Detailed information for compound 1389026

Basic information

Technical information
  • TDR Targets ID: 1389026
  • Name: N-(3-chloro-2-methylphenyl)-4-[2-oxo-2-(pheny lmethylamino)ethoxy]benzamide
  • MW: 408.877 | Formula: C23H21ClN2O3
  • H donors: 2 H acceptors: 2 LogP: 4.56 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccccc1)COc1ccc(cc1)C(=O)Nc1cccc(c1C)Cl
  • InChi: 1S/C23H21ClN2O3/c1-16-20(24)8-5-9-21(16)26-23(28)18-10-12-19(13-11-18)29-15-22(27)25-14-17-6-3-2-4-7-17/h2-13H,14-15H2,1H3,(H,25,27)(H,26,28)
  • InChiKey: RICXAQYZWUQNTG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chloro-2-methyl-phenyl)-4-[2-oxo-2-(phenylmethylamino)ethoxy]benzamide
  • 4-[2-(benzylamino)-2-keto-ethoxy]-N-(3-chloro-2-methyl-phenyl)benzamide
  • AP-906/42392738
  • ST5200076
  • 4-[2-(benzylamino)-2-oxoethoxy]-N-(3-chloro-2-methylphenyl)benzamide
  • MLS000581323
  • SMR000199941
  • ZINC02855621

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0046 0.0114 0.0692
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0042 0.1822
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0114 0.0692
Loa Loa (eye worm) Plekhf2 protein 0.0036 0.0073 0.0066
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0073 0.3393
Loa Loa (eye worm) hypothetical protein 0.0043 0.0104 0.0097
Echinococcus multilocularis plexin a4 0.0291 0.1135 0.135
Plasmodium falciparum glutathione reductase 0.0043 0.0102 0.4895
Schistosoma mansoni syntrophin 0.0036 0.0073 0.0066
Schistosoma mansoni myotubularin-related protein 0.0036 0.0073 0.0066
Echinococcus multilocularis regulator of G protein signaling 3 0.0392 0.1557 0.1854
Onchocerca volvulus 0.0036 0.0073 0.0708
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0104 0.5
Echinococcus multilocularis Immunoglobulin 0.0083 0.027 0.0315
Schistosoma mansoni growth factor receptor-bound protein 0.0036 0.0073 0.0066
Trypanosoma cruzi NIMA-related kinase, putative 0.0046 0.0114 0.5515
Brugia malayi Raf kinase 0.002 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Trypanosoma brucei aurora B kinase 0.0067 0.0201 1
Echinococcus granulosus cytohesin 1 0.0036 0.0073 0.0079
Loa Loa (eye worm) hypothetical protein 0.018 0.0675 0.0669
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0046 0.0114 0.5515
Echinococcus granulosus semaphorin 1A 0.0107 0.037 0.0434
Schistosoma mansoni regulator of G protein signaling 0.0392 0.1557 0.1551
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0104 0.0117
Brugia malayi hypothetical protein 0.0029 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0137 0.0492 0.0486
Leishmania major protein kinase, putative 0.0046 0.0114 0.5515
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.012 0.0728
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0392 0.1557 0.1551
Entamoeba histolytica hypothetical protein 0.0392 0.1557 1
Brugia malayi Guanylyl cyclase protein 23 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0104 0.0097
Schistosoma mansoni axis inhibition protein axin 0.0392 0.1557 0.1551
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0109 0.0377 1
Schistosoma mansoni nephrin 0.0083 0.027 0.0264
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0036 0.0073 0.0426
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0007 0.0007
Echinococcus granulosus aurora kinase A 0.0067 0.0201 0.0233
Echinococcus multilocularis axis inhibition protein axin 0.0392 0.1557 0.1854
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0104 0.0117
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0046 0.0114 0.5515
Brugia malayi glutathione reductase 0.0043 0.0102 0.0102
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Plasmodium falciparum calcium-dependent protein kinase 7 0.0046 0.0114 0.5515
Trichomonas vaginalis conserved hypothetical protein 0.0392 0.1557 1
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0116 0.011
Leishmania major protein kinase, putative 0.0067 0.0201 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0392 0.1557 0.1551
Brugia malayi protein-tyrosine kinase 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0119 0.0722
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0046 0.0114 0.5515
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0046 0.0114 0.5515
Mycobacterium ulcerans hypothetical protein 0.0043 0.0104 0.5
Brugia malayi Muscleblind-like protein 0.018 0.0675 0.0675
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Echinococcus multilocularis cytohesin 1 0.0036 0.0073 0.0079
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Schistosoma mansoni regulator of G protein signaling 0.0392 0.1557 0.1551
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Loa Loa (eye worm) acetyltransferase 0.0175 0.0653 0.0646
Echinococcus granulosus oxysterol binding protein 3 0.0036 0.0073 0.0079
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Leishmania major folate/biopterin transporter, putative 0.0046 0.0114 0.5515
Toxoplasma gondii hypothetical protein 0.0036 0.0073 0.3393
Brugia malayi PH domain containing protein 0.0036 0.0073 0.0073
Onchocerca volvulus Protein melted homolog 0.0036 0.0073 0.0708
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0653 0.0653
Echinococcus granulosus plexin a4 0.0291 0.1135 0.135
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0104 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0046 0.0114 0.5515
Trypanosoma cruzi hypothetical protein 0.0036 0.0073 0.3393
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0104 0.0023
