TDR Targets

Basic information

Technical information

TDR Targets ID: 1390133
Name: N'-(adamantane-1-carbonyl)pyrazine-2-carbohyd razide
MW: 300.356 | Formula: C16H20N4O2
H donors: 2 H acceptors: 4 LogP: 1.48 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1nccnc1)NNC(=O)C12CC3CC(C2)CC(C1)C3
InChi: 1S/C16H20N4O2/c21-14(13-9-17-1-2-18-13)19-20-15(22)16-6-10-3-11(7-16)5-12(4-10)8-16/h1-2,9-12H,3-8H2,(H,19,21)(H,20,22)
InChiKey: MRLKXHSOWPMBFD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N'-(1-adamantyl-oxomethyl)-2-pyrazinecarbohydrazide
N'-(adamantane-1-carbonyl)pyrazinohydrazide
N'-(1-adamantylcarbonyl)pyrazine-2-carbohydrazide
Adamantane-1-carboxylic acid N'-(pyrazine-2-carbonyl)-hydrazide
MLS000564012
SMR000176643
BAS 01206986
ZINC04893467

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Human immunodeficiency virus 1	Aberrant vpr protein	Starlite/ChEMBL	No references
Homo sapiens	huntingtin	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Brugia malayi	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.003	0.0145	0.0131
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Onchocerca volvulus		0.0286	0.3276	1
Plasmodium falciparum	phd finger protein, putative	0.0035	0.0205	1
Echinococcus multilocularis	geminin	0.0205	0.2279	0.2269
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0215	0.0216
Brugia malayi	hypothetical protein	0.002	0.0014	0.0001
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.0374	0.0361
Echinococcus granulosus	dro:myosuppressin receptor	0.003	0.0145	0.0131
Onchocerca volvulus	Huntingtin homolog	0.0148	0.1585	0.46
Brugia malayi	neuropeptide F receptor	0.003	0.0145	0.0131
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.003	0.0145	0.0145
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0145	0.0131
Brugia malayi	Pre-SET motif family protein	0.0251	0.2851	0.2842
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.003	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Schistosoma mansoni	opsin-like receptor	0.003	0.0145	0.0145
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	g protein coupled receptor	0.003	0.0145	0.0131
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.045	0.0437
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0021	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.003	0.0145	0.0131
Onchocerca volvulus	Alhambra homolog	0.0035	0.0205	0.0192
Loa Loa (eye worm)	bromodomain containing protein	0.0021	0.0035	0.0022
Loa Loa (eye worm)	TYRA-2 protein	0.003	0.0145	0.0131
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0145	0.0131
Brugia malayi	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	G protein coupled receptor 139	0.003	0.0145	0.0131
Onchocerca volvulus		0.0036	0.0215	0.0225
Echinococcus granulosus	neuropeptide receptor	0.003	0.0145	0.0131
Schistosoma mansoni	amine GPCR	0.003	0.0145	0.0145
Echinococcus multilocularis	zinc finger protein	0.0024	0.0063	0.005
Echinococcus multilocularis	neuropeptide FF receptor 2	0.003	0.0145	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0145	0.0145
Echinococcus multilocularis	G-protein coupled receptor, putative	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus multilocularis	dro:myosuppressin receptor	0.003	0.0145	0.0131
Onchocerca volvulus		0.0033	0.0173	0.0089
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0294	0.3375	0.8904
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0014	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0215	0.0216
Echinococcus granulosus	lamin	0.0033	0.0173	0.0159
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0205	0.9489
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Brugia malayi	putative neuropeptide receptor	0.003	0.0145	0.0131
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0205	0.3951
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0294	0.3375	0.8904
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0057	0.0467	0.0454
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.9978	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0145	0.0145
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.003	0.0145	0.0131
Schistosoma mansoni	growth hormone secretagogue receptor	0.003	0.0145	0.0145
Leishmania major	malonyl-coa decarboxylase-like protein	0.0328	0.3791	1
Toxoplasma gondii	hypothetical protein	0.0047	0.0355	0.7043
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.028	0.0739
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Brugia malayi	hypothetical protein	0.003	0.0146	0.0133
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.045	0.0437
Schistosoma mansoni	bromodomain containing protein	0.0076	0.0709	0.0711
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0014	0.0036
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0021	0.0026	0.0026
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0173	0.0159
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0145	0.0131
Echinococcus granulosus	geminin	0.0205	0.2279	0.2269
Brugia malayi	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	g protein coupled receptor	0.003	0.0145	0.0131
Onchocerca volvulus		0.0033	0.0173	0.0089
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0173	0.0159
Echinococcus granulosus	fmrfamide receptor	0.003	0.0145	0.0131
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0027	0.0107	0.0107
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0145	0.0145
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0145	0.0145
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0145	0.0131
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0145	0.0131
