8956
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.3571 1
Schistosoma mansoni DNA polymerase eta 0.0054 0.0322 0.0738
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0338
Echinococcus multilocularis cysteine protease 0.0148 0.1299 0.1299
Entamoeba histolytica cysteine proteinase, putative 0.0148 0.1299 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0037 0.0147 0.0338
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0037 0.0147 0.1134
Schistosoma mansoni cathepsin S (C01 family) 0.0037 0.0147 0.0338
Leishmania major cathepsin L-like protease 0.0148 0.1299 0.3638
Leishmania major DNA polymerase eta, putative 0.0054 0.0322 0.0901
Trypanosoma cruzi cruzipain precursor, putative 0.0045 0.0223 0.0512
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0322 0.0738
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1562 0.358
Giardia lamblia Cysteine protease 0.0037 0.0147 0.1015
Loa Loa (eye worm) hypothetical protein 0.044 0.4363 1
Onchocerca volvulus 0.0148 0.1299 0.9965
Giardia lamblia Encystation-specific protease 0.0037 0.0147 0.1015
Loa Loa (eye worm) hypothetical protein 0.0119 0.1 0.2292
Schistosoma mansoni hypothetical protein 0.0049 0.0271 0.062
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0082 0.0614 0.1408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0148 0.1299 0.3638
Schistosoma mansoni hypothetical protein 0.0205 0.1897 0.4348
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0056 0.0315
Loa Loa (eye worm) hypothetical protein 0.0045 0.0223 0.0512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0128
Entamoeba histolytica cysteine protease, putative 0.0037 0.0147 0.1134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0147 0.1015
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0037 0.0147 0.0338
Plasmodium vivax vivapain-2 0.0148 0.1299 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0056 0.0315
Entamoeba histolytica cysteine protease, putative 0.0037 0.0147 0.1134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0056 0.0315
Schistosoma mansoni hypothetical protein 0.0043 0.0211 0.0483
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0045 0.0223 0.0512
Giardia lamblia Cathepsin L precursor 0.0037 0.0147 0.1015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Giardia lamblia Cathepsin L precursor 0.0037 0.0147 0.1015
Loa Loa (eye worm) hypothetical protein 0.0148 0.1299 0.2979
Entamoeba histolytica hypothetical protein 0.0037 0.0147 0.1134
Onchocerca volvulus 0.0148 0.1299 0.9965
Echinococcus granulosus cathepsin l cysteine peptidase 0.0148 0.1299 0.2979
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0148 0.1299 0.3638
Giardia lamblia Cathepsin B precursor 0.0037 0.0147 0.1015
Schistosoma mansoni hypothetical protein 0.0049 0.0271 0.062
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Leishmania major cathepsin L-like protease 0.0148 0.1299 0.3638
Echinococcus multilocularis cathepsin L cysteine protease 0.0148 0.1299 0.1299
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0147 0.0338
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0147 0.0338
Entamoeba histolytica cysteine proteinase, putative 0.0148 0.1299 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.029 0.0665
Echinococcus multilocularis cathepsin b 0.044 0.4363 0.4363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0147 0.1015
Brugia malayi cathepsin L-like precursor 0.0103 0.0832 0.1908
Brugia malayi hypothetical protein 0.0043 0.0211 0.0483
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.0147 0.1015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0148 0.1299 0.8956
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0148 0.1299 0.1299
Trichomonas vaginalis rotamase, putative 0.0039 0.0168 0.1159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0082 0.0614 0.4234
Echinococcus granulosus cysteine protease 0.0082 0.0614 0.1408
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0168 0.016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.4363 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0147 0.1015
Onchocerca volvulus Huntingtin homolog 0.0148 0.1304 1
Giardia lamblia Cathepsin L precursor 0.0037 0.0147 0.1015
Plasmodium vivax vivapain-1 0.0082 0.0614 0.4054
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0499 0.1144
Giardia lamblia Hypothetical protein 0.0037 0.0147 0.1015
Brugia malayi hypothetical protein 0.0148 0.1304 0.2989
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0293 0.0819
Leishmania major cathepsin L-like protease 0.0148 0.1299 0.3638
Entamoeba histolytica cysteine protease, putative 0.0037 0.0147 0.1134
Echinococcus granulosus cathepsin l1 0.0148 0.1299 0.2979
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0148 0.1299 0.2979
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0223 0.0512
Trypanosoma cruzi cysteine peptidase, putative 0.0082 0.0614 0.1408
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0037 0.0147 0.0338
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0322 0.0738
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0056 0.0156
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0147 0.0338
Toxoplasma gondii cathepsin CPL 0.0148 0.1299 0.8838
Brugia malayi Cathepsin L-like precursor 0.0103 0.0832 0.1908
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.0147 0.0338
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0338
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0178 0.0408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0082 0.0614 0.172
Echinococcus multilocularis cathepsin L cysteine protease 0.0148 0.1299 0.1299
Trypanosoma brucei cysteine peptidase C (CPC) 0.0162 0.1451 0.4063
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0499 0.1144
Onchocerca volvulus Huntingtin homolog 0.0148 0.1304 1
Echinococcus multilocularis protein patched 0.0051 0.029 0.029
Leishmania major cathepsin L-like protease 0.0148 0.1299 0.3638
Schistosoma mansoni cathepsin C 0.0037 0.0147 0.0338
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1766 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0082 0.0614 0.4234
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0154 0.0049
Entamoeba histolytica hypothetical protein 0.0043 0.0211 0.1621