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0047 0.0119 0.0112
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Entamoeba histolytica PH domain containing protein 0.0036 0.0073 0.0426
Echinococcus multilocularis Rho GTPase activating protein 24 0.0036 0.0073 0.0079
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2416 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.0049
Trichomonas vaginalis protein transport protein sec7, putative 0.0036 0.0073 0.0426
Brugia malayi Dynamin 0.0036 0.0073 0.0073
Echinococcus granulosus regulator of G protein signaling 3 0.0392 0.1557 0.1854
Brugia malayi DNA-binding protein LAG-1 0.0047 0.0119 0.0119
Brugia malayi Flap endonuclease-1 0.003 0.0046 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Entamoeba histolytica protein kinase domain containing protein 0.003 0.0048 0.0266
Entamoeba histolytica cell surface protease gp63, putative 0.0047 0.0119 0.0722
Onchocerca volvulus Putative zinc finger protein 0.0036 0.0073 0.0708
Echinococcus multilocularis Pleckstrin y 0.0036 0.0073 0.0079
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0104 0.0023
Echinococcus multilocularis transcription factor collier 0.0047 0.0119 0.0134
Brugia malayi plexin A 0.0291 0.1135 0.1135
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0392 0.1557 1
Schistosoma mansoni semaphorin 5-related 0.0107 0.037 0.0363
Echinococcus multilocularis flap endonuclease 1 0.003 0.0046 0.0047
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0036 0.0073 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Echinococcus multilocularis beta 1 syntrophin 0.0036 0.0073 0.0079
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0036 0.0073 0.0426
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0104 0.0097
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0036 0.0073 0.0066
Echinococcus granulosus axis inhibition protein axin 0.0392 0.1557 0.1854
Schistosoma mansoni vesicular amine transporter 0.0086 0.0281 0.0274
Schistosoma mansoni hypothetical protein 0.0047 0.0119 0.0112
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0201 0.0195
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0392 0.1557 0.1854
Entamoeba histolytica hypothetical protein 0.0392 0.1557 1
Entamoeba histolytica hypothetical protein 0.0047 0.0119 0.0722
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0114 0.0107
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0036 0.0073 0.0426
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0104 0.0628
Echinococcus multilocularis muscleblind protein 0.018 0.0675 0.08
Onchocerca volvulus 0.0036 0.0073 0.0708
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0036 0.0073 0.0708
Echinococcus granulosus Pleckstrin y 0.0036 0.0073 0.0079
Brugia malayi Probable tyrosine-protein kinase kin-31 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0392 0.1557 1
Echinococcus multilocularis oxysterol binding protein 1 0.0036 0.0073 0.0079
Echinococcus granulosus Oxysterol binding protein 11 0.0036 0.0073 0.0079
Echinococcus multilocularis oxysterol binding protein 3 0.0036 0.0073 0.0079
Loa Loa (eye worm) hypothetical protein 0.0392 0.1557 0.1551
Trichomonas vaginalis centaurin beta, putative 0.0036 0.0073 0.0426
Entamoeba histolytica protein kinase, putative 0.0067 0.0201 0.1254
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Echinococcus granulosus oxysterol binding protein 1 0.0036 0.0073 0.0079
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0104 0.0117
Entamoeba histolytica protein kinase, putative 0.0046 0.0114 0.0692
Loa Loa (eye worm) RGS-3 protein 0.0392 0.1557 0.1551
Schistosoma mansoni fibrocystin l 0.0047 0.0119 0.0112
Schistosoma mansoni protein kinase 0.0067 0.0201 0.0195
Trypanosoma brucei PH domain containing protein, putative 0.0036 0.0073 0.3393
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0114 0.0692
Echinococcus multilocularis muscleblind protein 1 0.018 0.0675 0.08
Echinococcus multilocularis regulator of G protein signaling 3 0.0392 0.1557 0.1854
Entamoeba histolytica protein kinase, putative 0.0046 0.0114 0.0692
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Brugia malayi Probable exocyst complex component Sec5 0.0047 0.0119 0.0119
Loa Loa (eye worm) AUR protein kinase 0.0067 0.0201 0.0195
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0104 0.501
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Entamoeba histolytica hypothetical protein 0.0047 0.0119 0.0722
Entamoeba histolytica hypothetical protein 0.0036 0.0073 0.0426
Brugia malayi Cadps2 protein 0.0036 0.0073 0.0073
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0046 0.0114 0.5515
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0036 0.0073 0.0426
Echinococcus multilocularis GRB2 associated binding protein 3 0.0036 0.0073 0.0079
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0042 0.1822
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0036 0.0073 0.0426
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0104 0.0023
Trypanosoma cruzi hypothetical protein 0.0036 0.0073 0.3393
Brugia malayi hypothetical protein 0.0083 0.027 0.027
Schistosoma mansoni hypothetical protein 0.0036 0.0073 0.0066
Schistosoma mansoni axis inhibition protein axin 0.0392 0.1557 0.1551
Entamoeba histolytica PH domain containing protein 0.0036 0.0073 0.0426
Loa Loa (eye worm) hypothetical protein 0.0047 0.0119 0.0112
Trichomonas vaginalis alpha chimerin, putative 0.0036 0.0073 0.0426
