Detailed information for compound 1389880

Basic information

Technical information
  • TDR Targets ID: 1389880
  • Name: N-(3-acetylphenyl)-2,2-dichloro-3-phenylcyclo propane-1-carboxamide
  • MW: 348.223 | Formula: C18H15Cl2NO2
  • H donors: 1 H acceptors: 2 LogP: 3.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1C(C1(Cl)Cl)c1ccccc1)Nc1cccc(c1)C(=O)C
  • InChi: 1S/C18H15Cl2NO2/c1-11(22)13-8-5-9-14(10-13)21-17(23)16-15(18(16,19)20)12-6-3-2-4-7-12/h2-10,15-16H,1H3,(H,21,23)
  • InChiKey: KVKNEPHNDRRFMN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-acetylphenyl)-2,2-dichloro-3-phenyl-cyclopropane-1-carboxamide
  • N-(3-acetylphenyl)-2,2-dichloro-3-phenyl-1-cyclopropanecarboxamide
  • 2,2-dichloro-N-(3-ethanoylphenyl)-3-phenyl-cyclopropane-1-carboxamide
  • SMR000272005
  • MLS000676254
  • N-(3-acetylphenyl)-2,2-dichloro-3-phenylcyclopropanecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1882 0.2213
Loa Loa (eye worm) blistered cuticle protein 3 0.0237 0.8505 1
Onchocerca volvulus 0.0033 0.1055 0.1241
Entamoeba histolytica hypothetical protein 0.0043 0.1452 0.5
Brugia malayi Animal haem peroxidase family protein 0.0237 0.8505 1
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.2112 0.2483
Echinococcus granulosus tar DNA binding protein 0.0076 0.2658 0.3125
Loa Loa (eye worm) hypothetical protein 0.0005 0.0032 0.0037
Brugia malayi MH2 domain containing protein 0.0008 0.0164 0.0193
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2658 0.3125
Loa Loa (eye worm) hypothetical protein 0.0032 0.1033 0.1215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2063 0.2426
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.1453 0.1709
Echinococcus multilocularis lamin dm0 0.0033 0.1055 0.1241
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.1055 0.1241
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.1453 0.5
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.2112 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1453 0.1709
Brugia malayi MH1 domain containing protein 0.0008 0.0164 0.0193
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.1453 0.5
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.2112 0.2483
Loa Loa (eye worm) hypothetical protein 0.0015 0.0419 0.0492
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1882 0.2213
Loa Loa (eye worm) hypothetical protein 0.0043 0.1453 0.1709
Schistosoma mansoni hypothetical protein 0.0019 0.0562 0.0661
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2658 0.3125
Onchocerca volvulus Peroxidase homolog 0.0237 0.8505 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1882 0.2213
Loa Loa (eye worm) animal heme peroxidase 0.0237 0.8505 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0562 0.0661
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0562 0.0661
Brugia malayi beta-lactamase family protein 0.0043 0.1453 0.1709
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0164 0.0193
Schistosoma mansoni intermediate filament proteins 0.0033 0.1055 0.1241
Loa Loa (eye worm) Smad1 0.0008 0.0164 0.0193
Onchocerca volvulus 0.0043 0.1453 0.1709
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.2112 1
Echinococcus multilocularis transient receptor potential cation channel 0.0171 0.6122 0.7199
Loa Loa (eye worm) hypothetical protein 0.006 0.2063 0.2426
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.2112 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1453 0.1709
Echinococcus granulosus ankyrin repeat protein 0.0171 0.6113 0.7188
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.2112 1
Echinococcus granulosus transient receptor potential cation channel 0.0171 0.6113 0.7188
Onchocerca volvulus Chorion peroxidase homolog 0.0237 0.8505 1
Brugia malayi Animal haem peroxidase family protein 0.0237 0.8505 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1882 0.2213
Schistosoma mansoni lamin 0.0033 0.1055 0.1241
Schistosoma mansoni peroxidasin 0.0237 0.8505 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0562 0.0661
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.1452 0.1707
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2063 0.2426
Brugia malayi Animal haem peroxidase family protein 0.0237 0.8505 1
Onchocerca volvulus 0.0043 0.1453 0.1709
