Detailed information for compound 1389528

Basic information

Technical information
  • TDR Targets ID: 1389528
  • Name: 1-(1,3-benzodioxol-5-ylmethyl)-3-(3,4-dimethy lphenyl)-1-[1-(phenylmethyl)piperidin-4-yl]ur ea
  • MW: 471.591 | Formula: C29H33N3O3
  • H donors: 1 H acceptors: 1 LogP: 5.23 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N(C1CCN(CC1)Cc1ccccc1)Cc1ccc2c(c1)OCO2)Nc1ccc(c(c1)C)C
  • InChi: 1S/C29H33N3O3/c1-21-8-10-25(16-22(21)2)30-29(33)32(19-24-9-11-27-28(17-24)35-20-34-27)26-12-14-31(15-13-26)18-23-6-4-3-5-7-23/h3-11,16-17,26H,12-15,18-20H2,1-2H3,(H,30,33)
  • InChiKey: VHCJLTKZUYRSNK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(1,3-benzodioxol-5-ylmethyl)-3-(3,4-dimethylphenyl)-1-[1-(phenylmethyl)-4-piperidyl]urea
  • 1-(1,3-benzodioxol-5-ylmethyl)-3-(3,4-dimethylphenyl)-1-[1-(phenylmethyl)-4-piperidinyl]urea
  • 1-(1,3-benzodioxol-5-ylmethyl)-1-[1-(benzyl)-4-piperidyl]-3-(3,4-dimethylphenyl)urea
  • E641-1273
  • NCGC00123854-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia GTOR 0.0054 0.1536 0.5
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.1536 0.2767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0841 0.0761
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0219 0.0429
Brugia malayi Pre-SET motif family protein 0.0251 0.8732 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0871 0.1705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0624 0.0543
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.025 0.0489
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.1536 0.1759
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.1536 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.025 0.0286
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.1536 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0871 0.1568
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1057 0.1211
Echinococcus granulosus GPCR family 2 0.0019 0.025 0.0489
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.5106 1
Schistosoma mansoni hypothetical protein 0.0041 0.1057 0.1904
Loa Loa (eye worm) hypothetical protein 0.006 0.1753 0.2007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.1131 0.1054
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.1536 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.1536 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1536 0.1463
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0871 0.1568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0219 0.0134
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.1536 0.1759
Loa Loa (eye worm) hypothetical protein 0.0036 0.0871 0.0997
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.025 0.0286
Loa Loa (eye worm) hypothetical protein 0.0019 0.025 0.0286
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.1132 0.6934
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1028 0.095
Plasmodium vivax SET domain protein, putative 0.0036 0.0871 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1536 0.1463
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0219 0.0251
Schistosoma mansoni hypothetical protein 0.0019 0.025 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.1131 0.1054
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1028 0.095
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.5106 0.9197
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.1536 0.3008
Echinococcus multilocularis GPCR, family 2 0.0019 0.025 0.045
Brugia malayi Pre-SET motif family protein 0.0036 0.0871 0.0997
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.025 0.0286
Schistosoma mansoni hypothetical protein 0.0019 0.025 0.045
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8732 1
Onchocerca volvulus 0.0036 0.0871 0.0871
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0219 0.0251
Schistosoma mansoni thyroid hormone receptor 0.0164 0.5552 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0219 0.0134
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0219 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.1246 0.117
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.1536 0.5
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.1028 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0377 0.1204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.1131 0.1054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0871 0.1568
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1753 0.2007
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.1536 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0871 0.1568
Schistosoma mansoni hypothetical protein 0.0019 0.025 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0219 0.0134
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0822 0.161
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1028 0.095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0884 0.0805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0219 0.0134
Schistosoma mansoni thyroid hormone receptor 0.0164 0.5552 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1057 0.1211
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1028 0.095
Schistosoma mansoni hypothetical protein 0.0019 0.025 0.045
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.1536 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.025 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0727 0.0646
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.025 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1028 0.095
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1753 0.2007
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1028 0.095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1536 0.1463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0623 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0738 0.0658
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0219 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.1131 0.1054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0738 0.0658
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1753 0.2007
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.1132 0.6934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0219 0.0134
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0871 0.1568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0727 0.0646
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0738 0.0658
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1028 0.095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0624 0.0543
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0492 0.207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.1131 0.1054
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.1536 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.025 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0623 0.0541
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.1132 0.6934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0623 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0624 0.0543
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0871 0.1568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0624 0.0543
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.5552 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.1536 0.2767
Schistosoma mansoni hypothetical protein 0.0152 0.5106 0.9197

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.369 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 13.0918 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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