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0036 0.0073 0.0426
Loa Loa (eye worm) hypothetical protein 0.0047 0.0119 0.0112
Brugia malayi Tyrosine-protein kinase abl-1 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0083 0.027 0.0264
Brugia malayi PH domain containing protein 0.0036 0.0073 0.0073
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0036 0.0073 0.0079
Echinococcus multilocularis axis inhibition protein axin 0.0392 0.1557 0.1854
Echinococcus granulosus expressed protein 0.0392 0.1557 0.1854
Loa Loa (eye worm) hypothetical protein 0.0083 0.027 0.0264
Schistosoma mansoni serine/threonine protein kinase 0.1852 0.7647 0.7646
Echinococcus multilocularis Ras associated and pleckstrin y 0.0036 0.0073 0.0079
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0036 0.0073 0.0066
Echinococcus multilocularis calcium dependent secretion activator 1 0.0036 0.0073 0.0079
Brugia malayi A-kinase anchor protein 10, precursor 0.0392 0.1557 0.1557
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0036 0.0073 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0392 0.1557 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.037 0.0363
Toxoplasma gondii phosphatidylinositol transfer protein 0.0036 0.0073 0.3393
Loa Loa (eye worm) AUR protein kinase 0.0067 0.0201 0.0195
Brugia malayi serine/threonine kinase 12 0.0067 0.0201 0.0201
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0138 0.6724
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0103 0.0354 0.0348
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0138 0.6724
Trypanosoma cruzi hypothetical protein 0.0036 0.0073 0.3393
Brugia malayi Regulator of G protein signaling domain containing protein 0.0392 0.1557 0.1557
Loa Loa (eye worm) beta-lactamase 0.0043 0.0104 0.0097
Entamoeba histolytica hypothetical protein 0.0036 0.0073 0.0426
Trypanosoma cruzi hypothetical protein 0.0036 0.0073 0.3393
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0036 0.0073 0.0079
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0046 0.0114 0.5515
Brugia malayi PH domain containing protein 0.0036 0.0073 0.0073
Onchocerca volvulus 0.0036 0.0073 0.0708
Trypanosoma cruzi Protein kinase B 0.0046 0.0114 0.5515
Entamoeba histolytica hypothetical protein 0.0047 0.0119 0.0722
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0036 0.0073 0.0079
Entamoeba histolytica tyrosin kinase, putative 0.0067 0.0203 0.1263
Loa Loa (eye worm) hypothetical protein 0.0392 0.1557 0.1551
Echinococcus multilocularis beta adrenergic receptor kinase 0.1852 0.7647 0.914
Echinococcus multilocularis pleckstrin y domain containing family A 0.0036 0.0073 0.0079
Loa Loa (eye worm) rho-GTPase-activating 0.0036 0.0073 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Entamoeba histolytica protein kinase, putative 0.0046 0.0114 0.0692
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.002 0.0007 0.0007
Echinococcus multilocularis Pleckstrin y 0.0036 0.0073 0.0079
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Loa Loa (eye worm) AUR protein kinase 0.0067 0.0201 0.0195
Schistosoma mansoni vav2 0.0036 0.0073 0.0066
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0098 0.0331 0.2343
Echinococcus multilocularis rac serine:threonine kinase 0.0046 0.0114 0.0128
Schistosoma mansoni serine/threonine protein kinase 0.2416 1 1
Leishmania major protein kinase, putative 0.0046 0.0114 0.5515
Entamoeba histolytica protein kinase, putative 0.0046 0.0114 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0083 0.027 0.0315
Trypanosoma cruzi PH domain containing protein, putative 0.0036 0.0073 0.3393
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0036 0.0073 0.3393
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0047 0.0119 0.0722
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0036 0.0073 0.0426
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0046 0.2025
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0042 0.1822
Brugia malayi Receptor family ligand binding region containing protein 0.002 0.0007 0.0007
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0102 0.0095
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0036 0.0073 0.0066
Entamoeba histolytica hypothetical protein 0.0036 0.0073 0.0426
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Plasmodium falciparum oxysterol-binding protein, putative 0.0036 0.0073 0.3393
Echinococcus granulosus semaphorin 5B 0.0107 0.037 0.0434
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Schistosoma mansoni goodpasture antigen-binding protein 0.0036 0.0073 0.0066
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0036 0.0073 0.0066
Echinococcus granulosus flap endonuclease 1 0.003 0.0046 0.0047
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0036 0.0073 0.0073
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0104 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Brugia malayi MAX-1A 0.0036 0.0073 0.0073
Loa Loa (eye worm) cytohesin 3 0.0036 0.0073 0.0066
Echinococcus multilocularis regulator of G protein signaling 7 0.0392 0.1557 0.1854
Echinococcus granulosus pleckstrin y domain containing family A 0.0036 0.0073 0.0079
Brugia malayi Uncoordinated protein 104 0.0036 0.0073 0.0073
Brugia malayi Variant SH3 domain containing protein 0.0036 0.0073 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0076 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Brugia malayi Oxysterol-binding protein 0.0036 0.0073 0.0073
