Detailed information for compound 1390878

Basic information

Technical information
  • TDR Targets ID: 1390878
  • Name: 2-[6,7-dimethoxy-3-(3-methoxyphenyl)-2,4-diox oquinazolin-1-yl]-N-(5-methyl-1H-pyrazol-3-yl )acetamide
  • MW: 465.459 | Formula: C23H23N5O6
  • H donors: 2 H acceptors: 4 LogP: 2.21 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(cc1OC)c(=O)n(c(=O)n2CC(=O)Nc1n[nH]c(c1)C)c1cccc(c1)OC
  • InChi: 1S/C23H23N5O6/c1-13-8-20(26-25-13)24-21(29)12-27-17-11-19(34-4)18(33-3)10-16(17)22(30)28(23(27)31)14-6-5-7-15(9-14)32-2/h5-11H,12H2,1-4H3,(H2,24,25,26,29)
  • InChiKey: CSJPKRLBZNAWAB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[6,7-dimethoxy-3-(3-methoxyphenyl)-2,4-dioxo-quinazolin-1-yl]-N-(5-methyl-1H-pyrazol-3-yl)acetamide
  • 2-[6,7-dimethoxy-3-(3-methoxyphenyl)-2,4-dioxo-1-quinazolinyl]-N-(5-methyl-1H-pyrazol-3-yl)acetamide
  • 2-[2,4-diketo-6,7-dimethoxy-3-(3-methoxyphenyl)quinazolin-1-yl]-N-(5-methyl-1H-pyrazol-3-yl)acetamide
  • 2-[6,7-dimethoxy-3-(3-methoxyphenyl)-2,4-dioxo-quinazolin-1-yl]-N-(5-methyl-1H-pyrazol-3-yl)ethanamide
  • 2-[6,7-dimethoxy-3-(3-methoxyphenyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]-N-(3-methyl-1H-pyrazol-5-yl)acetamide
  • MLS000583048
  • SMR000206234
  • EU-0024418

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.001 0.0099 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Brugia malayi Hr1 repeat family protein 0.001 0.0099 0.0155
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0652 0.2498
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.001 0.0099 0.0155
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0427 0.1623
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.2575 1
Brugia malayi hypothetical protein 0.0035 0.0716 0.1167
Echinococcus granulosus tumor protein p63 0.0338 0.8233 0.8231
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0035 0.003
Brugia malayi Pre-SET motif family protein 0.0037 0.075 0.1223
Trichomonas vaginalis set domain proteins, putative 0.0287 0.6963 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0297 0.0426
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0649 0.0932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0035 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.075 0.0746
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1857 0.7198
Onchocerca volvulus 0.0024 0.0445 0.0623
Onchocerca volvulus 0.0029 0.0552 0.0778
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0049 0.0037
Loa Loa (eye worm) histone methyltransferase 0.001 0.0092 0.0144
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.001 0.0099 0.0088
Onchocerca volvulus Cathepsin L homolog 0.0024 0.0445 0.0623
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0652 0.1062
Echinococcus granulosus NDR protein kinase 0.001 0.0099 0.0088
Loa Loa (eye worm) hypothetical protein 0.0024 0.0445 0.0722
Plasmodium falciparum serine repeat antigen 7 0.0008 0.0035 0.0367
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.0445 0.13
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0297 0.3924
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0008 0.0035 0.0367
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0011 0.0016
Schistosoma mansoni cathepsin C 0.0008 0.0035 0.003
Trypanosoma brucei cysteine peptidase C (CPC) 0.005 0.1072 0.4138
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0256 0.3818
Onchocerca volvulus 0.0008 0.0035 0.0034
Brugia malayi pyruvate kinase, muscle isozyme 0.0007 0.001 0.0009
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.2575 0.7596
Loa Loa (eye worm) hypothetical protein 0.0018 0.0278 0.0449
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0011 0.0016
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0297 0.2527
Schistosoma mansoni ap endonuclease 0.0018 0.0297 0.0293
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0201 0.074
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.005 0.1072 0.4138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.075 0.0746
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0338 0.0327
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0578 0.8016
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.2575 0.2567
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0201 0.0322
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0578 0.5234
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0254 0.0948
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0024 0.0445 0.6765
Loa Loa (eye worm) hypothetical protein 0.0018 0.0278 0.0449
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0008 0.0035 0.0407
Brugia malayi pyruvate kinase 0.0007 0.001 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0278 0.04
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0652 0.1913
Echinococcus granulosus pyruvate kinase 0.0017 0.0256 0.0245
Echinococcus granulosus protein kinase C gamma type 0.001 0.0099 0.0088
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0008 0.0035 0.003
Loa Loa (eye worm) pyruvate kinase 0.0007 0.001 0.0009
Echinococcus granulosus cysteine protease 0.0015 0.0201 0.019
Loa Loa (eye worm) hypothetical protein 0.0143 0.3389 0.5552
Echinococcus granulosus protein kinase c iota type 0.001 0.0099 0.0088
Plasmodium vivax serine-repeat antigen (SERA) 0.0008 0.0035 0.0407
