Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | galactosylceramidase | No references | |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0091 | 0.0785 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0091 | 0.0785 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0091 | 0.0785 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0091 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0091 | 0.0785 | 0.0785 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0091 | 0.0785 | 0.0785 |
Brugia malayi | nuclear receptor NHR-88 | 0.0091 | 0.0785 | 0.0785 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0091 | 0.0785 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0091 | 0.0785 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0091 | 0.0785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0091 | 0.0785 | 0.0785 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0091 | 0.0785 | 0.0785 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0091 | 0.0785 | 0.0785 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0091 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0091 | 0.0785 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0091 | 0.0785 | 0.0785 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0091 | 0.0785 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0091 | 0.0785 | 0.0785 |
Schistosoma mansoni | thyroid hormone receptor | 0.0091 | 0.0785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0785 | 0.0785 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0091 | 0.0785 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0091 | 0.0785 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0091 | 0.0785 | 0.0785 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0091 | 0.0785 | 0.0785 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0091 | 0.0785 | 0.0785 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0091 | 0.0785 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0091 | 0.0785 | 0.0785 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0091 | 0.0785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0785 | 0.0785 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0091 | 0.0785 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0091 | 0.0785 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0091 | 0.0785 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0091 | 0.0785 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0091 | 0.0785 | 0.0785 |
Schistosoma mansoni | thyroid hormone receptor | 0.0091 | 0.0785 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0091 | 0.0785 | 0.0785 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0091 | 0.0785 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0091 | 0.0785 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0091 | 0.0785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0785 | 0.0785 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0091 | 0.0785 | 0.0785 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0091 | 0.0785 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0091 | 0.0785 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0091 | 0.0785 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0091 | 0.0785 | 1 |
Brugia malayi | steroid hormone receptor | 0.0091 | 0.0785 | 0.0785 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0091 | 0.0785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0091 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0091 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0091 | 0.0785 | 0.0785 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0091 | 0.0785 | 0.0785 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0091 | 0.0785 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0091 | 0.0785 | 0.0785 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0091 | 0.0785 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0091 | 0.0785 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0091 | 0.0785 | 0.0785 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0091 | 0.0785 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0091 | 0.0785 | 0.0785 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0091 | 0.0785 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0091 | 0.0785 | 0.0785 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0091 | 0.0785 | 0.0785 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0265 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1778 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.