Brugia malayi serine/threonine protein kinase 6 0.0067 0.0201 0.0201
Echinococcus multilocularis Oxysterol binding protein 11 0.0036 0.0073 0.0079
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0047 0.0119 0.0112
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0046 0.0114 0.5515
Echinococcus granulosus myotubularin protein 13 0.0036 0.0073 0.0079
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0046 0.0114 0.0692
Brugia malayi PH domain containing protein 0.0036 0.0073 0.0073
Trichomonas vaginalis centaurin/arf, putative 0.0036 0.0073 0.0426
Loa Loa (eye worm) hypothetical protein 0.0083 0.027 0.0264
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0046 0.2025
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0036 0.0073 0.0073
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0392 0.1557 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0048 0.2122
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0036 0.0073 0.0708
Brugia malayi beta-lactamase family protein 0.0043 0.0104 0.0104
Echinococcus multilocularis DCC interacting protein 13 beta 0.0036 0.0073 0.0079
Entamoeba histolytica hypothetical protein 0.0036 0.0073 0.0426
Mycobacterium ulcerans beta-lactamase 0.0043 0.0104 0.5
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0083 0.027 0.0315
Schistosoma mansoni voltage-gated potassium channel 0.004 0.009 0.0083
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1461 0.6014 0.7186
Trichomonas vaginalis protein transport protein sec7, putative 0.0036 0.0073 0.0426
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0036 0.0073 0.0079
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0036 0.0073 0.0426
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0048 0.2122
Echinococcus multilocularis expressed protein 0.0392 0.1557 0.1854
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0036 0.0073 0.0079
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0036 0.0073 0.0079
Onchocerca volvulus 0.0244 0.0939 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0653 0.0773
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.0201 0.1254
Brugia malayi beta-lactamase 0.0043 0.0104 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.002 0.0007 0.0007
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0104 0.0023
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0036 0.0073 0.0426
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0036 0.0073 0.0426
Brugia malayi serine/threonine-protein kinase 6 0.0067 0.0201 0.0201
Trypanosoma cruzi hypothetical protein 0.0036 0.0073 0.3393
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1081 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0104 0.0097
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0104 0.0104
Schistosoma mansoni goodpasture antigen-binding protein 0.0036 0.0073 0.0066
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0036 0.0073 0.0426
Leishmania major hypothetical protein, conserved 0.0029 0.0042 0.1822
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0104 0.501
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0104 0.0628
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0036 0.0073 0.0079
Echinococcus granulosus Rho GTPase activating protein 24 0.0036 0.0073 0.0079
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0036 0.0073 0.3393
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0036 0.0073 0.0426
Echinococcus granulosus regulator of G protein signaling 3 0.0392 0.1557 0.1854
Loa Loa (eye worm) hypothetical protein 0.0043 0.0104 0.0097
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0036 0.0073 0.0426
Echinococcus multilocularis neuroglian 0.0083 0.027 0.0315
Brugia malayi SRC-1 0.002 0.0007 0.0007
Echinococcus multilocularis actin binding protein anillin 0.0036 0.0073 0.0079
Schistosoma mansoni hypothetical protein 0.0036 0.0073 0.0066
Echinococcus granulosus GRB2 associated binding protein 3 0.0036 0.0073 0.0079
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0201 0.1254
Brugia malayi IPT/TIG domain containing protein 0.0047 0.0119 0.0119
Brugia malayi regulator of G-protein signaling egl-10 0.0392 0.1557 0.1557
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.012 0.5804
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0036 0.0073 0.0079
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0046 0.0254
Entamoeba histolytica protein kinase, putative 0.0067 0.0201 0.1254
Leishmania major hypothetical protein, conserved 0.0036 0.0073 0.3393
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0114 0.0692
Echinococcus multilocularis Pleckstrin y 0.0036 0.0073 0.0079
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Toxoplasma gondii ABC1 family protein 0.0043 0.0104 0.501
Echinococcus granulosus activin receptor type 0.003 0.0048 0.0049
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0046 0.2025
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0109 0.0377 0.2808
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.2025 0.8366 0.8366
Echinococcus granulosus calcium dependent secretion activator 1 0.0036 0.0073 0.0079
Trypanosoma cruzi NIMA-related kinase, putative 0.0046 0.0114 0.5515
Loa Loa (eye worm) hypothetical protein 0.0137 0.0492 0.0486
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0098 0.0331 0.8329
Schistosoma mansoni hypothetical protein 0.0036 0.0073 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.003 0.0048 0.2122
