Detailed information for compound 1390844

Basic information

Technical information
  • TDR Targets ID: 1390844
  • Name: 1-(2-chloro-5-nitrophenyl)-2,4-dihydro-1H-ben zo[f]quinolin-3-one
  • MW: 352.771 | Formula: C19H13ClN2O3
  • H donors: 1 H acceptors: 3 LogP: 4.23 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2ccc3c(c2C(C1)c1cc(ccc1Cl)[N+](=O)[O-])cccc3
  • InChi: 1S/C19H13ClN2O3/c20-16-7-6-12(22(24)25)9-14(16)15-10-18(23)21-17-8-5-11-3-1-2-4-13(11)19(15)17/h1-9,15H,10H2,(H,21,23)
  • InChiKey: KIYGAJORDVLONJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(2-chloro-5-nitro-phenyl)-2,4-dihydro-1H-benzo[f]quinolin-3-one
  • 1-(2-chloro-5-nitrophenyl)-1,4-dihydrobenzo[f]quinolin-3(2H)-one
  • MLS000583066
  • SMR000206252
  • IVK/2008407
  • EU-0091549

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ecdysone induced protein 78C 0.0241 0.6306 0.6306
Brugia malayi RNA, U transporter 1 0.0099 0.2281 0.3617
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0241 0.6306 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0464 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.6306 0.6306
Brugia malayi ecdysteroid receptor 0.0241 0.6306 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0278 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.6306 0.6306
Brugia malayi nuclear receptor NHR-88 0.0241 0.6306 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0241 0.6306 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0241 0.6306 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.6172 0.6172
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0241 0.6306 1
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0019 0.0029
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0204 0.416
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0236 0.6172 0.6172
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0464 1
Loa Loa (eye worm) hypothetical protein 0.003 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0236 0.6172 0.6172
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0019 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0241 0.6306 0.6306
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0241 0.6306 1
Schistosoma mansoni ran 0.0026 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0236 0.6172 0.6172
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0241 0.6306 0.6306
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.1127 0.1127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0241 0.6306 0.6306
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.034 1
Brugia malayi steroid hormone receptor 0.0241 0.6306 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0241 0.6306 0.6306
Brugia malayi Nuclear hormone receptor-like 1 0.0236 0.6172 0.9787
Loa Loa (eye worm) hypothetical protein 0.0241 0.6306 0.6306
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.034 0.7217
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.034 0.7217
Brugia malayi Nuclear hormone receptor-like 1 0.0241 0.6306 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0241 0.6306 0.6306
Schistosoma mansoni RAR-like nuclear receptor 0.0241 0.6306 0.6306
Brugia malayi hypothetical protein 0.0236 0.6172 0.9787
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0241 0.6306 1
Brugia malayi hypothetical protein 0.0236 0.6172 0.9787
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0204 0.5764
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0241 0.6306 1
Brugia malayi hypothetical protein 0.002 0.0035 0.0055
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0278 1
Loa Loa (eye worm) steroid hormone receptor 0.0241 0.6306 0.6306
Schistosoma mansoni importin beta-1 0.0035 0.0464 0.0464
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.034 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.1127 0.1127
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0204 0.416
Leishmania major importin beta-1 subunit, putative 0.0028 0.0278 0.806
Brugia malayi MH2 domain containing protein 0.0144 0.3559 0.5644
Schistosoma mansoni hypothetical protein 0.0372 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.034 0.7217
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0241 0.6306 0.6306
Loa Loa (eye worm) hypothetical protein 0.0241 0.6306 0.6306
Echinococcus multilocularis snurportin 1 0.0372 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0464 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.4643 0.4643
Schistosoma mansoni steroid hormone receptor ad4bp 0.0241 0.6306 0.6306
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0019 0.5
Brugia malayi nuclear receptor RXR 0.0236 0.6172 0.9787
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0204 0.416
Plasmodium falciparum importin beta, putative 0.0035 0.0464 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0204 0.0204
Schistosoma mansoni nuclear hormone receptor 0.0241 0.6306 0.6306
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.1127 0.1787
Echinococcus multilocularis FTZ F1 alpha 0.0241 0.6306 0.6306
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0464 0.0464
Brugia malayi Steroid receptor seven-up type 2 0.0241 0.6306 1
Onchocerca volvulus Bile acid receptor homolog 0.0241 0.6306 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0019 0.0019
Schistosoma mansoni retinoic acid receptor RXR 0.0241 0.6306 0.6306
Schistosoma mansoni coup transcription factor 0.0241 0.6306 0.6306
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0204 0.416
Loa Loa (eye worm) hypothetical protein 0.004 0.0605 0.0605
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0241 0.6306 0.6306
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0241 0.6306 0.6306
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0241 0.6306 0.6306
Onchocerca volvulus 0.0241 0.6306 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0241 0.6306 0.6306
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0241 0.6306 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0241 0.6306 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.6306 0.6306
Brugia malayi nuclear hormone receptor 0.0241 0.6306 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.6172 0.6172
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0241 0.6306 0.6306
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0019 0.0019
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0241 0.6306 0.6306
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0241 0.6306 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0241 0.6306 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0241 0.6306 0.6306
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0241 0.6306 0.6306
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0278 0.806
Brugia malayi hypothetical protein 0.003 0.034 0.0539
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0241 0.6306 0.6306
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0019 0.0019
Schistosoma mansoni ran 0.0026 0.0204 0.0204
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0241 0.6306 0.6306
Entamoeba histolytica hypothetical protein 0.0028 0.0278 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0241 0.6306 0.6306
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0236 0.6172 0.6172
Loa Loa (eye worm) hypothetical protein 0.0241 0.6306 0.6306
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0204 0.0204
Brugia malayi hypothetical protein 0.0182 0.4643 0.7363
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0278 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0464 0.0464
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0241 0.6306 0.6306
Loa Loa (eye worm) hypothetical protein 0.0236 0.6172 0.6172
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0241 0.6306 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.004 0.0605 0.0605
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0241 0.6306 0.6306
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0241 0.6306 0.6306
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.1127 0.1787
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0241 0.6306 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3559 0.3559
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0204 0.0323
Plasmodium vivax importin-beta 2, putative 0.0035 0.0464 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0241 0.6306 0.6306
Leishmania major GTP-binding protein, putative 0.0026 0.0204 0.5764
Echinococcus granulosus importin subunit beta 1 0.0035 0.0464 0.0464
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0241 0.6306 0.6306
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.034 0.7217
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0241 0.6306 0.6306
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3559 0.3559
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0241 0.6306 0.6306
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0204 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0236 0.6172 0.9787
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0241 0.6306 0.6306
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0241 0.6306 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.034 0.7217
Schistosoma mansoni thyroid hormone receptor 0.0241 0.6306 0.6306
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0241 0.6306 0.6306
Loa Loa (eye worm) hypothetical protein 0.0241 0.6306 0.6306
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0204 0.5764
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0241 0.6306 0.6306
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0236 0.6172 0.6172
Echinococcus granulosus FTZ F1 alpha 0.0241 0.6306 0.6306
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0241 0.6306 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0464 0.0736
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0605 0.096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0241 0.6306 0.6306
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0204 0.0204
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0236 0.6172 0.6172
Echinococcus multilocularis thyroid hormone receptor alpha 0.0241 0.6306 0.6306
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0236 0.6172 0.6172
Leishmania major hypothetical protein, conserved 0.003 0.034 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0241 0.6306 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0241 0.6306 0.6306
Brugia malayi isocitrate dehydrogenase 0.0019 0.0019 0.0029

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.0596 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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