Schistosoma mansoni smad1 5 8 and 0.0008 0.0164 0.0193
Onchocerca volvulus Peroxidasin homolog 0.0237 0.8505 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.2112 1
Echinococcus multilocularis tar DNA binding protein 0.0076 0.2658 0.3125
Brugia malayi Blistered cuticle protein 3 0.0237 0.8505 1
Trypanosoma brucei protein kinase, putative 0.0062 0.2112 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Onchocerca volvulus 0.0237 0.8505 1
Schistosoma mansoni hypothetical protein 0.0019 0.0562 0.0661
Plasmodium vivax hypothetical protein, conserved 0.0043 0.1453 0.5
Brugia malayi MH2 domain containing protein 0.012 0.4227 0.497
Loa Loa (eye worm) TAR-binding protein 0.0076 0.2658 0.3125
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0562 0.0661
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.1452 0.1707
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0164 0.0193
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Echinococcus multilocularis lamin 0.0033 0.1055 0.1241
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.2112 0.2483
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.1055 0.1241
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.4227 0.497
Onchocerca volvulus 0.0033 0.1055 0.1241
Schistosoma mansoni smad 0.0008 0.0164 0.0193
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1882 0.2213
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.2112 0.2483
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0504 0.0592
Schistosoma mansoni peroxidasin 0.0237 0.8505 1
Brugia malayi Animal haem peroxidase family protein 0.0237 0.8505 1
Loa Loa (eye worm) animal heme peroxidase 0.0237 0.8505 1
Brugia malayi RNA binding protein 0.0076 0.2658 0.3125
Echinococcus granulosus lamin dm0 0.0033 0.1055 0.1241
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2658 0.3125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1882 0.2213
Echinococcus granulosus GPCR family 2 0.0019 0.0562 0.0661
Onchocerca volvulus Dual oxidase homolog 0.0237 0.8505 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2658 0.3125
Schistosoma mansoni lamin 0.0033 0.1055 0.1241
Mycobacterium ulcerans beta-lactamase 0.0043 0.1453 0.5
Schistosoma mansoni smad1 5 8 and 0.0008 0.0164 0.0193
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.4227 0.497
Loa Loa (eye worm) hypothetical protein 0.0043 0.1453 0.1709
Schistosoma mansoni hypothetical protein 0.0041 0.1368 0.1609
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1453 0.1709
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Brugia malayi Animal haem peroxidase family protein 0.0237 0.8505 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Schistosoma mansoni hypothetical protein 0.0043 0.1452 0.1707
Mycobacterium leprae Probable lipase LipE 0.0043 0.1453 0.5
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0164 0.0193
Echinococcus multilocularis peroxidasin 0.0237 0.8505 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1453 0.1709
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.1453 0.1709
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0164 0.0193
Brugia malayi hypothetical protein 0.0237 0.8505 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0562 0.0661
Loa Loa (eye worm) animal heme peroxidase 0.0237 0.8505 1
Brugia malayi beta-lactamase 0.0043 0.1453 0.1709
Loa Loa (eye worm) nuclear factor I 0.0005 0.0032 0.0037
Echinococcus granulosus intermediate filament protein 0.0033 0.1055 0.1241
Mycobacterium leprae conserved hypothetical protein 0.0043 0.1453 0.5
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0441 0.0518
Loa Loa (eye worm) hypothetical protein 0.0043 0.1453 0.1709
Brugia malayi MAP kinase sur-1 0.0062 0.2112 0.2483
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.2112 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.2658 0.3125
Loa Loa (eye worm) hypothetical protein 0.0041 0.1368 0.1609
Echinococcus multilocularis musashi 0.0033 0.1055 0.1241
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1368 0.1609
Brugia malayi MH1 domain containing protein 0.0008 0.0164 0.0193
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.1453 0.1709
Schistosoma mansoni Smad4 0.0008 0.0164 0.0193