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Echinococcus multilocularis expressed conserved protein 0.0112 0.0925 0.0925
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0056 0.0315
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.029 0.0665
Loa Loa (eye worm) hypothetical protein 0.0103 0.0832 0.1908
Onchocerca volvulus 0.0037 0.0147 0.0734
Giardia lamblia Cathepsin B precursor 0.0037 0.0147 0.1015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0128
Leishmania major cathepsin L-like protease 0.0148 0.1299 0.3638
Onchocerca volvulus 0.0148 0.1299 0.9965
Entamoeba histolytica cysteine protease, putative 0.0037 0.0147 0.1134
Loa Loa (eye worm) hypothetical protein 0.0045 0.0223 0.0512
Brugia malayi Cathepsin L-like precursor 0.0148 0.1299 0.2979
Echinococcus multilocularis protein dispatched 1 0.0058 0.0365 0.0365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0056 0.5
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0103 0.0832 0.1908
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0147 0.1015
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0162 0.1451 0.4063
Loa Loa (eye worm) fibroinase 0.0148 0.1299 0.2979
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0148 0.1299 0.8956
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0148 0.1299 0.8956
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.029 0.0665
Mycobacterium ulcerans hypothetical protein 0.0029 0.0056 0.0315
Brugia malayi cathepsin L precursor 0.0037 0.0147 0.0338
Brugia malayi cathepsin F-like cysteine proteinase 0.0045 0.0223 0.0512
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0322 0.0901
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0147 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0162 0.1451 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0293 0.0671
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.044 0.4363 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.041 0.094
Echinococcus multilocularis geminin 0.0205 0.1897 0.1897
Brugia malayi jmjC domain containing protein 0.0071 0.0499 0.1144
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0037 0.0147 0.1134
Echinococcus granulosus cathepsin L 0.0082 0.0614 0.1408
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0168 0.1294
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0168 0.0471
Brugia malayi cathepsin F-like cysteine proteinase 0.0037 0.0147 0.0338
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0499 0.1144
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0168 0.0386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0148 0.1299 0.3638
Echinococcus multilocularis dna polymerase eta 0.0054 0.0322 0.0322
Echinococcus granulosus geminin 0.0205 0.1897 0.4348
Giardia lamblia Cysteine protease 0.0037 0.0147 0.1015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0056 0.0315
Giardia lamblia Cysteine protease 0.0037 0.0147 0.1015
Entamoeba histolytica cysteine protease, putative 0.0148 0.1299 1
Echinococcus granulosus expressed conserved protein 0.0112 0.0925 0.2119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0037 0.0147 0.1015
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0037 0.0147 0.1015
Schistosoma mansoni hypothetical protein 0.0049 0.0271 0.062
Schistosoma mansoni cathepsin B (C01 family) 0.0037 0.0147 0.0338
Schistosoma mansoni rotamase 0.004 0.0178 0.0408
Loa Loa (eye worm) hypothetical protein 0.0037 0.0147 0.0338
Giardia lamblia Cathepsin B precursor 0.0162 0.1451 1
Brugia malayi jmjC domain containing protein 0.0071 0.0499 0.1144
Entamoeba histolytica cysteine proteinase, putative 0.0082 0.0614 0.4728
Giardia lamblia Cathepsin B precursor 0.0037 0.0147 0.1015
Toxoplasma gondii cathepsin B 0.0162 0.1451 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0037 0.0147 0.0338
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3571 0.8187
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Trypanosoma cruzi cruzipain precursor, putative 0.0148 0.1299 0.2979
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0211 0.0483
Leishmania major cathepsin L-like protease 0.0148 0.1299 0.3638
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0302 0.0692
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.029 0.1998
Plasmodium falciparum cysteine proteinase falcipain 3 0.0148 0.1299 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0148 0.1299 0.3638
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0499 0.1144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0148 0.1299 0.3638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0148 0.1299 0.8956
Entamoeba histolytica hypothetical protein 0.0043 0.0211 0.1621
Giardia lamblia Cathepsin B precursor 0.0037 0.0147 0.1015
Entamoeba histolytica cysteine protease, putative 0.0082 0.0614 0.4728
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0148 0.1299 0.8956
Echinococcus multilocularis cysteine protease 0.0148 0.1299 0.1299
Trypanosoma cruzi cysteine peptidase, putative 0.0148 0.1299 0.2979
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0499 0.0499
Plasmodium vivax unspecified product 0.0045 0.0223 0.066
Entamoeba histolytica cysteine proteinase 2 0.0082 0.0614 0.4728
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0499 0.1144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0147 0.1015
Giardia lamblia Cathepsin L precursor 0.0037 0.0147 0.1015
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.0147 0.0338
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0154 0.0352
Onchocerca volvulus 0.0103 0.0832 0.6223
Leishmania major cathepsin L-like protease 0.0148 0.1299 0.3638
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1534 0.3515
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0211 0.0211

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2593 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 0.2936 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7569 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 1.1582 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 2.9093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 3.0131 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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