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0011 0.002
Leishmania major ATP-dependent phosphofructokinase 0.011 0.2575 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.0652 0.0641
Brugia malayi cathepsin Z-like cysteine proteinase 0.0008 0.0035 0.005
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0278 0.0274
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.001 0.0093 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Plasmodium falciparum cysteine proteinase falcipain 3 0.0024 0.0445 0.6765
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0008 0.0035 0.005
Brugia malayi cathepsin Z-like cysteine proteinase 0.0008 0.0035 0.005
Brugia malayi Cathepsin L-like precursor 0.0024 0.0445 0.0722
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0035 0.003
Giardia lamblia Kinase, AGC PKA 0.002 0.0344 0.2979
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0035 0.005
Echinococcus multilocularis protein kinase c epsilon type 0.001 0.0099 0.0088
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.2575 0.3698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0035 0.005
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0588
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0008 0.0035 0.0407
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0427 0.1623
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0427 0.0694
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0035 0.005
Echinococcus multilocularis serine:threonine protein kinase N2 0.001 0.0099 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0035 0.005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0652 0.1062
Schistosoma mansoni pyruvate kinase 0.0017 0.0256 0.0251
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Plasmodium falciparum serine repeat antigen 3 0.0008 0.0035 0.0367
Loa Loa (eye worm) hypothetical protein 0.0008 0.0035 0.005
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0008 0.0035 0.0407
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0011 0.002
Plasmodium falciparum serine repeat antigen 9 0.0008 0.0035 0.0367
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0297 0.0286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Schistosoma mansoni hypothetical protein 0.0409 1 1
Brugia malayi Cathepsin L-like precursor 0.0024 0.0445 0.0722
Loa Loa (eye worm) hypothetical protein 0.0024 0.0427 0.0694
Brugia malayi Protein kinase domain containing protein 0.001 0.0099 0.0155
Trichomonas vaginalis AGC family protein kinase 0.001 0.0099 0.0142
Plasmodium falciparum serine repeat antigen 2 0.0008 0.0035 0.0367
Brugia malayi CXXC zinc finger family protein 0.0029 0.0552 0.0898
Entamoeba histolytica protein kinase, putative 0.0033 0.0649 0.2487
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0008 0.0035 0.005
Leishmania major cathepsin L-like protease 0.0024 0.0445 0.169
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0652 0.0921
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0035 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0024 0.0445 0.0639
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0578 0.8844
Brugia malayi 6-phosphofructokinase 0.011 0.2575 0.4217
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0427 0.1623
Loa Loa (eye worm) hypothetical protein 0.0008 0.0035 0.005
Echinococcus multilocularis nervana 2 0.002 0.0338 0.0327
Echinococcus granulosus cathepsin L 0.0015 0.0201 0.019
Trichomonas vaginalis AGC family protein kinase 0.0012 0.0149 0.0214
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0024 0.0445 0.0434
Echinococcus multilocularis cathepsin L cysteine protease 0.0024 0.0445 0.0434
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0143 0.3389 0.3386
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0099 0.0094
Schistosoma mansoni cpg binding protein 0.003 0.0593 0.0588
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0024 0.0445 0.0722
Echinococcus multilocularis cpg binding protein 0.003 0.0593 0.0582
Giardia lamblia Pyruvate kinase 0.0033 0.0652 0.5948
Toxoplasma gondii cathepsin CPC1 0.0008 0.0035 0.018
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0024 0.0445 0.0639
Plasmodium falciparum serine repeat antigen 8 0.0008 0.0035 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1857 0.7198
Echinococcus multilocularis pyruvate kinase 0.0017 0.0256 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0035 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0008 0.0035 0.005
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Entamoeba histolytica cysteine protease, putative 0.0008 0.0035 0.0092
Trypanosoma cruzi cysteine protease, putative 0.0015 0.0201 0.0581
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0652 0.0921
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.61 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.001 0.0099 0.0155
Entamoeba histolytica hypothetical protein 0.0035 0.0716 0.2747
Brugia malayi cathepsin B-like cysteine proteinase 0.0143 0.3389 0.5552
Schistosoma mansoni 6-phosphofructokinase 0.011 0.2575 0.2572
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0427 0.1623
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0011 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0427 0.1623
Loa Loa (eye worm) hypothetical protein 0.001 0.0099 0.0155
Schistosoma mansoni serine/threonine kinase 0.001 0.0099 0.0094
