Detailed information for compound 1389752

Basic information

Technical information
  • TDR Targets ID: 1389752
  • Name: N'-[[1-(3,4-dimethylphenyl)-2,4,6-trioxo-1,3- diazinan-5-ylidene]methyl]pyridine-4-carbohyd razide
  • MW: 379.369 | Formula: C19H17N5O4
  • H donors: 3 H acceptors: 5 LogP: 2.22 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccncc1)NN/C=C/1\C(=O)NC(=O)N(C1=O)c1ccc(c(c1)C)C
  • InChi: 1S/C19H17N5O4/c1-11-3-4-14(9-12(11)2)24-18(27)15(17(26)22-19(24)28)10-21-23-16(25)13-5-7-20-8-6-13/h3-10,21H,1-2H3,(H,23,25)(H,22,26,28)/b15-10+
  • InChiKey: HMUAUSISSNDRLR-XNTDXEJSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-[[1-(3,4-dimethylphenyl)-2,4,6-trioxo-hexahydropyrimidin-5-ylidene]methyl]pyridine-4-carbohydrazide
  • N'-[[1-(3,4-dimethylphenyl)-2,4,6-trioxo-5-hexahydropyrimidinylidene]methyl]-4-pyridinecarbohydrazide
  • N'-[[1-(3,4-dimethylphenyl)-2,4,6-triketo-hexahydropyrimidin-5-ylidene]methyl]isonicotinohydrazide
  • SMR000220059
  • STOCK4S-05480
  • ZINC05025957
  • Isonicotinic acid N'-[1-(3,4-dimethyl-phenyl)-2,4,6-trioxo-tetrahydro-pyrimidin-(5E)-ylidenemethyl]-hydrazide
  • MLS000588070

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0099 0.006
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.1557 0.991 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.1571 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.025 0.0213
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.1571 1 1
Schistosoma mansoni hypothetical protein 0.0214 0.1253 0.1218
Trichomonas vaginalis fk506-binding protein, putative 0.0214 0.1253 0.1232
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.1554 0.9892 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.1554 0.9892 1
Brugia malayi RNA, U transporter 1 0.0099 0.0513 0.0479
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.2271 0.2265
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0056 0.0017
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0214 0.1253 0.1232
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0231 0.1361 0.1326
Giardia lamblia Hypothetical protein 0.0214 0.1253 0.1232
Trypanosoma brucei hypothetical protein, conserved 0.0214 0.1253 0.1232
Leishmania major importin beta-1 subunit, putative 0.0028 0.0056 0.0057
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0214 0.1253 0.1232
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1715 0.1682
Onchocerca volvulus 0.0217 0.1271 1
Schistosoma mansoni hypothetical protein 0.0058 0.025 0.0211
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.1554 0.9892 1
Entamoeba histolytica hypothetical protein 0.0028 0.0056 0.0017
Trichomonas vaginalis fk506-binding protein, putative 0.0214 0.1253 0.1232
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.1554 0.9892 1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0099 0.006
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0214 0.1253 1
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1253 0.1232
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0214 0.1253 0.1267
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.1554 0.9892 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0056 0.0017
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1715 0.1682
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.1554 0.9892 1
Loa Loa (eye worm) hypothetical protein 0.1343 0.8532 0.8619
Echinococcus multilocularis fk506 binding protein 0.1554 0.9892 0.9892
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.1554 0.9892 0.9892
Leishmania major peptidylprolyl isomerase-like protein 0.1554 0.9892 1
Schistosoma mansoni immunophilin 0.1571 1 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0214 0.1253 0.1232
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0214 0.1253 0.1232
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.1554 0.9892 1
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0214 0.1253 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0099 0.006
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0214 0.1253 0.1232
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.1554 0.9892 1
Loa Loa (eye worm) hypothetical protein 0.0286 0.1715 0.1701
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.1554 0.9892 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0214 0.1253 0.1232
Schistosoma mansoni fk506 binding protein 0.0214 0.1253 0.1218
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0099 0.0488
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.1554 0.9892 0.9892
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.1554 0.9892 1
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0214 0.1253 0.1218
Plasmodium falciparum importin beta, putative 0.0035 0.0099 0.006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.006
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0214 0.1253 0.5
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0214 0.1253 0.5
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.1554 0.9892 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.1571 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0214 0.1253 0.1232
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0214 0.1253 0.1232
Trichomonas vaginalis fk506-binding protein, putative 0.1554 0.9892 1
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0214 0.1253 0.1232
Echinococcus multilocularis snurportin 1 0.0372 0.2271 0.224
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0056 0.0017
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0214 0.1253 0.1232
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0214 0.1253 0.1229
Schistosoma mansoni immunophilin 0.1357 0.8621 0.8616
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0214 0.1253 0.1232
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.1554 0.9892 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.1357 0.8621 0.8616
Schistosoma mansoni importin beta-1 0.0035 0.0099 0.006
Echinococcus granulosus snurportin 1 0.0372 0.2271 0.224
Schistosoma mansoni survival motor neuron protein 0.0058 0.025 0.0211
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.1554 0.9892 1
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0214 0.1253 0.1232
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0056 0.0017
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0214 0.1253 0.5
Onchocerca volvulus 0.0214 0.1253 0.986
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0214 0.1253 1
Trichomonas vaginalis fk506 binding protein, putative 0.0214 0.1253 0.1232
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.1554 0.9892 1
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0214 0.1253 0.5
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0214 0.1253 0.1229
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0214 0.1253 0.1229
Echinococcus multilocularis 0.0214 0.1253 0.1218
Loa Loa (eye worm) FKBP5 protein 0.1554 0.9892 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0214 0.1253 1
Brugia malayi hypothetical protein 0.0286 0.1715 0.1698
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0214 0.1253 0.1218
Schistosoma mansoni immunophilin 0.1571 1 1
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0214 0.1253 0.1267
Brugia malayi Importin beta-1 subunit 0.0035 0.0099 0.006
Leishmania major fk506-binding protein 1-like protein 0.1554 0.9892 1
Echinococcus granulosus FK506 binding protein 2 0.0214 0.1253 0.1218
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0214 0.1253 0.1267
Plasmodium vivax importin-beta 2, putative 0.0035 0.0099 0.006
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.1554 0.9892 0.9982
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.1554 0.9892 1
Loa Loa (eye worm) hypothetical protein 0.0214 0.1253 0.1232
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0214 0.1253 0.1232
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0214 0.1253 0.1232
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0214 0.1253 0.1218
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0099 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1253 0.1232
Leishmania major GTP-binding protein, putative 0.0026 0.004 0.004
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0214 0.1253 0.1232
Schistosoma mansoni hypothetical protein 0.0372 0.2271 0.224
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0214 0.1253 0.1232
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0214 0.1253 1
Onchocerca volvulus 0.0058 0.025 0.1967
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.1357 0.8621 0.8616
Trichomonas vaginalis immunophilin, putative 0.1554 0.9892 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (binding) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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