Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 15-lipoxygenase, type B | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1815 | 0.2673 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1572 | 0.1403 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2066 | 0.4014 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1572 | 0.1403 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.6353 | 0.6353 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.5587 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2262 | 0.4395 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1823 | 0.3541 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.4383 | 0.4383 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5147 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4015 | 0.3895 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4015 | 0.3895 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] | ChEMBL. | No reference |
Potency (binding) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.