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.2575 1
Brugia malayi 6-phosphofructokinase 0.011 0.2575 0.4217
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0652 0.2498
Entamoeba histolytica hypothetical protein 0.0008 0.0035 0.0092
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.001 0.0099 0.0088
Onchocerca volvulus 0.0024 0.0445 0.0623
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0099 0.0094
Echinococcus granulosus serine:threonine protein kinase N2 0.001 0.0099 0.0088
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0008 0.0035 0.0407
Trypanosoma cruzi major cysteine proteinase, putative 0.0065 0.1447 0.4262
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0008 0.0035 0.0407
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0427 0.1623
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0254 0.0948
Loa Loa (eye worm) hypothetical protein 0.0008 0.0035 0.005
Leishmania major pyruvate kinase 0.0033 0.0652 0.2498
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0394 0.0383
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.2575 0.3698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Giardia lamblia Cathepsin B precursor 0.005 0.1072 1
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0445 0.0722
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0427 0.1623
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0008 0.0035 0.0407
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0011
Echinococcus granulosus nervana 2 0.002 0.0338 0.0327
Echinococcus granulosus cpg binding protein 0.003 0.0593 0.0582
Onchocerca volvulus 0.0024 0.0445 0.0623
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0297 0.048
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0297 0.0286
Leishmania major cysteine peptidase A (CPA) 0.0024 0.0445 0.169
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0578 0.7691
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0008 0.0035 0.003
Toxoplasma gondii cathepsin CPL 0.0024 0.0445 0.3313
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1857 0.7198
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0092 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0099 0.0094
Brugia malayi phosphofructokinase 0.011 0.2575 0.4217
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0652 0.1062
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0578 0.1232
Toxoplasma gondii cathepsin B 0.005 0.1072 0.8112
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1319 0.1315
Leishmania major cathepsin L-like protease 0.0024 0.0445 0.169
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0445 0.0639
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0011 0.0091
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0278 0.4171
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0201 0.0197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1857 0.7198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0201 0.0289
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0652 0.0936
Echinococcus granulosus cathepsin b 0.0143 0.3389 0.3381
Brugia malayi protein kinase C II. 0.001 0.0099 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0099 0.0094
Plasmodium vivax vivapain-3 0.0015 0.0201 0.2636
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0008 0.0035 0.0407
Entamoeba histolytica cysteine protease, putative 0.0008 0.0035 0.0092
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0278 0.1042
Echinococcus multilocularis cathepsin b 0.0143 0.3389 0.3381
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.001 0.0099 0.0088
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0578 0.4331
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0427 0.1623
Entamoeba histolytica phosphofructokinase, putative 0.011 0.2575 1
Loa Loa (eye worm) ctsf protein 0.0024 0.0445 0.0722
Echinococcus multilocularis dnaJ subfamily B 0.0409 1 1
Brugia malayi fibroinase precursor 0.0008 0.0035 0.005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1223 0.9266
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1319 0.5101
Echinococcus granulosus pyruvate kinase 0.0033 0.0652 0.0641
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0445 0.0639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0035 0.005
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0084 0.0131
Brugia malayi Cathepsin L-like precursor 0.0024 0.0445 0.0722
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0256 0.187
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0035 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0278 0.04
Echinococcus multilocularis cathepsin L 0.0015 0.0201 0.019
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0024 0.0445 0.6765
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.0201 0.0581
Echinococcus granulosus cathepsin L cysteine proteinase 0.0024 0.0445 0.0434
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0201 0.0581
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0008 0.0035 0.0407
Onchocerca volvulus Cathepsin L homolog 0.0024 0.0445 0.0623
Toxoplasma gondii cathepsin CPC2 0.0008 0.0035 0.018
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.005 0.1072 0.3155
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0297 0.0864
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.001 0.0099 0.0155