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0155	0.1671	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0305	0.0292
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.003	0.0145	0.0131
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0145	0.0145
Echinococcus multilocularis	allatostatin A receptor	0.003	0.0145	0.0131
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.045	0.0437
Echinococcus granulosus	serotonin receptor	0.003	0.0145	0.0131
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0145	0.0131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.003	0.0145	0.0145
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.0895	0.0898
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0057	0.0467	0.0468
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0145	0.0131
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.028	0.0739
Loa Loa (eye worm)	PHD-finger family protein	0.0025	0.0079	0.0065
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0027	0.0107	0.0094
Brugia malayi	Serotonin receptor	0.003	0.0145	0.0131
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0498	0.0499
Onchocerca volvulus	Huntingtin homolog	0.0148	0.1585	0.46
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0146	0.0386
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0173	0.0159
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.003	0.0145	0.0131
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.003	0.0145	0.0145
Schistosoma mansoni	amine GPCR	0.003	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1585	0.1574
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.045	0.0437
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0498	0.0485
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0145	0.0131
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0498	0.2923
Brugia malayi	intermediate filament protein	0.0033	0.0173	0.0159
Echinococcus multilocularis	g-protein coupled receptor	0.003	0.0145	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0376	0.0363
Schistosoma mansoni	biogenic amine receptor	0.003	0.0145	0.0145
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0145	0.0131
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.9978	0.9978
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Brugia malayi	follicle stimulating hormone receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1585	0.1574
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0328	0.3791	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.003	0.0145	0.0131
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0205	0.0192
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0021	0.0026	0.0012
Schistosoma mansoni	hypothetical protein	0.0205	0.2279	0.2284
Echinococcus granulosus	somatostatin receptor	0.003	0.0145	0.0131
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0014	0.0036
Schistosoma mansoni	amine GPCR	0.003	0.0145	0.0145
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.045	0.0437
Echinococcus granulosus	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0498	0.0485
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0215	0.0202
Mycobacterium ulcerans	hypothetical protein	0.0155	0.1671	1
Brugia malayi	hypothetical protein	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0145	0.0131
Echinococcus multilocularis	serotonin receptor	0.003	0.0145	0.0131
Brugia malayi	jmjC domain containing protein	0.0045	0.0324	0.0311
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0146	0.0386
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.9978	0.9978
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.1478	0.39
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Brugia malayi	ORL1-like opioid receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Brugia malayi	AKH receptor	0.003	0.0145	0.0131
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0467	0.0455
Echinococcus granulosus	lysine specific demethylase 5A	0.0045	0.0324	0.0311
Leishmania major	mitochondrial DNA polymerase beta	0.0294	0.3375	0.8904
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0145	0.0131
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0139	0.1478	0.39
Schistosoma mansoni	neuropeptide receptor	0.003	0.0145	0.0145
Schistosoma mansoni	hypothetical protein	0.0205	0.2279	0.2284
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.003	0.0145	0.0131
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.028	0.0739
Schistosoma mansoni	neuropeptide receptor	0.003	0.0145	0.0145
Echinococcus granulosus	neuropeptide s receptor	0.003	0.0145	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0145	0.0145
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0145	0.0131
Brugia malayi	PHD-finger family protein	0.003	0.0142	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0085	0.082	0.0807
Echinococcus granulosus	neuropeptide receptor A26	0.003	0.0145	0.0131
Brugia malayi	Tachykinin-like peptides receptor 99D	0.003	0.0145	0.0131
Echinococcus granulosus	alpha 1A adrenergic receptor	0.003	0.0145	0.0131
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.0205	0.0192
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0145	0.0145
Echinococcus multilocularis	peregrin	0.0038	0.024	0.0227
Brugia malayi	PHD-finger family protein	0.0035	0.0205	0.0192
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0173	0.0159
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.003	0.0145	0.0131
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0294	0.3375	0.8904
Echinococcus multilocularis	orexin receptor type 2	0.003	0.0145	0.0131
Schistosoma mansoni	amine GPCR	0.003	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0328	0.3791	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.003	0.0145	0.0145