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0046 0.2025
Mycobacterium tuberculosis Probable reductase 0.0098 0.0331 0.2343
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0042 0.1822
Loa Loa (eye worm) PH domain-containing protein 0.0036 0.0073 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0392 0.1557 0.1854
Loa Loa (eye worm) hypothetical protein 0.0107 0.037 0.0363
Entamoeba histolytica PH domain containing protein 0.0036 0.0073 0.0426
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.2025 0.8366 0.8365
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0036 0.0073 0.0066
Entamoeba histolytica protein kinase, putative 0.0046 0.0114 0.0692
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0046 0.0114 0.5515
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0392 0.1557 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0104 0.0097
Brugia malayi C-terminal src kinase protein 1 0.002 0.0007 0.0007
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0036 0.0073 0.0079
Echinococcus granulosus dual specificity testis-specific protein kinase 0.003 0.0048 0.0049
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0104 0.0117
Onchocerca volvulus outspread protein homolog 0.0036 0.0073 0.0708
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0104 0.0097
Loa Loa (eye worm) hypothetical protein 0.0244 0.0939 0.0933
Onchocerca volvulus 0.0036 0.0073 0.0708
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0046 0.0114 0.5515
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0046 0.0114 0.5515
Brugia malayi Pleckstrin Homology Domain 0.0036 0.0073 0.0073
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.0073 0.3393
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.1852 0.7647 0.7646
Brugia malayi hypothetical protein 0.0392 0.1557 0.1557
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0104 0.0628
Toxoplasma gondii protein kinase domain-containing protein 0.0046 0.0114 0.5515
Onchocerca volvulus 0.0107 0.037 0.3893
Schistosoma mansoni hypothetical protein 0.0107 0.037 0.0363
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0046 0.0114 0.5515
Loa Loa (eye worm) hypothetical protein 0.0107 0.037 0.0363
Brugia malayi Plexin repeat family protein 0.0244 0.0939 0.0939
Echinococcus multilocularis myotubularin protein 13 0.0036 0.0073 0.0079
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0073 0.0426
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.2025 0.8366 1
Schistosoma mansoni voltage-gated potassium channel 0.004 0.009 0.0083
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0036 0.0073 0.0426
Loa Loa (eye worm) oxysterol binding protein 0.0036 0.0073 0.0066
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0098 0.0331 0.2343
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0046 0.0114 0.5515
Trypanosoma cruzi PH domain containing protein, putative 0.0036 0.0073 0.3393
Echinococcus granulosus neuroglian 0.0083 0.027 0.0315
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0104 0.501
Loa Loa (eye worm) hypothetical protein 0.0107 0.037 0.0363
Echinococcus multilocularis G protein coupled receptor kinase 6 0.2025 0.8366 1
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0047 0.0119 0.0722
Echinococcus granulosus transcription factor collier 0.0047 0.0119 0.0134
Brugia malayi PH domain containing protein 0.0036 0.0073 0.0073
Schistosoma mansoni plexin 0.0137 0.0492 0.0486
Leishmania major serine/threonine-protein kinase a, putative 0.0046 0.0114 0.5515
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0067 0.0201 0.0233
Brugia malayi probable spectrin beta chain 0.0036 0.0073 0.0073
Mycobacterium ulcerans lipase LipD 0.0043 0.0104 0.5
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0083 0.027 0.0264
Loa Loa (eye worm) AGC/AKT protein kinase 0.0046 0.0114 0.0107
Echinococcus multilocularis activin receptor type 0.003 0.0048 0.0049
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0076 0.0082
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0036 0.0073 0.0079
Plasmodium vivax glutathione reductase, putative 0.0043 0.0102 0.4895
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0138 0.0156
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Loa Loa (eye worm) PXA domain-containing protein 0.0392 0.1557 0.1551
Echinococcus granulosus Regulator of G protein signaling 20 0.0392 0.1557 0.1854
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0104 0.0628
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.0073 0.3393
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0067 0.0201 1
Schistosoma mansoni regulator of G protein signaling 0.0392 0.1557 0.1551
Trypanosoma cruzi PH domain containing protein, putative 0.0036 0.0073 0.3393
Plasmodium falciparum PH domain-containing protein, putative 0.0036 0.0073 0.3393
Loa Loa (eye worm) sema domain-containing protein 0.0107 0.037 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0119 0.0722
Loa Loa (eye worm) hypothetical protein 0.0043 0.0104 0.0097
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2025 0.8366 0.8365
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0138 0.0843
Plasmodium falciparum serine/threonine protein kinase, putative 0.0067 0.0201 1
Echinococcus granulosus pdz domain containing protein 0.0036 0.0073 0.0079
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Brugia malayi PH domain containing protein 0.0036 0.0073 0.0073
Entamoeba histolytica ARF GTPase activating protein, putative 0.0036 0.0073 0.0426