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0427 0.1623
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.075 0.0746
Echinococcus granulosus pyruvate kinase 0.0017 0.0256 0.0245
Giardia lamblia Cathepsin B precursor 0.005 0.1072 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0427 0.0694
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0445 0.0639
Loa Loa (eye worm) phosphofructokinase 0.011 0.2575 0.4217
Loa Loa (eye worm) hypothetical protein 0.0037 0.075 0.1223
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0427 0.1623
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0201 0.074
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1319 0.1315
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0578 0.2209
Loa Loa (eye worm) hypothetical protein 0.0024 0.0427 0.0694
Echinococcus granulosus cathepsin l1 0.0024 0.0445 0.0434
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0011 0.002
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0024 0.0445 0.0722
Echinococcus granulosus protein kinase c epsilon type 0.001 0.0099 0.0088
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0297 0.1114
Onchocerca volvulus 0.0024 0.0445 0.0623
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0338 0.0327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1857 0.7198
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.002 0.0344 0.0333
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.2575 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0445 0.0639
Echinococcus multilocularis cathepsin b 0.0143 0.3389 0.3381
Trypanosoma cruzi cruzipain precursor, putative 0.0081 0.1857 0.5473
Plasmodium vivax SET domain protein, putative 0.0037 0.075 1
Echinococcus granulosus Protein kinase C brain isozyme 0.001 0.0099 0.0088
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0406 0.1538
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1857 0.7198
Onchocerca volvulus 0.0037 0.075 0.1062
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0599 0.0975
Echinococcus granulosus cathepsin l1 0.0018 0.0278 0.0267
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0427 0.0694
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0297 0.0426
Trypanosoma brucei rac serine-threonine kinase, putative 0.0033 0.0649 0.2487
Brugia malayi cathepsin F-like cysteine proteinase 0.0008 0.0035 0.005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0092 0.0081
Trypanosoma cruzi Protein kinase B 0.0022 0.0394 0.115
Onchocerca volvulus 0.0049 0.1067 0.1519
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1857 0.7198
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0652 0.8684
Entamoeba histolytica protein kinase 2, putative 0.002 0.0344 0.1297
Onchocerca volvulus 0.0024 0.0445 0.0623
Schistosoma mansoni cpg binding protein 0.0029 0.0552 0.0548
Echinococcus multilocularis cathepsin L cysteine protease 0.0024 0.0445 0.0434
Entamoeba histolytica cysteine protease, putative 0.0008 0.0035 0.0092
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0201 0.0322
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.002 0.0344 0.5191
Plasmodium falciparum serine repeat antigen 1 0.0008 0.0035 0.0367
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0049 0.0037
Echinococcus granulosus cathepsin b 0.0143 0.3389 0.3381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.0201 0.074
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1319 1
Giardia lamblia Pyruvate kinase 0.0017 0.0256 0.2131
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0278 0.3676
Giardia lamblia Cathepsin B precursor 0.005 0.1072 1
Echinococcus multilocularis cysteine protease 0.0024 0.0445 0.0434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1857 0.7198
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0445 0.0639
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0297 0.048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0445 0.0639
Echinococcus granulosus pyruvate kinase 0.0017 0.0256 0.0245
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1319 0.5101
Entamoeba histolytica hypothetical protein 0.0035 0.0716 0.2747
Loa Loa (eye worm) cathepsin B 0.005 0.1072 0.1751
Toxoplasma gondii preprocathepsin c precursor, putative 0.0008 0.0035 0.018
Entamoeba histolytica hypothetical protein 0.0035 0.0716 0.2747
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0008 0.0035 0.005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0716 0.0705
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0008 0.0035 0.0092
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0008 0.0035 0.0367
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0035 0.003
Brugia malayi Cathepsin L-like precursor 0.0018 0.0278 0.0449
Echinococcus granulosus cathepsin L 0.0008 0.0035 0.0024
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0297 0.1114
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0089 0.0139
Plasmodium falciparum pyruvate kinase 0.0033 0.0652 1
Entamoeba histolytica phosphofructokinase, putative 0.011 0.2575 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0075 0.1691 0.4982
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0652 0.0921
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0652 0.2498
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0445 0.169
Loa Loa (eye worm) hypothetical protein 0.0018 0.0278 0.0449