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.045	0.0437
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.0374	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0341	0.0328
Brugia malayi	putative malonyl-CoA decarboxylase	0.0835	0.9997	1
Schistosoma mansoni	opsin-like receptor	0.003	0.0145	0.0145
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.028	0.0739
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0014	0.0036
Echinococcus granulosus	neuropeptide FF receptor 2	0.003	0.0145	0.0131
Echinococcus granulosus	peregrin	0.0038	0.024	0.0227
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0205	0.3951
Brugia malayi	hypothetical protein	0.003	0.0145	0.0131
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	orexin receptor type 2	0.003	0.0145	0.0131
Echinococcus granulosus	7tm_1 domain containing protein	0.003	0.0145	0.0131
Schistosoma mansoni	hypothetical protein	0.003	0.0145	0.0145
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.003	0.0145	0.0131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Brugia malayi	Dopamine receptor protein 2	0.003	0.0145	0.0131
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.0296	0.0282
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Brugia malayi	Pre-SET motif family protein	0.0036	0.0215	0.0202
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0215	0.4164
Brugia malayi	Bromodomain containing protein	0.0038	0.024	0.0227
Schistosoma mansoni	lamin	0.0033	0.0173	0.0173
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0145	0.0145
Echinococcus granulosus	g protein coupled receptor	0.003	0.0145	0.0131
Brugia malayi	larval opioid receptor	0.003	0.0145	0.0131
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0498	1
Schistosoma mansoni	ap endonuclease	0.002	0.0014	0.0014
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0498	0.2923
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0146	0.6949
Brugia malayi	G-protein coupled receptor	0.003	0.0145	0.0131
Schistosoma mansoni	alpha-1 adrenergic receptor	0.003	0.0145	0.0145
Echinococcus granulosus	peptide allatostatin:somatostatin	0.003	0.0145	0.0131
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.3276	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0145	0.0145
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.1186	0.1174
Brugia malayi	Melatonin receptor type 1A	0.003	0.0145	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Echinococcus multilocularis	somatostatin receptor	0.003	0.0145	0.0131
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0145	0.0145
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.0657	0.0644
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0045	0.0324	0.0325
Echinococcus multilocularis	lamin dm0	0.0033	0.0173	0.0159
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.003	0.0145	0.0131
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0199	0.0186
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0145	0.0131
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0145	0.0131
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0498	0.1313
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0057	0.0467	0.0468
Brugia malayi	Dopamine receptor	0.003	0.0145	0.0131
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.1478	0.39
Echinococcus granulosus	7TM GPCR rhodopsin	0.003	0.0145	0.0131
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.003	0.0145	0.0131
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0305	0.0292
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0014	0.0036
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0146	0.2746
Brugia malayi	hypothetical protein	0.003	0.0145	0.0131
Schistosoma mansoni	amine GPCR	0.003	0.0145	0.0145
Plasmodium vivax	SET domain protein, putative	0.0036	0.0215	1
Brugia malayi	hypothetical protein	0.003	0.0145	0.0131
Brugia malayi	G protein-coupled receptor	0.003	0.0145	0.0131
Brugia malayi	hypothetical protein	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Brugia malayi	neuropeptide F receptor	0.003	0.0145	0.0131
Schistosoma mansoni	neuropeptide receptor	0.003	0.0145	0.0145
Schistosoma mansoni	hypothetical protein	0.0025	0.0079	0.0079
Echinococcus granulosus	tachykinin peptides receptor 99D	0.003	0.0145	0.0131
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0145	0.0131
Schistosoma mansoni	hypothetical protein	0.0035	0.0205	0.0205
Echinococcus multilocularis	serotonin receptor	0.003	0.0145	0.0131
Echinococcus granulosus	fetal alzheimer antigen falz	0.0027	0.0107	0.0094
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Brugia malayi	Bromodomain containing protein	0.0046	0.034	0.0327
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0664	0.0651
Schistosoma mansoni	neuropeptide f receptor 76f	0.003	0.0145	0.0145
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0145	0.0145
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Brugia malayi	hypothetical protein	0.003	0.0145	0.0131
Loa Loa (eye worm)	melatonin receptor type 1A	0.003	0.0145	0.0131
Echinococcus multilocularis	G protein coupled receptor 139	0.003	0.0145	0.0131
Brugia malayi	RE15519p	0.003	0.0145	0.0131
Echinococcus granulosus	neuropeptide receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0021	0.0026	0.0012
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0145	0.0131
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0173	0.0173
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0498	0.0499
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus multilocularis	neuropeptide s receptor	0.003	0.0145	0.0131
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.003	0.0145	0.0145