Loa Loa (eye worm) uncoordinated protein 104 0.0036 0.0073 0.0066
Onchocerca volvulus 0.0036 0.0073 0.0708
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.0203 0.1263
Schistosoma mansoni hypothetical protein 0.0107 0.037 0.0363
Brugia malayi PXA domain containing protein 0.0392 0.1557 0.1557
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0066 0.0378
Brugia malayi SH2 domain containing protein 0.002 0.0007 0.0007
Trypanosoma cruzi aurora B kinase, putative 0.0067 0.0201 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0632 0.0748
Mycobacterium tuberculosis Conserved protein 0.0043 0.0104 0.0023
Brugia malayi Variant SH3 domain containing protein 0.0036 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Echinococcus multilocularis dual specificity testis specific protein kinase 0.003 0.0048 0.0049
Brugia malayi SH2 domain containing protein 0.002 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0036 0.0073 0.0426
Schistosoma mansoni zinc finger protein 0.0036 0.0073 0.0066
Leishmania major protein kinase, putative 0.003 0.0048 0.2122
Trichomonas vaginalis kinesin light chain, putative 0.0036 0.0073 0.0426
Plasmodium falciparum thioredoxin reductase 0.0043 0.0102 0.4895
Echinococcus multilocularis Regulator of G protein signaling 20 0.0392 0.1557 0.1854
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Schistosoma mansoni hypothetical protein 0.0036 0.0073 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0119 0.0722
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Toxoplasma gondii hypothetical protein 0.0036 0.0073 0.3393
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0114 0.0692
Entamoeba histolytica hypothetical protein 0.0046 0.0114 0.0692
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0047 0.0119 0.0722
Leishmania major trypanothione reductase 0.0043 0.0102 0.4895
Echinococcus granulosus exocyst complex component 2 0.0047 0.0119 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0119 0.0722
Trypanosoma cruzi hypothetical protein 0.0036 0.0073 0.3393
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0392 0.1557 0.1551
Entamoeba histolytica hypothetical protein 0.0036 0.0073 0.0426
Loa Loa (eye worm) hypothetical protein 0.0107 0.037 0.0363
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0036 0.0073 0.0073
Schistosoma mansoni flap endonuclease-1 0.0027 0.0034 0.0028
Schistosoma mansoni zinc finger protein 0.0036 0.0073 0.0066
Mycobacterium tuberculosis Conserved protein 0.0043 0.0104 0.0023
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0083 0.027 0.0264
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0046 0.0114 0.5515
Echinococcus multilocularis pdz domain containing protein 0.0036 0.0073 0.0079
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Echinococcus granulosus beta 1 syntrophin 0.0036 0.0073 0.0079
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Echinococcus granulosus defective proboscis extension response 0.0083 0.027 0.0315
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0036 0.0073 0.0066
Entamoeba histolytica hypothetical protein 0.0046 0.0114 0.0692
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0076 0.0069
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0036 0.0073 0.0426
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0098 0.0331 0.2343
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0036 0.0073 0.0079
Echinococcus multilocularis regulator of G protein signaling 0.0392 0.1557 0.1854
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0201 0.1254
Echinococcus multilocularis oxysterol binding protein 9 0.0036 0.0073 0.0079
Plasmodium falciparum protein kinase, putative 0.003 0.0048 0.2122
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Brugia malayi hypothetical protein 0.002 0.0007 0.0007
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0653 0.0646
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0109 0.0377 0.2808
Schistosoma mansoni protein kinase 0.003 0.0048 0.0041
Loa Loa (eye worm) hypothetical protein 0.0083 0.027 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0042 0.1822
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0036 0.0073 0.3393
Echinococcus multilocularis dynamin 1 0.0036 0.0073 0.0079
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0042 0.1822
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0036 0.0073 0.0079
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0098 0.0331 0.2343
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0036 0.0073 0.0426
Schistosoma mansoni protein kinase 0.003 0.0048 0.0041
Trypanosoma brucei rac serine-threonine kinase, putative 0.0046 0.0114 0.5515
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0036 0.0073 0.0426
Onchocerca volvulus 0.0043 0.0104 0.1045
Trypanosoma cruzi PH domain containing protein, putative 0.0036 0.0073 0.3393
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0104 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0046 0.2025
Echinococcus granulosus twitchin 0.0093 0.0312 0.0365
Brugia malayi Plekhf2 protein 0.0036 0.0073 0.0073
Schistosoma mansoni regulator of G protein signaling 0.0392 0.1557 0.1551
Brugia malayi Furin-like cysteine rich region family protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.018 0.0675 0.0669
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0046 0.0114 0.5515
Echinococcus multilocularis aurora kinase A 0.0067 0.0201 0.0233
Schistosoma mansoni serine/threonine protein kinase 0.1852 0.7647 0.7646