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0338 0.0327
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.2575 0.4217
Echinococcus multilocularis protein kinase c iota type 0.001 0.0099 0.0088
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.075 0.0739
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0599 0.0975
Loa Loa (eye worm) hypothetical protein 0.0018 0.0278 0.0449
Echinococcus granulosus pyruvate kinase 0.0033 0.0652 0.0641
Onchocerca volvulus Cathepsin F homolog 0.0024 0.0445 0.0623
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.1857 0.5473
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0008 0.0035 0.0407
Plasmodium falciparum serine repeat antigen 6 0.0008 0.0035 0.0367
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0649 0.0932
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0652 0.0936
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.001 0.0099 0.0155
Onchocerca volvulus 0.0018 0.0278 0.0384
Loa Loa (eye worm) hypothetical protein 0.0008 0.0035 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1857 0.7198
Loa Loa (eye worm) hypothetical protein 0.0023 0.0406 0.0658
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1319 0.1309
Entamoeba histolytica cysteine protease, putative 0.0024 0.0445 0.169
Schistosoma mansoni hypothetical protein 0.0035 0.0716 0.0711
Echinococcus multilocularis pyruvate kinase 0.0017 0.0256 0.0245
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0024 0.0445 0.0434
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.002 0.0344 0.4552
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0297 0.0864
Schistosoma mansoni cathepsin S (C01 family) 0.0008 0.0035 0.003
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0008 0.0035 0.0407
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0427 0.1623
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0011 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0201 0.074
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0143 0.3389 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0649 0.1057
Leishmania major cathepsin L-like protease 0.0024 0.0445 0.169
Entamoeba histolytica hypothetical protein 0.0035 0.0716 0.2747
Schistosoma mansoni 6-phosphofructokinase 0.011 0.2575 0.2572
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1319 0.1309
Entamoeba histolytica phosphofructokinase, putative 0.011 0.2575 1
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.0201 0.0581
Echinococcus multilocularis pyruvate kinase 0.0026 0.048 0.047
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0099 0.0094
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0578 0.8844
Entamoeba histolytica cysteine protease, putative 0.0008 0.0035 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0254 0.0948
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0445 0.0639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Brugia malayi Cathepsin L-like precursor 0.0024 0.0445 0.0722
Entamoeba histolytica cysteine protease, putative 0.0008 0.0035 0.0092
Trypanosoma cruzi major cysteine proteinase, putative 0.0008 0.0035 0.009
Leishmania major cathepsin L-like protease 0.0024 0.0445 0.169
Echinococcus multilocularis pyruvate kinase 0.0033 0.0652 0.0641
Echinococcus granulosus cathepsin L cysteine protease 0.0015 0.0201 0.019
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0652 0.2498
Leishmania major cathepsin L-like protease 0.0081 0.1857 0.7198
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0297 0.1114
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.1857 0.5473
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0445 0.0639
Loa Loa (eye worm) hypothetical protein 0.0018 0.0278 0.0449
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0578 0.083
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0394 0.039
Mycobacterium ulcerans hypothetical protein 0.0024 0.0427 0.1623
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0099 0.0094
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0394 0.0383
Brugia malayi Protein kinase domain containing protein 0.001 0.0099 0.0155
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0649 0.0932
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0427 0.1623
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0011 0.0011
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0394 0.039
Echinococcus granulosus 6 phosphofructokinase 0.011 0.2575 0.2567
Echinococcus granulosus nervana 2 0.002 0.0338 0.0327
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0008 0.0035 0.005
Loa Loa (eye worm) hypothetical protein 0.0008 0.0035 0.005
Plasmodium falciparum serine repeat antigen 4 0.0008 0.0035 0.0367
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0256 0.3373
Brugia malayi cathepsin L-like cysteine proteinase 0.0008 0.0035 0.005
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.2575 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0578 0.083
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0011 0.0011
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0578 0.083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.3389 0.3386
Brugia malayi Cathepsin L-like precursor 0.0024 0.0445 0.0722
Echinococcus multilocularis cathepsin L 0.0008 0.0035 0.0024
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0008 0.0035 0.0092