Schistosoma mansoni	histamine h1 receptor	0.003	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0145	0.0131
Brugia malayi	putative neuropeptide receptor NPR1	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.003	0.0145	0.0131
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.045	0.0451
Schistosoma mansoni	lamin	0.0033	0.0173	0.0173
Echinococcus granulosus	histone lysine methyltransferase setb	0.0057	0.0467	0.0454
Schistosoma mansoni	hypothetical protein	0.003	0.0145	0.0145
Echinococcus multilocularis	sex peptide receptor	0.003	0.0145	0.0131
Schistosoma mansoni	adenoreceptor	0.003	0.0145	0.0145
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0145	0.0145
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.2851	0.2842
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0165	0.0152
Echinococcus granulosus	intermediate filament protein	0.0033	0.0173	0.0159
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.045	0.0451
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0146	0.0386
Brugia malayi	hypothetical protein	0.0148	0.1585	0.1574
Schistosoma mansoni	zinc finger protein	0.0024	0.0063	0.0063
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0045	0.0324	0.0325
Echinococcus granulosus	zinc finger protein	0.0024	0.0063	0.005
Schistosoma mansoni	myosin xvIII	0.003	0.0145	0.0145
Brugia malayi	sulfakinin receptor protein	0.003	0.0145	0.0131
Schistosoma mansoni	neuropeptide receptor	0.003	0.0145	0.0145
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.1186	0.1174
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0145	0.0131
Brugia malayi	Dopamine receptor protein 1	0.003	0.0145	0.0131
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.003	0.0145	0.0145
Loa Loa (eye worm)	jmjC domain-containing protein	0.0045	0.0324	0.0311
Schistosoma mansoni	biogenic amine receptor	0.003	0.0145	0.0145
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	0.0835	0.9997	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0391	0.1031
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0146	0.6594
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0145	0.0131
Brugia malayi	G-protein coupled receptor	0.003	0.0145	0.0131
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0498	0.2923
Loa Loa (eye worm)	hypothetical protein	0.003	0.0146	0.0133
Brugia malayi	GnHR receptor homolog	0.003	0.0145	0.0131
Brugia malayi	Serotonin receptor	0.003	0.0145	0.0131
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0014	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.003	0.0145	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0145	0.0145
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0328	0.3791	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.003	0.0145	0.0131
Brugia malayi	hypothetical protein	0.003	0.0145	0.0131
Echinococcus multilocularis	lamin	0.0033	0.0173	0.0159
Echinococcus multilocularis	neuropeptide receptor A26	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	lamin dm0	0.0033	0.0173	0.0159
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0146	0.6949
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	allatostatin A receptor	0.003	0.0145	0.0131
Echinococcus multilocularis	musashi	0.0033	0.0173	0.0159
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.003	0.0145	0.0131
Leishmania major	hypothetical protein, conserved	0.003	0.0146	0.0386
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.003	0.0145	0.0131
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0145	0.0131
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0145	0.0145
Brugia malayi	jmjC domain containing protein	0.0115	0.1186	0.1174
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.006	0.0513	0.05
Schistosoma mansoni	hypothetical protein	0.003	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0205	0.0192
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.045	0.0451
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0835	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.003	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0498	0.2923
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0205	0.0192
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0145	0.0131
Echinococcus granulosus	sex peptide receptor	0.003	0.0145	0.0131
Schistosoma mansoni	biogenic amine receptor	0.003	0.0145	0.0145
Schistosoma mansoni	hypothetical protein	0.003	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0835	0.9997	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.0657	0.0644
Brugia malayi	Bromodomain containing protein	0.0091	0.0883	0.0871
Schistosoma mansoni	ap endonuclease	0.002	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0404	0.0392
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0145	0.0131
Echinococcus granulosus	g-protein coupled receptor	0.003	0.0145	0.0131
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.003	0.0145	0.0131
Schistosoma mansoni	opsin-like receptor	0.003	0.0145	0.0145
Giardia lamblia	PHD finger protein 15	0.0035	0.0205	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.003	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.003	0.0145	0.0131
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.003	0.0145	0.0131

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 24.758 uM	PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007]	ChEMBL.	No reference
Potency (functional)	= 1.122 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 1.5849 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	4.4668 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	4.4668 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1524828

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1390133