Loa Loa (eye worm) hypothetical protein 0.0043 0.0104 0.0097
Entamoeba histolytica protein kinase , putative 0.0067 0.0201 0.1254
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.012 0.5804
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0114 0.0692
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0102 0.4895
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Echinococcus granulosus Pleckstrin y 0.0036 0.0073 0.0079
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0036 0.0073 0.3393
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0036 0.0073 0.0426
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0138 0.6724
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0036 0.0073 0.0708
Brugia malayi hypothetical protein 0.0107 0.037 0.037
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0114 0.0692
Schistosoma mansoni oxysterol-binding protein 1 0.0036 0.0073 0.0066
Loa Loa (eye worm) hypothetical protein 0.0392 0.1557 0.1551
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Echinococcus multilocularis roundabout 2 0.0083 0.027 0.0315
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.002 0.0007 0.0007
Echinococcus granulosus DCC interacting protein 13 beta 0.0036 0.0073 0.0079
Brugia malayi hypothetical protein 0.0036 0.0073 0.0073
Brugia malayi PXA domain containing protein 0.0392 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0083 0.027 0.0264
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0042 0.1822
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0036 0.0073 0.0079
Brugia malayi Oxysterol binding protein 0.0036 0.0073 0.0073
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0036 0.0073 0.3393
Schistosoma mansoni centaurin alpha 0.0036 0.0073 0.0066
Brugia malayi integrin-linked kinase 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Echinococcus granulosus axis inhibition protein axin 0.0392 0.1557 0.1854
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Giardia lamblia Aurora kinase 0.0067 0.0201 1
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0036 0.0073 0.3393
Echinococcus granulosus beta-adrenergic receptor kinase 0.1852 0.7647 0.914
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0067 0.0201 0.1254
Trypanosoma cruzi hypothetical protein 0.0036 0.0073 0.3393
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0201 0.1254
Trichomonas vaginalis conserved hypothetical protein 0.0392 0.1557 1
Toxoplasma gondii Oxysterol-binding protein 0.0036 0.0073 0.3393
Echinococcus granulosus oxysterol binding protein 9 0.0036 0.0073 0.0079
Echinococcus multilocularis Immunoglobulin 0.0083 0.027 0.0315
Loa Loa (eye worm) hypothetical protein 0.0083 0.027 0.0264
Trichomonas vaginalis AGC family protein kinase 0.0067 0.0201 0.1254
Echinococcus granulosus Pleckstrin y 0.0036 0.0073 0.0079
Schistosoma mansoni oxysterol-binding protein 1 0.0036 0.0073 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Schistosoma mansoni z-protein (S1r protein) 0.0392 0.1557 0.1551
Leishmania major hypothetical protein, conserved 0.0043 0.0104 0.501
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0035
Plasmodium vivax PH domain containing protein 0.0036 0.0073 0.3393
Trypanosoma brucei protein kinase, putative 0.003 0.0048 0.2122
Brugia malayi TBC domain containing protein 0.0036 0.0073 0.0073
Schistosoma mansoni dynamin 0.0036 0.0073 0.0066
Brugia malayi Probable tyrosine-protein kinase kin-31 0.002 0.0007 0.0007
Trypanosoma brucei trypanothione reductase 0.0043 0.0102 0.4895
Trichomonas vaginalis hypothetical protein 0.0036 0.0073 0.0426
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0046 0.0114 0.5515
Brugia malayi Thioredoxin reductase 0.0043 0.0102 0.0102
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0067 0.0201 0.0233
Entamoeba histolytica protein kinase, putative 0.0046 0.0114 0.0692
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Mycobacterium tuberculosis Probable dehydrogenase 0.0098 0.0331 0.2343
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0046 0.0114 0.5515
Trichomonas vaginalis centaurin/arf, putative 0.0036 0.0073 0.0426
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0083 0.027 0.0264
Echinococcus multilocularis exocyst complex component 2 0.0047 0.0119 0.0134
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0046 0.2025
Trichomonas vaginalis centaurin gamma, putative 0.0036 0.0073 0.0426
Echinococcus granulosus roundabout 2 0.0083 0.027 0.0315
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0392 0.1557 0.1551
Loa Loa (eye worm) glutathione reductase 0.0043 0.0102 0.0095
Loa Loa (eye worm) hypothetical protein 0.0392 0.1557 0.1551
Onchocerca volvulus 0.0043 0.0104 0.1045
Brugia malayi PH domain containing protein 0.0036 0.0073 0.0073
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0138 0.0843
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0047 0.0119 0.0722
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0067 0.0201 0.1254
Trichomonas vaginalis centaurin alpha, putative 0.0036 0.0073 0.0426
Toxoplasma gondii aurora kinase 0.0067 0.0201 1
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Loa Loa (eye worm) syntrophin-1 0.0036 0.0073 0.0066
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0046 0.0039
Schistosoma mansoni rho gtpase activating protein 0.0036 0.0073 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0119 0.0722
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0036 0.0073 0.0426