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0649 0.0932
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0649 0.0932
Toxoplasma gondii AGC kinase 0.0031 0.0599 0.4492
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0578 0.8016
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0008 0.0035 0.005
Leishmania major cathepsin L-like protease 0.0081 0.1857 0.7198
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0008 0.0035 0.005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0049 0.0037
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0011 0.0011
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0652 0.1062
Echinococcus multilocularis serine threonine protein kinase 0.001 0.0099 0.0088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.0201 0.074
Echinococcus multilocularis serine:threonine protein kinase 38 0.001 0.0099 0.0088
Schistosoma mansoni pyruvate kinase 0.0033 0.0652 0.0648
Entamoeba histolytica cysteine protease, putative 0.0008 0.0035 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1857 0.7198
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0008 0.0035 0.003
Loa Loa (eye worm) cysteine protease 0.0024 0.0445 0.0722
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0201 0.0197
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0201 0.0197
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0297 0.1114
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0394 0.1492
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.2575 0.3698
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0035 0.005
Echinococcus multilocularis nervana 2 0.002 0.0338 0.0327
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0652 0.1062
Loa Loa (eye worm) hypothetical protein 0.0049 0.1067 0.1743
Plasmodium vivax unspecified product 0.0008 0.0035 0.0407
Schistosoma mansoni pyruvate kinase 0.0033 0.0652 0.0648
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1319 0.5101
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0297 0.5
Trypanosoma cruzi rac serine-threonine kinase, putative 0.002 0.0344 0.1003
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0578 0.4331
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0427 0.1623
Plasmodium vivax vivapain-2 0.0024 0.0445 0.5905
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0578 0.083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.3389 0.3386
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0278 0.1042
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0011 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0445 0.169
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0008 0.0035 0.005
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0297 0.446
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0099 0.0094
Loa Loa (eye worm) hypothetical protein 0.0024 0.0427 0.0694
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0011 0.0011
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0008 0.0035 0.005
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0652 0.2498
Echinococcus multilocularis Protein kinase C, brain isozyme 0.001 0.0099 0.0088
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0011 0.0011
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0649 0.0932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0035 0.005
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0578 0.083
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0652 0.1062
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.2575 1
Entamoeba histolytica protein kinase, putative 0.001 0.0099 0.0342
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.075 0.0739
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.001 0.0099 0.0088
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.1067 0.1063
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0008 0.0035 0.0367
Entamoeba histolytica cysteine proteinase 2 0.0015 0.0201 0.074
Plasmodium vivax serine-repeat antigen (SERA) 0.0008 0.0035 0.0407
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0427 0.1623
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0649 0.0932
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0008 0.0035 0.005
Onchocerca volvulus Cathepsin L homolog 0.0008 0.0035 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0081 0.1857 0.7198
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0008 0.0035 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0652 0.1913
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0338 0.0327
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0394 0.115
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.001 0.0099 0.0088
Entamoeba histolytica protein kinase, putative 0.0031 0.0599 0.2291
Onchocerca volvulus 0.0024 0.0427 0.0599
Brugia malayi cathepsin L precursor 0.0008 0.0035 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0024 0.0445 0.0639
Loa Loa (eye worm) hypothetical protein 0.0018 0.0278 0.0449
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.1857 0.5473
Plasmodium falciparum cysteine proteinase falcipain 1 0.0015 0.0201 0.2961
Plasmodium falciparum serine repeat antigen 5 0.0008 0.0035 0.0367
Toxoplasma gondii exonuclease III APE 0.0018 0.0297 0.2184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Leishmania major cathepsin L-like protease 0.0024 0.0445 0.169