Echinococcus granulosus peroxidasin 0.0237 0.8505 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1882 0.2213
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.2112 1
Brugia malayi MH2 domain containing protein 0.0008 0.0164 0.0193
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Entamoeba histolytica hypothetical protein 0.0043 0.1452 0.5
Schistosoma mansoni hypothetical protein 0.0019 0.0562 0.0661
Echinococcus granulosus smad 0.0008 0.0164 0.0193
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0164 0.0193
Loa Loa (eye worm) hypothetical protein 0.0016 0.0441 0.0518
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Echinococcus multilocularis Smad4 0.0008 0.0164 0.0193
Echinococcus multilocularis ankyrin repeat protein 0.0171 0.6113 0.7188
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0441 0.0518
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0562 0.0661
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.2112 1
Brugia malayi Smad1 0.0008 0.0164 0.0193
Brugia malayi beta-lactamase family protein 0.0043 0.1453 0.1709
Loa Loa (eye worm) hypothetical protein 0.0015 0.0419 0.0492
Onchocerca volvulus 0.0237 0.8505 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.2112 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.2658 0.3125
Loa Loa (eye worm) hypothetical protein 0.0043 0.1453 0.1709
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1882 0.2213
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.2112 0.2483
Schistosoma mansoni hypothetical protein 0.0019 0.0562 0.0661
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0171 0.6113 0.7188
Loa Loa (eye worm) animal heme peroxidase 0.0237 0.8505 1
Brugia malayi MH1 domain containing protein 0.0005 0.0032 0.0037
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.1453 0.1709
Onchocerca volvulus 0.0237 0.8505 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Mycobacterium ulcerans hypothetical protein 0.0043 0.1453 0.5
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.1452 0.1707
Entamoeba histolytica hypothetical protein 0.0043 0.1452 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.1055 0.1241
Brugia malayi hypothetical protein 0.0043 0.1452 0.1707
Brugia malayi TAR-binding protein 0.0076 0.2658 0.3125
Entamoeba histolytica hypothetical protein 0.0043 0.1452 0.5
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.2112 0.2483
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.2112 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.2112 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0504 0.0592
Loa Loa (eye worm) beta-lactamase 0.0043 0.1453 0.1709
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1882 0.2213
Mycobacterium ulcerans lipase LipD 0.0043 0.1453 0.5
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0164 0.0193
Loa Loa (eye worm) hypothetical protein 0.0019 0.0562 0.0661
Brugia malayi intermediate filament protein 0.0033 0.1055 0.1241
Schistosoma mansoni smad1 5 8 and 0.0008 0.0164 0.0193
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0164 0.0193
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.2112 1
Onchocerca volvulus 0.0043 0.1453 0.1709
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0562 0.0661
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0562 0.0661
Onchocerca volvulus Peroxidasin homolog 0.0237 0.8505 1
Brugia malayi MH1 domain containing protein 0.0005 0.0032 0.0037
Onchocerca volvulus Peroxidase homolog 0.0237 0.8505 1
Echinococcus granulosus Smad4 0.0008 0.0164 0.0193
Loa Loa (eye worm) intermediate filament protein 0.0033 0.1055 0.1241
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2063 0.2426
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.2112 1
Brugia malayi Peroxidasin 0.0237 0.8505 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.2658 0.3125
Schistosoma mansoni tar DNA-binding protein 0.0076 0.2658 0.3125
Echinococcus granulosus lamin 0.0033 0.1055 0.1241
Loa Loa (eye worm) hypothetical protein 0.0237 0.8505 1
Echinococcus multilocularis smad 0.0008 0.0164 0.0193

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1413 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 0.8199 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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