Brugia malayi Dynamin 0.0036 0.0073 0.0073
Brugia malayi Syntrophin-1 0.0036 0.0073 0.0073
Mycobacterium tuberculosis Conserved protein 0.0043 0.0104 0.0023
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0036 0.0073 0.0426
Onchocerca volvulus 0.0036 0.0073 0.0708
Trypanosoma brucei protein kinase, putative 0.0046 0.0114 0.5515
Entamoeba histolytica hypothetical protein 0.0392 0.1557 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Loa Loa (eye worm) hypothetical protein 0.0392 0.1557 0.1551
Echinococcus granulosus G protein coupled receptor kinase 1 0.1461 0.6014 0.7186
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0067 0.0201 0.1254
Brugia malayi Sema domain containing protein 0.0107 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0083 0.027 0.0264
Loa Loa (eye worm) hypothetical protein 0.0392 0.1557 0.1551
Entamoeba histolytica p21-activated kinase 0.0046 0.0114 0.0692
Loa Loa (eye worm) plexin A 0.0291 0.1135 0.1129
Entamoeba histolytica hypothetical protein 0.0047 0.0119 0.0722
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0036 0.0073 0.3393
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0066 0.0378
Brugia malayi regulator of G-protein signaling rgs-7 0.0392 0.1557 0.1557
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0104 0.501
Entamoeba histolytica protein kinase, putative 0.0046 0.0114 0.0692
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Brugia malayi hypothetical protein 0.0107 0.037 0.037
Echinococcus granulosus regulator of G protein signaling 7 0.0392 0.1557 0.1854
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Schistosoma mansoni dynamin 0.0036 0.0073 0.0066
Brugia malayi Sema domain containing protein 0.0107 0.037 0.037
Schistosoma mansoni protein kinase 0.003 0.0048 0.0041
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0083 0.027 0.0264
Brugia malayi beta-lactamase family protein 0.0043 0.0104 0.0104
Brugia malayi Immunoglobulin I-set domain containing protein 0.0103 0.0354 0.0354
Echinococcus granulosus serine/threonine protein kinase 0.0046 0.0114 0.0128
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0076 0.0082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0102 0.4895
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0048 0.2122
Loa Loa (eye worm) hypothetical protein 0.0107 0.037 0.0363
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0104 0.5
Brugia malayi bone morphogenetic protein type 1 receptor 0.002 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0119 0.0722
Echinococcus multilocularis regulator of G protein signaling 7 0.0392 0.1557 0.1854
Entamoeba histolytica Flap nuclease, putative 0.003 0.0046 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0073 0.0426
Mycobacterium tuberculosis Probable oxidoreductase 0.0109 0.0377 0.2808
Echinococcus granulosus tyrosine protein kinase Lyn 0.003 0.0048 0.0049
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0047 0.0119 0.0722
Brugia malayi Protein kinase domain containing protein 0.0046 0.0114 0.0114
Brugia malayi ephrin receptor 1 precursor 0.002 0.0007 0.0007
Echinococcus granulosus dynamin 1 0.0036 0.0073 0.0079
Brugia malayi Tyrosine-protein kinase PR2 0.002 0.0007 0.0007
Echinococcus granulosus Immunoglobulin 0.0083 0.027 0.0315
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Schistosoma mansoni cell adhesion molecule 0.0083 0.027 0.0264
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0036 0.0073 0.0079
Plasmodium falciparum flap endonuclease 1 0.003 0.0046 0.2025
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0036 0.0073 0.0079
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0036 0.0073 0.0066
Toxoplasma gondii AtPH1 family protein 0.0036 0.0073 0.3393
Leishmania major hypothetical protein, conserved 0.0036 0.0073 0.3393
Toxoplasma gondii thioredoxin reductase 0.0043 0.0102 0.4895
Echinococcus multilocularis hypothetical protein 0.0107 0.037 0.0434
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0066
Brugia malayi Fibronectin type III domain containing protein 0.0083 0.027 0.027
Echinococcus granulosus regulator of G protein signaling 7 0.0392 0.1557 0.1854
Schistosoma mansoni regulator of G protein signaling 0.0392 0.1557 0.1551
Brugia malayi PH domain containing protein 0.0036 0.0073 0.0073
Brugia malayi Protein kinase domain containing protein 0.002 0.0007 0.0007
Onchocerca volvulus 0.0043 0.0104 0.1045
Brugia malayi PH domain containing protein 0.0036 0.0073 0.0073
Echinococcus multilocularis semaphorin 5B 0.0107 0.037 0.0434
Brugia malayi Cytohesin 3 0.0036 0.0073 0.0073
Loa Loa (eye worm) sema domain-containing protein 0.0107 0.037 0.0363
Echinococcus granulosus muscleblind protein 0.018 0.0675 0.08
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0036 0.0073 0.0079
Loa Loa (eye worm) hypothetical protein 0.0047 0.0119 0.0112
Schistosoma mansoni plexin 0.0244 0.0939 0.0933
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0114 0.0692
Brugia malayi Regulator of G protein signaling domain containing protein 0.0392 0.1557 0.1557
Brugia malayi hypothetical protein 0.0392 0.1557 0.1557
Trichomonas vaginalis esterase, putative 0.0043 0.0104 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0119 0.0722
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0104 0.0023

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 2.5119 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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