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0394 0.1492
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0445 0.044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0049 0.0037
Schistosoma mansoni atypical protein kinase C 0.001 0.0099 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0035 0.005
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0015 0.0201 0.0581
Plasmodium vivax vivapain-1 0.0015 0.0201 0.2636
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0427 0.1623
Leishmania major cathepsin L-like protease 0.0081 0.1857 0.7198
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0701 0.0691
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0552 0.0898
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.075 0.5648
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0254 0.0948
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0445 0.0639
Trichomonas vaginalis AGC family protein kinase 0.001 0.0099 0.0142
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0578 0.083
Loa Loa (eye worm) hypothetical protein 0.0018 0.0278 0.0449
Onchocerca volvulus 0.0287 0.6963 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0035 0.005
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.001 0.0099 0.0155
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0578 0.4331
Loa Loa (eye worm) hypothetical protein 0.0008 0.0035 0.005
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.2575 0.4217
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0011 0.0007
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0578 0.7691
Echinococcus granulosus cathepsin l cysteine peptidase 0.0024 0.0445 0.0434
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0008 0.0035 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0008 0.0035 0.005
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0716 0.0711
Brugia malayi cathepsin L-like precursor 0.0018 0.0278 0.0449
Leishmania major pyruvate kinase 0.0033 0.0652 0.2498
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.002 0.0344 0.0333
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0201 0.074
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0406 0.0658
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0578 0.083
Schistosoma mansoni cathepsin B (C01 family) 0.0008 0.0035 0.003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0427 0.1623
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.2575 0.3698
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1385 0.1381
Brugia malayi Cathepsin L-like precursor 0.0018 0.0278 0.0449
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0297 0.1114
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0445 0.044
Brugia malayi Cathepsin L-like precursor 0.0024 0.0445 0.0722
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0035 0.005
Brugia malayi Protein kinase domain containing protein 0.0033 0.0649 0.1057
Schistosoma mansoni ap endonuclease 0.0018 0.0297 0.0293
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0652 0.4898
Echinococcus multilocularis serine:threonine protein kinase N2 0.001 0.0099 0.0088
Entamoeba histolytica protein kinase, putative 0.0033 0.0649 0.2487
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0008 0.0035 0.003
Onchocerca volvulus 0.0024 0.0445 0.0623
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.075 0.0739
Echinococcus multilocularis tumor protein p63 0.0338 0.8233 0.8231
Onchocerca volvulus 0.0024 0.0445 0.0623
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Loa Loa (eye worm) oxidoreductase 0.0007 0.0011 0.0011
Brugia malayi Pre-SET motif family protein 0.0252 0.61 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0201 0.0289
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1319 0.5101
Loa Loa (eye worm) hypothetical protein 0.0018 0.0278 0.0449
Echinococcus multilocularis cysteine protease 0.0024 0.0445 0.0434
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0049 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0008 0.0035 0.005
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.3389 0.3386
Loa Loa (eye worm) AGC/NDR protein kinase 0.001 0.0099 0.0155
Echinococcus granulosus serine threonine protein kinase nrc 0.002 0.0344 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.1072 0.154
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.075 0.0746
Loa Loa (eye worm) fibroinase 0.0024 0.0445 0.0722
Chlamydia trachomatis pyruvate kinase 0.0033 0.0652 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0716 0.0705
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1319 0.5101
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.0278 0.0449
Trichomonas vaginalis AGC family protein kinase 0.001 0.0099 0.0142
Entamoeba histolytica cysteine proteinase 1, putative 0.0015 0.0201 0.074
Plasmodium vivax vivapain-2 0.0024 0.0445 0.5905
Echinococcus multilocularis pyruvate kinase 0.0017 0.0256 0.0245
Plasmodium vivax unspecified product 0.0015 0.0201 0.2636
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0278 0.1042
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.1072 0.1068
Entamoeba histolytica cysteine protease, putative 0.0015 0.0201 0.074
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0427 0.1623

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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